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`Prednisone vs. prednisolone
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`Prednisone vs. Prednisolone for Ulcerative Colitis
`Written by University of l|linois—Ch:cago, Drug information Group
`Medically Reviewed by Philip Gregory onjuly 7', 2016
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`introduction When it comes to ulcerative coiitis. there are different options for treatment. Many
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`défferent kinds of drugs are available. The treatment your doctor prescribes for you
`may often depend on the severity of your symptoms. Two drugs you may hear about for your treatment are
`prednisone and prednisolone. Here's the rundown on what these drugs are and how they can help treat
`ulcerative colitis, including how they're alike and how theyre different.
`
`Prednisone and preclnisolone
`
`Prednisone and prednisolone both beiong to a class of drugs called glucocorticoids. Glucocorticoids reduce
`inflammation throughout your body. They do this by interfermg with the way certain chemicals in your body
`cause infiamrnation. These drugs can work in different parts of your body, including your colon. Your colon is
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`the last section of your large intestine, just before your rectum. By reducing the inflammation there, these
`drugs help reduce the damage that colitis does to your colon.
`
`Neither of these drugs cures colitis, but both can help control it and improve your quality of life. These drugs
`relieve common symptoms such as:
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`- stomach cramps and pain
`- weightloss
`- diarrhea
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`- fatigue
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`Side-by-side comparison
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`Prednisone and prednisolone are very similar drugs. The following table compares the similarities and
`differences of several features of these two drugs.
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`Cost, availability, and insurance coverage
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`Prednisolone and prednisone cost about the same. Both drugs come in generic and brand-name versions.
`Like all drugs, the generic versions usuaily cost less. GoodRx.com can give you an idea of the current cost of
`the drug your doctor prescribes.
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`However, not all generics are available in the same forms or strengths as the brand-name versions. Ask your
`healthcare provider ifEt’s necessary for you to take the brand-name strength or form.
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`Prednisone vs. prednisolone
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`Most pharmacies stock the generic versions of both prednisone and prednisolone. The brand-name versions
`aren't always stocked, so call ahead before you fill your prescription if you take a brand-name version.
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`Most insurance pians also cover both prednisone and prednisoione. However, your insurance company may
`require a prior authorization from your doctor before they approve the prescription and cover the payment.
`
`Side effects
`
`These drugs are from the same drug class and work in a similar way. Because of this, the side effects of
`prednisone and prednisolone are also similar. However, they do differ in a couple of ways. Prednisone may
`cause your mood to change and may make you feel depressed. Preclnisolone may cause convulsions.
`
`Read more: Detailed drug info for prednisone. including side effects :2
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`Drug interactions
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`The following drugs interact with both prednisolone and prednisone:
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`- antiseizure drugs such as phenobarbital and phenytoin
`-
`rifampin, which treats tubercuiosis
`- ketoconazole, which treats funggi infections
`- aspirin
`- biood thinners such as warfarin
`- all live vaccines
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`Use with other medical conditions
`
`lfyou also have conditions other than ulcerative colitis, make sure your doctor knows about them. Both
`prednisone and prednisolone can make certain existing conditions worse. These include:
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`- hypothyroidism
`- cirrhosis
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`- herpes simplex of the eye
`- emotional problems
`- mental illness
`- ulcers
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`- kidney problems
`- high blood pressure
`- osteoporosis
`- myasthenia gravis
`-
`tuberculosis
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`Pharmacists advice
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`Prednisone and prednisolone have more similarities than differences. The biggest differences between these
`drugs are the other drugs they interact with. Give your doctor a compiete iist of the drugs and supplements
`that you take. This may be some of the best information you can give to your doctor to help them decide
`between these two drugs for treating your ulcerative colitis.
`
`References:
`
`- Crohn's & Colitis Foundation of America. (n.d.}. What are Crohn’s and colitis? Retrievedlfrom
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`http://www.ct:fa.org/what-are-crohns-and-colitis/what-is-crohns-diseasel
`- Deltasone - prednisone tablet. (2015, August 14). Retrieved from
`https://dailymed.nim.nih.gov/dailyrned/clruglnfo.cfm?setid=18bebd56-4848-32ae-e054-00144ff88e88
`- Rayos — prednisone tablet, delayed release. (2014, February 1.2). Retrieved from
`https://clailymed.n!m_nih.gov/dailyrned/druglnfo.cfm?seticl=281ab967—'7565-4bef-9c0c-a646589c67‘Ie
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`http :.'lwww.hea|tbline .comlheaithlulceraiive-colitislpreclnisone-vs-prednisoIone?print=true
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`Prednisone vs. prednisolone
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`- Miilipred - prednisofone tablet. (2016. Aprii 19). Retrieved from
`http://dai|ymed.n|m.nih.gov/daiiymeci/druginfo.cfm?setid=863ad743—eecO—46fO-beba-C1556384c636
`- Deltasone — prednisone tablet. (2007, March). Retrieved from
`http://dailymectnlm.nih.gov/daiiymed/druginfo.cfm?setid=3400d26a—4ficb-40e4»99b4-780e1e0ec561
`- Prednisone — prednisone tablet: Prednisone- prednisone soiution: Prednisone intenso|- prednisone
`solution, concentrate. (2015, May 29]. Retrieved from http://daiiymed.nfm.nih.gov/daiiymed/druglnfo.cfm?
`setii:f=3i 1 Saef0—fd50—4ec8—aO64—3effb695f3f2
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`- Prednisolone « prednisoione syrup. (2010,January 5). Retrieved from
`https://dai|yrned.nEm.nih.gov/daitymed/druglnfo.cfm?setid=b4f7f1e5-c73d--Med-8c3e-b177ida678d3
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`Copyright © 2005 - 2018 Healthline Networks, Inc. All rights reserved. Healthiine is for informational purposes and shouid not be considered medical
`advice, diagnosis or treatment recommendations.
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