Curriculum Vitae
`(Updated May 29, 2015)
`
`
`JAYANTH PANYAM
`
`CONTACT INFORMATION
`Department of Pharmaceutics
`College of Pharmacy
`University of Minnesota
`Minneapolis, MN 55445
`Phone: 612-624-0951
`Fax: 612-626-2125
`Email: jpanyam@umn.edu
`URL: http://www.pharmacy.umn.edu/faculty/panyam_jayanth
`
`EDUCATION
`2003 Ph.D. (Pharmaceutical Sci.), University of Nebraska Medical Center, Nebraska
`1999 M.Pharm. (Pharmaceutics), Banaras Hindu University, Banaras, India
`1997
`B.Pharm. (Pharmacy), The T.N. Dr. MGR Medical University, India
`
`FORMAL POSITIONS
`2015 –
`Professor with tenure, University of Minnesota, Minneapolis, MN
`2010 – 2015 Associate Professor with tenure, University of Minnesota, Minneapolis, MN
`2007 –
`Member, Masonic Cancer Center, Minneapolis, MN
`2007 – 2010 Assistant Professor, University of Minnesota, Minneapolis, MN
`2005 – 2007 Member, Karmanos Cancer Institute, Detroit, MI
`2003 –2007 Assistant Professor, Wayne State University, Detroit, MI
`1996 – 1997 Lecturer, SRM college of Pharmacy, Chennai, India
`
`HONORS AND AWARDS
`1996 Best Outgoing Student of the Year 1996, SRM College of Pharmacy
`1997
`IDMA - Dr. G.P. Nair Award awarded by Indian Drug Manufacturer’s Association’s (IDMA)
`1997 Prof. E. Venugopal Endowment Gold Medal awarded by The T.N. Dr. M.G.R. Medical
`University
`1997 Shri Nageshwar Rao Pantulu Prize awarded by The T.N. Dr. M.G.R. Medical University
`1997 First Prize in B. Pharm awarded by Pharmacy Council, Tamilnadu
`1997 Junior Research Fellowship, University Grants Commission, India
`1999 Gold Medal in M.Pharm. awarded by Banaras Hindu University
`2000 Graduate Research Fellowship, University of Nebraska Medical Center, Omaha, NE
`2001 Predoctoral Fellowship (2001-2003), American Heart Association
`2001 Widaman Fellowship Supplement (2001-2003)
`2002 Travel Grant to present a paper the 5th International Symposium on Polymer Therapeutics:
`From Laboratory to Clinical Practice, Jan 2002, Cardiff, UK.
`2002 First Place, Oral Presentation (UNMC), 34th Annual Pharmaceutics Graduate Student
`Research Meeting, Omaha, NE, June 13th – June 15th, 2002
`2003 Predoctoral Fellowship (2003-2004), American Heart Association
`2004 Thomas Jefferson Ingenuity Award for Creativity and Ingenuity in Doctoral Research,
`University of Nebraska Medical Center, Omaha, NE
`2006 Who's Who in Medicine and Healthcare, 2006-2007
`2007 Wilson Scholar, Ralph C. Wilson Foundation
`2013 Member, Editorial Advisory Board, Journal of Pharmaceutical Sciences
`
`1
`
`TEVA EXHIBIT 1034
`TEVA PHARMACEUTICALS USA, INC. V. MONOSOL RX, LLC
`
`

`
`2013 Elected to the inaugural cohort of the Academic Research Fellows Program
`2015 Professor of the Semester, Pharm.D. Class of 2018
`
`PUBLICATIONS
`1. Panyam, J., Kumar, V., and Mishra, B. (1999) Recent trends in drug delivery systems:
`Lymphatic drug targeting and transportation. Acta Pharm Turc, 41(3): 131-139.
`2. Mishra, B., Panyam, J., and Sharma, A.V. (1999) Mechanisms of drug release control
`from multiple W/O/W emulsions containing diclofenac sodium. Acta Pharm Turc, 41(2):
`42-45.
`3. Mishra, B., Panyam, J., and Sharma, A.V. (1999) In vitro release of diclofenac sodium
`from multiple emulsions: Effect of location of drug and pH of the aqueous phase. Acta
`Pharm Turc, 41(2): 58-61.
`4. Panyam, J., Lof, J., O’Leary, E., and Labhasetwar, V. (2002) Efficiency of Dispatch® and
`Infiltrator® cardiac infusion catheters in arterial localization of nanoparticles in a porcine
`coronary model of restenosis. J Drug Targeting, 10(6): 515-523.
`5. Panyam, J., Zhou, W.Z., Prabha, S., Sahoo, S. and Labhasetwar, V. (2002) Rapid endo-
`lysosomal escape of poly (D,L-lactide-co-glycolide) nanoparticles: implications for drug
`and gene delivery. FASEB J, 16(10): 1217-1226.
`6. Sahoo, S. K., Panyam, J., Prabha, S. and Labhasetwar V. (2002) Residual polyvinyl
`alcohol associated with poly (DL-lactide-co-glycolide) nanoparticles affects their physical
`and cellular uptake properties. J Control Release, 82(10): 105-114.
`7. Prabha, S., Zhou, W. Z., Panyam, J. and Labhasetwar, V. (2002) Particle size
`dependency of nanoparticle mediated gene transfection: Effect of particle size. Int J
`Pharm, 244 (1-2): 105-115.
`8. Panyam, J., Dali, M., Sahoo, S.K., Ma, W., Chakravarthi, S.S., Amidon, G.L., Levy, R.J.
`and Labhasetwar, V. (2003) Polymer degradation and in vitro release of a model protein
`from poly(dl-lactide-co-glycolide) nano- and microparticles. J Control Release, 92(1-2):
`173-187.
`9. Panyam, J., Sahoo, S.K., Prabha, S. and Labhasetwar, V. (2003) Fluorescence and
`electron microscopy probes for poly(D,L-lactide-co-glycolide) nanoparticles. Int J Pharm,
`262(1-2): 1-11.
`10. Panyam, J. and Labhasetwar, V. (2003) Biodegradable nanoparticles for drug and gene
`delivery to cells and tissue. Adv Drug Deliv Rev, 55(3): 329-347.
`11. Panyam, J. and Labhasetwar, V. (2003) Dynamics of endocytosis and exocytosis of poly
`(DL-lactide-co-glycolide) nanoparticles in vascular smooth muscle cells. Pharm Res,
`20(2): 110-118.
`12. Mishra, B., Panyam, J. and Sankar C. (2003) Development of chitosan-alginate
`microcapsules for colon-specific delivery of metronidazole. Indian Drugs 40 (12): 695-
`700.
`13. Panyam, J. and Labhasetwar, V. (2004) Targeting Intracellular Targets. Current Drug
`Del, 1(3): 235-247.
`14. Panyam, J. Williams, D., Dash, A., Leslie-Pelecky, D. and Labhasetwar, V., (2004) Solid-
`state drug-polymer solubility: a determinant for the encapsulation of hydrophobic drugs in
`PLGA/PLA nanoparticles. J Pharm Sci, 93(7): 1804-1814.
`15. Panyam, J. and Labhasetwar, V. (2004) Sustained cytoplasmic delivery of drugs with
`intracellular receptors using biodegradable nanoparticles. Mol Pharm, 1(1): 77-84.
`16. Mandaogade, P.M., Satturwar, P.M., Mundhada, D.R., Panyam, J., Fulzele, S.V., Gogte,
`B.B., Labhasetwar, V., Dorle, A.K. (2004) Synthesis and evaluation of rosin derivatives
`for pharmaceutical coating. Int J Pharm, 270(1-2): 27-36.
`17. Mishra, B., Panyam, J. and Sankar C. (2004) Development of guar gum-alginate based
`microcapsules of metronidazole for delivery to colon. Acta Pharm Turc, 46:121-130.
`
`2
`
`TEVA EXHIBIT 1034
`TEVA PHARMACEUTICALS USA, INC. V. MONOSOL RX, LLC
`
`

`
`18. Chavanpatil, M., Khdair, A., and Panyam, J.* (2006) Nanoparticles for cellular drug
`delivery: mechanisms and factors influencing delivery. J Nanosci Nanotech, 6: 2651-63.
`19. Chavanpatil, M., Patil, Y., and Panyam, J.* (2006) Susceptibility of nanoparticle-
`encapsulated paclitaxel to P-glycoprotein-mediated drug efflux. Int J Pharm, 320: 150-
`156.
`20. Chavanpatil, M., Khdair, A., Patil, Y., and Panyam, J.* (2007) Surfactant-Polymer
`Nanoparticles: A Novel Platform for Sustained and Enhanced Cellular Delivery of Water-
`soluble Molecules. Pharm Res, 24: 803-10.
`21. Chavanpatil, M., Handa, H., Mao, G. and Panyam, J. (2007) Incorporation of
`Phospholipids Enhances Cellular Uptake and Retention of Surfactant-Polymer
`Nanoparticles. J Biomed Nanotech, 3:291-296.
`22. Chavanpatil, M., Khdair, A., Y., Patil, Y., Handa, H., Mao, G., and Panyam, J.* (2007)
`Polymer-Surfactant Nanoparticles for Sustained Release of Water-Soluble Drugs. J
`Pharm Sci, 96:3379-3389.
`23. Chavanpatil, M., Khdair, A., Gerard, B., Bachmeier, C., Shekar, M., Miller, D.W., and
`Panyam, J.* (2007) Surfactant-Polymer Nanoparticles Overcome P-glycoprotein-
`Mediated Drug Efflux. Mol Pharm, 4:730-738.
`24. Shahani, K., Jonnalagadda, K., Handa, H., Mao, G. and Panyam, J.* (2007) Phospholipid
`Nanoparticles: Process Optimization Using Factorial Design and Atomic Force
`Microscopy. J Biomed Nanotech, 3:394-400.
`25. Wu, L., Bharatwaj, B., Panyam, J., Da Rocha, S. (2007) Core-shell Particles for the
`Dispersion of Small Polar Solutes and Biomolecules in Hydrofluoroalkane Propellants.
`Pharm Res, 25:289-301.
`26. Khdair, A., Gerard, B., Handa, H., Mao, G., Shekar, M.P.V., and Panyam, J.* (2008)
`Aerosol OT-alginate nanoparticles enhance the effectiveness of anticancer photodynamic
`therapy. Mol Pharm, 5: 795-807.
`27. Sudakar, C., Dixit, A., Regmi, R., Naik, R., Lawes, G., Naik, V. M., Vaishnava, P. P., Toti
`U., and Panyam, J. (2008) Fe3O4 incorporated AOT-Alginate nanoparticles for drug
`delivery. IEEE Trans Magnetics, 44: 2800-2803.
`28. Patil, Y. and Panyam, J.* (2009) Polymeric Nanoparticles for siRNA Delivery and Gene
`Silencing. Int J Pharm, 367(1-2):195-203.
`29. Khdair, A. Handa, H., Mao, G., and Panyam, J.* (2009) Nanoparticle-mediated
`combination photodynamic therapy and chemotherapy overcomes tumor drug resistance
`in vitro. Eur J Pharm Biopharm, 71(2):214-222.
`30. Patil, Y., Toti, U., Khdair, A., Ma, L., and Panyam, J.* (2009) Facile Single-Step
`Multifunctionalization of Nanoparticles
`for Targeted Drug Delivery. Biomaterials,
`30(5):859-66.
`31. Patil, Y., Sadhuka, T., and Panyam, J.* (2009) Nanoparticle-mediated simultaneous and
`targeted delivery of paclitaxel and tariquidar overcomes tumor drug resistance. J
`Controlled Release, 136(1):21-9.
`32. Grill, A.E., Johnston, N.W, Sadhukha, T., and Panyam, J. * (2009) A review of select
`recent patents on novel nanocarriers. Recent Pat Drug Deliv Formul, 3(2): 137-142.
`33. Khdair, A., Chen, D., Dou, P., Shekar, M.P.V., and Panyam, J.* (2010) Nanoparticle-
`mediated combination photodynamic therapy and chemotherapy overcomes tumor drug
`resistance in vivo. J Controlled Release, 141(2): 137-144.
`34. Patil, Y., Swaminathan, S., Sadhuka, T., Ma, L., and Panyam, J.* (2010) The use of
`nanoparticle-mediated targeted gene silencing and drug delivery to overcome tumor drug
`resistance. Biomaterials, 31(2): 358-365.
`35. Shahani, K., Swaminathan, S., Freeman, D., Blum, A., Ma, L., and Panyam, J.* (2010)
`Injectable sustained
`release microparticles of curcumin: A novel concept
`for
`chemoprevention. Cancer Res, 70(11):4443-52.
`
`3
`
`TEVA EXHIBIT 1034
`TEVA PHARMACEUTICALS USA, INC. V. MONOSOL RX, LLC
`
`

`
`36. Toti, U., Grill, A.E., and Panyam, J.* (2010) Interfacial Activity Assisted Surface
`Functionalization: A Novel Approach to Incorporate Maleimide Functional Groups and
`cRGD peptide on Polymeric Nanoparticles for Targeted Drug Delivery. Mol Pharm, 7(4):
`1108–1117.
`37. Swaminathan, S., Olin, M.R., Forster, C.L., Santa Cruz, K.S., Panyam, J.*, and Ohlfest,
`J.R.* (2010) Identification of a novel monoclonal antibody recognizing CD133. J Immunol
`Methods, 361(1-2):110-5.
`38. Sharma, B., Ma, W., Adjei, I., Panyam, J., Dimetrijevic, S., and Labhasetwar, V. (2011)
`Nanoparticle-mediated p53 gene therapy for tumor inhibition. Drug Del Transl Res, 1(1):
`43-52.
`39. Shahani, K., and Panyam, J.* (2011) Sustained release curcumin microspheres for
`chemoprevention: formulation considerations. J Pharm Sci, 100(7):2599-609.
`40. Toti, U.S., Guru, B.R., Hali, M., McPharlin, C., Wykes, S.M., Panyam, J*., Whittum-
`Hudson, J.A.* (2011) Targeted Delivery of Antibiotics to Intracellular Chlamydial
`Infections using PLGA Nanoparticles. Biomaterials, 32(27):6606-13.
`41. Wiedmann, T.S., Sadhukha, T., Hammer, B.E., Panyam, J.* (2012) Image-guided drug
`delivery in lung cancer. Drug Del Transl Res, 2(1): 31-44.
`42. Schaefers, M.M., Breshears, L.M., Anderson, M.J., Lin, Y-C., Grill, A.E., Panyam, J.,
`Southern, P.J., Schlievert, P.M., and Peterson, M.L. (2012) Toxic Shock Syndrome (TSS)
`Toxin-1 Induces NF-κB in Vaginal Epithelial Cells and Curcumin Prevents TSS in
`Rabbits. PlosOne, 7(3):e32813.
`43. Rogers, E., Guru, B.R., Whittum-Hudson, J.A., Panyam, J*. (2012) Folic acid-
`Functionalized Nanoparticles to Enhance Oral Delivery of Encapsulated Drug. Mol
`Pharmaceutics, 9(7):2103–2110.
`44. Arora, S., Singh, S., Piazza, G.A., Contreas, C.M., Panyam, J., Singh, A.P. (2012)
`Honokiol: a novel natural agent for cancer prevention and therapy. Curr Mol Med,
`12(10):1244-52.
`45. Ohlfest, J.R., Panyam, J., Swaminathan, S.K., Oh, S., Waldron, N., Toma, S., and
`Vallera, D.A. (2013) Targeting CD133+ breast carcinoma Cells by systemic
`administration of a novel deimmunized immunotoxin showing selective in vitro and in vivo
`cell anti-tumor activity. Drug Del Translational Res, 3(2): 143-151.
`46. Swaminathan, S., Vallera, D., Ohlfest, J., Panyam, J*. (2013) Identification and
`characterization of a novel scFv recognizing human and mouse CD133. Drug Del
`Translational Res, 3(2): 195-204.
`47. Sadhukha, T., Niu, L., Panyam, J*. (2013) Effective Elimination of Cancer Stem Cells by
`Magnetic Hyperthermia. Mol Pharmaceutics, 10(4):1432-41
`48. Sadhukha, T., Swaminathan, S., Panyam, J*. (2013) Inhalable Magnetic Nanoparticle
`Mediated Targeted Magnetic Hyperthermia for Lung Cancer Therapy. Biomaterials,
`34(21); 5163-71.
`49. Swaminathan, S., Niu, L., Roger, E., Ohlfest, J., Panyam, J*. (2013) CD133-Targeted
`Paclitaxel Delivery Inhibits Local Tumor Recurrence in a Mouse Model of Breast Cancer.
`J Controlled Release, 171(3): 280-7.
`50. Kirtane, A., Kalscheuer, S., Panyam, J*. (2013) Exploiting Nanotechnology to Overcome
`Tumor Drug Resistance: Challenges and Opportunities. Adv Drug Del Rev. 65(13-14):
`1731-47.
`51. Pustulka, K., Wohl, A.R., Han, J., McCormick, A., Macosko, C.W., Panyam, J., and Hoye,
`T.R. (2013) Flash Nanoprecipitation: Particle Structure and Stability. Mol Pharmaceutics,
`10 (11): 4367-4377.
`52. Kirtane AR, Panyam J. (2013) Polymer nanoparticles: Weighing up gene delivery. Nature
`Nanotechnol. 8(11): 805-6 (Invited editorial).
`
`4
`
`TEVA EXHIBIT 1034
`TEVA PHARMACEUTICALS USA, INC. V. MONOSOL RX, LLC
`
`

`
`53. Panyam, J. (2013) Cancer stem cells. Drug Del Translational Res, 3(2): 111-112 (Invited
`editorial).
`54. Wohl, A.R., Kalscheuer, S., Lee, H.S., Han, J., McCormick, A., Macosko, C.W., Panyam,
`J., and Hoye, T.R. (2014) A Silicate Ester Prodrug Strategy for Improving the Therapeutic
`Index of Paclitaxel. J Med Chem, 57(6):2368-79.
`55. Arora, S., Swaminathan, S., Kirtane, A.R., Panyam, J., and Singh, A. (2014) Synthesis,
`characterization and evaluation of Poly (D, L-lactide-co-glycolide)-based nanoformulation
`of miRNA-150: potential implications for pancreatic cancer therapy. Int J Nanomed,
`18(9):2933-42.
`56. Grill, A., Panyam, J*. (2014) Co-delivery of natural metabolic inhibitors in a self-
`microemulsifying drug delivery system for improved oral bioavailability of curcumin. Drug
`Del Translational Res, 4(4):344-352.
`57. Sadhukha, T., Swaminathan, S., Panyam, J*. (2014) Enhancing Therapeutic Efficacy
`through Designed Aggregation of Nanoparticles, Biomaterials, 35(27):7860-9.
`58. Usacheva, M., Swaminathan, S., Kirtane, a., Panyam, J*. (2014) Encapsulation of
`methylene blue in nanoparticles enhances PDT efficacy under hypoxia. Mol
`Pharmaceutics, 11(9):3186-95.
`59. Song, J.*, Kirtane, A.R.*, Upadhyaya, P.*, Qian, X., Balbo, S., Panyam, J., Kassie F.
`(2014) Intranasal delivery of liposomal indole-3-carbinol: A promising strategy for lung
`cancer chemoprevention. Int J Pharmaceutics, 9:2933-42.
`60. Kirtane, A., Siegel, A.R., Panyam, J. (2014) A pharmacokinetic model for quantifying the
`effect of vascular physiology on the choice of drug carrier: A framework for personalized
`nanomedicine. J Pharm Sci, In Press.
`
`Pending
`61. Kirtane, A.R., Lis, L., Georg, G., Gurvich, V., Panyam, J. (2015) Reformulating
`tylocrebrine in EGFR targeted polymeric nanoparticles improves its therapeutic index. In
`revision
`62. Grill, A., Koniar, B., Panyam, J*. (2015) Systemic inflammation with PLGA microparticles.
`In preparation.
`63. Kirtane, A., Siegel, A.R., Panyam, J. (2014) Assessing the benefits of drug delivery by
`nanocarriers: a partico/pharmacokinetic framework. In preparation.
`64. Kirtane, A.R., Narayan, P., Panyam, J. (2015) Encapsulation in AOT-alginate
`nanoparticles improves the oral bioavailability of doxorubicin. In preparation
`65. Kirtane, A., Toti, U.S., Hali, M., McPharlin, C., Wykes, S.M., Whittum-Hudson, J.A.,
`Panyam, J*. (2015) Nanoparticle-mediated targeted delivery of antibiotics to intracellular
`Chlamydial infections. In preparation.
`
`
`BOOK CHAPTERS
`1. Panyam, J., and Patil, Y. Distribution - Movement of Drugs through the Body. In:
`Preclinical Development Handbook: ADME and Biopharmaceutical Properties, Gad, S.C.
`(Ed). Wiley International, 2008.
`2. Mohammad, M., Grill, A., Panyam, J. and Khdair, A. Cancer Therapeutics and Tumor
`Drug Resistance. In: Targeted Drug Delivery in Cancer Therapeutics, Firer, M. (Ed).
`Research Signpost, 2010.
`3. Rogers, E., Grill, A., and Panyam, J. Surface plasmon resonance analysis of
`nanoparticles for targeted drug delivery. In: Biosensors for Cancer Diagnostics, Rasooly,
`A. and Herold, K. E. (Eds.). CRC Press, 2011
`
` corresponding author
`
` *
`
`5
`
`TEVA EXHIBIT 1034
`TEVA PHARMACEUTICALS USA, INC. V. MONOSOL RX, LLC
`
`

`
`4. Pantazis, P., Dimas, K., Wyche, J.H., Anant, S., Houchen, C.W., Panyam, J. and
`Ramanujam, R.P. Preparation and evaluation of siRNA--encapsulated PLGA
`nanoparticles: A potential therapy for cancer. In: Nanoparticles in Biology and Medicine,
`Soloviev, M. (Ed.). Humana Press, 2011.
`5. Niu, L. and Panyam, J. Intracellular trafficking of nanoparticles: Implications for
`therapeutic efficacy of the encapsulated drug. In: Drug Delivery with Nanoparticles:
`Strategies, Technologies, and Applications, Yeo, Y. (Ed.). John Wiley & Sons, 2012.
`
`PATENTS/INVENTION DISCLOSURES
`1. Hudson, A.P., Panyam, J., Whittum-Hudson, J. Nanoparticles for imaging and treating
`chlamydial infection. US #8,647,673; Issued 2/11/14.
`2. Panyam, J. and Chavanpatil, M. Polymer-surfactant nanoparticles for sustained release
`of compounds. PCT/US2007/075925, Pending.
`3. Ohlfest, J., Panyam, J., Swaminathan, S., Vallera, D. Single-chain variable fragment anti-
`CD133 antibodies and uses thereof. PCT/US2010/059827, Pending.
`4. Hoye, T. R., Wohl, A. R., Macosko, C. W., Panyam, J. Silicate prodrugs and
`nanoparticles. PCT/US2012/040247, Pending.
`5. Panyam, J., Sadhukha, T., Kirtane, A.R. Functionalized nanoparticles and methods of
`use thereof. US 13/755,746, Pending.
`6. Kalscheuer, S., Panyam, J. Antibody fragments for detecting cancer and methods of use.
`Provisional patent application, Pending
`
`CONFERENCE PROCEEDINGS/ABSTRACTS
`1. J. Panyam, M. Chavan Patil, Meena Rani and B. Mishra. Formulation and evaluation of
`colon targeted delivery system of metronidazole. The 51st Indian Pharmaceutical
`Congress, Dec 1999, Indore, India.
`2. J. Panyam, M. L. Dali, G. L. Amidon, R. J. Levy, and V. Labhasetwar. Degradation
`characteristics of PLGA nano- and microparticles: Effect of particle size. The 2000
`Annual Meeting & Exposition of the AAPS, Oct - Nov 2000, Indianapolis, IN.
`3. J. Panyam, E. O'Leary, J. Lof, and V. Labhasetwar. Localized arterial delivery of
`nanoparticles for restenosis: Comparative efficacy of two cardiac infusion catheters. The
`2000 Annual Meeting & Exposition of the AAPS, Oct - Nov 2000, Indianapolis, IN.
`4. J. Panyam, E. O’Leary, J. Lof and V. Labhasetwar. Biodegradable nanoparticles for
`restenosis. The 32nd Annual Midwest Student Biomedical Research Forum, Feb 2001,
`Omaha, NE.
`5. J. Panyam and V. Labhasetwar. Biodegradable dexamethasone nanoparticles for
`sustained inhibition of smooth muscle cell proliferation. The 5th Annual Cardiovascular
`Research Symposium, University of Nebraska Medical Center, Feb 2001, Omaha, NE.
`6. J. Panyam, E. O’Leary, J. Lof, and V. Labhasetwar. Biodegradable dexamethasone
`nanoparticles for restenosis. The 33rd Pharmaceutics Graduate Student Research
`Meeting, University of Wisconsin, Jun 2001, Madison, WI.
`7. J. Panyam, S. Prabha, S. Sahoo and V. Labhasetwar. Evidence of rapid escape of
`from endosomes. The 5th
`nanoparticles
`International Symposium on Polymer
`Therapeutics: From Laboratory to Clinical Practice, Jan 2002, Cardiff, UK.
`8. J. Panyam, S. Prabha, S. Sahoo and V. Labhasetwar. Evidence of rapid escape of
`nanoparticles from endosomes. The 6th Annual Cardiovascular Research Symposium,
`University of Nebraska Medical Center, Feb 2002, Omaha, NE.
`9. V. Labhasetwar, J. Panyam, S. Prabha, S. K. Sahoo and W. Z. Zhou. Nanoparticles for
`Drug and Gene Delivery. The 29th Annual Meeting and Exposition of the Controlled
`Release Society, July 2002, Seoul, Korea.
`
`6
`
`TEVA EXHIBIT 1034
`TEVA PHARMACEUTICALS USA, INC. V. MONOSOL RX, LLC
`
`

`
`10. J. Panyam, S. Prabha, S. Sahoo and V. Labhasetwar. Selective cationization of PLGA
`nanoparticles in endo-lysosomal compartment results in their cytoplasmic escape. The
`34th Annual Pharmaceutics Graduate Student Research Meeting, University of Nebraska
`Medical Center, June 2002, Omaha, NE.
`11. S. Prabha, J. Panyam and V. Labhasetwar. Fractionated DNA-loaded nanoparticles show
`different levels of gene transfection in vitro. The 34th Annual Pharmaceutics Graduate
`Student Research Meeting, University of Nebraska Medical Center, June 2002, Omaha,
`NE.
`12. S. Chakravarthi, J. Panyam, S.K. Sahoo and V. Labhasetwar. Polymer degradation of
`is particle size-independent. The 34th Annual
`PLGA nano- and microparticles
`Pharmaceutics Graduate Student Research Meeting, University of Nebraska Medical
`Center, June 2002, Omaha, NE.
`13. S.K. Sahoo, J. Panyam, S. Prabha and V. Labhasetwar. Residual polyvinyl alcohol
`associated with poly (DL-lactide-co-glycolide) nanoparticles affects their physical and
`cellular uptake properties. The 34th Annual Pharmaceutics Graduate Student Research
`Meeting, University of Nebraska Medical Center, June 2002, Omaha, NE.
`14. J. Panyam and V. Labhasetwar, Dynamics of endocytosis and exocytosis of PLGA
`nanoparticles. The Globalization of Pharmaceutical Education Network, University of
`Michigan, November 2002, Ann Arbor, MI.
`15. S.K. Sahoo, J. Panyam, S. Prabha and V. Labhasetwar. Residual polyvinyl alcohol
`associated with poly (DL-lactide-co-glycolide) nanoparticles affects their physical and
`cellular uptake properties. The Globalization of Pharmaceutical Education Network,
`University of Michigan, November 2002, Ann Arbor, MI.
`16. J. Panyam, S. Prabha, S. Sahoo and V. Labhasetwar. Selective cationization of PLGA
`nanoparticles in endo-lysosomal compartment results in their cytoplasmic escape. The
`34th Annual Midwest Student Biomedical Research Forum, Feb 2003, Omaha, NE.
`17. J. Panyam and V. Labhasetwar, Correlating drug-polymer solid-state solubility with drug
`loading and release from PLGA/PLA nanoparticles. The 30th Annual Meeting and
`Exposition of Controlled Release Society, July 2003, Glasgow, Scotland, UK.
`18. J. Panyam and V. Labhasetwar, Enhancing Therapeutic Efficacy by Modulating
`Intracellular Drug Release from Nanoparticles. The 30th Annual Meeting and Exposition
`of Controlled Release Society, July 2003, Glasgow, Scotland, UK.
`19. J. Panyam, D. Williams, D. Leslie-Pelecky and V. Labhasetwar, Different characteristics
`of the drug encapsulated in nano- and microparticles. The 35th Annual Pharmaceutics
`Graduate Student Research Meeting, University of Illinois Chicago, June 2003, Chicago,
`IL.
`20. J. Panyam and V. Labhasetwar, Intracellular Drug Delivery with Nanoparticles:
`Correlating Drug Release with Therapeutic Efficacy. The 2003 Annual Meeting &
`Exposition of the AAPS, Oct 2003, Salt Lake City, UT.
`21. J. George and J. Panyam, Formulation of Methylene Blue-loaded Alginate Nanoparticles.
`Undergraduate Research Conference, Wayne State University, October 2004, Detroit,
`MI.
`22. M. Chavanpatil, Y. Patil and J. Panyam, Susceptibility of nanoparticle-encapsulated drug
`to P-glycoprotein-mediated drug efflux. Second Annual Research Day, Wayne State
`University, September 2005, Detroit, MI.
`23. C. Cundiff, Y. Patil and J. Panyam, Alginate-polyethyleneimine nanoparticles for gene
`delivery, Second Annual Research Day, Wayne State University, September 2005,
`Detroit, MI.
`24. Y. Patil and J. Panyam, Nanoparticles for sustained gene silencing. ACS regional
`meeting, October 2005, Midlands, MI.
`
`7
`
`TEVA EXHIBIT 1034
`TEVA PHARMACEUTICALS USA, INC. V. MONOSOL RX, LLC
`
`

`
`25. A. Khdair and J. Panyam, Surfactant-polymer nanoparticles for enhanced chemotherapy
`and photodynamic therapy. The 2006 Annual Meeting & Exposition of the AAPS, Nov
`2006, San Antonio, TX.
`26. A. Khdair, D. Chen, Q. P. Dou, and J. Panyam, Nanoparticle-mediated Chemo- and
`Photodynamic Therapy for Drug Resistant Tumors. 10th Annual Meeting of the Regional
`Cancer Center Consortium for the Biological Therapy of Cancer, Feb 2007, Cleveland,
`OH.
`27. Y. Patil and J. Panyam, A Novel Approach to Surface Functionalization of Nanoparticles:
`I. PEGylation. 34th Annual Meeting & Exposition of Controlled Release Society, July
`2007, Long Beach, CA.
`28. Y. Patil and J. Panyam, Novel Approach to Surface Functionalization of Nanoparticles: II.
`Folic Acid Conjugated Nanoparticles. 34th Annual Meeting & Exposition of Controlled
`Release Society, July 2007, Long Beach, CA.
`29. A. Khdair, D. Chen, Q. P. Dou, and J. Panyam, Nanoparticle-mediated Chemo- and
`Photodynamic Therapy Overcomes Tumor Drug Resistance. The 2007 Annual Meeting &
`Exposition of the AAPS, Nov 2007, San Diego, CA.
`30. R. Regmi, C. Sudakar, A. Dixit, R. Naik, G. Lawes U. Toti, and J. Panyam, Magnetite-
`Alginate-AOT nanoparticles based drug delivery platform. The 2008 APS March Meeting,
`March 2008, New Orleans, LA.
`31. Y. Patil and J. Panyam, Next Generation Targeting: Multifunctionalized Nanoparticles for
`Enhanced Cancer Chemotherapy, 35th Annual Meeting & Exposition of Controlled
`Release Society, July 2008, New York City, NY.
`32. Y. Patil and J. Panyam, Sustained Gene Silencing Using PLGA-PEI Nanoparticles, 35th
`Annual Meeting & Exposition of Controlled Release Society, July 2008, New York City,
`NY.
`33. U. Toti and J. Panyam, cRGD Peptide Functionalized Polymeric Nanoparticles for Tumor
`Targeting, The 2008 Annual Meeting & Exposition of the AAPS, Nov 2008, Atlanta, GA.
`34. K. Sekhon, S. Wykes, A. Sovinski, U. Toti, M. Hali, H. Gérard, A. Hudson, J. Panyam, J.
`Whittum-Hudson, Use of nanotechnology to target acutely and persistently Chlamydia-
`infected cells for therapy and imaging in vitro and in vivo. 2009 Chlamydia Basic
`Research Society Meeting, Little Rock, AK.
`35. K. Shahani and J. Panyam. Sustained release depot formulation of curcumin: a novel
`approach to chemoprevention. The 41st Annual Pharmaceutics Graduate Student
`Research Meeting, West Lafayette, IN (June 2009)
`36. A. Grill, U.S. Toti and J. Panyam. Interfacial Activity Assisted Surface Functionalization A
`Novel Approach to Introduce Functional Groups on Nanoparticle Surface. The 2009
`NanoDDS, Indianapolis, IN (October 2009).
`37. K. Shahani and J. Panyam. Sustained release depot formulation of curcumin: a novel
`approach to chemoprevention. The 2009 Annual Meeting & Exposition of the AAPS, Nov
`2009, Los Angeles, CA.
`38. B. Sharma, W. Ma, J. Panyam, I. Adjei, S. Dimitrijevic, V. Labhasetwar. Nanoparticle-
`mediated p53 Gene Delivery for Tumor Inhibition. The 2010 BMES Conference, Oct
`2010, Austin, TX.
`39. Sadhukha, T., Wiedmann, T., Panyam, J. Targeted magnetic hyperthermia for lung
`cancer. IPrime 2010, Minneapolis, MN.
`40. Sadhukha, T., Wiedmann, T., Panyam, J. Magnetic hyperthermia for lung cancer. Nano
`Drug Delivery Symposium 2010, Omaha, NE.
`41. Sadhukha, T., Wiedmann, T., Panyam, J. Magnetic hyperthermia for lung cancer.
`Minnesota Nanotechnology Conference 2010, Minneapolis, MN.
`42. Sadhukha, T., Wiedmann, T., Panyam, J. Magnetic hyperthermia for lung cancer.
`Globalization of Pharmaceutics Education Network 2010, Chapel Hill, NC.
`
`8
`
`TEVA EXHIBIT 1034
`TEVA PHARMACEUTICALS USA, INC. V. MONOSOL RX, LLC
`
`

`
`43. Guru, B.R., Panyam, J. EGFR Targeted PLGA Nanoparticles for Anticancer Drug
`Delivery. Nano Drug Delivery Symposium 2010, Omaha, NE.
`44. Sadhukha, T., Wiedmann, T., Panyam, J. Magnetic hyperthermia for lung cancer. Rho
`Chi Research Symposium 2011, Minneapolis, MN.
`45. Sadhukha, T., Wiedmann, T., Panyam, J. Magnetic hyperthermia as an effective
`approach to kill cancer stem cells. Masonic Cancer Center Research Symposium 2011,
`Minneapolis, MN.
`46. Sadhukha, T., Wiedmann, T., Panyam, J. Are cancer stem cells susceptible to magnetic
`hyperthermia? IPrime 2011, Minneapolis, MN
`47. Sadhukha, T., Wiedmann, T., Panyam, J. Magnetic hyperthermia as an effective
`approach to kill cancer stem cells. The 43rd Annual Pharmaceutics Graduate Student
`Research Meeting, University Wisconsin, June 2011, Madison, WI.
`48. Grill, A., Panyam, J. Sustained release curcumin microparticles delay mammary
`tumorigenesis in BALB-neuT mice. The 102nd Annual Meeting of AACR, April 2011,
`Orlando, Florida.
`49. Grill, a., Shahani, K., Koniar, B., Kalscheuer, S., Panyam, J. Sustained release curcumin
`microparticles delay mammary tumorigenesis in BALB-neuT+/- mice. The 43rd Annual
`Pharmaceutics Graduate Student Research Meeting, University Wisconsin, June 2011,
`Madison, WI.
`50. Niu, L., Panyam, J. Rapamycin Delivery to Dendritic Cells Using PLGA Nanoparticles.
`The 43rd Annual Pharmaceutics Graduate Student Research Meeting, University
`Wisconsin, June 2011, Madison, WI.
`51. Panyam, J., Toti, U.S., Hali, M., Sekhon, K., Wykes, S.M., Gerard, H., Hudson, A.P.,
`Whittum-Hudson, J.A. Targeted Delivery of Antibiotics to Intracellular Chlamydial
`Infections using PLGA Nanoparticles. The 38th Annual Meeting & Exposition of the
`Controlled Release Society, July 30 – August 3, 2011, National Harbor, Maryland.
`52. Panyam, J., Toti, U.S., Hali, M., Sekhon, K., Wykes, S.M., Gerard, H., Hudson, A.P.,
`Whittum-Hudson, J.A. Chlamydial Infection Induces Folic Acid Receptor Overexpression
`in Host Cells: Implications for Targeted Antibiotic Delivery. The 38th Annual Meeting &
`Exposition of the Controlled Release Society, July 30 – August 3, 2011, National Harbor,
`Maryland.
`53. Grill, A., Shahani, K., Koniar, B., Kalscheuer, S., Panyam, J. Chemopreventive efficacy of
`sustained release curcumin microparticles depends on tumorigenesis stage during initial
`treatment. The 103rd Annual Meeting of AACR, April 2012, Chicago, IL.
`54. Sadhu, T., Wiedmann, T.S., Panyam, J. Acute necrosis and reactive oxygen species
`generation by magnetic hyperthermia leads to effective elimination of cancer stem cells.
`9th International Conference on the Scientific and Clinical Applications of Magnetic
`Carriers 2012, May 2012, Minneapolis, MN.
`55. Sadhu, T., Wiedmann, T.S., Panyam, J. Iron oxide particle size determines the
`anticancer effectiveness of magnetic hyperthermia.
`IPRIME 2012, June 2012,
`Minneapolis, MN
`56. Kirtane, A., Lis, L., Georg, G., Gurvich, V., Panyam, J. Polymeric Nanoparticles for Tumor
`Targeted Delivery of Tylocrebrine. The 44th Annual Pharmaceutics Graduate Student
`Research Meeting, University of Nebraska Medical Center, June 2012, Omaha, NE.
`57. Liu, G., Grill, A., Panyam, J. β--Glucuronidase Activity in Breast Cancer. The 44th Annual
`Pharmaceutics Graduate Student Research Meeting, University of Nebraska Medical
`Center, June 2012, Omaha, NE.
`58. Niu, L., Panyam, J. Biodegradable Nanoparticle as Adjuvant Delivery Carrier for the
`Activation of Dendritic Cells. The 44th Annual Pharmaceutics Graduate Student Research
`Meeting, University of Nebraska Medical Center, June 2012, Omaha, NE.
`
`9
`
`TEVA EXHIBIT 1034
`TEVA PHARMACEUTICALS USA, INC. V. MONOSOL RX, LLC
`
`

`
`59. Sadhu, T., Wiedmann, T.S., Panyam, J. Aggregate Size of Superparamagnetic Iron
`Oxide Nanoparticles Determines the Anticancer Effectiveness of Magnetic Hyperthermia.
`The 2012 Annual Meeting & Exposition of the AAPS, Oct 2012, Chicago, IL.
`60. Ameya Kirtane, Lev Lis, Gunda Georg, Vadim Gurvich, Jayanth Panyam. Improving
`Therapeutic Index of Tylocrebrine through Nanoparticle-Based Reformulation Strategy.
`The 2013 Annual Meeting & Exposition of the AAPS, Nov 2013, San Antonio, TX.
`61. Tanmoy Sadhukha, Timothy Wiedmann, Jayanth Panyam.
`Inhalable Magnetic
`Nanoparticles for Targeted Hyperthermia in Lung Cancer Therapy. The 2013 Annual
`Meeting & Exposition of the AAPS, Nov 2013, San Antonio, TX.
`62. Lin Niu, Charles Schiaffo, Junzhe Xia, John Ohlfest, David Ferguson, Michael Olin,
`Jayanth Panyam.
`Immunostimulatory Nanoparticle-Facilitated
`Immunotherapy
`for
`Melanoma. The 2013 Annual Meeting & Exposition of the AAPS, Nov 2013, San Antonio,
`TX.
`63. Suresh Kumar Swaminathan, Udaya Toti, Lin Niu, John Ohlfest, Jayanth Panyam.
`Targeting Tumor Initiating Cells Using Polymeric Nanoparticles. The 2013 Annual
`Meeting & Exposition of the AAPS, Nov 2013, San Antonio, TX.
`64. Ameya Kirtane, Timothy Wiedmann, Jayanth Panyam. Surface-functionalized
`nanoparticles for inhalation delivery of chemotherapeutics to lung cancer. The 105th
`Annual Meeting of AACR, April 2014, San Diego, CA.
`65. Sumit Arora, Suresh K.