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`Entered: June 3, 2016
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`UNITED STATES PATENT AND TRADEMARK OFFICE
`_______________________
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`BEFORE THE PATENT TRIAL AND APPEAL BOARD
`_______________________
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`PAR PHARMACEUTICAL, INC.
`Petitioner
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`v.
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`NOVARTIS AG.
`Patent Owner
`_______________________
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`
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`Case IPR2016-00084
`U.S. Patent No. 5,665,772
`_______________________
`
`Before LORA M. GREEN, CHRISTOPHER L. CRUMBLEY, and
`ROBERT A. POLLOCK, Administrative Patent Judges.
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`PETITIONER’S UPDATED EXHIBIT LIST
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`Case IPR2016-00084
`U.S. Patent No. 5,665,772
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`Pursuant to 37 C.F.R. § 42.63(e), Petitioner Par Pharmaceutical, Inc.
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`respectfully submits the following current exhibit list.
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`Exhibit
`1001
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`Description
`U.S. Patent No. 5,665,772 (“the ’772 Patent”)
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`1002
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`1003
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`1004
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`1005
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`1006
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`1007
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`1008
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`1009
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`1010
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`1011
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`1012
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`File History for the ’772 Patent
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`Declaration of William L. Jorgensen, Ph.D. in Support of Petition for
`Inter Partes Review of U.S. Patent No. 5,665,772
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`Curriculum Vitae of William L. Jorgensen
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`Randall Ellis Morris, Rapamycins: Antifungal, Antitumor, Antiprolif-
`erative, and Immunosuppressive Macrolides, 6 TRANSPLANTATION
`REVIEWS 39 (1992) (“Morris”)
`
`Gregory D. Van Duyne et al., Atomic Structure of the Rapamycin
`Human Immunophilin FKBP-12 Complex, 113 J. AM. CHEMICAL
`SOC’Y 7433 (1991) (“Van Duyne”)
`
`Samuel H. Yalkowsky, Estimation of Entropies of Fusion of Organic
`Compounds, 18 INDUS. & ENG’G CHEMISTRY FUNDAMENTALS 108
`(1979) (“Yalkowsky”)
`
`Thomas L. Lemke, Chapter 16: Predicting Water Solubility, REVIEW
`OF ORGANIC FUNCTIONAL GROUPS 113 (2d ed. 1988)
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`U.S. Patent No. 5,233,036 (“Hughes”)
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`U.S. Patent No. 4,650,803 (“Stella”)
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`U.S. Patent No. 5,100,883 (“Scheihser”)
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`Stuart L. Schreiber, Chemistry and Biology of the Immunophilins and
`Their Immunosuppressive Ligands, 251 SCI. 283 (1991) (“Schreiber”)
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`1
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`Case IPR2016-00084
`U.S. Patent No. 5,665,772
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`Exhibit
`1013
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`Description
`Joseph B. Moon & W. Jeffrey Howe, Computer Design of Bioactive
`Molecules: A Method for Receptor-Based de Novo Ligand Design, 11
`PROTEINS: STRUCTURE, FUNCTION, & GENETICS 314 (1991)
`(“Moon”)
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`1014
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`1015
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`1016
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`1017
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`1018
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`1019
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`1020
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`1021
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`1022
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`Hans-Joachim Böhm, LUDI: rule-based automatic design of new
`substituents for enzyme inhibitor leads, 6 J. COMPUTER-AIDED MO-
`LECULAR DESIGN 593 (1992) (“Böhm”)
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`Silverman, Chapter 2: Drug Discovery, Design, and Development,
`THE ORGANIC CHEMISTRY OF DRUG DESIGN & ACTION 4 (1992) (“Sil-
`verman”)
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`Julianto Pranata & William L. Jorgensen, Computational Studies on
`FK506: Conformational Search and Molecular Dynamics Simulation
`in Water, 113 J. AM. CHEMICAL SOC’Y 9483 (1991)
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`William L. Jorgensen, Rusting of the Lock and Key Model for Pro-
`tein-Ligand Binding, 254 SCI. 954 (1991)
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`Modesto Orozco et al., Mechanism for the Rotamase Activity of
`FK506 Binding Protein from Molecular Dynamics Simulations, 32
`BIOCHEMISTRY 12864 (1993)
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`Michelle L. Lamb & William L. Jorgensen, Investigations of Neu-
`rotrophic Inhibitors of FK506 Binding Protein via Monte Carlo Simu-
`lations, 41 J. MED. CHEMISTRY 3928 (1998)
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`Michelle L. Lamb et al., Estimation of Binding Affinities of FKBP12
`Inhibitors Using a Linear Response Method, 7 BIOORGANIC & MEDIC-
`INAL CHEMISTRY 851 (1999)
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`Thomas W. Bell, Construction of a Soluble Heptacyclic Terpyridine,
`51 J. ORGANIC CHEMISTRY 764 (1986) (“Bell”)
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`M. Ballauff, Phase Equilibria in Rodlike Systems with Flexible Side
`Chains, 19 MACROMOLECULES 1366 (1986) (“Ballauff”)
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`2
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`Case IPR2016-00084
`U.S. Patent No. 5,665,772
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`Exhibit
`1023
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`Description
`R. Stern et al., Rigid rod polymers with flexible side chains, 32 POL-
`YMER 2096 (1991) (“Stern”)
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`1024
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`1025
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`1026
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`1027
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`1028
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`1029
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`10301
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`1031
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`Michael G. Rossmann et al., Three-Dimensional Coordinates from
`Stereodiagrams of Molecular Structures, B36 ACTA CRYSTALLO-
`GRAPHICA 819 (1980) (“Rossmann”)
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`William L. Jorgensen & Julian Tirado-Rives, The OPLS Potential
`Functions for Proteins. Energy Minimizations for Crystals of Cyclic
`Peptides and Crambin, 110 J. AM. CHEMICAL SOC’Y 1657 (1988)
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`Julian Tirado-Rives & William L. Jorgensen, Molecular Dynamics of
`Proteins with the OPLS Potential Functions. Simulation of the Third
`Domain of Silver Pheasant Ovomucoid in Water, 112 J. AM. CHEMI-
`CAL SOC’Y 2773 (1990)
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`Michael L. Connolly, Solvent-Accessible Surfaces of Proteins and
`Nucleic Acids, 221 SCI. 709 (1983)
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`Yoshihiko Nisibata et al., Automatic Creation of Drug Candidate
`Structures Based on Receptor Structure. Starting Point for Artificial
`Lead Generation., 47 TETRAHEDRON 8985 (1991)
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`Stephen W. Michnick et al., Solution Structure of FKBP, a Rotamase
`Enzyme and Receptor for FK506 and Rapamycin, 252 SCI. 836
`(1991)
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`Declaration of Scott Bennett, Ph.D.
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`Transcript of June 1, 2016 Conference Call
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`Respectfully submitted,
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`By:
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`/Daniel G. Brown/
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`Dated: June 3, 2016
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`1 Ex. 1030 was served, but not filed, on May 27, 2016.
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`Case IPR2016-00084
`U.S. Patent No. 5,665,772
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`Daniel G. Brown (Reg. No. 54,005)
`Latham & Watkins LLP
`885 Third Avenue
`New York, NY 10022-4834
`212-906-1200; 212-751-4864 (Fax)
`
`Counsel for Petitioner
`Par Pharmaceutical, Inc.
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`4
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`Case IPR2016-00084
`U.S. Patent No. 5,665,772
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`CERTIFICATE OF SERVICE
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`Pursuant to 37 C.F.R. § 42.6(e), I certify that on this 3rd day of June, 2016, a
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`true and correct copy of the foregoing PETITIONER’S UPDATED EXHIBIT
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`LIST was served by electronic mail on Patent Owner’s lead and backup counsel at
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`the following email address:
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`Nicholas N. Kallas (Reg. No. 31,530)
`Raymond R. Mandra (Reg. No. 34,382)
`Fitzpatrick, Cella, Harper & Scinto
`1290 Avenue of the Americas
`New York, NY 10104-3800
`ZortressAfinitorIPR@fchs.com
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`By: /Daniel G. Brown/
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`Daniel G. Brown (Reg. No. 54,005)
`Latham & Watkins LLP
`885 Third Avenue
`New York, NY 10022-4834
`212-906-1200; 212-751-4864 (Fax)
`
`Counsel for Petitioner