throbber
PETITIONER’S DEMONSTRATIVES
`
`March 16, 2017
`Oral Argument
`
`Neptune Generics, LLC,
`Apotex Inc., Apotex Corp., Teva Pharmaceuticals,
`Fresenius Kabi USA, LLC, and
`Wockhardt Bio AG,
`
`Petitioners,
`
`v.
`
`Eli Lilly & Company,
`Patent Owner.
`
`IPR2016-002371 -002402
`Unless otherwise indicated, all exhibit and paper numbers refer to the -00237 proceeding.
`
`1Cases IPR2016-01190, IPR2016-01335 and IPR2016-01341 have been joined with the instant proceeding.
`2Cases IPR2016-01191, IPR2016-01337 and IPR2016-01343 have been joined with the instant proceeding.
`NEPTUNE DX - 1
`
`

`

`U.S. PATENT No. 7,772,209
`INSTITUTION OF IPRS
`
`NEPTUNE DX - 2
`
`

`

`Grounds for Institution of IPR
`Institution Decision -00237
`
`Source: Paper 13 (-00237), Institution Decision, at 19.
`
`NEPTUNE DX - 3
`
`

`

`Grounds for Institution of IPR
`Institution Decision -00237
`
`Source: Paper 13 (-00237), Institution Decision, at 3-4.
`
`NEPTUNE DX - 4
`
`

`

`Grounds for Institution of IPR
`Institution Decision -00240
`
`Source: Paper 14 (-00240), Institution Decision, at 19.
`
`NEPTUNE DX - 5
`
`

`

`’209 PATENT
`‘209 PATENT
`
`
`NEPTUNE DX - 6
`
`

`

`’209 Patent Claims
`
`’209 Patent
`
`Source: Ex. 1001 at claims; Paper 1 at passim.
`
`NEPTUNE DX - 7
`
`

`

`’209 Patent Claims
`
`’209 Patent
`
`Source: Ex. 1001 at claims; Paper 1 at passim.
`
`NEPTUNE DX - 8
`
`

`

`’209 Patent
`’209 Patent Specification
`
`Source: Ex. 1001 at 2:14-26; Paper 1 at 58; Paper 13 at 3-4.
`
`NEPTUNE DX - 9
`
`

`

`POSA
`POSA
`
`
`NEPTUNE DX - 10
`
`

`

`POSA
`
`POSA Definition
`
`Source: Ex. 1025 at ¶¶ 20-21; Paper 1 at 24-25.
`
`NEPTUNE DX - 11
`
`

`

`PRIOR ART:
`PRIOR ART:
`NIYIKIZA
`NIYIKIZA
`
`
`NEPTUNE DX - 12
`
`

`

`Prior Art: Niyikiza
`
`Niyikiza
`
`Source: Ex. 1008 at 126-127; Paper 1 at 18, 26-27, 40-41, 49, 59.
`
`NEPTUNE DX - 13
`
`

`

`PRIOR ART:
`’974 PATENT
`
`NEPTUNE DX - 14
`
`

`

`Prior Art: ’974 Patent
`’974 Patent
`
`Source: Ex. 1009 at 1:47-53; Paper 1 at 27-28, 53.
`
`NEPTUNE DX - 15
`
`

`

`Prior Art: ’974 Patent
`’974 Patent
`
`Source: Ex. 1009 at 6:22-36, 6:37-47; Paper 48 at 30.
`
`NEPTUNE DX - 16
`
`

`

`Prior Art: ’974 Patent
`’974 Patent
`
`Source: Ex. 1009 at 8:49-56; Paper 48 at 30.
`
`NEPTUNE DX - 17
`
`

`

`PRIOR ART:
`PRIOR ART:
`EP 005
`=a tke
`
`
`NEPTUNE DX - 18
`
`

`

`Prior Art: EP 005
`
`EP 005
`
`Source: Ex. 1010 at 1; Paper 1 at 41-42, 45.
`
`NEPTUNE DX - 19
`
`

`

`Prior Art: EP 005
`
`EP 005
`
`Source: Ex. 1010 at 2:1-3; 2:25-29; Paper 1 at 22, 34, 36, 41.
`
`NEPTUNE DX - 20
`
`

`

`Prior Art: EP 005
`
`EP 005
`
`Source: Ex. 1010 at 3; Paper 48 at 21-22.
`
`NEPTUNE DX - 21
`
`

`

`Prior Art: EP 005
`
`EP 005
`
`Source: Ex. 1010 at 4; Paper 48 at 21-22.
`
`NEPTUNE DX - 22
`
`

`

`Prior Art: EP 005
`
`EP 005
`
`Source: Ex. 1010 at 9; Paper 48 at 22.
`
`NEPTUNE DX - 23
`
`

`

`Prior Art: EP 005
`
`EP 005
`
`Source: Ex. 1010 at 11:43-46; Paper 1 at 46-47.
`
`NEPTUNE DX - 24
`
`

`

`Prior Art: EP 005
`
`EP 005
`
`Source: Ex. 1010 at 18; Paper 48 at 21.
`
`NEPTUNE DX - 25
`
`

`

`PRIOR ART:
`PRIOR ART:
`RUSTHOVEN
`RUSTHOVEN
`
`
`NEPTUNE DX - 26
`
`

`

`Prior Art: Rusthoven
`
`Rusthoven
`
`Source: Ex. 1011 at abstract; Paper 1 (-00240) at 23-24, 53.
`
`NEPTUNE DX - 27
`
`

`

`Prior Art: Rusthoven
`
`Rusthoven
`
`Source: Ex. 1011 at 1198; Paper 48 at 12.
`
`NEPTUNE DX - 28
`
`

`

`FA, MTA, AND THE
`oeeee)8
`THERAPEUTIC INDEX
`THERAPEUTIC INDEX
`
`
`NEPTUNE DX - 29
`
`

`

`FA, MTA and the Therapeutic Index
`Rusthoven
`
`Hammond I
`
`Hammond II
`
`Source: Ex. 1011 at 1195; Ex. 1022 at 129; Ex. 2035 at 225a; Paper 48 at 14-15, 22.
`
`NEPTUNE DX - 30
`
`

`

`FA, MTA and the Therapeutic Index
`Rusthoven
`
`Source: Ex. 1011 at 1195; Paper 48 at 14-15, 22.
`
`NEPTUNE DX - 31
`
`

`

`FA, MTA and the Therapeutic Index
`Hammond
`
`Source: Ex. 1022 at 129; Paper 48 at 14-15, 22.
`
`NEPTUNE DX - 32
`
`

`

`FA, MTA and the Therapeutic Index
`Hammond II
`
`Source: Ex. 2035 at 225a; Paper 48 at 14-15, 22.
`
`NEPTUNE DX - 33
`
`

`

`FA, MTA and the Therapeutic Index
`Worzalla
`
`Source: Ex. 1005 at 3238-3239; Paper 48 at 15, 22.
`
`NEPTUNE DX - 34
`
`

`

`B12 + FA
`B12 + FA
`
`NEPTUNE DX - 35
`NEPTUNE DX- 35
`
`

`

`B12 + Folic Acid
`
`EP 005
`
`Brattström
`
`Bronstrup I
`
`Source: Ex. 1010 at 11:20-24, 18:25-26, 40-44; Ex. 1063 at 1277S-78S; Ex. 1019 at 1109; Paper 1 at 19; Paper 48 at 21.
`
`NEPTUNE DX - 36
`
`

`

`B12 + Folic Acid
`
`EP 005
`
`Source: Ex. 1010 at 11:20-24; Paper 1 at 19.
`
`NEPTUNE DX - 37
`
`

`

`B12 + Folic Acid
`
`EP 005
`
`Source: Ex. 1010 at 18:25-26, 40:44; Paper 48 at 21.
`
`NEPTUNE DX - 38
`
`

`

`B12 + Folic Acid
`
`Brattström
`
`Source: Ex. 1063 at 1277S-1278S; Paper 48 at 21.
`
`NEPTUNE DX - 39
`
`

`

`B12 + Folic Acid
`
`Bronstrup I
`
`Source: Ex. 1019 at 1109; Paper 48 at 21.
`
`NEPTUNE DX - 40
`
`

`

`B12 + Folic Acid
`
`Bronstrup II
`
`Source: Ex. 1099 at 190; Paper 48 at 21.
`
`NEPTUNE DX - 41
`
`

`

`B12 + Folic Acid
`
`Ubbink II
`
`Source: Ex. 2067 at 321; Paper 48 at 25-26.
`
`NEPTUNE DX - 42
`
`

`

`DOSE AND SCHEDULE
`DOSE AND SCHEDULE
`
`
`NEPTUNE DX - 43
`
`

`

`B12 Dose and Schedule
`’209 Patent Specification
`
`Source: Ex. 1001 at 5:19-50; Paper 1 at 38, 44; Paper 48 at 31.
`
`NEPTUNE DX - 44
`
`

`

`FA Dose and Schedule
`’209 Patent Specification
`
`Source: Ex. 1001 at 6:35-52; Paper 1 at 58.
`
`NEPTUNE DX - 45
`
`

`

`B12 and FA Dosing
`
`EP 005
`
`Source: Ex. 1010 at 5:48-56; Paper 48 at 30.
`
`NEPTUNE DX - 46
`
`

`

`B12 and FA Dosing
`
`EP 005
`
`Source: Ex. 1010 at 8; Paper 48 at 35.
`
`NEPTUNE DX - 47
`
`

`

`B12 and FA Dosing
`
`EP 005
`
`Source: Ex. 1010 at 9; Paper 48 at 22.
`
`NEPTUNE DX - 48
`
`

`

`B12 and FA Dosing
`
`EP 005
`
`Source: Ex. 1010 at claims; Paper 1 at 28, 36, 42.
`
`NEPTUNE DX - 49
`
`

`

`B12 and FA Dosing
`
`’126 Patent
`
`Source: Ex. 1104 at 7:3-32; Paper 48 at 30.
`
`NEPTUNE DX - 50
`
`

`

`B12 Dosing
`
`EP 005
`
`Source: Ex. 1010 at claims; Paper 1 at 28, 36, 42-44, 47.
`
`NEPTUNE DX - 51
`
`

`

`FA Dosing
`
`Morgan
`
`Source: Ex. 2085 at 838; Paper 48 at 30.
`
`NEPTUNE DX - 52
`
`

`

`FA Dosing
`
`’974 Patent
`
`Source: Ex. 1009 at 8:49-56; Paper 48 at 30.
`
`NEPTUNE DX - 53
`
`

`

`FA Dosing
`
`Brattström
`
`Source: Ex. 1063 at 1278S; Paper 48 at 21.
`
`NEPTUNE DX - 54
`
`

`

`FA Dosing
`
`Clarke
`
`Source: Ex. 1098 at 343; Paper 48 at 20.
`
`NEPTUNE DX - 55
`
`

`

`FA Dosing
`
`Mendelsohn
`
`Source: Ex. 2043 at 274; Paper 48 at 16.
`
`NEPTUNE DX - 56
`
`

`

`FA Dosing
`
`Ubbink I
`
`Source: Ex. 2066 at 1931; Paper 48 at 20.
`
`NEPTUNE DX - 57
`
`

`

`B12 and FA Dose and Schedule
`EP 005
`
`Source: Ex. 1010 at 17-18; Paper 1 at 47; Paper 1 at 47; Paper 48 at 21.
`
`NEPTUNE DX - 58
`
`

`

`B12 and FA Schedule
`
`EP 005
`
`Source: Ex. 1010 at 6; Paper 48 at 34.
`
`NEPTUNE DX - 59
`
`

`

`B12 and FA Schedule
`
`EP 005
`
`Source: Ex. 1010 at claims; Paper 1 (-00240) at 22, 32, 40-43.
`
`NEPTUNE DX - 60
`
`

`

`B12 Dose and Schedule
`Lindenbaum 1990
`
`Source: Ex. 1070 at 100; Paper 48 at 30-31.
`
`NEPTUNE DX - 61
`
`

`

`B12 Dose and Schedule
`
`Tamura
`
`Source: Ex. 2089 at 30; Paper 48 at 30.
`
`NEPTUNE DX - 62
`
`

`

`B12 Dose and Schedule
`
`Tamura
`
`Source: Ex. 2089 at 29; Paper 48 at 30.
`
`NEPTUNE DX - 63
`
`

`

`B12 Dose and Schedule
`
`Wray
`
`Source: Ex. 2090 at 491; Paper 48 at 30.
`
`NEPTUNE DX - 64
`
`

`

`B12 Schedule
`
`Bronstrup II
`
`Source: Ex. 1099 at 190; Paper 48 at 21.
`
`NEPTUNE DX - 65
`
`

`

`FA Dose and Schedule
`’974 Patent
`
`Source: Ex. 1009 at 6:22-36, 6:37-47; Paper 48 at 30.
`
`NEPTUNE DX - 66
`
`

`

`FA and B12 Dose and Schedule
`Brattström
`
`Source: Ex. 1063 at 1277S; Paper 48 at 21.
`
`NEPTUNE DX - 67
`
`

`

`FA and B12 Dose and Schedule
`Beutler
`
`Source: Ex. 2088 at 302; Paper 48 at 30.
`
`NEPTUNE DX - 68
`
`

`

`STATE OF THE ART
`STATE OF THE ART
`
`
`NEPTUNE DX - 69
`
`

`

`State of the Art
`
`Mason
`
`Source: Ex. 1049 at 197; Paper 48 at 20.
`
`NEPTUNE DX - 70
`
`

`

`State of the Art
`
`Calvert 1998
`
`Source: Ex. 1013 at 35; Paper 1 at 15
`
`NEPTUNE DX - 71
`
`

`

`State of the Art
`
`Calvert 1998
`
`Source: Ex. 1013 at 38; Paper 48 at 8, 11.
`
`NEPTUNE DX - 72
`
`

`

`State of the Art
`
`Calvert 1998
`
`Source: Ex. 1013 at 39; Paper 48 at 8, 11, 15, 22.
`
`NEPTUNE DX - 73
`
`

`

`State of the Art
`
`Calvert 1999
`
`Source: Ex. 1014 at 7; Paper 48 at 15, 18-19, 20, 22.
`
`NEPTUNE DX - 74
`
`

`

`State of the Art
`
`Calvert 1999
`
`Source: Ex. 1014 at 8-9; Paper 48 at 20, 23, 25.
`
`NEPTUNE DX - 75
`
`

`

`State of the Art
`
`Thodtmann
`
`Source: Ex. 1021 at 129; Paper 48 at 12.
`
`NEPTUNE DX - 76
`
`

`

`State of the Art
`
`Brattström
`
`Source: Ex. 1063 at 1276S; Paper 48 at 14.
`
`NEPTUNE DX - 77
`
`

`

`State of the Art
`
`Brattström
`
`Source: Ex. 1063 at 1277S-1278S; Paper 48 at 21.
`
`NEPTUNE DX - 78
`
`

`

`State of the Art
`
`Zervos
`
`Source: Ex. 1016 at 256a; Paper 48 at 15, 20, 22, 24.
`
`NEPTUNE DX - 79
`
`

`

`State of the Art
`
`Farber 1947
`
`Source: Ex. 1066 at 620; Paper 48 at 17.
`
`NEPTUNE DX - 80
`
`

`

`State of the Art
`
`Farber 1948
`
`Source: Ex. 2042 at 787; Paper 48 at 17.
`
`NEPTUNE DX - 81
`
`

`

`State of the Art
`
`Halpern
`
`Source: Ex. 1064 at 4022; Paper 48 at 17.
`
`NEPTUNE DX - 82
`
`

`

`State of the Art
`
`Carrasco
`
`Source: Ex. 1020 at 767; Paper 48 at 25-26.
`
`NEPTUNE DX - 83
`
`

`

`State of the Art
`
`Carrasco
`
`Source: Ex. 1020 at 768; Paper 48 at 25-26.
`
`NEPTUNE DX - 84
`
`

`

`State of the Art
`
`Priestman
`
`Source: Ex. 1073 at 71-72; Paper 48 at 18-19.
`
`NEPTUNE DX - 85
`
`

`

`State of the Art
`
`O’ Dwyer
`
`Source: Ex. 1015 at 104; Paper 48 at 20.
`
`NEPTUNE DX - 86
`
`

`

`State of the Art
`
`Clarke
`
`Source: Ex. 1098 at 343; Paper 48 at 20.
`
`NEPTUNE DX - 87
`
`

`

`State of the Art
`
`Bronstrup II
`
`Source: Ex. 1099 at 190; Paper 48 at 21.
`
`NEPTUNE DX - 88
`
`

`

`State of the Art
`
`Bronstrup I
`
`Source: Ex. 1019 at 1104; Paper 48 at 25-26.
`
`NEPTUNE DX - 89
`
`

`

`State of the Art
`
`Bronstrup I
`
`Source: Ex. 1019 at 1109; Paper 48 at 21, 24, 26, 29.
`
`NEPTUNE DX - 90
`
`

`

`State of the Art
`
`Rinaldi II
`
`Source: Ex. 2030 at 86; Paper 48 at 11-12.
`
`NEPTUNE DX - 91
`
`

`

`State of the Art
`
`Shih 1998
`
`Source: Ex. 2078 at 142; Paper 48 at 13.
`
`NEPTUNE DX - 92
`
`

`

`State of the Art
`
`PDR 1999
`
`Source: Ex. 2020 at 1398-1399; Paper 48 at 15-16.
`
`NEPTUNE DX - 93
`
`

`

`State of the Art
`
`Mendelsohn
`
`Source: Ex. 2043 at 274; Paper 48 at 16.
`
`NEPTUNE DX - 94
`
`

`

`State of the Art
`
`Laohavinij
`
`Source: Ex. 2031 at 326; Paper 48 at 16.
`
`NEPTUNE DX - 95
`
`

`

`State of the Art
`
`Laohavinij
`
`Source: Ex. 2031 at 330; Paper 48 at 18.
`
`NEPTUNE DX - 96
`
`

`

`State of the Art
`
`Laohavinij
`
`Source: Ex. 2031 at 333; Paper 48 at 17.
`
`NEPTUNE DX - 97
`
`

`

`State of the Art
`
`Laohavinij
`
`Source: Ex. 2031 at 334; Paper 48 at 17.
`
`NEPTUNE DX - 98
`
`

`

`State of the Art
`Niyikiza ASCO
`
`Source: Ex. 2015 at 558a; Paper 48 at 18-20.
`
`NEPTUNE DX - 99
`
`

`

`State of the Art
`
`Ubbink I
`
`Source: Ex. 2066 at 1931; Paper 48 at 20.
`
`NEPTUNE DX - 100
`
`

`

`State of the Art
`
`Allen
`
`Source: Ex. 1017 at 97; Paper 48 at 24.
`
`NEPTUNE DX - 101
`
`

`

`State of the Art
`Lindenbaum 1994
`
`Source: Ex. 1094 at 9; Paper 48 at 25-26.
`
`NEPTUNE DX - 102
`
`

`

`State of the Art
`
`Nilsson-Ehle
`
`Source: Ex. 1072 at 277; Paper 48 at 26.
`
`NEPTUNE DX - 103
`
`

`

`State of the Art
`
`Vu 1993
`
`Source: Ex. 1074 at 208; Paper 48 at 26.
`
`NEPTUNE DX - 104
`
`

`

`State of the Art
`
`Cubeddu
`
`Source: Ex. 1061 at 810; Paper 48 at 26.
`
`NEPTUNE DX - 105
`
`

`

`State of the Art
`
`PDR 1998
`
`Source: Ex. 1101 at 2696; Paper 48 at 28.
`
`NEPTUNE DX - 106
`
`

`

`State of the Art
`
`McLean
`
`Source: Ex. 2058 at 4015; Paper 48 at 28.
`
`NEPTUNE DX - 107
`
`

`

`State of the Art
`Sofyina v. Arsenyan
`
`Source: Ex. 2041 at 1, Ex. 2055 at 1299; Paper 48 at 28.
`
`NEPTUNE DX - 108
`
`

`

`State of the Art
`Sofyina v. Arsenyan
`
`Source: Ex. 2041 at 2, Ex. 2055 at 1301; Paper 48 at 28.
`
`NEPTUNE DX - 109
`
`

`

`State of the Art
`
`Tamura
`
`Source: Ex. 2089 at 28; Paper 48 at 28.
`
`NEPTUNE DX - 110
`
`

`

`State of the Art
`
`Tamura
`
`Source: Ex. 2089 at 31; Paper 48 at 28.
`
`NEPTUNE DX - 111
`
`

`

`State of the Art
`
`Bodian 1963
`
`Source: Ex. 1059 at 608; Paper 48 at 28.
`
`NEPTUNE DX - 112
`
`

`

`State of the Art
`
`Bodian 1959
`
`Source: Ex. 1060 at 458; Paper 48 at 28.
`
`NEPTUNE DX - 113
`
`

`

`State of the Art
`
`Lockwood
`
`Source: Ex. 1071 at S233; Paper 48 at 28.
`
`NEPTUNE DX - 114
`
`

`

`State of the Art
`
`Lockwood
`
`Source: Ex. 1071 at S234; Paper 48 at 28.
`
`NEPTUNE DX - 115
`
`

`

`State of the Art
`
`Barber
`
`Source: Ex. 1058 at 80; Paper 48 at 28.
`
`NEPTUNE DX - 116
`
`

`

`State of the Art
`
`Barber
`
`Source: Ex. 1058 at 86; Paper 48 at 28.
`
`NEPTUNE DX - 117
`
`

`

`State of the Art
`
`Kirkemo
`
`Source: Ex. 1069 at 1003; Paper 48 at 28.
`
`NEPTUNE DX - 118
`
`

`

`LILLY PUBLICATIONS
`LILLY PUBLICATIONS
`
`
`NEPTUNE DX - 119
`
`

`

`Lilly Publications
`12/3/99 Lilly to FDA:
`
`Source: Ex. 2103 at 19-20; Paper 48 at 6, 8.
`
`NEPTUNE DX - 120
`
`

`

`Lilly Publications
`12/3/99 Lilly to FDA:
`
`Source: Ex. 2103 at 14; Paper 48 at 6, 17.
`
`NEPTUNE DX - 121
`
`

`

`Lilly Publications
`2/16/00 Lilly to FDA:
`
`Source: Ex. 2107 at 10; Paper 48 at 10, 14, 18.
`
`NEPTUNE DX - 122
`
`

`

`Lilly Publications
`2/16/00 Lilly to FDA:
`
`Source: Ex. 2107 at 11; Paper 48 at 13.
`
`NEPTUNE DX - 123
`
`

`

`Lilly Publications
`2/16/00 Lilly to FDA:
`
`Source: Ex. 2107 at 15; Paper 48 at 27.
`
`NEPTUNE DX - 124
`
`

`

`Lilly Publications
`Oncologist Article
`
`Source: Ex. 1047 at 372-373; Paper 48 at 6, 9, 33.
`
`NEPTUNE DX - 125
`
`

`

`DR. CHABNER
`DR. CHABNER
`
`
`NEPTUNE DX - 126
`
`

`

`Dr. Chabner
`Dr. Chabner’s Testimony
`
`Source: Ex. 1075 at 233:15-234:12; Paper 48 at 2.
`
`NEPTUNE DX - 127
`
`

`

`Dr. Chabner
`Dr. Chabner’s Testimony
`
`Source: Ex. 1075 at 228:11-229:3; Paper 48 at 2.
`
`NEPTUNE DX - 128
`
`

`

`Dr. Chabner
`Dr. Chabner’s Testimony
`
`Source: Ex. 1075 at 88:25-89:8; Paper 48 at 2.
`
`NEPTUNE DX - 129
`
`

`

`Dr. Chabner
`Dr. Chabner’s Testimony
`
`Source: Ex. 1075 at 89:20-25; Paper 48 at 2.
`
`NEPTUNE DX - 130
`
`

`

`Dr. Chabner
`Dr. Chabner’s Testimony
`
`Source: Ex. 1075 at 227:20-228:24; Paper 48 at 2.
`
`NEPTUNE DX - 131
`
`

`

`Dr. Chabner
`Dr. Chabner’s Testimony
`
`Source: Ex. 1075 at 90:19-91:25; Paper 48 at 3.
`
`NEPTUNE DX - 132
`
`

`

`Dr. Chabner
`Dr. Chabner’s Testimony
`
`Source: Ex. 1075 at 92:1-93:25; Paper 48 at 3.
`
`NEPTUNE DX - 133
`
`

`

`Dr. Chabner
`Dr. Chabner’s Testimony
`
`Source: Ex. 1075 at 94:1-3; Paper 48 at 3.
`
`NEPTUNE DX - 134
`
`

`

`Dr. Chabner
`Dr. Chabner’s Testimony
`
`Source: Ex. 1075 at 214:9-215:4; Paper 48 at 3.
`
`NEPTUNE DX - 135
`
`

`

`Dr. Chabner
`Dr. Chabner’s Testimony
`
`Source: Ex. 1075 at 149:18-150:25; Paper 48 at 4.
`
`NEPTUNE DX - 136
`
`

`

`Dr. Chabner
`Dr. Chabner’s Testimony
`
`Source: Ex. 1075 at 151:1-152:4; Paper 48 at 4.
`
`NEPTUNE DX - 137
`
`

`

`Dr. Chabner
`Dr. Chabner’s Testimony
`
`Source: Ex. 1075 at 308:20-310:2; Paper 48 at 4.
`
`NEPTUNE DX - 138
`
`

`

`Dr. Chabner
`Dr. Chabner’s Testimony
`
`Source: Ex. 1075 at 102:3-103:16; Paper 48 at 4.
`
`NEPTUNE DX - 139
`
`

`

`Dr. Chabner
`Dr. Chabner’s Testimony
`
`Source: Ex. 1075 at 105:8-12; Paper 48 at 5.
`
`NEPTUNE DX - 140
`
`

`

`Dr. Chabner
`Dr. Chabner’s Testimony
`
`Source: Ex. 1075 at 101:7-24; Paper 48 at 5.
`
`NEPTUNE DX - 141
`
`

`

`Dr. Chabner
`Dr. Chabner’s Testimony
`
`Source: Ex. 1075 at 109:24-110:4; Paper 48 at 5.
`
`NEPTUNE DX - 142
`
`

`

`Dr. Chabner
`Dr. Chabner’s Testimony
`
`Source: Ex. 1075 at 111:5-15; Paper 48 at 5.
`
`NEPTUNE DX - 143
`
`

`

`Dr. Chabner
`Dr. Chabner’s Testimony
`
`Source: Ex. 1075 at 112:20-113:6; Paper 48 at 5.
`
`NEPTUNE DX - 144
`
`

`

`Dr. Chabner
`Dr. Chabner’s Testimony
`
`Source: Ex. 1075 at 103:17-104:13; Paper 48 at 5.
`
`NEPTUNE DX - 145
`
`

`

`Dr. Chabner
`Dr. Chabner’s Testimony
`
`Source: Ex. 1075 at 136:2-13; Paper 48 at 5.
`
`NEPTUNE DX - 146
`
`

`

`Dr. Chabner
`Dr. Chabner’s Testimony
`
`Source: Ex. 1075 at 34:13-20; Paper 48 at 6.
`
`NEPTUNE DX - 147
`
`

`

`Dr. Chabner
`Dr. Chabner’s Testimony
`
`Source: Ex. 1075 at 147:1-148:14; Paper 48 at 6.
`
`NEPTUNE DX - 148
`
`

`

`Dr. Chabner
`Dr. Chabner’s Testimony
`
`Source: Ex. 1075 at 82:25-84:20; Paper 48 at 7.
`
`NEPTUNE DX - 149
`
`

`

`Dr. Chabner
`Dr. Chabner’s Testimony
`
`Source: Ex. 1075 at 141:25-142:19; Paper 48 at 9.
`
`NEPTUNE DX - 150
`
`

`

`Dr. Chabner
`Dr. Chabner’s Testimony
`
`Source: Ex. 1075 at 146:11-148:14; Paper 48 at 9.
`
`NEPTUNE DX - 151
`
`

`

`Dr. Chabner
`Dr. Chabner’s Testimony
`
`Source: Ex. 1075 at 167:14-168:21; Paper 48 at 9.
`
`NEPTUNE DX - 152
`
`

`

`Dr. Chabner
`Dr. Chabner’s Testimony
`
`Source: Ex. 1075 at 180:13-181:25; Paper 48 at 9.
`
`NEPTUNE DX - 153
`
`

`

`Dr. Chabner
`Dr. Chabner’s Testimony
`
`Source: Ex. 1075 at 182:1-183:25; Paper 48 at 9.
`
`NEPTUNE DX - 154
`
`

`

`Dr. Chabner
`Dr. Chabner’s Testimony
`
`Source: Ex. 1075 at 184:1-15; Paper 48 at 9.
`
`NEPTUNE DX - 155
`
`

`

`Dr. Chabner
`Dr. Chabner’s Testimony
`
`Source: Ex. 1075 at 160:5-20; Paper 48 at 9.
`
`NEPTUNE DX - 156
`
`

`

`Dr. Chabner
`Dr. Chabner’s Testimony
`
`Source: Ex. 1075 at 160:22-161:12; Paper 48 at 10.
`
`NEPTUNE DX - 157
`
`

`

`Dr. Chabner
`Dr. Chabner’s Testimony
`
`Source: Ex. 1075 at 157:5-158:25; Paper 48 at 10.
`
`NEPTUNE DX - 158
`
`

`

`Dr. Chabner
`Dr. Chabner’s Testimony
`
`Source: Ex. 1075 at 159:1-20; Paper 48 at 10.
`
`NEPTUNE DX - 159
`
`

`

`Dr. Chabner
`Dr. Chabner’s Testimony
`
`Source: Ex. 1075 at 165:5-166:25; Paper 48 at 10.
`
`NEPTUNE DX - 160
`
`

`

`Dr. Chabner
`Dr. Chabner’s Testimony
`
`Source: Ex. 1075 at 167:1-13; Paper 48 at 10.
`
`NEPTUNE DX - 161
`
`

`

`Dr. Chabner
`Dr. Chabner’s Testimony
`
`Source: Ex. 1075 at 219:23-220:25; Paper 48 at 10.
`
`NEPTUNE DX - 162
`
`

`

`Dr. Chabner
`Dr. Chabner’s Testimony
`
`Source: Ex. 1075 at 221:1-5; Paper 48 at 10.
`
`NEPTUNE DX - 163
`
`

`

`Dr. Chabner
`Dr. Chabner’s Testimony
`
`Source: Ex. 1075 at 249:12-250:20; Paper 48 at 10.
`
`NEPTUNE DX - 164
`
`

`

`Dr. Chabner
`Dr. Chabner’s Testimony
`
`Source: Ex. 1075 at 269:3-270:25; Paper 48 at 10
`
`NEPTUNE DX - 165
`
`

`

`Dr. Chabner
`Dr. Chabner’s Testimony
`
`Source: Ex. 1075 at 271:1-272:25; Paper 48 at 10.
`
`NEPTUNE DX - 166
`
`

`

`Dr. Chabner
`Dr. Chabner’s Testimony
`
`Source: Ex. 1075 at 273:1-274:25; Paper 48 at 10.
`
`NEPTUNE DX - 167
`
`

`

`Dr. Chabner
`Dr. Chabner’s Testimony
`
`Source: Ex. 1075 at 275:1-277:22; Paper 48 at 10.
`
`NEPTUNE DX - 168
`
`

`

`Dr. Chabner
`Dr. Chabner’s Testimony
`
`Source: Ex. 1075 at 251:19-24; Paper 48 at 10.
`
`NEPTUNE DX - 169
`
`

`

`Dr. Chabner
`Dr. Chabner’s Testimony
`
`Source: Ex. 1075 at 254:3-255:25; Paper 48 at 10.
`
`NEPTUNE DX - 170
`
`

`

`Dr. Chabner
`Dr. Chabner’s Testimony
`
`Source: Ex. 1075 at 256:1-257:25; Paper 48 at 10.
`
`NEPTUNE DX - 171
`
`

`

`Dr. Chabner
`Dr. Chabner’s Testimony
`
`Source: Ex. 1075 at 153:2-14; Paper 48 at 12.
`
`NEPTUNE DX - 172
`
`

`

`Dr. Chabner
`Dr. Chabner’s Testimony
`
`Source: Ex. 1075 at 184:17-21; Paper 48 at 15.
`
`NEPTUNE DX - 173
`
`

`

`Dr. Chabner
`Dr. Chabner’s Testimony
`
`Source: Ex. 1075 at 172:23-25; Paper 48 at 16.
`
`NEPTUNE DX - 174
`
`

`

`Dr. Chabner
`Dr. Chabner’s Testimony
`
`Source: Ex. 1075 at 178:2-179:13; Paper 48 at 16.
`
`NEPTUNE DX - 175
`
`

`

`Dr. Chabner
`Dr. Chabner’s Testimony
`
`Source: Ex. 1075 at 179:3-18; Paper 48 at 17.
`
`NEPTUNE DX - 176
`
`

`

`Dr. Chabner
`Dr. Chabner’s Testimony
`
`Source: Ex. 1075 at 280:10-20; Paper 48 at 19.
`
`NEPTUNE DX - 177
`
`

`

`Dr. Chabner
`Dr. Chabner’s Testimony
`
`Source: Ex. 1075 at 158:11-14; Paper 48 at 22.
`
`NEPTUNE DX - 178
`
`

`

`Dr. Chabner
`Dr. Chabner’s Testimony
`
`Source: Ex. 1075 at 343:9; Paper 48 at 29.
`
`NEPTUNE DX - 179
`
`

`

`Dr. Chabner
`Dr. Chabner’s Testimony
`
`Source: Ex. 1075 at 274:8-9; Paper 48 at 28.
`
`NEPTUNE DX - 180
`
`

`

`Dr. Chabner
`Dr. Chabner’s Testimony
`
`Source: Ex. 1075 at 95:13, 215:3-4, 274:8-9; Paper 48 at 29.
`
`NEPTUNE DX - 181
`
`

`

`Dr. Chabner
`Dr. Chabner’s Testimony
`
`Source: Ex. 1075 at 352:5-9; Paper 48 at 30.
`
`NEPTUNE DX - 182
`
`

`

`Dr. Chabner
`Dr. Chabner’s Testimony
`
`Source: Ex. 1075 at 351:16-352:9; Paper 48 at 31.
`
`NEPTUNE DX - 183
`
`

`

`Dr. Chabner
`Dr. Chabner’s Testimony
`
`Source: Ex. 1075 at 350:21-351:25; Paper 48 at 31.
`
`NEPTUNE DX - 184
`
`

`

`Dr. Chabner
`Dr. Chabner’s Testimony
`
`Source: Ex. 1075 at 352:1-9; Paper 48 at 31.
`
`NEPTUNE DX - 185
`
`

`

`Dr. Chabner
`Dr. Chabner’s Testimony
`
`Source: Ex. 1075 at 198:6-199:25; Paper 48 at 33.
`
`NEPTUNE DX - 186
`
`

`

`Dr. Chabner
`Dr. Chabner’s Testimony
`
`Source: Ex. 1075 at 200:1-201:11; Paper 48 at 33.
`
`NEPTUNE DX - 187
`
`

`

`Dr. Chabner
`Dr. Chabner’s Testimony
`
`Source: Ex. 1075 at 204:2-206:2; Paper 48 at 33.
`
`NEPTUNE DX - 188
`
`

`

`Dr. Chabner
`Dr. Chabner’s Testimony
`
`Source: Ex. 1075 at 209:7-210:2; Paper 48 at 33.
`
`NEPTUNE DX - 189
`
`

`

`Dr. Chabner
`Dr. Chabner’s Testimony
`
`Source: Ex. 1075 at 208:15-20; Paper 74 at 2.
`
`NEPTUNE DX - 190
`
`

`

`Dr. Chabner
`Dr. Chabner’s Testimony
`
`Source: Ex. 1075 at 214:2-25; Paper 74 at 2.
`
`NEPTUNE DX - 191
`
`

`

`Dr. Chabner
`Dr. Chabner’s Testimony
`
`Source: Ex. 2120 ¶96; Paper 48 at 9.
`
`NEPTUNE DX - 192
`
`

`

`Dr. Chabner
`Dr. Chabner’s Testimony
`
`Source: Ex. 2120 ¶157; Paper 48 at 10.
`
`NEPTUNE DX - 193
`
`

`

`Dr. Chabner
`Dr. Chabner’s Testimony
`
`Source: Ex. 2120 ¶164; Paper 48 at 14, 27.
`
`NEPTUNE DX - 194
`
`

`

`Dr. Chabner
`Dr. Chabner’s Testimony
`
`Source: Ex. 2120 ¶67; Paper 48 at 17-18.
`
`NEPTUNE DX - 195
`
`

`

`DR. ZEISEL
`DR. ZEISEL
`
`
`NEPTUNE DX - 196
`
`

`

`Dr. Zeisel
`Dr. Zeisel’s Testimony
`
`Source: Ex. 2118 at ¶23; Paper 48 at 12-13.
`
`NEPTUNE DX - 197
`
`

`

`Dr. Zeisel
`Dr. Zeisel’s Testimony
`
`Source: Ex. 1076 at 124:20-125:15; Paper 48 at 16.
`
`NEPTUNE DX - 198
`
`

`

`Dr. Zeisel
`Dr. Zeisel’s Testimony
`
`Source: Ex. 1076 at 83:18-20; Paper 48 at 31.
`
`NEPTUNE DX - 199
`
`

`

`Dr. Zeisel
`Dr. Zeisel’s Testimony
`
`Source: Ex. 1076 at 40:10-19; Paper 48 at 19.
`
`NEPTUNE DX - 200
`
`

`

`Dr. Zeisel
`Dr. Zeisel’s Testimony
`
`Source: Ex. 1076 at 41:5-12; Paper 48 at 19.
`
`NEPTUNE DX - 201
`
`

`

`Dr. Zeisel
`Dr. Zeisel’s Testimony
`
`Source: Ex. 1076 at 34:16-23; Paper 48 at 20.
`
`NEPTUNE DX - 202
`
`

`

`Dr. Zeisel
`Dr. Zeisel’s Testimony
`
`Source: Ex. 1076 at 139:9-14; Paper 48 at 20.
`
`NEPTUNE DX - 203
`
`

`

`Dr. Zeisel
`Dr. Zeisel’s Testimony
`
`Source: Ex. 1076 at 116:12-20; Paper 48 at 24.
`
`NEPTUNE DX - 204
`
`

`

`Dr. Zeisel
`Dr. Zeisel’s Testimony
`
`Source: Ex. 1076 at 41:5-12; Paper 48 at 25.
`
`NEPTUNE DX - 205
`
`

`

`Dr. Zeisel
`Dr. Zeisel’s Testimony
`
`Source: Ex. 1076 at 98:4-17; Paper 48 at 25-26.
`
`NEPTUNE DX - 206
`
`

`

`Dr. Zeisel
`Dr. Zeisel’s Testimony
`
`Source: Ex. 1076 at 145:17-22; Paper 48 at 27.
`
`NEPTUNE DX - 207
`
`

`

`Dr. Zeisel
`Dr. Zeisel’s Testimony
`
`Source: Ex. 1076 at 41:22-42:17; Paper 48 at 29.
`
`NEPTUNE DX - 208
`
`

`

`Dr. Zeisel
`Dr. Zeisel’s Testimony
`
`Source: Ex. 1076 at 83:18-20; Paper 48 at 14, 31.
`
`NEPTUNE DX - 209
`
`

`

`Dr. Zeisel
`Dr. Zeisel’s Testimony
`
`Source: Ex. 1076 at 88:7-89:25; Paper 48 at 31.
`
`NEPTUNE DX - 210
`
`

`

`Dr. Zeisel
`Dr. Zeisel’s Testimony
`
`Source: Ex. 1076 at 90:1-91:11; Paper 48 at 31.
`
`NEPTUNE DX - 211
`
`

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