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`Juvenile Idiopathic
`Arthritis
`How Is JIA Diagnosed?
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`Juvenile Idiopathic Arthritis (JIA)
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`Juvenile Idiopathic Arthritis (JIA) consists of a group of childhood chronic (long term)
`arthritis including what has been formerly called Juvenile Rheumatoid Arthritis (JRA) and
`Juvenile Chronic Arthritis (JCA).
`
`It now also includes other forms of chronic childhood arthritis such as psoriatic arthritis,
`enthesitis-related arthritis and undifferentiated arthritis.
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`JIA is an autoimmune disease, which is defined by the presence of arthritis for at least six
`weeks in a child less than 17 years of age.
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`Arthritis is joint inflammation, which may cause joint swelling, pain and/or stiffness.
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`JIA is the most common cause of chronic arthritis in children and affects children
`worldwide, with no racial predilection.
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`Approximately 1/1,000 children, or more than 300,000 children in the U.S. have JIA.
`Although children of all ages may get JIA, it is rare before six months of age.
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`Arthritis may affect any joint, even your jaw and spine.
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`JIA may be categorized into several subtypes, some of which may be associated with
`other diseases, which may affect the eyes or gastrointestinal tract, for example.
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`Although there are several sub-types of JIA, all patients are affected by chronic arthritis.
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`The severity of arthritis is variable, and patients may have an unpredictable flare
`(worsening) of their arthritis. Sometimes this flare may relate to the weather, viral
`infections or inactivity.
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`Learn More
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`How is JIA diagnosed?
`What causes JIA?
`Types of JIA
`How is JIA treated?
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`http://pediatrics.med.nyu.edu/rheumatology/patient-care/juvenile-idiopathic-arthritis-jia[11/18/14 1:00:28 PM]
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`Medac Exhibit 2078
`Frontier Therapeutics v. Medac
`IPR2016-00649
`Page 00001
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`Juvenile Idiopathic Arthritis (JIA)
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