IN THE UNITED STATES PATENT AND TRADEMARK OFFICE
`
`In Re:
`
`US. Patent of Cottens er al.
`
`Proceeding No.:
`
`IPR2016-00084
`
`Patent No.:
`
`5,665,732
`
`Application No.:
`
`08f416,673
`
`For:
`
`O-ALKYLATED RAPAMYCIN DERIVATIVES AND THEIR
`
`USE, PARTICULARLY AS IMMUNOSUPPRESSANTS
`
`PATENT OVVNER’S POWER OF ATTORNEY IN AN INTER PAR TES REVIEW
`
`Patent Owner Novartis AG (“Novartis”) hereby appoints Nicholas N. Kallas (Reg.
`
`No. 31,530), Raymond R. Mandra (Reg. No. 34,382), and Christina Schwarz as its attorneys to
`
`prosecute the aforementioned proceeding and to transact all business in the United Patent and
`
`Trademark Office connected therewith.
`
`Please address all correspondence as follows:
`
`Nicholas N. Kallas
`
`Fitzpatrick, Cella, Harper & Scinto
`1290 Avenue of the Americas
`
`New York, NY 10104-3800
`Telephone: (212) 213-2100
`Facsimile: (212) 218-2200
`n.kallas@fchs.com
`
` eter J. Waibel -
`Gregor
`aro
`Novartis Pharmaceuticals Corporation
`Novartis Pharmaceuticals Corporation
`One Health Plaza
`One Health Plaza
`
`East Hanover, NJ 07936-1080
`
`East Hanover, NJ 0793 6-1080
`
`Witnessed by:
`
`Witnessed by:
`
`ignature
`
`Signature
`
`.5. 071/14164
`Lam-w‘e..
`Printed name
`
`Laurie. S. O’//A/be?
`Printed name
`
`

`
`~
`
`~ i I I I
`
`I
`r
`
`ll) NOVARTIS
`
`Power of Attorney
`(To Novartis IP colleagues based in US, DE, SG, CN)
`
`By this Power of Attorney, effective 01 January 2016, Novartis AG, a company
`incorporated under the laws of Switzerland and having its principal place of business at
`Lichtstrasse 35, 4056 Basel, Switzerland ("the Company"), hereby grants to the Novartis
`Group Companies listed below ("the Corporate Signatories"):
`
`a) the revocable authority to sign documents on behalf of the Company in
`connection with filing, prosecution, maintenance, and administration of any
`intellectual property
`right
`for copyright, design, domain name, patent,
`supplementary protection certificate (SPC) and trademark registration or any
`application therefore standing in the name ofthe Company ("IP");
`
`b) the revocable authority to sign documents on behalf of the Company in
`connection with litigation relating to defense of IP before a governmental
`authority; and
`
`c) the revocable authority to sign Confirmatory Assignments on behalf of the
`Company. "Confirmatory Assignments" are agreements between the Company
`and a third party or a Novartis Group entity that do not create new rights or
`obligations for the Company, such rights having been created by an underlying
`agreement (e.g. acquisition/divestment agreement, research funding/collaboration
`agreement, and the like) and whereby the Confirmatory Assignment merely
`executes the transfer of IP as agreed in such underlying agreement;
`
`and for no other purposes.
`
`This Power of Attorney excludes the power to conclude contracts, other than
`Confirmatory Assignments, or to enter into settlements on behalf of the Company.
`The
`terms
`"contracts"
`and
`"settlements"
`include
`license
`agreements,
`acquisition/divestment agreements, assignments, prior right agreements and/or letters of
`consent.
`
`This Power of Attorney includes the power to appoint external agents within the scope of
`this Power of Attorney.
`
`To be legally binding upon the Company, all relevant documents require the signature of
`two employees of a Corporate Signatory as set out below ("Personal Signatories")
`authorized to sign for the respective Corporate Signatory, except where a single Personal
`Signatory is permitted according to the Novartis internal "Intellectual Property Signature
`· Guidelines" .
`
`

`
`Corporate Signatories
`
`Personal Signatories
`
`Alcon Research, Ltd.
`
`Barbara McKenzie
`Barry L. Copeland
`Candy Sanders
`Christianne K. Garrow
`Christine Bohmann
`Darden Weiss
`Darien L. Reddick
`Deborah Weinschenk
`Deena Nutt
`Denise C. Vivar
`Gergely T. Zimanyi
`Glenda Wolfe
`Janis M. Mendolia
`Jason Finch
`Jason J. Derry
`Jian Zhou
`Keiko Ichiye
`Kelly Bryant
`Kenneth D. Bassinger
`Mark E. Flanigan
`Martha J. Martin
`Mary Lozano
`Michael Rein
`Patrick M. Ryan
`Robert Ambrose
`Russell E. Henrichs
`Matthew A. Hayenga
`Scott A. Chapple
`Shelley Rose-Johnson
`Sheng-Hsin Hu
`Stephanie J. Boyle
`Steven Brannon Latimer
`Tamika Adams
`Tracy Humphreys
`Yolanda I. Sanchez
`
`Page 2 of 5
`
`

`
`Corporate Signatories
`
`Personal Signatories
`
`Sandoz International GmbH
`
`Andrea Felbermeir
`Britta Chamberlain
`David Lossignol
`Manuela Hillewaert
`Meike Urban
`Susanne Groeschel-Jofer
`Timo Getting
`
`Novartis Institutes for BioMedical Research, Inc. Adam Poulin-Kerstein
`Arlene Musser
`David Carpenter
`Mary Elizabeth O'Brien
`Forrester Liddle
`Grace Law
`Jean Silveri
`John B. Alexander
`John Prince
`Jonathan Wood
`Joshua Roth
`Laura Madden
`Laurie Butler Lawrence
`Elissa Marie Nash
`Mei Benni
`Michael G. Smith
`Paul Paglierani
`Qian Zhang [5*~1
`Rona Nardone
`Safiya Watson
`Shawn Britt
`Simonne Corriveau
`Scott Brown
`Scott Loftus-Reid
`Sophie Binet Cross
`Stephanie Geis
`Stephen Wolfolds
`Susan Dillon
`Xiaoguang Gao
`
`Page 3 of 5
`
`

`
`Corporate Signatories
`
`Personal Signatories
`
`Novartis Institute for Functional Genomics, Inc.
`
`Chihang Smith
`Daniel E. Raymond
`EmilyT. Wu
`Jill R. Clarke
`Julie McCarthy
`Kerri Pollard Schray
`Susan Sesnovich
`
`Ciba Vision Vertriebs GmbH
`
`Frank Kaul
`Frank Hauerken
`Jan-Thore Fohrenbach
`
`Novartis Institute for Tropical Diseases Pte. Ltd. Younbeen Kim
`
`Beijing Novartis Pharma Co. Ltd.
`[~I::Eti;fi:f¥flliJ~ff~~0-q]J
`
`Fan (Kent) Yang [if%~JL]
`Lu Dai [.X!fi]
`John Ti Li [~5LDft]
`Juan (Jane) Ye [llt~~]
`Zheng (Aileen) Wei[~~~]
`Wen (Lucia) Tang [~:i:]
`Xiaoning (Remy) Wang [.±.11'9]
`
`China Novartis Institutes for BioMedical Research Co., Ltd.
`[i,~i~ C9='00) ~tm~~:UJfJl.~~lH~i'fJJ
`
`Novartis Services Incorporated
`
`Novartis Healthcare Private Limited
`
`Betty Ryberg
`Cynthia L. Lopez
`Frank Smith
`Juerg Baenziger
`
`Atul Bade
`Ashish Jogi
`
`Page 4 of 5
`
`

`
`Corporate Signatories
`
`Personal Signatories
`
`Novartis Pharmaceuticals Corporation
`
`Andrea Jacquin
`Andrew Holmes
`Annette Cromer
`Bernadeta Adach
`Christine McCormack
`Cindy Klepacky
`Daniel Woods
`David Kurlandsky
`Denise Cooper
`Diane Leone
`Gregory Ferraro
`Gregory Houghton
`Jennifer Chapman
`Jim Lynch
`Kamalam Suppiah
`Kelly Stritenberger
`Lauren Bosco
`Leslie Fischer
`Linda Adams
`Lydia McNally
`Maria Stachura
`Marie Collazo
`Matthew Mulkeen
`Mehdi Ganjeizadeh
`Michael Mazza
`Michelle Han
`Peter Waibel
`Sandra Rueck
`Sherri Rose
`Sudipta Rao
`Svetlana Korzhin
`
`This Power-of-Attorney is valid until 31st December 2016 and supersedes as of its
`effective date all previous versions of Powers of Attorney relating to the subject matter
`herein.
`
`Basel, 17 December 2015,
`
`NOVARTISAG 'M__
`-
`---~--::~-~------~-----------
`
`~
`
`---~-----~
`
`Authorized Signattry
`OL/t/c-/? M4'17&1cr~~
`
`Authorized Signatory
`
`Alisa Harbin
`Authorized Signatory
`
`Page 5 of 5
`
`

`
`ATTESTATION
`
`I, the undersigned Civil Law Notary in Basel , Switzerland, Dr. Conradin Cramer, certify
`herewith that the signatures attached heretofore are the genuine signatures of
`Dr. Oliver Mark Brupbacher, citizen of Wadenswil, Switzerland,
`residing
`in
`Feusisberg, Switzerland; and of Ms. Alisa Harbin, citizen of the United States of
`America, residing in Reinach BL, Switzerland; both acting for Novartis AG , in Basel,
`Switzerland , both as authorized signatories and both with joint signature.
`
`The authenticity of the signatures was established by means of comparison.
`
`BASEL, Switzerland, this 18th (eighteenth) day of December 2015 (two thousand and fifteen)