Steven H. Zeisel, MD, PhD
`
`UNC Nutrition Research Institute
`University of North Carolina at Chapel Hill
`500 Laureate Way, Room 2218
`Kannapolis, NC 28081
`Phone: 704 250-5003
`Fax: 704 250-5001
`EMAIL: steven_zeisel@unc.edu
`
`
`
`Experience, Professional
`2006–present University of North Carolina at Chapel Hill. Director, Nutrition Research Institute
`2005-present University of North Carolina at Chapel Hill. Kenan Distinguished University
`Professor of Nutrition and Pediatrics
`1999– 2007 University of North Carolina at Chapel Hill. Associate Dean for Research, School
`of Public Health
`University of North Carolina at Chapel Hill. Chairman, Department of Nutrition,
`School of Public Health and School of Medicine
`1990-present University of North Carolina at Chapel Hill. Professor of Nutrition and Pediatrics
`2004-2005
`University of North Carolina at Chapel Hill. AICR/WCRF Professor in Food,
`Nutrition and Prevention of Cancer
`Boston University School of Medicine. Assistant, Associate and Full Professor,
`Department of Pathology
`Boston City Hospital Department of Pediatrics. Assistant, Associate Visiting
`Physician
`
`1990-2005
`
`1982–1990
`
`1982–1990
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`
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`Education
`Postdoctoral Fellow in Neurochemistry. Massachusetts Institute of Technology
`1980-1981
`Fellow in Human Nutrition. Children's Hospital Medical Center, Boston.
`1978-1981
`Doctor of Philosophy. Nutrition. Massachusetts Institute of Technology.
`1977-1980
`Pediatric Resident. Yale-New Haven Hospital.
`
`1975-1977
`1971-1975 Doctor of Medicine. Harvard Medical School
`1967-1971 Bachelor of Science. Massachusetts Institute of Technology
`
`National and International Service
`National Panel Service
`2001-2005
`Scientific Advisory Panel, Dietary Supplements, Food and Drug Administration
`USA.
`National Academy of Sciences, U.S.A., Committee on Dietary Required Intakes,
`Panel on Folate, B-vitamins and Choline.
`Scientific panel, second version of “Food, Nutrition and the Prevention of Cancer:
`a global perspective”, World Cancer Research Fund.
`
`1997-1999
`
`2004-2011
`
`
`National Institutes of Health Study sections
`2014
`NIH Special Emphasis Review Panel – Diabetes Research Center
`2012 NIDDK Diabetes Research Centers (P30)
`2011 Chair, Molecular Mechanisms for Actions of Botanicals Study Section, NIH.
`2010 Nutrition Obesity Research Centers study section, NIH
`2004-2006
`Chair, Integrative Nutrition and Metabolic Processes study section, NIH
`2003
`Chair, Special Emphasis Panel, NIH
`2000-2006
`Integrative Nutrition and Metabolic Processes study section, NIH
`
`Editorial Board Service
`Editor, Present Knowledge in Nutrition Volume 10, 2010-present.
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`Section Editor, Frontiers in Nutrigenomics, 2010-present.
`Editorial Board, FASEB Journal, 2005-present.
`Editorial Board, Functional Food Reviews, 2009-present.
`Associate Editor, Functional Food Reviews, 2008-present.
`Editorial Board, Annual Review of Nutrition, 2003-2008.
`Consultant editor, Nutrition Research, 1996-present.
`
`Professional Society and Industry Service
`External Advisory Board for the Nutrition Obesity Research Center at Harvard (NORC-H)
`Member, Academy of Nutrition and Dietetics Research Advisory Board (formerly the American
`Dietetic Association), 2012
`Member, Hershey Health & Wellness Advisory Board, 2005-2009.
`Member, Board of Trustees of the North American branch of the International Life Sciences
`Institute (ILSI N.A.), 2004-2007.
`President, American Society for Nutrition 2002-2003; (this is the premier nutrition research
`society and a component of FASEB Journal). Strategic Oversight Committee, 2004-present;
`Chair, Long-Range Planning Committee, 2000-2001; Chair, Graduate Nutrition Education
`Committee, 1997-1999; Chair, Standing Committee on Medical/Dental School Residency
`Nutrition Education and Subspecialty Training, 1995-1997; Councilor, 1991-1994; Chair,
`Membership Committee, 1990-1994.
`Member, Board of Scientific and Policy Advisors, American Council on Science and Health, 2000-
` present.
`Member, NCI/FDA Biomarker and Cancer Risk Workshop, 2006.
`Member, Dupont Health Advisory Board, 2005-present.
`Member, Solae Scientific Advisory Board, 2005-present.
`Member, Western Pistachio Association, 2011-present.
`Member, Metabolon Scientific Advisory Board, 2009-present.
`Member, GenoVive Scientific Advisory Board, 2012-present.
`Member, Advisory Board to the Commission on Secretion and Absorption, International Union of
`Physiological Sciences, 2003-2005.
`Member, Grant Review Panel, American Institute for Cancer Research; 1998-2000.
`External Advisory Board, South Carolina’s Center for Cancer Research
` Excellence, 2009
`External Advisory Board, University of Alabama at Birmingham, Nutrition Obesity Research
`Center, 2000-present.
`External Advisory Board, Washington University, Nutrition Obesity Research Center, 2000-
`present.
`
`
`Honors
`Bernard G. Greenberg Alumni Endowment Award, The University of North Carolina at Chapel
`Hill, 2013
`Mildred A. Reeves Distinguished Visiting Professor in Nutrition, University of Tennessee, 2011
`Hans Falk Memorial Lecturer, National Institute of Environmental Health Sciences, 2010
`W.O. Atwater Lecturer, U.S. Department of Agriculture's Agricultural Research Service, 2009
`The American Society for Nutrition Osborne and Mendel Award, 2008.
`The American College of Nutrition Award for Outstanding Achievements in Nutrition, 2007.
`Bristol-Meyers Squibb/Mead Johnson Award for Distinguished Achievement in Nutrition
`Research, 2006.
`Who’s Who in the World, 2004-present.
`
`Membership in Professional Societies
`American Society for Nutrition (formerly American Institute of Nutrition and American Society for
`Clinical Nutrition), 1987-present.
`
`
`Grant Support - Current
`NIDDK, P30 DK56350, University of North Carolina Nutrition Obesity Research Center (S. Zeisel,
`P.I.) 09/30/99-03/31/16, $725,756 annual direct ($7,257,560 total award).
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`US Department of Agriculture, 58-1235-0-185, Choline Content of Commonly Eaten Foods (S.
`Zeisel, P.I.) 09/17/05 – 08/31/15, $1,900 annual direct.
`Pfizer (No Number), Develop a screening platform using cell culture and mouse models (S.Zeisel,
`P.I.) 02/01/12 – 01/31/17, $200,000 annual direct ($1,000,000).
`Pfizer (No Number), Human metabolomics profiling studies on breast milk and microbiome (S.
`Zeisel, P.I.) 02/01/12 – 01/31/17, $150,000 annual direct ($750,000 total award).
`NIH R25 GM103802-01, Online learning platform: introducing clinicians and researchers to
`metabolomics (S. Zeisel, Co-PI) 09/01/12 – 08/31/2017, $51,552 annual direct ($489,999
`total award).
`NIH R01DK104371, Transition to a western diet and cardiometabolic risk: Biomarkers derived
`from the microbiome (S. Zeisel, Co-P.I.) 07/01/2015 – 06/30/2020, $198,158 annual direct
`($3,490,987 total award).
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`3.
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`4.
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`5.
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`6.
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`7.
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`Publications (last 5 years from more than 250 publications)
`Peer Reviewed
`Zeisel, S.H. (2011) What choline metabolism can tell us about the underlying mechanism
`1.
`of fetal alcohol spectrum disorders. Molecular Neurobiology. doi 10.1007/s12035-011-
`8165-5. PMID: 21259123.
`da Costa, K-A, Sanders, L.M., Fischer, L.M., Zeisel, S.H., (2011) Docosahexaenoic acid in
`plasma phosphatidylcholine may be a potential marker for in vivo
`phosphatidylethanolaminie N-methyltransferase activity in humans. American Journal of
`Clinical Nutrition. 93(5): 968-74. PMCID: PMC3076652.
`Zeisel, S.H. (2011) The supply of choline is important for fetal progenitor cells. Seminars in
`Cell and Development Biology. 22: 624 - 628. PMCID: PMC3188336.
`Teng, Y-W, Mehedint, M.G., Garrow, T.A., Zeisel, S.H. (2011) Deletion of betaine-
`homocysteine S-methyltransferase in mice perturbs choline and 1-carbon metabolism,
`resulting in fatty liver and hepatocellular carcinoma. Journal of Biological Chemistry.
`286(42): 36258 – 67. PMCID: PMC3196139.
`Zeisel, S.H. (2011) Dietary choline deficiency causes DNA strand breaks and alters
`epigenetic marks on DNA and histones. Mutation Research. 733: 34 – 38. PMCID:
`PMC3319504.
`Zeisel, S.H. (2011) Choline Metabolism Provides Novel Insights into Non-alcoholic Fatty
`Liver Disease and is Progression. Current Opinion in Gastroeneterology. 28(2): 159 –
`165. PMID: 22134222.
`Teng, Y-W, Ellis, J.M., Coleman, R.A., Zeisel, S.H. (2012) Mouse Betaine-Homocysteine
`S-Methyltransferase deficiency reduces body fat via increasing energy expenditure and
`impairing lipid synthesis and enhancing glucose oxidation in white adipose tissue. Journal
`of Biological Chemistry. 287(20): 16187 – 98. PMID: 22362777.
`Johnson, A.R., Lao, S., Wang, T., Galanko, J.A., Zeisel, S.H., (2012) Choline
`dehydrogenase polymorphism rs12676 is a functional variation and is associated with
`changes in human sperm cell function. PLoS ONE. 7(4): e36047. PMID: 22558321.
`Richman, E.L., Kenfield, S.A., Stampfer, M.J., Giovannucci, E.L., Zeisel, S.H., Willett,
`W.C., Chan, J.M. (2012) Choline intake and risk of lethal prostate cancer: incidence and
`survival. American Journal of Clinical Nutrition. 96(4): 855 – 863. PMID: 22952174.
`10. Cheatham, C.L., Goldman, B.D., Fischer, L.M., da Costa, K-A, Reznick, S., Zeisel, S.H.
`(2012) Phosphatidylcholine supplementation in pregnant women consuming moderate
`choline diets does not enhance infant cognitive function: a randomized double-blind
`placebo-controlled trial. American Journal of Clinical Nutrition. 96(6): 1465 – 72.
`PMCID: PMC3497930.
`11. Tsang, V., Fry,R., Niculescu, M., Saunders, J., Paul, D., Zeisel, S.H., Waalkes, M., Styblo,
`M., Drobna, Z. (2012) The epigenetic effects of a high prenatal folate intake in male
`mouse fetuses exposed in utero to arsenic. Toxicology and Applied Pharmacology.
`264(3): 439 – 50. PMCID: PMC3478409.
`12. Zeisel, S.H., Waterland, R.A., Ordovas, J.M., Muoio, D., Jia, W., Fodor, A. (2012)
`Highlights of the 2012 Research Workshop: Using Nutrigenomics and Metabolomics in
`Clinical Nutrition Research. Journal of Parenteral and Enteral Nutrition. doi:
`10.1177/0148607112462401. PMCID: PMC3593226.
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`13. Zeisel, S.H. (2012) Metabolic crosstalk between choline/1-carbon metabolism and energy
`homeostatis. Clinical Chemistry and Laboratory Medicine. 51(3): 467 - 75. PMCID:
`PMC3624053.
`14. Teng, Y-W, Cerdena, I., Zeisel, S.H. (2012) Homocysteinemia in Mice with Genetic Betaine
`Homocysteine S-Methyltransferase Deficiency Is Independent of Dietary Folate Intake.
`The Journal of Nutrition. 142(11): 1964 – 7. PMCID: PMC3497933.
`15. Corbin, K.D., Abdelmalek, M.F., Spencer, M.D., da Costa, K-A, Galanko, J.A., Sha, W.,
`Suzuki, A., Guy, C., Cardona, D.M., Torquati, A., Diehl, A.M., Zeisel, S.H. (2013) Genetic
`signatures in choline and 1-carbon metabolism are associated with the severity of hepatic
`steatosis. FASEB Journal. 1674 – 1689. PMCID: PMC3606533.
`16. Dominguez-Salas, Paula, Moore, S.E., Cole, D., Cox, S.E., da Costa, K-A, Dyer, R.A.,
`Fulford, T., Innis, S.M., Waterland, R.A., Zeisel, S.H., Prentice, A.M., Henning, B.J.
`(2012) DNA methylation potential: dietary intake and blood concentrations of one-
`carbon metabolites and cofactors in rural African women. American Journal of Clinical
`Nutrition, 1217 - 1227. PMCID: PMC3652920.
`17. Xie, G., Zhong, W., Li, H., Li, Q., Qiu, Y., Zhen, X., Chen, H., Zhao, X., Zhang, S., Zhou, Z.,
`Zeisel, S.H., Jia, W. (2013) Alteration of bile acid metabolism in the rat induced by
`chronic ethanol consumption. FASEB Journal. 3583 – 93. PMCID: PMC3752538.
`18. Fuglestad, A.J., Fink, B.A., Eckerle, J.K., Boys, C.J., Hoecker, H.L., Kroupina, M.G., Zeisel,
`S.H., Georgieff, M.K., & Wozniak, J.R. (2013) Inadequate intake of nutrients essential
`for neurodevelopment in children with fetal alcohol spectrum disorders (FASD).
`Neurotoxicology and Teratology. 128 – 32. PMCID: PMC3795902.
`19. Wozniak, J. R., Fuglestad, A. J., Eckerle, J. K., Kroupina, M. G., Miller, N. C., Boys, C. J.,
`Brearley, A. M., Fink, B. A., Hoecker, H. L., Zeisel, S.H., & Georgieff, M. K. (2013)
`Choline supplementation in children with Fetal Alcohol Spectrum Disorders (FASD) has
`high feasibility and tolerability. Nutrition Research. 897 – 904. PMCID: PMC3815698.
`20. da Costa, K-A, Corbin, K., Niculescu, M., Galanko, J., Zeisel, S.H. (2014) Identification of
`new genetic polymorphisms that alter the dietary requirement for choline and vary in their
`distribution across ethnic and racial groups. FASEB Journal. 28(7): 2970-8. Fj.14-
`249557. PMCID: PMC4015319.
`21. Xiaojiao, Z., Qiu, Y., Zhong, W., Baxter, S., Su, M., Li, Q., Xie, G., Ore, B., Qiao, S.,
`Spencer, M., Zeisel, S.H., Zhou, Z., Zhao, A., Jia, W. (2013) A targeted metabolomics
`protocol for short-chain fatty acids and branched-chain amino acids. Metabolomics. 9:
`818 – 827. PMCID: PMC3756605.
`22. Dominguez-Salas, P., Moore, S.E., Baker, M.S., Bergen, A.W., Cox, S.E., Dyer, R.A.,
`Fulford, A.J., guan, y., Laritsky, E., Silver, M., Swan, G.E., Zeisel, S.H., Innis, S.M.,
`Waterland, R.A., Prentice, A.M., Hennig, B.J. (2014) Maternal nutrition at conception
`modulates DNA methylation of human metastable epialleles. Nature Communications
`http://dx.doi.org/10.1038/ncomms4746. PMCID: PMC4015319.
`23. Miller, C.A., Corbin, K.D., da Costa, K-A, Zhang, S., Zhao, X., Galanko, J.A., Blevins, T.,
`Bennett, B.J., O’Connor, A., Zeisel, S.H. (2014) Effect of egg ingestion on TMAO
`production in humans: a randomized controlled, dose-response study. American Journal
`of Clinical Nutrition. 100: 778-86. PMCID: PMC4135488.
`24. Martinez-Vega, R., Carrido, F., Cediel, R., Partearroyo, T., Vallecillo, N., Zeisel, S.H.,
`Varela-Moreiras, G., Martinez-Alvarez, C., Varela-Nieto, I., Parajes,M. (2014) Folic acid
`deficiency induces premature hearing loss through mechanisms involving cochlear
`oxidative stress and impairment of homocysteine metabolism. FASEB Journal. 29(2)
`418 – 32. PMCID: PMC4314232.
`25. Schenkel, L.C., Singh, R.K., Michel, V., Zeisel, S.H., da Costa, K-A, Johnson, A.R., Mudd,
`H.S., Bakovic, M. (2014) Mechanism of choline deficiency and membrane alteration in
`postural orthostatic tachycardia syndrome primary skin fibroblasts. FASEB Journal.
`29(5):1663-75. PMCID: PMC4415014.
`26. Tsuchiya, H., da Costa, K-A, Lee, S., Renga, B., Zhang, Y., Jaeschke, H., Smalling, R.,
`Zeisel, S.H., Fiorucci, S., Wang, L. (2015) Interactions Between Nuclear receptor SHP
`and FOXA1 Maintain Oscillatory Homocysteine Homeostasis in Mice. Gastroenerology.
`148(5):1012-1023. PMCID: PMC4409521.
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`27. Silver, M., Corbin, K., Hellenthal, G., da Costa, K., Dominguez-Salas, P., Moore, S., Owen,
`J., Prenctice, A., Hennig, B., Zeisel, S.H. (2015) Evidence for negative selection of gene
`variants that increase dietary choline requirement in a Gambian cohort. FASEB Journal.
`29(8): 3426 - 35. PMCID: PMC4511208.
`28. Orena, S., Owen, J., Jin, F., Fabian, M., Gillitt, N., Zeisel, S.H. (2015) Extracts of fruits and
`vegetables activate the anti-oxidant response element (ARE) in IMR-32 cells. Journal of
`Nutrition. 145(9): 2006- 11.
`29. Zhao, X., Zeisel, S.H., Zhang, S. (2015) A rapid LC-MRM/MS assay for simultaneous
`quantification of choline, betaine, trimethylamine, trimethylamine N-oxide and creatinine
`in human plasma and urine. Electrophoresis. 36: 2207–2214.
`30. Strauss, K.A., Ferreira, C., Bottiglieri, T., Zhao, X., Arning, E., Zhang, S., Zeisel, S.H.,
`Escolar, M.L., Presnick, N. Puffenberger, E.G., Vugrek, O., Kovacevic, L., Wagner, C.,
`Mazariegos, G.V., Mudd, S.H., Soltys, K., (2015) Liver transplantation for treatment of
`severe S-adenosylhomocysteine hydrolase deficiency. Molecular Genetics and
`Metabolism. 116(1-2): 44 – 52.
`31. Zwart, S.R., Gregory, J.F., Zeisel, S.H., Gibson, C.R., Mader, T.H., Kinchen, T.H., Ueland,
`P.M., Ploutz-Snyder, R., Heer, M., Smith, S.M. (2015) Genotype, B-vitamin status, and
`adrogens affect space flight-induced ophthalmic changes FASEB Journal. 30(1): 141 –
`148. PMCID: PMC4684521.
`32. Wozniak, J.R., Fuglestad, A.J., Eckerle, J.K., Fink, B.A., Hoecker, H.L., Boys, C.J., Radke,
`J.P., Kroupina, M.G., Miller, N.C., Brearley, A.M., Zeisel, S.H., Georgieff, M.K. (2015)
`Choline supplementation in children with Fetal Alcohol Spectrum Disorders (FASD)
`improves memory performance in 2-3 year-olds: A randomized, double-blind, placebo-
`controlled trial. American Journal of Clinical Nutrition. 102(5): 1113 – 25. PMCID:
`PMC4625582.
`33. Wang, Y., Surzenko, N., Friday, W., Zeisel, S.H. (2016) Maternal Dietary Intake of Choline
`in Mice Regulates Development of the Cerebral Cortex in the Offspring. FASEB Journal.
`30(4): 1566 – 78. PMCID: PMC4799499.
`34. Nilsson, T., Hurtig-Wennlof, A., Sjostrom, M., Herrmann, W., Obeid, R., Zeisel, S.H. (2015)
`Plasma 1-carbon metabolities and academic achievement in 15-year-old adolescents.
`FASEB Journal. 30: 1683 – 88. PMCID: PMC4799502.
`35. Meyer, K.A., Benton, T.Z., Bennett, B.J., Jacobs, D.R., Lloyd-Jones, D.M., Gross, M.D.,
`Carr, J., Gordon-Larsen, P., Zeisel, S.H. (2016) The microbiota-dependent metabolite
`trimethylamine N-oxide (TMAO) and coronary artery calcium in the Coronary Artery Risk
`Development in Young Adults Study (CARDIA). Journal of the American Heart
`Association. [IN PRESS].
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`Non-Peer Reviewed Publications (from last 5 years)
`1. Zeisel, S.H. (2011) Dietary choline, betaine, methionine, and epigenetic mechanisms
`influencing brain development. In Nutrition in Epigenetics, edited by M. Niculescu, Wiley-
`Blackwell, UK. 225-240.
`2. Caudill, M.A., da Costa, K-A, Zeisel, S.H. (2012) Elevating awareness and intake of an
`essential nutrient for public health. Nutrition Today. 46(5): 235 - 241.
`3. Zeisel, S.H., (2012) Diet-Gene interactions underlie metabolic individuality and influence
`brain development: implications for clinical practice derived from studies on choline
`metabolism. Annuals of Nutrition and Metabolism. 60: 19-25. PMID: 22614815.
`Johnson, A., Zeisel, S.H. (2012) Dietary Choline for brain development. In International
`Handbook of Behavior, Diet and Nutrition, edited by Victor R. Preedy, Springer, New
`York, NY 2089 – 2104.
`5. Zeisel, S.H. (2011) Choline and Phosphatidylcholine. (2012) In Modern Nutrition in Health
`and Disease, 11th Edition. edited by C. Ross, B. Caballero, R. Cousins, K. Tucker, T.
`Ziegler, Lippincott Williams & Wilkins, Monkton, VT 416 – 426.
`6. Zeisel, S.H., Corbin, K. (2012) Choline and Brain Development. In 10th Edition of Present
`Knowledge of Nutrition, jointly edited by J.W. Erdman, I.A. MacDonald and S.H. Zeisel,
`Wiley-Blackwell, Hoboken, NJ. 405 – 418.
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`7. Zeisel, S.H., Corbin, K.D. (2012) The nutrigenetics and nutrigenomics of the dietary
`requirement for choline. In Recent Advances in Nutrigenetics and Nutrigenomics, edited
`by Claude Bouchard and Jose M. Ordovas, Elsevier, India. 159 - 177. PMID:
`22656377.
`8. Zeisel, S.H. (2012) A brief history of choline. World Review of Nutrition and Dietetics. 61:
`254 – 258. PMCID: PMC4422379.
`9. Zeisel, S.H. (2013) Nutrition in pregnancy: The argument for including a source of choline.
`International Journal of Women’s Health. 193 - 199. PMCID: PMC3639110.
`10. Mehedint, M.G., Zeisel, S.H. (2013) Choline’s role in maintaining liver function: new
`evidence for epigenetic mechanisms. Current Opinion in Clinical Nutrition and Metabolic
`Care. 16:339 – 345. PMCID: PMC3729018.
`11. Du, X., Zeisel, S.H. (2013) Spectral deconvolution for gas chromatography mass
`spectrometry-based metabolomics: current status and future perspectives.
`Computational and Structural Biotechnology Journal. 4(5): e201301013. doi:
`http://dx.doi.org/10.5936/csbj.201301013. PMCID: PMC3962095.
`12. Zeisel, S.H. (2015) How nutrigenetics can help prove that nutrient-based interventions
`reduce disease risk. Sight and Life. 29(1) 60 - 63.
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`Courses Taught
`1990-2013 NUTR 880 (formerly NUTR 371 and NUTR 389) Elements of Being a Scientist, 3
`credit hours, Zeisel course director.
`1991, 1993, 1995-2009, 2011, 2012.
`NUTR 620 Nutrition and Cancer – Guest Lecturer, Spring 2013
`NUTR 390 Nutrition Research, 9 credit hours, Zeisel - laboratory director. 1991-1996.
`NUTR 862 Epigenetics in Nutrition – Guest Lecturer, Spring 2013
`NUTR 868 (formerly NUTR 323) Nutrients and Brain Function, 2 credit hours, Zeisel course
`director, 1997, 1999, 2001, 2002, 2004, 2008, 2009.
`NUTR 885 Doctoral Seminar, 2010
`Medical School Nutrition Course - Zeisel course director, 1996-1998; instructor 2005.
`MCH 302 Doctoral Research Skills Colloquium, 1 credit hour, Zeisel guest lecture on Effective
`Proposal Writing. 2005.
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`Personal
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`Citizenship:
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`Marital status: Married (wife: Susan; children: Katherine, Rebecca)
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`USA
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