`
`Reference
`Kohn 1988
`Kohn 1988
`Kohn 1988
`Kohn 1988
`Kohn 1988
`Kohn 1988
`Conley 1987
`Conley 1987
`Conley 1987
`Kohn 1990, 1991
`Kohn 1990
`Kohn 1990
`Kohn 1991
`Kohn 1990
`Kohn 1990
`Kohn 1990
`Kohn 1991
`Kohn 1991
`Kohn 1990
`Kohn 1990
`Kohn 1990
`Kohn 1990
`Kohn 1990
`Kohn 1990
`Kohn 1990
`Kohn 1990
`Kohn 1990
`Kohn 1990
`Kohn 1990
`Kohn 1990
`Kohn 1990
`Kohn 1991
`Kohn 1991
`Kohn 1991
`Kohn 1991
`Kohn 1993
`Kohn 1993
`Kohn 1993
`Kohn 1993
`Kohn 1990
`Kohn 1993
`
`Compound
`Compound D, L-AAB
`Compound D-AAB
`Compound L-AAB
`Compound D, L-APB
`Compound D-APB
`Compound L-APB
`Compound 1a
`Compound 1d
`Compound 1m
`Compound (R, S) 2a
`Compound (R) 2a
`Compound (S) 2a
`Compound 2b
`Compound (R, S) 2b
`Compound (R) 2b
`Compound (S) 2b
`Compound 2c
`Compound 2d
`Compound 2f
`Compound (R,S) 2g
`Compound (R) 2g
`Compound (S) 2g
`Compound 2h
`Compound 2i
`Compound 2l
`Compound 2m
`Compound 2n
`Compound 2o
`Compound 2p
`Compound 3b
`Compound 3c
`Compound 3l
`Compound 3n
`Compound 3s
`Compound 3t
`Compound 3
`Compound 4 (2g, 2d)
`Compound (R) 4 (2g)
`Compound (S) 4 (2g)
`Compound 5
`Compound 5 (2i)
`
`Protective Index:
`5.93
`3.90
`1.53
`> 1.25
`> 3.03
`> 0.33 < 1
`5.93
`4.77 (i.p.); 5.17 (orally)
`> 6.46
`5.93
`3.91
`1.53
`4.77
`> 1.25
`> 3.03
`> 0.33 < 1
`> 1.86 < 6.21
`≈ 3.88
`> 1
`≈ 3.88
`7.21
`> 8
`3.93
`> 1.86 < 6.21
`> 0.67 < 2.23
`> 1.14
`≈ 1
`≈ 1
`≈ 1
`10.23
`11.34
`7.42
`7.54
`> 1.02 < 3.05
`> 1.81
`> 1.25
`≈ 3.88
`7.21
`> 8
`> 1.81
`> 1.86 < 6.21
`
`ARGENTUM Exhibit 1218
` Argentum Pharmaceuticals LLC v. Research Corporation Technologies, Inc.
`IPR2016-00204
`
`Page 00001
`
`
`
`Summary of the Protective Indices of all FAA Compounds in Dr. Kohn’s References
`
`Kohn 1993
`Kohn 1993
`Kohn 1993
`Kohn 1993
`Kohn 1993
`Kohn 1993
`Kohn 1993
`Kohn 1993
`Kohn 1993
`Kohn 1993
`Kohn 1991
`Kohn 1991
`Kohn 1991
`Kohn 1994
`Kohn 1994
`Bardel 1994
`Bardel 1994
`Bardel 1994
`Bardel 1994
`Bardel 1994
`Bardel 1994
`Bardel 1994
`Bardel 1994
`Bardel 1994
`Bardel 1994
`Bardel 1994
`
`Compound 7 (2l)
`Compound 8 (2m)
`Compound 18
`Compound 19
`Compound 30
`Compound (R) 30
`Compound 34
`Compound 41
`Compound 49
`Compound 50
`Phenytoin
`Phenobarbital
`Valproate
`Compound 2c
`Compound 2d
`Compound 2
`Compound 3
`Compound 4
`Compound 5
`Compound 6
`Compound 9
`Compound 10
`Compound 11
`Compound 12
`Compound 13
`Compound 24
`
`> 0.67 < 2.23
`> 1.14
`3.71
`5.71
`11.34
`4.11
`> 1
`> 1
`< 3 > 1
`5.93
`6.89
`3.17
`1.57
`7.42
`7.54
`≈ 3.88
`> 1.86 < 6.21
`> 0.67 < 2.23
`> 1.14
`3.71
`5.71
`> 1.25
`> 2.31 < 9.26
`3.93
`7
`7.42
`
`Page 00002
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