CURRICULUM VITAE
`Carl W. Bazil, M.D., Ph.D.
`
`
`Director, Epilepsy and Sleep Division
`Caitlin Tynan Doyle Professor of Neurology at CUMC
`Columbia University College of Physicians and Surgeons
`
`(212)305-1742
`(212)305-1450
`
`
`
`
`
`
`
`
`
`
`
`
`The Neurological Institute of Columbia University
`710 West 168th Street
`New York, NY 10032
`e-mail: cwb11@columbia.edu
`
`
`Title:
`
`
`
`
`
`Address:
`
`
`
`
`
`
`
`Telephone:
`FAX:
`
`
`Academic training:
`Massachusetts Institute of Technology, S.B., 1983.
`Emory University, M.S., 1987.
`Emory University, Ph.D.(Pharmacology), 1989.
`
`Thesis title: Volatile anesthetics and synaptic neurochemistry.
`
`Sponsor: Kenneth P. Minneman, Ph.D.
`Emory University, M.D., 1989.
`
`Medical Licensure:
`New York State #184430.
`New Jersey #25MA07516600 (inactive)
`
`Clinical Training:
`Internal medicine resident, Emory University, July 1989- June 1990.
`Neurology resident, New York University, July 1990- June 1993.
`Neurology Chief Resident and Instructor, New York University, July 1992- June 1993.
`Clinical fellow in epilepsy/EEG, The Neurological Institute of Columbia Presbyterian Medical Center,
`Columbia University, July 1993-June 1995.
`
`Professional Societies:
`
`American Academy of Neurology (Fellow)
`American Clinical Neurophysiology Society (Fellow)
`American Epilepsy Society
`American Medical Association
`American Neurological Association
`American Academy of Sleep Medicine
`
`Argentum Pharm. v. Research Corp. Techs., IPR2016-00204
`RCT EX. 2039 - 1/24
`
`

`
`Carl W. Bazil, M.D., Ph.D.
`
`
`
`Academic appointments:
`Instructor in Neurology, New York University, New York, NY 1992-3.
`Postdoctoral Clinical Fellow/Assistant in Clinical Neurology, College of Physicians and Surgeons of
`Columbia University, New York, NY 1993-95.
`Adjunct Associate Professor, Department of Pharmacy Practice, Long Island University, Brooklyn, NY
`1995.
`Assistant Professor of Neurology, Mount Sinai School of Medicine, New York, NY 1995-1996.
`Assistant Professor of Neurology, College of Physicians and Surgeons, Columbia University, New
`York, NY 1996-2003.
`Associate Professor of Clinical Neurology, College of Physicians and Surgeons, Columbia University,
`New York, NY 2003-8.
`Professor of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY
`2008-present.
`Director, Epilepsy and Sleep Division, Columbia University Department of Neurology, 2008-present
`
`Hospital Appointments:
`Assistant Attending Physician, Mount Sinai Hospital, 1995-6.
`Assistant Attending Neurologist, New York Presbyterian Hospital 1996-2003
`Associate Attending Neurologist, New York Presbyterian Hospital 2003-2008
`Acting Director, Columbia Comprehensive Epilepsy Center, April-November 2004
`Attending Neurologist, New York Presbyterian Hospital 2008-present
`Director, Columbia Comprehensive Epilepsy Center, 2008-present
`
`Grants and Awards:
`
`Past:
`NS054864.01, “Consolidation of Motor Skills and Sleep Homeostasis in Parkinson's Disease." Role:
`Subinvestigator, Columbia subcontract. 2006-2011, total subcontract $442,000, 5% effort.
`Open-Label Study to Assess the Safety and Tolerability of Intravenous Carbamazepine as Short-Term
`Replacement for Oral Carbamazepine in Adult Patients with Epilepsy. 2012. Sponsor: Lundbeck. Role: PI
` “Eszopiclone for insomnia in epilepsy,” investigator initiated grant, 2007-11,sponsor: Sepracor, Inc.
`$127,900.
`“Effects of pregabalin on insomnia in patients with epilepsy,” investigator initiated grant, 2006-10.
`sponsor: Pfizer, Inc. $119,500.
`NIH 1RO1NS32375-01A1, “Multicenter study of outcomes after epilepsy surgery”, Columbia
`subcontract principle investigator, 2001-2006, $400,000.
`Columbia University Office of Clinical Trials Pilot Study Award, “Gabapentin for alcohol-induced sleep
`disruption”, $50,000, 2003-2004.
`UCB Pharma, “Effects of Levetiracetam on Sleep in Normal Volunteers”, $107,000, 2003-4
`A 7-week multicenter, randomized, double-blind, placebo-controlled, parallel group study to determine
`the effects of adjunctive levetiracetam on the sleep architecture of adult subjects with partial onset
`epilepsy receiving a first generation anti-epileptic drug. 2002-2004
` “Drowsiness, sleep, and circadian rhythms in patients with temporal lobe epilepsy”
`Epilepsy Foundation of America, $40,000, July 1998-June 1999.
`NIH 1RO1NS32375-01A1, “Multicenter study of outcomes after epilepsy surgery”, Columbia
`subcontract principle investigator, 1998-2001, $151,000.
`Individual predoctoral fellow, National Institute of Mental Health; 1986-88.
`
`
`
`
`2
`
`Argentum Pharm. v. Research Corp. Techs., IPR2016-00204
`RCT EX. 2039 - 2/24
`
`

`
`Carl W. Bazil, M.D., Ph.D.
`
`Multicenter Investigational Drug/device Trials:
`Current: Responsive Neurostimulator (RNS) system long-term treatment clinical investigation.
`Columbia PI 2012-2016; sub-I 2016-present.Sponsor: NeuroPace.
`
` A
`
` Double-Blind, Placebo-Controlled, Parallel-Group Study of Rufinamide Given as Adjunctive Therapy
`in Patients with Refractory Partial Seizures
`A Multicenter, Double-blind, Randomized, Placebo-controlled, Parallel Group Trial to Investigate the
`Efficacy and Safety of SPM 927 (200 mg/day, 400 mg/day, 600 mg/day) as Adjunctive Therapy in
`Subjects with Partial Seizures with or without Secondary Generalization. 2002-4
`Stimulation of the Anterior Nucleus of the Thalamus for Epilepsy (SANTE ), 2004-9
`A Multicenter, Double-blind, Randomized, Placebo-controlled, Parallel Group Trial to Investigate the
`Efficacy and Safety of SPM 927 (200 mg/day, 400 mg/day, 600 mg/day) as Adjunctive Therapy in
`Subjects with Partial Seizures with or without Secondary Generalization 2002-8 (open label follow on)
`Pregabalin add-on trial: a double blind, placebo-controlled, multicenter study in patients with refractory
`complex partial seizures with or without secondary generalization, 1997-2006 (successfully audited by
`FDA 2004; no form 487 received)
`Pregabalin BID Open-Label Add-on Titration Trial: A Randomized, Double-Blind, Placebo-Controlled,
`Parallel-Group, Multicenter Study in Patients With Partial Seizures, 2000 (study terminated by sponsor)
`A multicenter, open-label, safety study to evaluate the use of 25 mg and 50 mg Zonegran (zonisamide)
`in the initiation of therapy in patients with epilepsy, 2000-2001
`An open-label, multicenter study to assess the safety and effectiveness of Diastat (diazepam rectal gel)
`in the treatment of seizures in adults. 2000-2001.
`Multicenter, double-blind, randomized, parallel group study comparing the safety and efficacy of 3,000
`mg levetiracetam to 1,000 mg of valproate used as monotherapy in epileptic patients with complex
`partial seizures, 1999 (study terminated by sponsor).
`
`Open label assessment of the clinical utility of Trileptal in monotherapy in patients with partial seizures,
`1999-2000.
`Open-label dose titration assessment of the clinical utility of a slow, low dose titration schedule of
`Zonegran in the initiation of therapy in patients with partial seizures, 1999-2000.
`An open label, multicenter study to evaluate the safety, tolerability, and therapeutic effect of GP 47779
`administered intravenously in subjects with epilepsy. 1998-99 (study terminated by sponsor)
`Safety and efficacy of high versus low dose rufinamide monotherapy in patients with inadequately
`controlled partial seizures, 1997-2001
`Pregabalin in-patient monotherapy trial: a double-blind, positive-controlled, multicenter study in patients
`with refractory partial epilepsy, 1997-98.
`Gabapentin monotherapy for newly diagnosed patients with partial seizures, 1997-98
`Cost Analysis of the Routine Use of Parenteral IM Fosphenytoin Versus IV Fosphenytoin in the
`Management of Seizures within the Hospital Setting", Mount Sinai Medical Center 1996.
`
`Board Certification:
`National Board of Medical Examiners, 1990
`American Board of Neurology and Psychiatry #41900, 1995
`
`
`Recertified 2005, 2015
` Added Qualification in Clinical Neurophysiology, #993, 1999
`
`
`Recertified 2011
` Added Qualification in Sleep Medicine, #371, 2009
` Added Qualification in Epilepsy #54, 2013
`American Board of Clinical Neurophysiology, 1996
`American Board of Sleep Medicine #2836, 2005
`
`
`3
`
`Argentum Pharm. v. Research Corp. Techs., IPR2016-00204
`RCT EX. 2039 - 3/24
`
`

`
`Carl W. Bazil, M.D., Ph.D.
`
`
`
`Other Professional Activities:
`Epilepsy Section Editor, Current Neurology and Neuroscience Reports, 2003-present.
`Contributing Editor, The Medical Letter, 2009-present.
`Editorial Board, JAMA Neurology, 2014-present; Epilepsy Research, 2001-2006; Epilepsy.com, 2002-
`present.
`Stroke Division Director search committee, Columbia University, 2007
`Abstract reviewer, American Academy of Neurology, 2007-9.
`Director of Clinical Anticonvulsant Drug Trials, Columbia University 1996-2008
`Board member, American Clinical Neurophysiology Society, 2003-2006
`Contributing editor, Epilepsy Currents, 2001-2004
`Ad-hoc reviewer, Epilepsia, Epilepsy & Behavior, Epileptic Disorders, Epilepsy Research, European
`Journal of Epilepsy, Seizure, European Journal of Neurology, Physiology and Behavior, Sleep, Journal
`of Clinical Sleep Medicine, Sleep Medicine, Neurology, Acta Neurologica Scandanavia, Annals of
`Neurology, Archives of Neurology, JAMA Neurology, JAMA, Neuropharmacology, British Medical
`Journal, Brain, Clinical Therapeutics, Neuroscience Letters, Neuropediatrics, Pediatrics, International
`Journal of Psychopathology.
`Examiner, American Board of Clinical Neurophysiology, 1997-2004; Journal of the Neurological
`Sciences, 2015- present.
`NIH peer review panel
`Grant reviewer, Citizens United for Research in Epilepsy (CURE), 2009
`AAN Practice Parameter Guideline Committee on New AEDs, 2003-4.
`
`Teaching courses:
`Columbia University Medical Student Neurosciences, 2014-present
`Columbia University neurology residency lectures in epilepsy and sleep, 1998-present
`Columbia University clinical neurophysiology residency lectures in epilepsy and sleep, 1998-present
`Columbia University Occupational Therapy Program, lectures in epilepsy 2000-2012
`City University of New York, lectures in epilepsy and sleep disorders, 2006-present
`Mount Sinai School of Medicine, lecture in sleep disorders, 1996-7
`
`Trainees:
`Clinical neurophysiology/epilepsy fellows (current position):
`Keith Nagle, M.D. 1996-7 (University of Vermont)
`Luis Castro, M.D. 1997-8 (University of Sao Paulo)
`Susan Herman, M.D. 1997-1999 (Harvard University)
`Alison Pack, M.D. 1998-2000 (Columbia University)
`Alexandra McBride 1998-2000 (Westchester Medical Group)
`Anil Mendiratta, M.D. 1999-2001 (Columbia University)
`Linda Leary, M.D. (University of Texas, San Antonio)
`Hyunmi Choi, M.D. 2000-2 (Columbia University)
`Tina Shih M.D. 2000-2 (UCSF)
`Aaron Johnson, M.D. 2001-2 (ACGME)
`Catherine Schevon, M.D. 2002-4 (Columbia University)
`Kelly Knupp, M.D. 2003-4 (Children’s Hospital Colorado)
`Derek Chong, M.D. 2004-6 ACGME (New York University)
`Nathalie Jette, M.D. 2004-5 (University of Calgary)
`Leonie Van Passel 2004-5 ACGME
`Sheetal Malik 2004-6 (ACGME 04-05); University of Cincinnati
`David Friedman, M.D. 2005-2007 (ACGME 05-06)
`
`
`4
`
`Argentum Pharm. v. Research Corp. Techs., IPR2016-00204
`RCT EX. 2039 - 4/24
`
`

`
`Carl W. Bazil, M.D., Ph.D.
`
`Peter Tai, M.D. 2005-6 ACGME, Toronto Western Hospital
`Andrew Mower 2005-6 ACGME
`Karine Abou-Khaled 2006-7 ACGME Beirut
`Sudha Kilaru 2006-7 ACGME
`Zarya Rubin 2006-7 ACGME (UCB Pharma)
`Sean Hwang, M.D. 2006-2008 (Assistant Professor, Long Island Jewish)
`Mill Etienne, M.D. 2006-2009 Walter Reed Hospital
`Nishi Rampal M.D. 2007-8 (continuous EEG)
`Danielle McBrian, M.D. 2007-2009 Columbia University
`Sara Inati, M.D. 2007-2009 NIH
`Alfred T. Frontera, M.D.; 2007-2009 University of South Florida
`Elizabeth Gerard, M.D. 2007-2009 (Northwestern University)
`Daniel Freidman M.D. 2008-2010 (New York University)
`Kim Pargeon M.D. 2009-11 Cornell University
`Jeremy Moeller 2009-11 Yale University
`Maja Ilic 2010-11 (ACGME)
`Jay Varma 2010-12 Barrow Neurological Institute
`Heidi Munger-Clary 2011-13: Wake Forest University
`Andres Rodriguez-Ruiz 2012-14: Emory University
`Robert Connors 2012-2014: private practice
`Cynthia Correll 2012-2014: Geisinger Health System
`Suda Jirasakuldej 2013-14 (ACGME)
`Alexis Dallara (ACGME) 2014-2015
`Nicole Odom 2013-2015
`Amy Jongeling 2013-2015 (NYU)
`Deepti Anbarasen 2015-16 (Columbia)
`Manisha Gupte Holmes 2014-16 (NYU)
`
`Medical student research:
`Jesse Thon, 2011-12, Effects of seizures on sleep and learning.
`Andrew Rose, Jun-August 2001; Rose AB, McCabe PH, Gilliam FG, Smith BJ, Boggs JG, Ficker DM,
`Moore JL, Passaro EA, Bazil CW; for the Consortium for Research in Epilepsy (CoRE). Occurrence of
`seizure clusters and status epilepticus during inpatient video-EEG monitoring. Neurology 2003;60:975-
`978.
`Courtney Coursey, June-August 2000, Analysis of the effects of new antiepileptic drugs on EEG activity
`in patients with diagnosed epilepsy
`Christopher Anderson, June-August 1999, effects of status epilepticus on sleep.
`
`Sc.D.
`Tzena Smith, 2009 (Tulane University School of Public Heath and Tropical Medicine; “Determinants of
`health system utilization in a national sample of patients with epilepsy.”)
`
`Media appearances
`Reuters RE jet lag, June 29, 2016: http://www.reuters.com/video/2016/06/29/how-snoring-can-kill-
`you?videoId=369113885&videoChannel=118240
`
`Reuters RE sleep apnea, June 17, 2016: http://www.reuters.com/video/2016/06/16/how-to-beat-jet-
`lag?videoId=368945407&videoChannel=118240&channelName=Health+Watch
`
`
`
`
`5
`
`Argentum Pharm. v. Research Corp. Techs., IPR2016-00204
`RCT EX. 2039 - 5/24
`
`

`
`Carl W. Bazil, M.D., Ph.D.
`
`The Today Show, “Are you an elite sleeper?” April 6, 2016: http://www.today.com/video/are-you-an-
`elite-sleeper-why-some-people-are-healthy-with-4-or-5-hours-of-sleep-660010563718
`
`Fox News, New York RE peripheral nerve stimulators for insomnia. February 1, 2016
`http://mms.tveyes.com/MediaCenterPlayer.aspx?u=aHR0cDovL21lZGlhY2VudGVyLnR2ZXllcy5jb20
`vZG93bmxvYWRnYXRld2F5LmFzcHg%2FVXNlcklEPTMzNTMwMiZNRElEPTU3MzgzNzUmTU
`RTZWVkPTgxNzYmVHlwZT1NZWRpYQ%3D%3D
`
`
`
`CBS news, New York RE sleeping times for children, September 14, 2015:
`http://67.214.100.182/Player?ClipId=,S,201509,80E8BF33-FFF1-4609-88B0-
`1602036B271C&ReqServer=NDS7\NDS7&QueryName=NY%20Presbyterian&Offset=3403&rai=28ed
`7e79-0312-4df0-b718-6fca4286e2e8&ran=360%20mediawatch&roi=28ed7e79-0312-4df0-b718-
`6fca4286e2e8&ron=360%20mediawatch&run=&rut=0&E=12gl27HY27zYi7Ic2WJfr7JchWy72i&Time
`=12gf(74fHi4S(74f(74f(74lb7xf(74frj&Related=PV_3&pbp=Y
`
`HCP Live MD Coverage of American Academy of Neurology annual meeting April 18-25, 2015:
`http://www.hcplive.com/conference-coverage/aan-2015/QandA-With-Carl-Bazil-MD-PhD-FAAN-of-Columbia-
`University-Latest-Epilepsy-Medical-Treatments;
`http://www.hcplive.com/conference-coverage/aan-2015/QandA-With-Carl-Bazil-MD-PhD-FAAN-of-Columbia-
`University-When-is-Surgery-the-Best-Treatment-for-Epilepsy;
`http://www.hcplive.com/conference-coverage/aan-2015/QandA-With-Carl-Bazil-MD-PhD-FAAN-of-Columbia-
`University-Diagnosing-Epilepsy-and-Finding-the-Right-Medication;
`http://www.hcplive.com/conference-coverage/aan-2015/QandA-With-Carl-Bazil-MD-PhD-FAAN-of-Columbia-
`University-Finding-Alternative-Treatments-for-Epilepsy
`
`CNN “Be a champion” RE sleep, December 10,2014
`http://www.cnn.com/interactive/2014/12/specials/dhani-jones-be-a-champion/?hpt=hp_c3#sleep
`Today Show RE sleep, November 10, 2014, http://www.today.com/video/today/56397727#56397727
`and November 13, 2014 http://www.today.com/video/today/56416357#56416357
`
`The Today Show, “Snooze or lose.” November 10, 2014: http://www.today.com/video/today/56397727
`and November 13, 2014: http://www.today.com/video/today/56416357
`
`CBS 11 o’clock News RE sleep learning. September 19,2014.
`NY1 regarding sleep apnea, August 22, 2014.
`http://www.ny1.com/content/lifestyles/healthy_living/214217/often-overlooked-sleep-apnea-can-lead-
`to-health-problems/
`KCBS radio San Francisco RE ASMR and insomnia, August 5, 2014.
`Tbs eFM This Morning, Seoul, Korea regarding sleep deprivation effects of the Word Cup, June 23,
`2014. https://itunes.apple.com/kr/podcast/tbs-efm-this-morning/id564557750?mt=2
`WNBC news, “Clock your sleep project.” http://www.nbcnewyork.com/video/#!/on-air/as-seen-
`on/Survey-Looks-to-Clock-Your-Sleep/261313871 and “Campaign for better sleep”
`http://www.nbcnewyork.com/video/#!/on-air/as-seen-on/Campaign-for-Better-Sleep-in-
`NYC/259591941 May 2014.
`WNYC, The Brian Lehrer Show, “Clock your sleep: Adults.” April 23, 2014,
`http://www.wnyc.org/story/clock-your-sleep-adults/
`WNYC, The Brian Lehrer Show, “Family meeting: Sleep.” April 2, 2014,
`http://www.wnyc.org/story/the-brian-lehrer-show-2014-04-02/
`
`
`
`6
`
`Argentum Pharm. v. Research Corp. Techs., IPR2016-00204
`RCT EX. 2039 - 6/24
`
`

`
`Carl W. Bazil, M.D., Ph.D.
`
`CBS evening News, “Insomnia may be a 24 hour condition.” April 1, 2014,
`http://newyork.cbslocal.com/2014/04/01/seen-at-11-insomnia-may-be-a-24-hour-condition-research-
`shows/
`CBS evening News, “position yourself for a good night’s sleep.” March 24, 2014,
`http://newyork.cbslocal.com/2014/03/24/seen-at-11-position-yourself-for-a-good-nights-sleep/
`CBS This Morning regarding sleeping pill risks, February 28, 2012 http://www.cbsnews.com/8301-
`505269_162-57386446/new-study-finds-big-risk-for-sleeping-pills/?tag=hdr;cnav
`WNYC (National Public Radio, New York affiliate), The Brian Lehrer Show, “The science of subway
`sleeping”, December 13, 2011 http://audio.wnyc.org/bl/bl121311fpod.mp3
`Podcast regarding retigabine 9-20-10:
`http://professionals.epilepsy.com/page/hallway_2010_podcasts.html
`NY1 News, ‘The science of sleep: Rising tide of sleep meds battles widespread insomnia.” March 17,
`2010,” March 15, 2010; http://www.ny1.com/content/news/115345/the-science-of-sleep--rising-tide-of-
`sleep-meds-battles-widespread-insomnia/
`NY1 News, ‘The science of sleep: Exhaustion not unusual in NYC.” March 15, 2010,
`http://manhattan.ny1.com/content/115211/the-science-of-sleep--exhaustion-not-unusual-in-nyc/
`WPIX-TV News, Catching up on lost sleep? Nearly impossible. February 3, 2010;
` New York One, Gene for benign rolandic epilepsy, 1-28-09:
`http://www.ny1.com/content/ny1_living/health/92982/researchers-find-gene-linked-to-
`epilepsy/Default.aspx
`http://www.vmsdigital.com/download/012609/SNY025898_01.WMV
`New York One, “Yoga classes now offer power naps,” 1-27-09:
`http://www.ny1.com/content/ny1_living/health/92894/yoga-classes-now-offer-power-naps/Default.aspx
`Martha Steward Radio, “Sleep Awareness Week.” March 3, 2008.
`WNYC (National Public Radio, New York affiliate), The Leonard Lopate Show, “Insomnia”, November
`9, 2007
`60 minutes, “I am a U.S. soldier” (regarding his epilepsy); CBS, November 3, 2004
`
`Media quotes
`The Guardian RE night mild as a sleep aid. December 15, 2015,
`http://www.theguardian.com/lifeandstyle/2015/dec/15/night-milk-milk-cows-night-sleep-aid-you-
`need#_=_
`NYMag.com RE sleep starts, September 24, 2015, http://nymag.com/thecut/2015/09/why-do-i-jerk-
`awake-right-as-im-falling-asleep.html
`Mic.com, “The science behind why we should all be taking naps at work.” September 2015,
`http://mic.com/articles/126102/naps-at-work-increase-productivity
`Men’s Fitness, “Why am I always tired?”, July 31, 2015
` http://www.mensfitness.com/life/entertainment/why-am-i-always-tired
`VanWinkles, “Hoarders can’t hoard sleep”, June 24, 2015, https://vanwinkles.com/hoarder-s-can-t-
`hoard-sleep-study-shows#.VYrTFQsMZxY.gmail
`Prevention, “ 5 scary signs sleep loss is messing with your mind.” October 31, 2014,
`http://www.prevention.com/health/health-concerns/effects-insomnia-and-sleep-deprivation-your-brain
`Women’s Health, “What to do when you can’t freaking sleep.” September 18, 2014.
`http://www.womenshealthmag.com/health/cant-sleep
`Women’s Health, “The very real dangers of taking sleeping pills.” August 15, 2014.
`http://www.womenshealthmag.com/health/sleeping-pill-dangers
`New York Times, “Rustle, tingle, relax: The compelling world of ASMR. July 29, 2014;
`http://well.blogs.nytimes.com/2014/07/28/rustle-tingle-relax-the-compelling-world-of-a-s-m-
`r/?_php=true&_type=blogs&_php=true&_type=blogs&_r=1
`
`
`
`7
`
`Argentum Pharm. v. Research Corp. Techs., IPR2016-00204
`RCT EX. 2039 - 7/24
`
`

`
`Carl W. Bazil, M.D., Ph.D.
`
`New York Times, “Taking a restful position.” January 27, 2014,
`http://www.nytimes.com/2014/01/28/science/taking-a-restful-position.html?_r=1
`New York Times, “A mental alarm clock.” January 14, 2014 :
`http://www.nytimes.com/2014/01/14/science/a-mental-alarm-clock.html?_r=0
`Reuter’s Health. Poor sleep tied to kid’s lower academic performance. August 16, 2013
`http://reut.rs/14VZwRg
`
`Prevention April 2013, “8 New Mistakes that Mess Up Your Sleep.
`http://www.prevention.com/health/sleep-energy/8-sleep-problems-explain-why-youre-tired-all-
`time
`US News & World Report, “Experimental insomnia drug shows promise.” 2012:
`http://health.usnews.com/health-news/news/articles/2012/11/28/experimental-insomnia-drug-
`shows-promise
`http://blogs.marketwatch.com/encore/2012/11/16/the-true-cost-of-sleeplessness/
`http://www.foxnews.com/science/2012/11/21/mystery-substance-discovered-in-brain/
`Wall Street Journal, “The true cost of sleeplessness.” November 16, 2012;
`http://blogs.marketwatch.com/encore/2012/11/16/the-true-cost-of-sleeplessness/
`New York Times, “To sleep on the subway. Maybe, but to dream/ Poor chance.” December 7, 2011,
`http://www.nytimes.com/2011/12/08/nyregion/to-sleep-on-the-subway-maybe-but-to-dream-poor-
`chance.html?_r=2 (also covered by Village Voice and ABC News)
`
`
`
`8
`
`Argentum Pharm. v. Research Corp. Techs., IPR2016-00204
`RCT EX. 2039 - 8/24
`
`

`
`
`Publications
`
`
`Carl W. Bazil, M.D., Ph.D.
`
`1. Choi H, Hayat MJ, Hirsch LJ, Bazil CW, Mendiratta A, Kato K, Javed A, Legge AW,
`Buchsbaum R, Resor S, Heiman GA. Drug-resistant epilepsy in adults: Outcome trajectories
`after failure of two medications. Epilepsia 2016 e-pub. PMID: 27265407
`2. Jongeling A, Richins R, Bazil CW. Safety and tolerability of an oral zonisamide loading dose.
`Seizure 2015; 32:69-71.
`3. Javed A, Cohen B, Detyniecki K, Hirsch LJ, Legge A, Chen B, Bazil C, Kato K, Buchsbaum R,
`Choi H. Rates and predictors of patient-reported cognitive side effects of antiepileptic drugs: An
`extended follow-up. Seizure. 2015 Jul;29:34-40.PMID:26076842
`4. Jongeling AC, Bazil CW, Claassen J. Status Epilepticus: Redefined or Increasingly Detected?
`JAMA Neurol. 2015 Jun 1;72(6):631-3 PMID:25915727
`5. Foreman B, Westwood AJ, Claassen J, Bazil CW. Sleep in the neurological intensive care unit:
`feasibility of quantifying sleep after melatonin supplementation with environmental light and
`noise reduction.J Clin Neurophysiol. 2015 Feb;32(1):66-74 PMID:25647773
`6. Tu B, Hirsch LJ, Bazil CW, Hamberger MJ, Assassi N. Quantitative EEG is an objective, sensitive
`and reliable indicator of transient anesthetic effects during Wada Tests. J Clin Neurophysiol 2015;
`32:152-8.
`7. Correll CM, Bazil CW. Management of seizures in the elderly. Curr Geri Rep 2014 3:73-82.
`8. Heck CN; King-Stephens D; Massey AD; Nair DR; Jobst BC; Barkley GL; Salanova V; Cole AJ;
`Smith MC; Gwinn RP; Skidmore C; Van Ness PC; Bergey GK; Park YD; Miller I; Geller E;
`Rutecki PA; Zimmerman R; Spencer DC; Goldman A; Edwards JC; Leiphart JW; Wharen RE;
`Fessler J; Fountain NB; Worrell GA; Gross RE; Eisenschenk S; Duckrow RB; Hirsch LJ; Bazil, C
`O'Donovan CA; Sun FT; Courtney TA; Seale CG; Morrell MJ.Two-year seizure reduction in
`adults with medically intractable partial onset epilepsy treated with responsive neurostimulation:
`final results of the RNS System Pivotal trial. Epilepsia. 55(3):432-41, 2014
`9. Hamid H; Blackmon K; Cong X; Dziura J; Atlas LY; Vickrey BG; Berg AT; Bazil CW Langfitt
`JT; Walczak TS; Sperling MR; Shinnar S; Devinsky O. Mood, anxiety, and incomplete seizure
`control affect quality of life after epilepsy surgery. Neurology. 82(10):887-94, 2014
`10. Brown FC, Westerveld M, Langfitt JT, Hamberger M, Hamid H, Shinnar S, Sperling MR,
`Devinsky O, Barr W, Tracy J, Masur D, Bazil CW, Spencer SS. Influence of anxiety on memory
`performance in temporal lobe epilepsy. Epilepsy & Behavior 2014; 31:19-24.
`11. Rektor I, Schachter SC, Arzy S, Baloyennis SJ, Bazil C et al. Epilepsy, behavior, and art
`(Epilepsy, Brain, and Mind, part 1). Epilepsy & Behavior 2013.
`12. Di Rocco , Loggini A, Di Rocco M, Di Rocco P, Rossi R, Gimelli G, Bazil C. Paradoxical
`Worsening Of Seizure Activity With Pregabalin In An Adult With Isodicentric 15 (IDIC-15)
`Syndrome Involving Duplications Of The GABRB3, GABRA5 And GABRG3 Genes. BMC
`Neurology 2013; 13:43.
`13. Bazil CW, Dave J, Cole J, Stalvey J, Drake E. Pregabalin increases slow-wave sleep and may
`improve attention in patients with partial epilepsy and insomnia. Epilepsy & Behavior 2012;
`23:422-5.
`14. Boden-Albala B, Roberts ET, Bazil C, Moon Y, Elkind MS, Rundek T, Paik MC, Sacco RL.
`Daytime sleepiness and risk of stroke and vascular disease: findings from the Northern Manhattan
`Study (NOMAS). Circ Cardiovasc Qual Outcomes 2012; 5:500-7.
`15. Bazil CW. Epilepsy surgery: still underutilized after all these years. Curr Neurol Neursci Rep
`2012; 12:348-9.
`
`
`
`9
`
`Argentum Pharm. v. Research Corp. Techs., IPR2016-00204
`RCT EX. 2039 - 9/24
`
`

`
`
`
`
`
`Carl W. Bazil, M.D., Ph.D.
`16. Hamid H, Lui H, Cong X, Devinsky O, Berg AT, Vickrey G, Sperling MR, Shinnar S, Langfitt JT,
`Walczak TS, Barr WB, Dziura J, Bazil CW, Spencer SS. Long-term association between seizure
`outcome and depression after respective epilepsy surgery. Neurology 2011; 77(22): 1972-6.
`17. Moeller J, Tu B, Bazil CW. Quantitative and qualitative analysis of ambulatory EEG during mild
`traumatic brain injury. Arch Neurol 2011 68(12):1595-8.
`18. Hamid H, Devinsky O, Sperling MR, Berg AT, Vickrey G, Shinnar S, Langfitt JT, Walczak TS,
`Bazil CW, Spencer SS. Suicide outcomes after resective epilepsy surgery, Epilepsy & Behavior
`2011; 20(3):462-4.
`19. Bazil, CW. Effects of sleep on the postictal state. Epilepsy and Behavior 2010; 19:146-50.
`20. Chong DJ, Bazil CW. Update on anticonvulsant drugs. Curr Neurol Neurosci Rep 2010 10(4):308-
`18.
`21. Arif H, Buchsbaum R, Pierro J, Whalen M, Sims J, Resor SJ, Bazil CW, Hirsch LJ. Comparative
`effectiveness of 10 antiepileptic drugs in older adults with epilepsy. Arch Neurol 2010; 67(4):408-
`15.
`22. Uthman BM, Bazil CW, Beydoun A, Schulze-Bonhage A, Benabou R, Whalen E, Emir B,
`Griesing T, Leon T. Long-term add-on pregabalin treatment in patients with partial-onset epilepsy:
`Pooled analysis of open-label clinical trials. Epilepsia 2010; 51:968-78.
`23. Fisher R; Salanova V; Witt T; Worth R; Henry T; Robert Gross; Kalarickal Oommen; Ivan Osorio;
`Jules Nazzaro; Douglas Labar; Michael Kaplitt; Michael Sperling; Evan Sandok; John Neal;
`Adrian Handforth; John Stern; Antonio DeSalles; Steve Chung; Andrew Shetter; Donna Bergen;
`Roy Bakay; Jaimie Henderson; Jackie French; Gordon Baltuch; William Rosenfeld; Andrew
`Youkilis; William Marks, Jr.; Paul Garcia; Nicolas Barbaro; Nathan Fountain; Carl Bazil; Robert
`Goodman; Guy McKhann; K. Babu Krishnamurthy; Steven Papavassiliou; Charles Epstein; John
`Pollard; Lisa Tonder; Joan Grebin; Robert Coffey; Nina Graves. Electrical Stimulation of the
`Anterior Nucleus of Thalamus for Treatment of Refractory Epilepsy. Epilepsia 2010; 51(5):899-
`908.
`24. Bazil, CW. Epilepsy : Generic substitution – are antiepileptic drugs different ? Nature Rev Neurol
`2009 ; 5 :587-8.
`25. Bazil CW. Is it time for drug sensitivity genetic screening ? Curr Neurol Neurosci Rep 2009;
`9:268-9.
`26. Bazil CW. Nocturnal seizures and the effects of anticonvulsants on sleep. Curr Neurol Neurosci
`Rep 2008;8(2) : 149-54.
`27. Hirsch LJ, Arif H, Nahm EA, Buchsbaum R, Resor SR, and Bazil CW. Cross sensitivity of skin
`rashes with antiepileptic drug use. Cross-sensitivity of skin rashes with antiepileptic drug use.
`Neurology 2008; 71:1527-34.
`28. Bazil, CW. Leaving AEDs behind: When to withdraw therapy in seizure-free patients. Practical
`Neurology 2008;7(10):38-43.
`29. Bazil CW. Many options for epilepsy: Comparisons of first- and second-generation AEDs. Curr
`Neurol Neurosci Rep 2008; 8:323-4.
`30. Rogawski MA, Bazil CW. New molecular targets for antiepileptic drugs: α2δ, SV2A, and
`Kv7/KCNQ/M potassium channels. Curr Neurol Neurosci Rep 2008; 8:345-352.
`31. Chin PS, Berg AT. Spencer SS. Sperling MR. Haut SR. Langfitt JT. Bazil CW. Walczak TS. Pacia
`SV. Vickrey BG. Employment outcomes following resective epilepsy surgery. Epilepsia 2007;
`48(12):2253-7.
`32. Spencer SS. Berg AT. Vickrey BG. Sperling MR. Bazil CW. Haut S. Langfitt JT. Walczak TS.
`Devinsky O. Multicenter Study of Epilepsy Surgery. Health-related quality of life over time since
`resective epilepsy surgery. Annals of Neurology 2007 62(4):327-34.
`33. Bazil CW. Are the first line recommendations for antiepileptic drug therapy still valid ? Nature
`Clin Pract Neurol 2007 ; 3 :484-5.
`
`10
`
`Argentum Pharm. v. Research Corp. Techs., IPR2016-00204
`RCT EX. 2039 - 10/24
`
`

`
`
`
`
`
`Carl W. Bazil, M.D., Ph.D.
`34. Bazil CW. Long-term prognosis in intractable epilepsy : Looking beyond a year. Curr Neurol
`Neurosci Rep 2007 ; 7(4) :313-314.
`35. Hirsch LJ, Arif H, Buchsbaum R, Weintraub D, Lee J, Chang JT, Resor SR, Bazil CW. Effect of
`age and comedication on levetiracetam pharmacokinetics and tolerability. Epilepsia 2007 ;
`48(7) :1351-9.
`36. Liow K, Barkley GL, Pollard JR, Harden CL, Bazil CW. The American Academy of Neurology.
`Position statement on the coverage of anticonvulsant drugs for the treatment of epilepsy.
`Neurology 2007 ; 68(16) :1249-50.
`37. Arif H, Buchsbaum R, Weintraub D, Koyfman S, Salas-Humara C, Bazil CW, Resor, SR Jr, and
`Hirsch LJ. Comparison and predictors of rash associated with 15 antiepileptic drugs. Neurology
`2007;68 1701-1709
`38. Langfitt JT. Holloway RG. McDermott MP. Messing S. Sarosky K. Berg AT. Spencer SS. Vickrey
`BG. Sperling MR. Bazil CW. Shinnar S. Health care costs decline after successful epilepsy
`surgery. Neurology 2007; 68(16):1290-8.
`39. Bazil CW, Hauser WA. Highlight and Commentary. First seizure: Do multiple seizures predict
`recurrence ? Neurology 2006; 67:927.
`40. Xu X, Brandenburg NA, McDermott AM, Bazil CW. Sleep Disturbances Reported by Refractory
`Partial-Onset Epilepsy Patients Receiving Polytherapy. Epilepsia 2006; 47(7):1176-83.
`41. A.T.Berg, B.G. Vickrey, J. T. Langfitt, M.R. Sperling, S Shinnar, MD, C. Bazil, T. Walczak, S. S.
`Spencer For the Multicenter Study of Epilepsy Surgery. Reduction of AEDs in postsurgical
`patients who attain remission. Epilepsia 2006; 47(1):64-71.
`42. Bazil, C.W. and Hirsch, L.J. Autoantibodies: A novel etiology for refractory epilepsy? Current
`Neurol Neurosci Rep 2006; 6(4):309-10.
`43. Chin PS, Berg AT, Spencer SS, Lee ML, Shinnar S, Sperling MR, Langfitt JT, Walczak TS, Pacia
`SV, Bazil CW, Vassar S, and Vickrey BG. Patient-perceived impact of resective epilepsy surgery.
`Neurology 2006;66(12):1882-1887
`44. Sachdeo RC. Gates JR. Bazil CW. Barkley GL. Tatum W. D'Souza J. McCague K. Improved
`quality of life in patients with partial seizures after conversion to oxcarbazepine monotherapy.
`Epilepsy & Behavior 2006; 9(3):457-63.
`45. Langfitt JT. Vickrey BG. McDermott MP. Messing S. Berg AT. Spencer SS. Sperling MR. Bazil
`CW. Shinnar S. Validity and responsiveness of generic preference-based HRQOL instruments in
`chronic epilepsy. Quality of Life Research 2006; 15(5):899-914.
`46. Gilliam FG. Mendiratta A. Pack AM. Bazil CW. Epilepsy and common comorbidities: improving
`
`the outpatient epilepsy encounter. Epileptic Disorders 2005; 7 Suppl 1:S27-33.
`47. Devinsky O, Barr WB, Vickrey BG, , Berg AT, Bazil CW, Pacia, Langfitt JT, Walczak TS,
`Sperling MR, Shinnar S, Spencer SS. Changes in depression and anxiety after resective epilepsy
`surgery. Neurology 2005; 65:1744-1749.
`48. Langfitt, JT, Vickrey, BG, McDermott, MP, Messing, S, Berg, AT , Spencer, SS Sperling, MR,
`Bazil, CW & Shinnar, S. Validity & Responsiveness of Generic Preference-Based HRQOL
`Instruments In Chronic Epilepsy. Quality of Life Research 2006; 15(5):899-914.
`49. Bazil CW, Battista J, Basner RC. Effects of levetiracetam on sleep in normal volunteers. Epilepsy
`
`& Behavior 2005; 7(3):539-542.
`50. Spencer SS, Berg AT, Vickrey BG, Sperling MR, Bazil CW, Shinnar S, Langfitt JT, Walczak TS,
`Pacia for The Multicenter Study of Epilepsy Surgery. Predicting long-term seizure