Home Address:
`
`Office Address:
`
`Kathryn Adamiak Davis, MD, MSTR
`
`600 North Chester Road
`Swarthmore, PA 19081
`
`Hospital of the University of Pennsylvania
`Neurology Department, Penn Epilepsy Center
`3400 Spruce Street
`3 West Gates Building
`Philadelphia, PA 19104
`
`Phone:
`
`Email:
`
`Work: (215) 349-5166
`Cell:
`(609) 306-5746
`Fax:
`(215) 349-5733
`
`Kathryn.Davis@uphs.upenn.edu
`Katedavis1234@gmail.com
`
`Education and Training:
`
`7/09-7/11
`
`Masters in Translational Research Program, University of Pennsylvania
`Thesis entitled: “Novel Methods in the Localization of Epileptic Networks”
`•
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`7/08-6/09
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`Epilepsy Fellow at the University of Pennsylvania
`
`7/05-6/08
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`Neurology Resident at the University of Pennsylvania (Board Certified 2008)
`Research project entitled Detection of Cerebral Ischemia After SAH Using
`•
`Continuous EEG Monitoring
`
`6/04-6/05
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`Medical Internship at the University of Pennsylvania
`
`9/00-5/04
`
`MD
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`Yale University School of Medicine
`Thesis based on blood flow as measure by SPECT imaging and
`•
`consciousness during epileptic seizures in lab of Hal Blumenfeld, MD, PhD
`
`9/95-5/99
`
`BS
`
`Brown University (Neuroscience)
`• Honors thesis: GABA staining throughout the development of the bullfrog’s
`auditory brainstem
`
`Board Certifications:
`• American Board of Clinical Neurophysiology diplomate (2010-present)
`• Advanced Examination in Central Clinical Neurophysiology with added competency in
`Epilepsy Monitoring
`Board Certified by the American Board of Psychiatry and Neurology (2009-present)
`
`•
`
`Employment Appointments:
`
`2/13-present
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`8/11-1/13
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`Neurology Department Hospital of the University of Pennsylvania
`• Assistant Professor, Penn Epilepsy Center
`• Associate Director, Penn Epilepsy Center
`• Medical Director of Epilepsy Monitoring Unit and Surgical Program
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`Neurology Department Crozer Chester Medical Center
`Clinical Assistant Professor, Drexel University
`•
`• Adjunct Assistant Professor, Temple University
`• Adjunct Assistant Professor, University of Pennsylvania
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`ARGENTUM Exhibit 1089
` Argentum Pharmaceuticals LLC v. Research Corporation Technologies, Inc.
`IPR2016-00204
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`7/09-7/11
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`2001-2004
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`2001-2002
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`1999-2000
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`1998-1999
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`• Director of the EEG lab and Epilepsy Monitoring Unit
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`Neurology Department Hospital of the University of Pennsylvania
`•
`Instructor of Neurology, Epilepsy Division
`• Teaching Assistant in second year Medical Student Neurology course
`• Lecturer to rotating third year Medical students on Epilepsy
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`Neurology Department Yale University School of Medicine
`• Research assistant in the laboratory of Dr. Hal Blumenfeld
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`Yale University Cell Biology Department
`• Teaching assistant for cell biology and histology
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`National Institute of Mental Health Bethesda, MD
`• Pre-doctoral Intramural Research Fellow under Dr. David Rubinow in
`Behavioral Endocrinology Branch
`
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`Neuroscience Department Brown University
`• Laboratory assistant for Doctor Andrea Simmons
`• Received Honors BS degree based on thesis work in lab
`
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`Awards, Honors and Memberships in Honorary Societies:
`
`
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`Membership in Professional and Scientific Societies:
`• American Neurological Association 2005-present
`• American Epilepsy Society 2008-present
`• American Clinical Neurophysiology Society 2010-2014
`• Association for Clinical Research Training 2010-2011
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`Committees:
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`2016-present
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`
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`Residency Interviews Committee, Neurology Department, University of Pennsylvania
`
`2016
`2015
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`
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`2015-2017
`2015
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`2015
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`2013
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`2013
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`2012
`2009-2011
`2009-2011
`2008
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`2007
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`2004
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`1999
`1999
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`Fellow of the American Epilepsy Society (FAES)
`NIH Director’s BLOG posting (10/2015)
`• First author on paper: “Glutamate Imaging (GluCEST) Lateralized Epileptic
`Foci in Non-Lesional Temporal Lobe Epilepsy”
`Penn Faculty Pathways Program
`Best Doctors Recognition, Philadelphia Life
`Young Investigator Award
`• Neurobiology of Disease in Children (elected by Dr. Brandy Fureman)
`McCabe Pilot Award
`• Localizing Epileptic Networks using Novel Glutamate Imaging
`
`CBICA (Center for Biomedical Image Computing and Analytics) Seed Award
`• Hippocampal Subfield Volumetry and Functional Connectivity on 7T MRI:
`Potential Biomarkers in Medically Refractory Temporal Lobe Epilepsy
`Top Doctors, Main Line Today
`National Epilepsy Foundation Research Grant
`K12 Award from the NIH
`Top Scholar Epilepsy Fellow
`National Epifellow Scientific Forum Participant
`Merck Book Award, Yale University School of Medicine
`Honors BS degree in Neuroscience, Brown University
`Associate Member of Sigma Xi, Brown University chapter
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`Clinical Operations Committee, Neurology Department, University of Pennsylvania
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`Epilepsy Foundation of Eastern Pennsylvania: Board Member
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`Patient Oriented Research Committee, Neurology Department, University of
`Pennsylvania
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`Research Committee, Neurology Department, University of Pennsylvania
`
`Neuroscience Service Line: Physician Leader
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`American Epilepsy Society: Annual Course Committee, Membership Committee,
`Epilepsy Benchmarks Committee
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`Patient Safety and Quality of Care Committee, Neurology Department, University of
`Pennsylvania
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`Member of Residency Committee Crozer Chester Medical Center
`
`Internal Review Board University of Pennsylvania
`§ Member of IRB responsible for reviewing, revising and approving research protocols
`
`SIGN (Student Interest Group in Neurology)
`• Cofounder of organization at Yale University
`
`Human Investigation Committee Yale University
`• Member of Internal Review Board responsible for reviewing, revising, and
`approving research protocols
`
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`2015-present
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`2015-present
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`2013-present
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`2014-present
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`2013-present
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`2013-present
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`2013-present
`
`
`2011-2013
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`2009-2010
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`2000-2004
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`2000-2002
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`Brown University Class Officer
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`Ad hoc reviewer, 2016
`Ad hoc reviewer, 2016
`Ad hoc reviewer, 2013-2016
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`Ad hoc reviewer, 2016
`
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`1998-present
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`Editorial Activities:
`Journal of Computational Methods in Sciences and Engineering
`Neurocomputing
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`Epilepsia
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`Grant Review Activities:
`PSI Foundation
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`Bibliography:
`
`Original Papers
`
`Hill C, Thomas B, Sansalone K, Davis KA, Shea JA, Litt B, Dahodwala N. “Improved
`Availability and Quality of Care with Epilepsy Nurse Practioners.” Neurology:
`Clinical Practice, Accepted with revision, 2016.
`
`
`Kini LG, Nasrallah IM, Coto C, Ferraro LC, Davis KA. “Advanced structural
`multimodal imaging of a patient with subcortical band heterotopia.” Epilepsia
`Open, 2016
`
`
`Hudgins E, Brown M, Litt B, Davis K, Richardson AG, Lucas T. “Focal seizures induced
`by intracranial electroencephalogram grids.” Cureus, 2016.
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`Jacobs, J, Miller J, Lee SA, Coffey T, Watrous A, Sperling MR, Sharan A, Worrell G,
`Kucewicz MT, Lega B, Jobst B, Davis K, Gross B, Sheth S, Ezzyet Y, Das S,
`Stein J, Gorniak R, Kahana M, Rizzuto D. “Direct electrical stimulation of
`human entorhinal cortex impairs memory.” In press. Neuron, 2016.
`
`Kragel JE, Ezzyat Y, Burke JF, Sperling MR, Gorniak R, Worrell GA, Davis KA, Lin J,
`Jobst BC, Sheth SA, Zaghloul KA, Inman C, Stein J, Das SR, Rizzuto DS,
`Kahana MJ. “Core episodic encoding and retrieval processes revealed by
`dynamics of neural activity.” Submitted to eNeuro, 2016.
`
`
`Davis KA, Ung H, Wulsin D, Wagenaar J, Fox E, McDonnell JJ, Patterson N, Vite CH,
`Worrell G, Litt B. “Temporal behavior of seizures and interictal bursts in
`prolonged intracranial recordings from epileptic canines.” Epilepsia, 2016 Nov
`3.
`
`
`Horak P, Meisenhelter S, Song Y, Testorf M, Kahana M, Viles W, Bujarski K, Connolly
`A, Robbins A, Sperling M, Sharan A, Worrell G, Kucewicz M, Gross R, Davis
`KA, Roberts D, Lega B, Sheth S, Zaghloul K, Stein J, Das S, Rizzuto D, Jobst
`B. “Interictal Epileptiform Discharges Impair Word Recall in Multiple Brain
`Areas.” In press. Epilepsia, 2016.
`
`
`Khambhati AN, Davis KA, Lucas TH, Litt B, Bassett DS. “Virtual cortical resection
`reveals push-pull network control preceding seizure evolution.” Neuron, 2016
`Sep 7;91(5):1170-82.
`
`
`Ezzyat Y, Burke JF, Levy DF, Lyalenko A, Sperling MR, Sharan AD, Worrell GA,
`Kucewicz MT, Jobst BC, Davis KA, Lucas TH, Gross RE, Lega BC, Stein JM,
`Das S, Gorniak R, Rizzuto DS, Kahana MJ. “Targeted brain stimulation to
`modulate memory performance in humans.” Submitted to PNAS, 2016.
`
`
`Khambhati AN, Bassett DS, Oommen B, Chen S, Lucas T, Davis KA, Litt B. “Recurring
`functional interactions predict network architecture of interictal and ictal states
`in neocortical epilepsy.” Accepted with revision in eNeuro, 2016.
`
`
`Dlugos D, Worrell G, Davis K, Stacey W, Szaflarski J, Kanner A, Sunderam S,
`Rogawski M, Jackson-Ayotunde P, Loddenkempter T, Diehl B, Fureman B,
`Dingledine R. “2014 Epilepsy Benchmarks Area III: Improve Treatment
`Options for Controlling Seizures and Epilepsy-Related Conditions Without Side
`Effects.” Epilepsy Currents. 2016 May-June;16(3):192-7.
`
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`Thibault DP, Mendizabal A, Abend NS, Davis KA, Crispo J, Willis AW. “Hospital Care
`for Mental Health and Substance Abuse in Children with Epilepsy.” Epilepsy &
`Behavior, 57:161-6, 2016.
`
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`Davis KA, Ung H, Wulsin DF, Wagenaar J, Fox E, Patterson N, Vite C, Worrell G, Litt
`B. “Mining continuous intracranial EEG in focal canine epilepsy: Relating
`interictal bursts to seizure onsets.” Epilepsia, 57(1), 2016.
`
`Khambhati A, Davis KA, Oommen B, Chen S, Worrell GA, Lucas TH, Litt B, Bassett
`DS. “Dynamic network drivers of seizure generation, propagation and
`termination in human neocortical epilepsy.” PLOS Computational Biology,
`17;11(12), 2015.
`
`Davis KA, Nanga RP, Das S, Chen SH, Hadar PN, Pollard JR, Lucas TH, Shinohara RT,
`Litt B, Hariharan H, Elliot MA, Detre JA, Reddy R. “Glutamate Imaging
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`(GluCEST) Lateralized Epileptic Foci in Non-Lesional Temporal Lobe
`Epilepsy.” Science Translational Medicine, 14;7(309), 2015.
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`Chen IH, Bohman L, Emery L, Martinez-Lage M, Richardson A, Davis K, Pollard JR,
`Litt B, Gausas RE, Lucas TH. “Lateral Transorbital Endoscopic Access to the
`Hippocampus, Amygdala, and Entorhinal Cortex: Initial Clinical Experience.”
`ORL, 77(6):321-332, 2015.
`
`Gliske SV, Irwin ZT, Davis K, Sahay K, Chestek C, Stacey WC. “Universal automated
`high frequency oscillation detector for real-time, long term EEG.” Clinical
`Neurophys, July 2015.
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`
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`Kini LG, Davis KA, Wagenaar JB. “Data Integration: Combined Imaging and
`Electrophysiology Data in the Cloud.” NeuroImage, 2015.
`
`Burke JF, Sharan D, Evans JJ, Healy K, Sperling MR, Beck EN, Davis KA, Lucas TH,
`Kahana MJ. “Theta and high-frequency activity mark spontaneous episodic
`retrieval during free recall.” J. Neuroscience, 2014.
`
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`Wu J, Azarion A, Pearce A, Wagenaar J, Zheng Y, Wang H, Gee JC, Litt B, Davis KA.
`“An open source and fully automated pipeline for visualization of subdural
`electrodes using 3D CT-MRI co-registration.” Epilepsia, 2014.
`
`Wu J, Davis K, Azarion A, and Zheng Y, "Brain Parcellation Aids in Electrode
`Localization in Epileptic Patients," Augmented Environments for Computer-
`Assisted Interventions, Lecture Notes in Computer Science, vol. 7264, pp.
`130-137, 2012.
`
`Viventi J, Kim D, Vigeland L, Frechette ES, Blanco JA, Kim Y, Arvin A, Tiruvadi VR,
` Hwang S, Vanleer AC, Wulson DF, Davis K, Gelber CE, Palmer L, Van der
` Speigel J, Wu J, Xiao J, Huang Y, Contreras D, Rogers JA, Litt B. (2011)
` Flexible, foldable, actively multiplexed, high-density electrode array for
` mapping brain activity in vivo. Nature Neuroscience 14: 1599-1605
`
`Davis KA, Sturges B, Vite CH, Ruedebusch V, Worrell G, Gardner A, Chamberlain A,
`Leyde K, Sheffield WD, Litt B. (2011) Recording and analyzing continuous
`intracranial EEG in ambulatory epileptic dogs. Epilepsy Research 96: 116-122.
`
`Anderson CT, Davis KA, Baltuch G. (2009) An update on brain stimulation for epilepsy.
`Current Neurology and Neuroscience Reports, 9(4): 1528-4042.
`
`Blumenfeld H, Rivera M, McNally KA, Davis K, Spencer DD, Spencer SS. (2004). Ictal
`neocortical slowing in temporal lobe epilepsy. Neurology 63: 1015-1021.
`
`Blumenfeld H, McNally KA, Vanderhill SD, Paige AL, Chung R, Davis K, Norden AD,
`
`Stokking R, Studholme C, Novotny EJ, Zubal IG, Spencer SS. (2004). Positive
`and negative network correlations in temporal lobe epilepsy. Cerebral Cortex,
`
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`14(8): 892-902.
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`Reviews/Book Chapters
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`Yi D, Davis KA, Levine J. (2016) Management of Status Epilepticus.
`Evidence-Based Practice of Critical Care. Deutschman & Neligan (Editors).
`Elsevier. Second Edition.
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`Davis K, Herman ST. (2008) How Should Status Epilepticus Be Managed? Evidence-
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`Based Practice of Critical Care. Deutschman & Neligan (Editors). Elsevier.
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`Case Report
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`Davis K.A., Cantor C., Maus D., Herman S.T. (2008) A Neurological Cause of Recurrent
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`Choking During Sleep. Journal of Clinical Sleep Medicine, 4(6): 586-587.
`
`Abstracts
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`Williams S, Davis KA, Pollard J (2015). Encephalocele as a Complication of Intracranial
`EEG Monitoring: Case Report. AES meeting abstract.
`
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`Kini A, Davis KA, Litt B, Bassett DS (2015). Probing Controllers of the Epileptic
`Network with Virtual Cortical Resection. AES meeting abstract.
`
`Ferraro L, Schmitt S, Becker D, Davis KA (2015). The Effects of Anticonvulsant
`Therapy in Post-Anoxic Status Epilepticus. AES meeting abstract.
`
`Coto CA, Jacobs LM, Balu R, Lucas T, Martinez-Lage M, Davis KA, Talos DM, Jensen
`F (2015). Evidence for Altered Glutamate Homeostasis in Human Temporal
`Lobe Epilepsy. AES meeting abstract.
`
`
`Jacobs LM, Coto C, Sun H, Lucas T, Martinez-Lage M, Davis KA, Jensen F, Talos DM
`(2015). Over-activation of MTOR Signaling Pathway in Human Therapy-
`Resistant Temporal Lobe Epilepsy. AES meeting abstract.
`
`
`Chen S, Nanga R, Das S, Coto C, Hadar P, Hariharan H, Elliott M, Detre J, Reddy R,
`Davis KA (2015). Mapping Epileptic Networks using a Novel Imaging
`Technique (GluCEST): a Comparison of Lesional and Nonlesional Refractory
`Temporal Lobe Epilepsy. AES meeting abstract.
`
`Chen H, Bohman L, Emery L, Martinez-Lage M, Richardson A, Davis KA, Pollard J,
`Litt B, Gausas R, Lucas T (2015). Lateral Transorbital Endoscopic Access to the
`Mesial Temporal Lobe. AES meeting abstract.
`
`Davis KA, Chen S, Yushkevich P, Wisse L, Geerlings M, Hadar P, Coto C, Das S
`(2015). Hippocampal Subfield Volumetry and Functional Connectivity on 7T
`MRI in Temporal Lobe Epilepsy. AES meeting abstract.
`
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`Kini L, Stein J, Coto C, Davis KA (2015). Advanced diffusion imaging of periventricular
`nodular heterotopia in 2 drug resistant epilepsy patients. AES meeting abstract.
`
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`Davis KA, Ravi PR, Das S, Chen S, Hadar P, Lucas T, Litt B, Detre J, Hariharan H,
`Elliot MA, Reddy R (2015). Application of GluCEST in Detection of
`Epileptogenic Foci in Temporal Lobe Epilepsy. ISMRM abstract.
`
`Kini A, Coto C, Stein JM, Davis KA (2015). Advanced Diffusion Imaging of
`Periventricular Nodular Heterotopia in 2 Drug-Resistant Epilepsy Patients. AES
`meeting abstract.
`
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`Pollard J, Crino P, Mueller G, Eidelman O, Dalgard C, Brand E, Anderson C, Cai P,
`Wamil M, Stauman M, Burakgazi-Dalkili E, Davis K, Pollard H (2014). A
`Diagnostic Blood Test for Epilepsy: A Soluble ICAM-5 Based Panel. AES
`meeting abstract.
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`Gelfand M, Davis K (2014). Resting State fMRI Lateralizes Seizure Onset but Fails to
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`Predict Cognitive Change after Anterior Temporal Lobectomy in Temporal
`Lobe Epilepsy. AES meeting abstract.
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`Kini L, Das S, Davis K, Litt B (2014). Brain Morphometry on Multi-Modal Imaging for
`the Detection of Epileptogenic Cortical Dysplasia. AES meeting abstract.
`
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`Ung H, Davis K, Wulsin D, Litt B (2014). Spectral Analysis of Intracranial Interictal
`Bursts may Localize Seizure Onset. AES meeting abstract.
`
`DeVries S, Davis K, Wagenaar, Stacey W (2014). How High is High Enough? Do Faster
`EEG Sampling Rates Lead to Improved Seizure Onset Localization? AES
`meeting abstract.
`
`Mealey R, Pollard J, Davis K, Kohler C, Schmuts R, Chen S, Oommen B, Hill C (2014)
`Improving Quality of Care Following EMU Discharge. AES meeting abstract.
`
`Thaker A, Dubroff J, Brown M, Davis K (2014) Quantitative fdg-PET Neuroimaging in
`Medically Refractory Epilepsy: UPenn Experience. AES meeting abstract.
`
`Chen S, Schmitt S, Davis K (2014) A Case of Periodic Lateralized Epileptiform
`Discharges (PLEDs) Causing Concordant Reversible MRI Changes. AES
`meeting abstract.
`
`Davis KA, Wulsin D, Wu C, Litt B. (2013) Transient Disruption of the
`Epileptic Network with Intracranial Electrodes. AES meeting abstract.
`
`Becker DA, Nanivadekar AC, Davis KA, Kahana M, Litt B. (2013) Interictal
`Spikes Outside the Epileptic Network Disrupt Cognitive Function. AES meeting
`abstract.
`
`Davis K.A., Levine J., LeRoux P., Herman S. (2008) Clinical Utility of Graphical
`Displays of Continuous EEG for Detection of Cerebral Infarction or Vasospasm
`after Subarachnoid Hemorrhage. AES meeting abs., 2.067. Online at
`http://www.aesnet.org/
`
`Marfeo, A. T., Yu, L., Gordon, A., Agarwal, R., Ellens, D. J, Golomb, J. D., Shamy, M.,
`Levin, A. R., Davis, K. A., McNally, K., Vives, K., Spencer, D., Spencer, S.,
`Schevon, C., Zaveri, H., Blumenfeld, H. (2008) Intracranial EEG Quantitative
`Analysis and Behavioral Impairment in Temporal Lobe Epilepsy. AES meeting
`abs., 1.045. Online at http://www.aesnet.org/
`
`Marfeo A., Yu L., Gordon A., Agarwal R., Ellens D.J., Golomb J.D., Shamy M., Levin
`A.R., Davis K., McNally K.A., Vives K., Spencer D.D., Spencer S.S., Schevon
`C., Zaveri H., Blumenfeld H. (2008) Quantitative analysis of intracranial EEG
`changes associated with impaired consciousness in temporal lobe seizures. Soc.
`Neurosci. Abs.
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`McNally KA, Venderhill SD, Paige AL, Doernberg S, Chung, R, Adamiak K, Novotny
`EJ, Zubal IG, Spencer SS, Blumenfeld H (2003). Network mechanisms for loss
`of consciousness in temporal lobe epilepsy. Soc. Neurosci. Abs., Online at
`http://web.sfn.org/
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`McNally KA, Venderhill SD, Paige AL, Doernberg S, Chung, R, Adamiak K, Novotny
`EJ, Zubal IG, Spencer SS, Blumenfeld H (2003). Excitatory and inhibitory
`network interactions during loss of consciousness in temporal lobe epilepsy.
`Epilepsia (AES meeting abstracts). 44
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`Blumenfeld H, Vanderhill S, Ahoya L, Chung R, Adamiak K, Paige L, Corsi M,
`Novotny EJ, Zubal IG, Spencer SS (2002). Cortical and Subcortical Networks in
`Human Temporal Lobe Seizures. Soc. Neurosci. Abs., 796.2. Online at
`http://web.sfn.org/
`
`
`Invited Lectures, Presentations and Grand Rounds:
`
`
`•
`
`•
`
`Invited lecture, 10th International Workshop on Advances in Electrocorticography, “Multi-site
`ECoG: What We Can Learn from the Restoring Active Memory Trial.” 11/11/15, San Diego,
`Society for Neuroscience Annual Meeting (approximately 150 in attendance)
`Invited lecture, Zoobiquity Neurology Psychiatry Conference, “Seizure Prediction in Canine and
`Human Epilepsy.” 10/21/16 (approximately 200 in attendance)
`• Lecturer to Penn Neurology Residents and Medical Students, “Introduction to the EMU and
`epilepsy surgical evaluation,” 8/18/16 (approximately 50 medical students and residents in
`attendance)
`Invited Medical Grand Rounds, Christiana Hospital, “Advances in Epilepsy: New Treatment
`Options,” Newark, DE, 7/7/16 (approximately 100 in attendance)
`• Lecturer to CTSA Summer Undergraduate Internship Program, “Identifying the Epileptic
`Network,” Philadelphia, PA, 6/17/16 (approximately 20 in attendance)
`Invited lecture, University of Pennsylvania Neuro-Oncology CME Course, “Seizures in Brain
`Tumor Patients, When and How to Treat,” Philadelphia, PA, 5/13/16 (approximately 100 in
`attendance)
`• Medical Scientist Training Program Panel participant, “Careers in Neurology,” Philadelphia, PA,
`4/1/16 (approximately 80 in attendance)
`• Speaker at Neuroscience Nursing Epilepsy Bootcamp, “Seizure Semiology,” Philadelphia, PA,
`3/10/16 (approximately 20 in attendance)
`Invited Neurology Grand Rounds, Rutgers, “Advances in the Care of Drug Resistant Epilepsy:
`Localizing the Network,” New Brunswick, NJ, 3/16/16 (approximately 75 in attendance)
`Invited Neurology Grand Rounds, University of Wisconsin, “Advances in the Care of Drug
`Resistant Epilepsy: Localizing the Network,” 3/4/16 (approximately 100 in attendance)
`Invited Neurology Grand Rounds, University of Pennsylvania, “Advances in the Care of Drug
`Resistant Epilepsy: Localizing the Network,” 2/24/16 (approximately 150 in attendance)
`• Small Group Leader, Brain and Behavioral Medical Student Course, University of Pennsylvania:
`2/23/16 (Movement Disorders and the Brainstem), 2/24/16 (Neurological Exam), 3/17/16 (Brain
`Tumors)
`Invited Neurology Grand Rounds, Temple University, “Advances in the Care of Epilepsy:
`Localizing the Network,” 2/5/16 (approximately 100 in attendance)
`Invited lecture, American Epilepsy Society Annual Course, “Noon: A Seizure-Related Crash on
`the News,” 12/6/2015 (approximately 3,000 in attendance)
`• Speaker at the Penn-CEST 2015 meeting, “Utilizing GluCEST to localize epileptic networks,”
`10/27/15 (approximately 150 in attendance)
`• Lecturer to Penn Neurology Residents and Medical Students: “Seizure Semiology and More,”
`10/2015
`• Lecturer to epilepsy fellows and EEG technicians, “Drug and Toxic effects on EEG,” 10/2015
`• Lecturer to Penn epilepsy center and EEG technicians, “Introduction to the EEG Labs,” 7/7/15
`• Lecturer in EMU bootcamp for nursing staff, “Seizure semiology and Advances in Epilepsy
`Care,” 6/2015
`• ACVIM SOTA Lecture: 6/3/2015: “Current Advances in the Care of Epilepsy Patients”
`(approximately 300 in attendance)
`Invited lecturer in CBICA Lecture Series, “Hippocampal Subfield Volumetry and Functional
`Connectivity on 7T MRI: Potential Biomarkers in Medically Refractory Temporal Lobe Epilepsy”
`(Center for Biomedical Image Computing and Analytics), 5/14/15 (approximately 150 in
`attendance)
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`• Lecturer to Penn Psychiatry Residents, “Epilepsy and Psychiatry,” 4/30/15 (approximately 15
`residents in attendance)
`• Lecturer to epilepsy fellows and EEG technicians, “Diffuse EEG findings,” 3/24/15
`• Lecturer to Penn Neurology Residents and Medical Students, “Autoimmune Epilepsy,” 3/26/15
`(approximately 45 medical students and residents in attendance)
`• Speakers Panel for the Junior Investigator Symposium, “Integrating goals for work/family life and
`developing an individual career development plan,” 3/16/14 (approximately 200 in attendance)
`• Lecturer to Penn Neurology Residents, “Career Decision Making,” 3/9/15 (approximately 40 in
`attendance
`Invited Lecturer, American Epilepsy Society Ask the Experts Webinar, “Clinical Uses of New
`Devices for Epilepsy Treatment,” 2/23/15
`Invited Lecturer, Nazareth Hospital Grand Rounds, “Advances in Epilepsy: New Treatment
`Options,” 12/10/2014 (approximately 50 in attendance)
`Invited Lecturer, American Epilepsy Society Presidential Symposium, “State of the Art of
`Seizure Detection and Devices,” 12/6/2014 (approximately 4,000 in attendance)
`• Lecturer to Penn Neurology Residents and Medical Students, “Epilepsy Presurgical Evaluation
`and Neuroimaging,” 9/2014 (approximately 30 students in attendance)
`• Lecturer to Penn Psychiatry Residents, “Epilepsy and Psychiatry,” 5/22/14 (approximately 15
`residents in attendance)
`• Lecturer to Penn epilepsy center and EEG technicians, “Diffuse EEG Abnormalities,” 3/11/2014
`• Lecturer to Penn epilepsy center and EEG technicians, “Review of interesting EEGs,” 1/6/2014
`• Lecturer to nursing staff, University of Pennsylvania, “Introduction to the Epilepsy Monitoring
`Unit and Identifying Seizures,” 12/2013
`• Lecturer to epilepsy fellows and EEG technicians, “Diffuse EEG findings,” 11/2013
`• Lecturer to epilepsy fellows and EEG technicians, “Record Review: challenging EEGs,” 9/2013
`• Lecturer to medical students and neurology residents, University of Pennsylvania, “Introduction to
`the EEG lab and EEG equipment,” 8/2013
`• Lecturer to medical students and neurology residents, University of Pennsylvania, “Epilepsy
`Presurgical Evaluation and the Epilepsy Monitoring Unit,” 8/2013
`• Lecturer to medical students and neurology residents, University of Pennsylvania, “Introduction to
`Epilepsy and Seizure Week,” 8/2013
`• Epilepsy Foundation of Eastern Pennsylvania Women’s and Men’s Conference, “Women’s Issues
`in Epilepsy: Preparing for Pregnancy,” 5/2013.
`• Lecturer to medical students and neurology residents, University of Pennsylvania, “Career
`Decision Making.” 3/2013 (approximately 30 students attended)
`• Neurology Rounds, Department of Neurology, Crozer Chester Medical Center, Upland, PA.
`“Autoimmune Epilepsy,” 12/2012.
`• Grand Rounds, Departments of Medicine and Neurology, Crozer Chester Medical Center, Upland,
`PA. “Continuous EEG monitoring in the EMU and ICU,” 10/2011.
`• Lecturer to Oncology Nurse Practioners, University of Pennsylvania on Epilepsy, 2010
`• Lecturer for third and fourth year medical students, Drexel and Temple Universities, 2011-2012
`• Lecturer for third and fourth year medical students, University of Pennsylvania, 2008-2011
`
`
`Mentorship Roles:
`
`• David Kersen (MD PhD candidate, University of Pennsylvania), 2016 summer rotation
`• Peter Hadar (MD candidate, University of Pennsylvania), 2013-present: Mentor for Masters in
`Translational Research Degree, University of Pennsylvania, 2016-
`• Erin Conrad (faculty mentor for Neurology Resident, University of Pennsylvania), 2016-present
`• Preya Shah: Co-mentor for PhD in Bioengineering, University of Pennsylvania, 2015-
`• Hoameng Ung: Co-mentor for PhD in Bioengineering, University of Pennsylvania, 2014-
`• Lohith Kini: Co-mentor for PhD in Bioengineering, University of Pennsylvania, 2014-
`• Stephanie Chen, MD: Mentor for Masters in Translational Research Degree, University of
`Pennsylvania, 2014-2016
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`• Michael Gelfand, MD, PhD: Mentor for Neurology Residency research project, University of
`Pennsylvania, entitled, “Can Resting-State fMRI outperform Wada Testing in Predicting the
`Cognitive Outcomes of Temporal Lobectomy”, 2014
`• Katherine Beattie (MD candidate, University of Pennsylvania), 2013-present
`
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`Thesis Committees:
`• Mark Attiah (MTR candidate, University of Pennsylvania), 2015
`• Lohith Kini (MD, PhD candidate, University of Pennsylvania), 2015
`• Preya Shaw (MD, PhD candidate, University of Pennsylvania), 2016
`
` 1.0 calendar
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`Ongoing Research Support
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`R01 NS099346-01(Litt) 09/01/2016 – 05/31/2020
`NINDS/NIH $ 371,799
`Virtual Resection to Treat Epilepsy
`
`
`• The goal of this grant is to develop a new method to localize epileptic networks from intracranial
`EEG that: (1) uses an automated, objective method; (2) removes the need for precipitating acute
`seizures during evaluation; (3) allows clinicians to simulate effects of different brain surgeries or
`device placements for individual patients.
`
`4/1/2016-3/30/2021
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`K23
`
`
`
`Davis (PI)
`Localizing Epileptic Networks Using Novel 7T MRI Glutamate Imaging
`• The goal of this K23 award is to utilize whole brain glutamate imaging (GluCEST) to map
`epileptic networks in lesional and nonlesional drug resistant epilepsy patients.
`• Role: Principal Investigator
`
`
`Translational Biomedical Imaging Center Pilot Grant Program, University of Pennsylvania
`Davis (PI)
`
`
`
`
`
`
`
`2/1/2016-1/31/2018
`Utilizing Novel 3-Dimensional GluCEST Method to Identify the Seizure Focus
`• This study aims to validate a novel 3-dimensional GluCEST technique and apply this quantitative
`imaging biomarker to localize the seizure onset zone in drug resistant epilepsy patients.
`• Role: Principal Investigator
`
`
`Neuro-Oncology Innovation Award
`8/1/15-7/31/16
`
`
`
`Davis (PI)
`Glutamate Imaging: Potential Biomarker of Glioma Treatment Response and Seizure Risk
`• This study investigates the role of increased glutamate as measured by GluCEST on 7T MRI in
`the risk of seizures and response to therapy in glioma patients.
`• Role: Principal Investigator
`
`
`R01 EB017255 Yushkevich (PI)
`
`
`
`Adaptive Large-Scale Framework for Automatic Biomedical Image Segmentation
`• This study utilizes multi-atlas label fusion to automatically detect and label anatomical structures
`in biomedical images from multiple disease states including epilepsy.
`• Role: Co-investigator
`
`7/1/14-6/30/19
`
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`DARPA N66001-14-2-4032 Kahana (PI)
`
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`
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`Memory Enhancement with Modeling, Electrophysiology, and Stimulation (MEMES)
`• The goal of this multicenter study is to investigate whether memory functions following
`neurological injury or disease can be restored using responsive neurostimulation.
`• Role: Co-investigator
`
`7/1/14-6/30/18
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`Completed Research Support
`P20 NS12006 Engel (PI)
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`9/1/13-8/31/15
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`Re-entry Supplement to The Epilepsy Bioinformatics Study
`• The EpiBioS (Epilepsy Bioinformatics Study) is a P20 planning grant proposing to develop a
`bioinformatics platform for identifying reliable epilepsy biomarkers, a critical need for a Center
`with Walls (CwW) focused on antiepileptogenesis.
`• Role: Co-investigator
`
`
`
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`Center for Biomedical Image Computing and Analytics Seed Award, UPenn Davis (PI) 7/1/13-6/30/15
`Hippocampal Subfield Volumetry and Functional Connectivity on 7T MRI: Potential Biomarkers in
`Medically Refractory Temporal Lobe Epilepsy
`• The goal of this pilot study is to investigate novel imaging biomarkers of epileptic networks on 7T
`MRI.
`• Role: PI
`
`
`
` Davis (PI)
`
`McCabe Pilot Award
`Localizing Epileptic Networks Using Novel Glutamate Imaging
`• University of Pennsylvania Internal Award
`• The goal of this pilot study is to investigate novel glutamate imaging biomarkers of epileptic
`networks on 7T MRI.
`• Role: PI
`
`
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`
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`7/2013-6/2014
`
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`Epilepsy Foundation of America, Research and Training Fellowship for Clinicians 1/2009-12/2011
`Does High Frequency Intracranial EEG Improve Seizure Localization?
`• The goal of this study is to determine if higher bandwidth recording can improve localization of
`seizures and outcome from epilepsy surgery, and improve the accuracy of implantable devices to
`treat epilepsy.
`• Role: PI
`
`
`The University of Pennsylvania, The Institute of Translational Medicine and Therapeutics (ITMAT)
`Institutional Clinical and Translational Science Award (K12) Davis (PI)
`7/2009-7/2011
`Does High Frequency Intracranial EEG Improve Seizure Localization?
`• The goal of this grant is to provide rigorous training in translational medicine and clinical trials,
`which will result in the acquisition of a Master’s in Translational Research. Education and
`guidance received through this masters program has provided the opportunity to expand research
`in neuroimaging as it relates to epilepsy.
`• Role:PI
`
`
`Media Coverage:
`• NIH Director’s Blog (Frances Collins): “Brain Imaging: Advance Aims for Epilepsy’s Hidden Hot
`Spots,” 10/27/15
`• The Naked Scientist (broadcast by BBC in the United Kingdom and ABC Radio National,
`Australia): “Brain scan to locate source of epilepsy,” 10/16/15
`• National Public Radio: “New brain scan spots hard-to-see epilepsy lesions, Penn Study finds,”
`10/18/15
`• Spectrum News: “Imaging technique reveals elusive epileptic lesions,” 10/28/15
`• Applied Radiology: “New MRI technique identifies previously undetected epileptic seizure sites,”
`11/19/15
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