CURRICULUM VITAE
`
`SAMUEL H. YALKOWSKY
`
`www.pharmacy.arizona.edu/faculty/yalkowsky/
`
`College of Pharmacy
`University of Arizona
`Tucson, AZ 85721
`
`FAX: 520-626-4063
`VOICE: 520-626-1289
`YALKOWSK@ PHARMACY.ARIZONA.EDU
`
`Education
`College
`College of Pharmacy
`Columbia University, New York
`College of Pharmacy
`University of Michigan
`Dissertation Advisor:
`Dissertation Title:
`
`Date
`
`1960-1965
`
`Degree
`
`B.S.
`
`Major
`
`Pharmacy
`
`1965-1969
`George Zografi
`Potentiometric Titration of Some Acylcarnitines
`
`Ph.D.
`
`Pharm. Chem
`
`Academic and Professional Appointments
`
`Date
`1982-Present
`
`1975-1982
`
`Appointment
`Professor of Pharmaceutical
`Sciences
`Senior Research Scientist III
`
`1972-1975
`
`Research Scientist II
`
`1969-1972
`
`Scientist I
`
`Organization
`College of Pharmacy,
`University of Arizona, Tucson, Arizona
`Pharmacy Research Unit,
`The Upjohn Company, Kalamazoo, Michigan
`Pharmacy Research Unit,
`The Upjohn Company, Kalamazoo, Michigan
`Pharmacy Research Unit,
`The Upjohn Company, Kalamazoo, Michigan
`
`Current Research Interests
`1. The relationship between chemical structure and physicochemical properties.
`2. The effect of the above on transport through synthetic and biological membranes.
`3. Solubilization by surfactants, cosolvents, and complexing agnets.
`4. Dosage form design.
`5. Melting phenomena.
`
`AGILA ET AL - EXHIBIT 1003
`
`0001
`
`

`
`Academic Awards and Honors
`Award
`Recognition for Undergraduate Research
`Rho Chi Award
`Dean's List
`Harry Taub Memorial Fellowship
`Ebert Prize* (Publication #6)
`Ebert Prize* (Publication #15)
`Fellow, Academy of Pharmaceutical Sciences
`Geigy Visiting Professorship, Univ of Manchester
`Fellow, American Association \ of Pharmaceutical Scientists
`Proctor and Gamble Award Symposium
`Proctor and Gamble Award Symposium
`Proctor and Gamble Award Symposium
`U of A Graduate Teaching and Mentoring Award
`* Yearly award given to the author(s) of the most outstanding original
`research article in the Journal of Pharmaceutical Sciences.
`
`Date
`1961-1963
`1962
`1964-1965
`1965
`1973
`1975
`1980
`1984
`1986
`1989
`2000
`2001
`2001
`
`Current Research Support
`Granting Agency
`National Cancer Institute
`
`Project Title and Number
`Development of dosage forms and
`delivery systems for antitumor agents
`
`Begin
`06-07
`
`End
`06-12
`
`Total $
`$1,963,561
`
`Cempra Pharma
`
`Formulation studies
`
`01-12
`
`130,000
`
`Previous Research Support
`Granting Agency
`Novartis
`
`Pfizer
`
`Abbott
`
`Proctor and Gambel
`
`Proctor and Gambel
`
`Project Title and Number
`Unspecified
`
`Begin
`01-07
`
`End
`01-08
`
`Total $
`$20,000
`
`Unspecified
`
`01-07
`
`01-08
`
`$10,000
`
`Evaluation of Pyrrolidone Dimer
`
`01-07
`
`01-08
`
`$30,000
`
`Technology Gift of 103 patents for
`cancer, AIDS and Hep C drugs
`
`1-03
`
`--------- 87,000,000
`
`Development of formulation for
`cancer, AIDS and Hep C drugs
`
`01-03
`
`01-05
`
`$1,200,000
`
`TheraQuest Biosciences
`
`Development of Ketoprofen Salts
`
`06-04
`
`06-05
`
`$30,000
`
`Novartis
`
`Novartis
`
`Unspecified
`
`Unspecified
`
`01-05
`
`01-06
`
`$15,000
`
`1-00
`
`12-04
`
`30,000
`
`0002
`
`

`
`Previous Research Support (Continued)
`Granting Agency
`Project Title
`Wyeth-Ayerst Laboratories
`Precipitation of amiodarone
`
`Novartis (Mexico)
`
`Evaluation of cyclosporine
`formulations
`
`Begin
`01-02
`
`End
`12-02
`
`Total $
`$150,000
`
`06-02
`
`12-02
`
`$ 30,000
`
`National Cancer
`Institute
`
`Development of dosage Forms and
`delivery systems for new drugs
`
`7-97
`
`6-02
`
`1,079,000
`
`Direct Therapeutics
`
`Formulation development
`
`Johnson and Johnson
`
`Formulation evaluation
`
`1-01
`
`12-01
`
`1-01
`
`12-01
`
`Wyeth Ayerst
`
`Evaluation of ampoules
`
`11-01
`
`10-02
`
`Zila
`
`Evaluation of oral anaesthetics
`
`9-01
`
`12-01
`
`Research Corporation
`
`Studies on Fluesterone
`
`Pharm Development Group Formulation of Peptide
`
`Otsuka America
`Pharmaceutical Company
`
`Formulation of OPC-41061
`For Clinical Trials
`
`1/1/98
`
`6/1/98
`
`7/1/98 10/1/98
`
`1/1/98
`
`7/1/98
`
`45,000
`
`30,000
`
`45,000
`
`20,000
`
`10,000
`
`30,000
`
`60,300
`
`PhRMA
`
`Measurement of Vapor Pressure
`
`9/1/97
`
`8/31/99
`
`25,500
`
`Pharmaceutical Research
`and Manufacturing Ass’n
`
`Dynamic Determination of
`Hemolysis
`
`9/1/97
`
`8/31/98
`
`5,500
`
`Otsuka America
`Pharmaceutical Company
`
`Developoment of Dosage
`Forms
`
`1/1/97
`
`4/1/98
`
`50,000
`
`Parke Davis
`
`Evaluation of Dosage Forms
`
`1/1/97
`
`3/1/97
`
`Otsuka America
`Pharmaceutical Company
`
`Developoment of Dosage Forms
`
`6/1/96
`
`1/1/97
`
`Knoll Pharmaceuticals
`
`Formulation of Dexverapamil
`
`6/1/93
`
`1/1/96
`
`Knoll Pharmaceuticals
`
`Phlebitic Evaluation of Prototype
`Formulation
`
`1/1/92
`
`12/31/93
`
`12,000
`
`30,000
`
`72,000
`
`36,000
`
`Environmental Protection
`Agency
`
`Estimation of Vapor Pressure
`
`10/1/92 9/31/94
`
`240,642
`
`0003
`
`

`
`Previous Research Support (Continued)
`Begin
`Granting Agency
`Project Title
`Wyeth-Ayerst Laboratories
`Formulation of Rapamycin Injection 1/1/93
`
`End
`12/31/93
`
`AQUASOL dATAbASE
`
`7/1/93
`
`6/30/94
`
`Total $
`48,000
`
`34,347
`
`Commission of the
`European Communities
`
`National Cancer
`Institute
`
`Development of Dosage Forms and 7/1/92
`Delivery Systems for New Drugs
`
`6/30/97
`
`996,898
`
`The NutraSweet Company
`
`Stabilization of Aspartame
`
`6/1/90
`
`5/31/91
`
`55,000
`
`Nelson Research
`
`Formulation of N0861
`
`10/1/89- 11/15/89
`
`15,000
`
`Merrell Dow
`
`Formulation of Terfenadine
`
`9/1/88- 8/31/89
`
`25,000*
`
`Environmental
`Protection Agency
`P.I.: R.C. Bales
`
`Environmental
`Protection Agency
`P.I.: S. Rao
`
`U. S. Environmental
`Protection Agency
`
`Sorption and Partitioning of Hydro- 7/15/87- 7/14/89
`phobic Organic Compounds
`CO-P.I.: S.H. Yalkowsky
`
`200,000
`
`60,000*
`
`Sorption of Organic
`Pollutants on Soil Systems
`CO-P.I.: S.H. Yalkowsky
`Cosolvent Solubility
`Contract 812581-01
`
`8/15/87- 8/14/89
`
`200,000
`
`9/1/85- 2/28/87
`
`69,000*
`153,237
`
`Lederle
`
`Formulation of Bisantrene
`
`6/1/84- 5/30/85
`
`25,000
`
`Department of Defense
`
`Estimation of Melting Point
`
`3/1/84- 2/30/86
`
`160,000
`
`Environmental
`Protection Agency
`
`Solubility Database
`
`3/1/84- 3/30/86
`
`168,000
`
`Travenol Laboratories
`
`Low Temperature Solubility Studies 1/1/84- 12/31/84
`
`10,000
`
`Parenteral Drug Association Formulation of Insoluble Drugs
`
`11/1/83- 10/30/84
`
`10,000
`
`University of Arizona
`P.I.: M. Furst
`
`National Cancer Institute
`
`Otitis Media Prosthetic Device
`Co-P.I.: S.H. Yalkowsky
`Formulation of Insoluble Drugs
`
`11/1/83- 10/30/84
`
`6/30/83- 6/29/86
`
`12,000
`9,000*
`353,000
`
`Environmental Protection
`Agency
`P.I.: R. Pearlman
`
`Predicton of Aqueous Solubilities
`CO-Op CR-810771
`Co-P.I.: S.H. Yalkowsky
`
`6/1/83- 5/31/86
`
`248,000
`
`60,000*
`
`0004
`
`

`
`Symposia, Conferences, Short Courses and Lectureships
`Academy of Pharmaceutical Sciences, Washington (1970
`Academy of Pharmaceutical Sciences, Chicago (1972)
`Academy of Pharmaceutical Sciences, Orlando (1976)
`Guest Faculty Member, Arden House Conference on Preformulation Research (1976)
`Guest Faculty Member, School of Solution Therapy and Thermodynamics, London, England (1977)
`Academy of Pharmaceutical Sciences, Hollywood, Florida (1978)
`Conference on Prodrugs, Land O'Lakes (1978)
`Adjunct Associate Professor, University of Wisconsin (1979)
`Academy of Pharmaceutical Sciences, Kansas City, MO (1979)
`Gordon Conference, Environmental Sciences-Water, NH (1980)"
`Academy of Pharmaceutical Sciences, San Antonio, TX (1981)
`Environmental Protection Agency Workshop, San Antonio, TX (1981)
`Adjunct Associate Professor, SUNY at Buffalo (1982)
`Association of Environmental Engineering Professors' Workshop, Purdue University (1982)
`Academy of Pharmaceutical Sciences, San Diego, CA (1982)
`American Chemical Society, Washington, DC (1983) "Sorption of Organic Materials"
`Gordon Conference, Medicinal Chemistry, NH (1983)
`Geigy Visiting Professor, University of Manchester, Manchester, England (1984)
`Workshop on Physical Properties, University of California, Irvine, CA (1986).
`SETAC Meeting, Washington, DC (1986).
`SETAC, Alexandria, VA (1986) .
`Arden House Workshop, New York (1987).
`Visiting Scientist, Brookhaven National Laboratories, Upton, New York (1987)
`Beilstein Workshop on the Estimation of Physical Data for Organic Compounds, Tyrol, Italy (1988)
`North Eastern Region Pharmaceutical Association (1988)
`Arden House Workshop, New York (1988)
`Land O Lakes, International Industrial Pharmaceutical Research Conference (1988).
`Pharm Tech Conference, New Jersey (1988)
`International Workshop on QSAR in Environmental Toxicology Utrecht, The Netherlands (1990).
`27 Congreso Nacional de Ciencias Farmaceuticas, Los Cabos, Mexico (1994)
`American Association of Pharmaceutical Scientists, Seattle, (1996)
`American Association of Pharmaceutical Scientists, Seattle, (2000)
`Short Course on Solubility and Solubilization, Tucson, (2002)
`Land o Lakes, Madison, (2002)
`Short Course on Solubility and Solubilization, Ann Arbor, (2002)
`QSAR Worksohp, Ottowa, (2002)
`Short Course on Solubility and Solubilization, Tucson, (2003)
`American Association of Pharmaceutical Scientists, Seattle, (2004)
`Short Course on Solubility and Solubilization, Tucson, (2004)
`Short Course on Solubility and Solubilization, Tucson, (2005)
`Short Course on Solubility and Solubilization, Tucson, (2006)
`Short Course on Solubility and Solubilization, Tucson, (2007)
`Short Course on Solubility and Solubilization, Tucson, (2008)
`Short Course on Solubility and Solubilization, Tucson, (2009)
`
`0005
`
`

`
`Publications
`
`1.
`
`2.
`
`3.
`
`4.
`
`5.
`
`6.
`
`7.
`
`8.
`
`9.
`
`Yalkowsky, S.H. and Zografi, G., "Some Micellar Properties of Long Chain Acylcarnitines," J.
`Coll. and Interface Sci., 34, 525-533 (1970).
`
`Yalkowsky, S.H. and Zografi, G., "Potentiometric Titration of Monomeric and Micellar
`Acylcarnitines," J. Pharm. Sci., 59, 798-802 (1970).
`
`Flynn, G.L., Carpenter, O.S., and Yalkowsky, S.H., "Total Mathematical Resolution of Diffusion
`Layer Control of Barrier Flux," J. Pharm. Sci., 61(2), 312-314 (1972).
`
`Zografi, G. and Yalkowsky, S.H., "Comments on the Apparent Shape of Micelles," J. Pharm. Sci.,
`61, 651-652 (1972).
`
`Yalkowsky, S.H. and Zografi, G., "Calculation of Partial Molal Volume in Micellar Systems," J.
`Pharm. Sci., 71, 793-795 (1972).
`
`# Flynn, G.L. and Yalkowsky, S.H., "Correlation and Prediction of Mass Transport Across
`Membrane I: Influence of Alkyl Chain Length on Flux Determining Properties of Barrier and
`Diffusant," J. Pharm. Sci., 61, 838-852 (1972).
`
`"Importance of Chain Length on
`Yalkowsky, S.H., Flynn, G.L., and Slunick, T.G.
`Physicochemical and Crystalline Properties of Organic Homologs," J. Pharm. Sci., 61, 852-857
`(1972).
`
`Yalkowsky, S.H., Flynn, G.L., and Amidon, G.L., "Solubility of Nonelectrolytes in Polar
`Solvents," J. Pharm. Sci., 61, 983-984 (1972).
`
`Yalkowsky, S.H. and Flynn, G.L., "Transport of Alkyl Homologues Across Synthetic and
`Biological Membranes: A New Model for Chain Length-Activity Relationships," J.Pharm. Sci.,
`62, 210-216 (1973).
`
`10. Roseman, T.J. and Yalkowsky, S.H., "Physicochemical Properties of Prostaglandin F2 alpha
`(Tromethamine Salt): Solubility Behavior, Surface Properties, and Ionization Constants,"
`J.
`Pharm. Sci., 62, 1680-1685 (1973).
`
`11. Yalkowsky, S.H., Carpenter, O.S., Flynn, G.L., and Slunick, T.G., "Drug Absorption Kinetics in
`Goldfish," J. Pharm.Sci., 62, 1949-1954 (1973).
`
`12. Flynn, G.L., Yalkowsky, S.H., and Weiner, N.D., "General Influence of Physicochemical
`Properties on Drug-Receptor Combination," J. Pharm. Sci., 63, 300-304 (1974).
`
`0006
`
`

`
`13. Flynn, G.L., Yalkowsky, S.H., and Roseman, T.J., "Mass Transport Phenomena and Models:
`Theoretical Concepts," J. Pharm. Sci., 63, 479-509 (1974).
`
`14. Yalkowsky, S.H., Slunick, T.G., and Flynn, G.L., "Effects of Alkyl Chain Length on Biological
`Activity: Alkyl p-Amino benzoate-Induced Narcosis in Goldfish," J. Pharm. Sci., 63, 691-695
`(1974).
`
`15. # Amidon, G.L., Yalkowsky, S.H., and Leung, S., "Solubility of Non-electrolytes in Polar
`Solvents II: Solubility of Aliphatic Alcohols in Water," J. Pharm. Sci., 63, 1858-1866 (1974).
`
`16. Yalkowsky, S.H. and Flynn, G.L., "Correlation and Prediction of Mass Transport Across
`Membranes II: Influence of Vehicle Polarity on Flux from Solutions and Suspension," J. Pharm.
`Sci., 63, 1276- 1280 (1974).
`
`17. Zografi, G. and Yalkowsky, S.H., "Interfacial Properties of Polar Liquids Against Nonpolar
`Phases," J. Pharm. Sci., 63, 1533-1535 (1974).
`
`18. Roseman, T.J. and Yalkowsky, S.H., "Influence of Solute Properties on the Release of p-
`Aminobenzoic Acid Esthers from Silicone Rubber: Theoretical Considerations," J. Pharm. Sci.,
`63, 1639-1641 (1974).
`
`19. Yalkowsky, S.H., Amidon, G.L., Zografi, G., and Flynn, G.L., "Solubility of Nonelectrolytes in
`Polar Solvents III: Alkyl p-Aminobenzoates in Polar and Mixed Solvents," J. Pharm. Sci., 64, 48-
`52 (1975).
`
`20. Sinkula, A.A. and Yalkowsky, S.H., "Rationale for the Design of Biologically Reversible Drug
`Derivatives - Prodrugs," J. Pharm. Sci., 64, 181-210 (1975).
`
`21. Amidon, G.L., Yalkowsky, S.H., Anik, S.T., and Valvani, S.C., "Solubility of Nonelectrolytes in
`Polar Solvents V: Estimation of the Solubility of Aliphatic Monofunctional Compounds in Water
`Using a Molecular Surface Area Approach," J. Phys. Chem., 79, 2239-2246 (1975).
`
`22. Yalkowsky, S.H. and Valvani, S.C., "Partition Coefficients and Surface Areas of Some
`Alkylbenzenes," J. Med. Chem., 19, 727-728 (1976).
`
`23. Yalkowsky, S.H., Valvani, S.C., and Amidon, G.L., "Solubility of Nonelectrolytes in Polar
`Solvents IV: Nonpolar Drugs in Mixed Solvents," J. Pharm. Sci., 65, 1488-1493 (1976).
`
`24. Valvani, S.C., Yalkowsky, S.H., and Amidon, G.L., "Solubility of Nonelectrolytes in Polar
`Solvents VI: Refinements in Molecular Surface Area Computations," J. Phys. Chem., 80, 829-835
`(1976).
`
`25. ** Roseman, T.J. and Yalkowsky, S.H., "Importance of Solute Partitioning on the Kinetics of
`Drug Release From Matrix Systems," ACS Symposium Series No. 33, 33-52 (1976).
`
`0007
`
`

`
`26. Flanagan, D.R. and Yalkowsky, S.H., "Convective Diffusional Analysis of Drug Transport
`Through Tubular Polymeric Membranes," J. Pharm. Sci., 66, 337-340 (1977).
`
`27. ** Yalkowsky, S.H., "Solubility and Melting Point Considerations in Drug Design," in Design of
`Biopharmaceutical Properties
`through Prodrugs and Analogs, Ed: E.R. Roche, APhA,
`Washington, p.392-408 (1977).
`
`28. Yalkowsky, S.H. and Valvani, S.C., "Precipitation of Solubilized Drugs Due to Injection or
`Dilution," Drug Intelligence, 11, 417-419 (1977).
`
`29. Millie, M., Yalkowsky, S.H., and Zografi, G., "Limitations in the Use of Acylcarnitine Titration
`Data," J. Coll. and Interface Sci., 62, 361-365 (1977).
`
`30. Yalkowsky, S.H. and Roseman, T.J., "Stability of E-Type Prostaglandins," J. Pharm. Sci., 68, 114-
`115 (1979).
`
`31. Yalkowsky, S.H., "Estimation of Entropies of Fusion of Organic Compounds," I & EC
`Fundamentals, 18, 108-111 (1979).
`
`32. Yalkowsky, S.H. and Valvani, S.C., "Solubility and Partitioning II: Relationship Between
`Aqueous Solubilities, Partition Coefficients and Molecular Surface Areas of Rigid Aromatic
`Hydrocarbons," J Chem. Eng. Data, 24, 127-129 (1979).
`
`33. Martin, E., Yalkowsky, S.H., and Wells, J.E., "Fusion of Disubstituted Benzenes," J. Pharm. Sci.,
`68, 565-568 (1979).
`
`34. Yalkowsky, S.H., Orr, R.J., and Valvani, S.C., "Solubility and Partitioning III: The Solubility of
`Halobenzenes in Water," I & EC Fundamentals, 18, 351-353 (1979).
`
`35. ** Yalkowsky, S.H. and Morozowich, W., "A Physical Chemical Basis for the Design of Orally
`Active Prodrugs," Drug Design, 9, ed: E.J. Ariens, Academic, New York, pp.121-185 (1980)
`
`36. Yalkowsky, S.H. and Valvani, S.C., "Solubility and Partitioning I: Solubility of Nonelectrolytes in
`Water," J. Pharm. Sci., 69, 912-922 (1980).
`
`37. **Valvani, S.C. and Yalkowsky, S.H., "Solubility and Partitioning in Drug Design," in Physical
`Chemical, Properties of Drugs, Edited by: S.H. Yalkowsky, A.A. Sinkula, and S.C. Valvani,
`Marcel Dekker, New York, pp.201-229 (1980).
`
`38. Banerjee, S., Yalkowsky, S.H., and Valvani, S.C., "Water Solubility and Octanol/Water Partition
`Coefficients of Organics: Limitations of the Solubility-Partition Coefficient Correlation," Environ.
`Sci. Technol., 14, 1227-1229 (1980).
`
`39. MacKay, D., Bobra, A.M.; Shiu, W.Y., and Yalkowsky, S.H., "Relationships Between Aqueous
`Solubility and Octanol-Water Partition Coefficients," Chemosphere, 9, 701-711 (1980).
`
`0008
`
`

`
`40. MacKay, D., Mascarenhas, R., Shui, W.Y., Valvani, S.C., and Yalkowsky, S.H., "Aqueous
`Solubility of Polychlorinate Biphenyls," Chemosphere, 9, 257-264 (1980).
`
`41. Valvani, S.C., Yalkowsky, S.H., and Roseman, T.J., "Solubility and Partitioning IV: Aqueous
`Solubility and Octanol-Water Partition Coefficients of Liquid Nonelectrolytes," J. Pharm. Sci., 70,
`502-507 (1981).
`
`42. ** Yalkowsky, S.H., "Solubility and Solubilization of Nonelectrolytes," in Techniques of
`Solubilization of Drugs, Edited by: S.H. Yalkowsky, Marcel Dekker, New York, p.1-13 (1981).
`
`43. Yalkowsky, S.H., "Solubility and Partitioning V: Dependence of Solubility on Melting Point," J.
`Pharm. Sci., 70, 971-973 (1981).
`
`44. ** Yalkowsky, S.H., "Solubilization of Drugs by Cosolvents," Techniques of Solubilization of
`Drugs, Edited by: S.H. Yalkowsky, Marcel Dekker, New York, pp.91-134 (1981).
`
`45. Yalkowsky, S.H. and Valvani, S.C., “Correlation of Water Solubility with Octanol-Water
`Partition Coefficient: A Response," J. Pharm. Sci., 70, 1177-1178 (1981).
`
`46. Yalkowsky, S.H., Valvani, S.C., and MacKay, D., "Estimation of the Aqueous Solubility of Some
`Aromatic Compounds," Residue Reviews, 85, 43-55 (1983).
`
`47. Yalkowsky, S.H., Valvani, S.C., and Johnson, B.W., "In Vitro Method for Detecting Precipitation
`of Parenteral Formulations After Injection," J. Pharm. Sci., 72, 1014-1017 (1983).
`
`48. Yalkowsky, S.H., Valvani, S.C., and Roseman, T.J., "Solubility and Partitioning VI: Octanol
`Solubility and Octanol-Water Partition Coefficient," J. Pharm. Sci., 72, 866-870 (1983).
`
`49. Patton, J.S., Stone, B., Papa, C., Abramowitz, R., and Yalkowsky, S.H., "Solubility of Fatty Acids
`and Other Hydrophobic Molecules in Liquid Trioleylglycerol," J. Lipid Res., 25, 189 (1984).
`
`50. Pearlman, R.S., Yalkowsky, S.H., and Banerjee, S., "Water Solubilities of Polynuclear Aromatic
`and Heteroaromatic Compounds," J. Phys. Chem. Ref. Data, 13, 555 (1984).
`
`51. Rubino, J.T., Blanchard, J., and Yalkowsky, S.H., "Solubilization by Cosolvents II: Phenytoin in
`Binary and Ternary Solvents," J. Paren. Sci. & Tech., 38, 215 (1984).
`
`52. Yalkowsky, S.H. and Rubino, J.T., "Solubilization by Cosolvents I: Organic Solutes in Propylene
`Glycol-Water Mixtures," J. Pharm. Sci., 74, 416-421 (1985).
`
`53. Rubino, J.T. and Yalkowsky, S.H., "Solubilization by Cosolvents III: Diazepam and Benzocaine
`in Binary Solvents," J. Paren. Sci. & Tech., 39, 106 (1985).
`
`0009
`
`

`
`54. Kuu, W-Y. and Yalkowsky, S.H., "Multiple Hole Approach to Zero-Order Release," J. Pharm.
`Sci., 74, 926 (1985).
`
`55. Reed, K. and Yalkowsky, S.H., "Lysis of Human Red Blood Cells in the Presence of Various
`Cosolvents," J. Paren. Sci. & Tech., 39, 64 (1985).
`
`56. Bates, R.B., Roberts, S.A., Siahaan, T.J., Gnanasambandan, T., and Yalkowsky, S.H., "9,10-
`Anthracenedicarbaldehyde
`Bis[(4,5)-dihydro-1H-imidazol-2-yl)hydrazone]
`Acetic
`Acid
`Hydrochloric Acid (Bisantrene), Acta Cryst., C42, 186-188 (1986).
`
`57. Pywell, E.J., Yalkowsky, S.H., and Collett, J.H., "The Effect of a Rate Controlling Membrane on
`Release from Polyhema Hydrogels," Drug Dev. Ind. Pharm., 12, (11-13), 1767-1775 (1986).
`
`58. Reed, K.W. and Yalkowsky, S.H., "Lysis of Human Red Blood Cells in the Presence of Various
`Cosolvents II. The Effect of Differing NaCl Concentrations, " J. Paren. Sci. and Tech., 40, 88
`(1986).
`
`59. Tarr, B.D. and Yalkowsky, S.H., "A New Parenteral Vehicle for the Adminstration of Some
`Poorly Water Soluble Anticancer Drugs," J. Paren. Sci. and Tech., 41 (1), 31-33 (1987).
`
`60. Patel, S. and Yalkowsky, S.H., "Development of an Intravenous Formulation for the Antiviral
`Drug 9-(beta-D-Arabino-Furanosyl)- Adenine," J. Paren. Sci. and Tech., 41 (1), 15-20 (1987).
`
`61. Pinal, R. and Yalkowsky, S.H., "Solubility and Partitioning VII: Solubility of Barbiturates in
`Water," J. Pharm. Sci., 76 (1), 75-85 (1987).
`
`62. Rubino, J.T. and Yalkowsky, S.H., "Cosolvency and Deviations from Log-Linear Solubilization,"
`Pharm. Res., 4, 231 (1987).
`
`63. Rubino, J.T. and Yalkowsky, S.H., "Cosolvency and Cosolvent Polarity," Pharm. Res., 4, 220
`(1987).
`
`64. Chawla, M., Pinal, R., Morris, K.R., and Yalkowsky, S.H. "Cosolvency I. Some Non-hydrogen
`Bonding Solutes with Non-hydrogen Bonding Solvents," J. Tox. and Environ. Chem., 15, 237-247
`(1987).
`
`65. Reed, K.W. and Yalkowsky, S.H., "Lysis of Human Red Blood Cells in the Presence of Various
`Cosolvents III. The Relationship between Hemolytic Potential and Structure," J. Parent. Sci. and
`Tech., 41 (1), 37-39 (1987).
`
`66. Tarr, B.D., Sambandan, T.G., and Yalkowsky, S.H., "A New Parenteral Emulsion for the
`Administration of Taxol, "Pharm. Res., 4 (2), 162-165 (1987).
`
`0010
`
`

`
`67. Rubino, J.T., Blanchard, J., and Yalkowsky, S.H., "Solubilization by Cosolvents IV: Benzocaine,
`Diazepam and Phenytoin in Aprotic Cosolvent-Water Mixtures," J. Paren. Sci. and Tech., 41 (5),
`172-176 (1987).
`
`68. Yalkowsky, S.H., Pinal, R., and Banerjee, S., "Water Solubility: A Critique of the Solvatochromic
`Approach," J. Pharm. Sci., 77 (1), 74-77 (1988).
`
`69. Tsakanikas, P.D. and Yalkowsky, S.H., "Estimation of Melting Point of Flexible Molecules:
`Aliphatic Hydrocarbons," Tox. Env. Chem., 17, 19 (1988).
`
`70. ** Yalkowsky, S.H., "Estimation of the Aqueous Solubility of Organic Compounds," Physical
`Property Prediction in Organic Chemistry, Springer-Verlag, 469 (1988).
`
`71. ** Dannenfelser, R-M. and Yalkowsky, S.H., "The Arizona Database: An Aqueous Solubility
`Database for Nonelectrolytes," Physical Property Prediction in Organic Chemistry, Springer-
`Verlag, 499 (1988).
`
`"Cosolvent-Induced Solubilization of Hydrophobic
`72. Banerjee, S. and Yalkowsky, S.H.,
`Compounds into Water," Anal. Chem., 60, 2153 (1988).
`
`73. Dannenfelser, R-M. and Yalkowsky, S.H., "An Aqueous Solubility Database for Nonelectrolytes,"
`Proceedings of the Pharm Tech Conference '88, Aster Publishing Corp., 107 (1988).
`
`74. Mishra, D.S., Patel, S.D., Marsh, D. and Yalkowsky, S.H., "Low Temperature Solubility of
`Antibiotics: Oxacillin Sodium," J. Parent. Sci. and Tech., 42, 177-180 (1988).
`
`75. Morris, K.R., Abramowitz, R., Pinal, R., Davis, P. and Yalkowsky, S.H., "Solubility of Aromatic
`Pollutants in Mixed Solvents," Chemosphere, 17, 285-298 (1988).
`
`76. Pinal, R. And Yalkowsky, S.H., "Solubility and Partitioning IX: Solubility of Hydantoins in
`Water," J. Pharm. Sci., 77 (6), 518-522 (1988).
`
`77. Tarr, B.D. and Yalkowsky, S.H., "Enhanced Intestinal Absorption of Cyclosporine in Rats
`Through the Reduction of Emulsion Droplet Size," Pharm. Res., 6, 40-43 (1989).
`
`78. Patel, S.D., Gupta, B., and Yalkowsky, S.H., "Acceleration of Heat Transfer in Vial Freeze-
`Drying of Pharmaceuticals I: Corrugated Aluminum Quilt," J. Parent. Sci. and Tech., 43, 8 (1989).
`
`79. Neau, S.H., Flynn, G.L., and Yalkowsky, S.H., "The Influence of Heat Capacity Assumptions on
`the Estimation of Solubility Parameters from Solubility Data," Int. J. Pharm., 49, 223- 229 (1989).
`
`80. Dannenfelser, R-M. and Yalkowsky, S.H., "Database for Aqueous Solubility of Nonelectrolytes,"
`Comput. Appl. Biosci., 5, 235-236 (1989).
`
`0011
`
`

`
`81. Rao, P.S.C., Lee, L.S., Nkedi-Kizza, P., and Yalkowsky, S.H., "Sorption and Transport of Organic
`Pollutants at Waste Disposal Sites," Ecol. Stud., 73, 176-192 (1989).
`
`82. Pinal, R., Rao, P.S.C., Lee, L.S., Cline, P.V., and Yalkowsky, S.H., "Cosolvency of Partially-
`Miscible Organic Solvents on the Solubility of Hydrophobic Organic Chemicals," Environ. Sci.
`and Tech., 24 (5), 639-647 (1990).
`
`83. Yalkowsky, S.H. and Bolton, S., "Particle Size and Content Uniformity," Pharm. Res., 7, 962-966
`(1990).
`
`84. Abramowitz, R. and Yalkowsky, S.H., "Melting Point, Boiling Point and Symmetry," Pharm.
`Res., 7, 942-947 (1990).
`
`85. Mishra, D.S. and Yalkowsky, S.H., "A Flat Circular Hole Device for Zero-Order Release of
`Drugs: Characterization of the Moving Dissolution Boundary," Pharm. Res., 7, 1195-1197 (1990).
`
`86. Abramowitz, R. and Yalkowsky, S.H., "Estimation of Aqueous Solubility and Melting Point of
`PCB Congeners," Chemosphere, 21, 1221-1229 (1990).
`
`87. Yalkowsky, S.H., Mishra, D.S., and Morris, K., "Dependence of Vapor Pressure of Solids and
`Liquids on Various Thermodynamic Parameters," Chemosphere, 21, 107-110 (1990).
`
`88. Mishra, D.S. and Yalkowsky, S.H., "Estimation of Entropy of Vaporization: Effect of Chain
`Length," Chemosphere, 21, 111-117 (1990).
`
`89. Mishra, D.S. and Yalkowsky, S.H., "Solubility of Organic Compounds in Non-Aqueous Systems:
`Polycyclic Aromatic Hydrocarbons in Benzene," Ind. & Eng. Chem. Res., 29, 2278-2283 (1990).
`
`90. Yalkowsky, S.H. and Mishra, D.S., "Comment on 'Prediction of Aqueous Solubility of Organic
`Chemicals Based on Molecular Structure. 2. Applications to PNAs, PCBs, PCDDs, etc.,'"
`Environ. Sci. & Tech., 24, 927-929 (1990).
`
`91. Ward, G.H., Nolan, P.E., Chawla, M., and Yalkowsky, S.H., "Studies in Phlebitis: Detection and
`Quantitation Using a Thermographic Camera," Pharm. Res., 8, 76-79 (1991).
`
`92. Hardaway, L.A. and Yalkowsky, S.H., "Cosolvent Effects on Diuron Solubility," J. Pharm. Sci.,
`80 (1991).
`
`93. Mishra, D.S. and Yalkowsky, S.H., "Estimation of Vapor Pressure of Some Organic Compounds,"
`Ind. Eng. Chem. Res., 30, 1609-1612 (1991).
`
`94. Yalkowsky, S.H. and Mishra, D.S., "Vapor Pressure Estimation for Organic Compounds," Sci.
`Total Environ., 109 (110), 243-250 (1991).
`
`0012
`
`

`
`95. Ward, G.H., Nolan, P.E., White, M., and Yalkowsky, S.H., "Studies in Phlebitis. II. Early
`Detection of Amiodarone-Induced Phlebitis in a Rabbit Model," Pharm. Res., 8, 801-803 (1991).
`
`96. White, M. and Yalkowsky, S.H., "Studies in Phlebitis. III. Evaluation of Diazepam and
`Phenytoin," Pharm. Res., 8, 1340-1341 (1991).
`
`97. Dannenfelser, R-M., Paric, M., White, M., and Yalkowsky, S.H., "A Compilation of Some
`Physico-Chemical Properties for Chlorobenzenes," Chemosphere, 23, 141-165 (1991).
`
`98. Gupta, B., Mishra, D.S., Cheng, C-H., and Yalkowsky, S.H., "Solubility of Anthracene in
`Complex Solvent Systems," Tox. Environ. Chem., 33, 7-21 (1991).
`
`99. ** Dannenfelser, R-M. and Yalkowsky, S.H., "Data Base of Aqueous Solubility for Organic Non-
`electrolytes," QSAR in Environmental Toxicology - IV, Elsevier, 625-628 (1991).
`
`100. Mishra, D.S. and Yalkowsky, S.H., "Ideal Solubility of a Solid Solute: Effect of Heat Capacity
`Assumptions," Pharm. Res., 9 (7), 958-959 (1992).
`
`101. Yalkowsky, S.H. and Patel, S., "Acceleration of Heat Transfer in Vial Freeze-Drying of
`Pharmaceuticals II: Fluid Cushion Device," Pharm. Res., 9, 753-758 (1992).
`
`102. Myrdal, P., Ward, G.H., Dannenfelser, R-M., Mishra, D.S., and Yalkowsky, S.H., "AQUAFAC 1:
`Aqueous Functional Group Activity Coefficients: Application to Hydrocarbons," Chemosphere,
`24, 1047-1061 (1992).
`
`103. Ward, G.H. and Yalkowsky, S.H., "The Role of the Effective Concentration in Interpreting
`Hemolysis Data," J. of Parenter. Sci. & Technol., 46, 161-162 (1992).
`
`104. Ward, G.H. and Yalkowsky, S.H., "Studies in Phlebitis IV: Injection Rate and Amiodarone-
`Induced Phlebitis," J. Parenter. Sci. & Technol., 47, 40-43 (1993).
`
`105. Ward, G.H. and Yalkowsky, S.H., "Studies in Phlebitis V: Hemolysis as a Model for Phlebitis," J.
`Parenter. Sci. & Technol., 47, 44-46 (1993).
`
`106. Nadkarni, S.R. and Yalkowsky, S.H., "Controlled Delivery of Pilocarpine. 1.
`Characterization of Gelfoam Matrices," Pharm. Res., 10, 109-112 (1993).
`
`In Vitro
`
`107. Yalkowsky, S.H., "A Two Dimensional Model for Water," J. Chem. Ed., 70, 614 (1993).
`
`108. Ward, G.H. and Yalkowsky, S.H., "Studies in Phlebitis VI: Dilution-Induced Precipitation of
`Amiodarone HCl," J. Parenter. Sci. & Technol., 47, 161-165 (1993).
`
`109. Simamora, P., Miller, A.H., and Yalkowsky, S.H., "Melting Point and Normal Boiling Point
`Correlations: Applications to Rigid Aromatic Compounds," J. Chem. Inf. Comput. Sci., 33, 437-
`440 (1993).
`
`0013
`
`

`
`110. Simamora, P. and Yalkowsky, S.H., "Quantitative Structure Property Relationship in the
`Prediction of Melting Point and Boiling Point of Rigid Non-Hydrogen Bonding Organic
`Molecules," SAR QSAR Environ. Res., 1, 293-300 (1993).
`
`111. Myrdal, P., Ward, G.H., Simamora, P., and Yalkowsky, S.H., "AQUAFAC: Aqueous Functional
`Group Activity Coefficients," SAR QSAR Environ. Res., 1, 55-61 (1993).
`
`112. Yalkowsky, S.H. and Pinal, R., "Estimation of the Aqueous Solubility of Complex Organic
`Compounds," Chemosphere, 26, 1239 (1993).
`
`113. Yalkowsky, S.H., Davis, E., and Clark, T., "Stabilization of Aspartame by Polyethylene Glycol
`400," J. Pharm. Sci., 82, 978 (1993).
`
`114. Dannenfelser, R-M., Surendran, N., and Yalkowsky, S.H., "Molecular Symmetry and Related
`Properties," SAR QSAR Environ. Res., 1, 273-292 (1993).
`
`115. Surakitbanharn, Y., Simamora, P., Ward, G.H., and Yalkowsky, S.H., "Precipitation of pH
`Solubilized Phenytoin," Int. J. Pharm., 109, 27-33 (1994).
`
`116. Yalkowsky, S.H., Krzyzaniak, J.F., and Myrdal, P.B., "Relationships Between Melting Point and
`Boiling Point of Organic Compounds," Ind. Eng Chem. Res, 33, 1872-1877 (1994).
`
`117. Yalkowsky, S.H., Dannenfelser, R-M., Myrdal, P.B., Simamora, P., and Mishra, D.S., "Unified
`Physical Property Estimation Relationships (UPPER)," Chemosphere, 28, 1657-1673 (1994).
`
`118. Yalkowsky, S.H., Myrdal, P.B., Dannenfelser, R-M., and Simamora, P., "UPPER II: Calculation
`of Physical Properties of the Chlorobenzenes," Chemosphere, 28, 1675-1688 (1994).
`
`119. Simamora, P. and Yalkowsky, S.H., "Group Contribution Methods for Predicting the Melting
`Points and Boiling Points of Aromatic Compounds," Ind. & Eng. Chem. Res., 33, 1405-1409
`(1994).
`
`120. Li, A. and Yalkowsky, S.H., "Solubility of Organic Solutes in Ethanol/Water Mixtures," J. Pharm.
`Sci., 83, 1735-1740 (1994).
`
`121. Myrdal, P. and Yalkowsky, S.H., "A Simple Scheme for Calculating Aqueous Solubility, Vapor
`Pressure and Henry's Law Constant: Application to the Chlorobenzenes," SAR QSAR Environ.
`Res., 2, 17-28 (1994).
`
`122. Myrdal, P.B., Manka, A., and Yalkowsky, S.H. “AQUAFAC 3: Aqueous Functional Group
`Activity Coefficients: Applications to the Estimation of Aqueous Solubility,” Chemosphere , 30,
`1619-1637 (1995).
`
`0014
`
`

`
`123. Simamora, P., Pinsuwan, S., Alvarez, J., Myrdal, P., and Yalkowsky, S.H., "Effect of pH on
`Injection Phlebitis," J. Pharm. Sci. , 84, 520-522 (1995).
`
`124. Li, A., Pinsuwan, S., and Yalkowsky, S.H., "Estimation of Solubility of Organic Compounds in 1-
`Octanol," Ind. & Eng. Chem. Res., 34, 915-920 (1995).
`
`125. Myrdal, P.B., Simamora, P., Surakitbanharn, Y., and Yalkowsky, S.H., “Studies in Phlebitis VII:
`In vitro and in vivo Evaluation of pH Solubilized Levomopamil,” J. Pharm. Sci., 84, 849-852
`(1995).
`
`126. Walters, A.E., Myrdal, P.B., and Yalkowsky, S.H., “A Method for Estimating the Boiling Points
`of Organic Compounds from their Melting Points,” Chemosphere, 31, 3001-3008 (1995).
`
`127. Surakitbanharn, Y., McCandless, R., Krzyzaniak, J.F., Dannenfelser, R-M., and Yalkowsky, S.H.,
`“Self-Association of Dexverapamil in Aqueous Solution,” J. Pharm. Sci., 84, 720-723 (1995).
`
`128. Krzyzaniak, J.F., Myrdal, P.B., Simamora, P., and Yalkowsky, S.H., “Boiling Point and Melting
`Point Prediction of Aliphatic, Non-Hydrogen Bonding Molecules,” Ind. & Eng. Chem. Res., 34,
`2530-2535 (1995).
`
`129. Pinsuwan, S., Li, A., and Yalkowsky, S.H., “Correlation of Octanol/Water Solubility Ratio and
`Partition Coefficient,” J. Chem. Eng. Data, 40, 623-626 (1995).
`
`130. Chow, H., Chen, H., Ng., T., Myrdal, P., and Yalkowsky, S.H., “Using Backpropagation
`Networks for the Estimation of Aqueous Activity Coefficients of Aromatic Organic Compounds,”
`J. Chem. Inf. Comput. Sci., 35, 723-728 (1995).
`
`131. Dannenfelser, R-M. and Yalkowsky, S.H., “Estimation of Entropy of Melting from Molecular
`Structure: A Non-Group Contribution Method,” Ind. & Eng. Chem. Res., 35, 1483-1486 (1996).
`
`132. Dannenfelser, R-M., Surakitbanharn, Y., Tabibi, S.E., and Yalkowsky, S.H., “Parenteral
`Formulation of Flavopiridol (NSC-649890),” PDA J. Pharm. Sci., Technol., 50, 356-359 (1996).
`
`133. Walters, P. and Yalkowsky, S.H., “ESCHER-A Computer Program for the Determination of
`External Rotational Symmetry Numbers from Molecular Topology,” J. Chem. Info. Computer
`Sci., 36, 1015-1017 (1996).
`
`134. Li, A., Andren, A., and Yalkowsky, S.H., “Choosing a Cosolvent: Solubilization of Naphthalene,
`"Env. Tox. Chem., 15, 2233-2239(1996).
`
`135. Simamora, P., Pinsuwan, S.; Surakitbanharn, Y., and Yalkowsky, S.H., “Studies in Phlebitis. VIII:
`Evaluation of pH solubilized intravenous dexverapamil formulations,” PDA J. Pharm. Sci
`Technol., 50, 123-128 (1996).
`
`0015
`
`

`
`136. Krzyzaniak, J.F., Raymond, E.M., and Yalkowsky, S.H., “Lysis of Human Red Blood Cells 1.
`Effect of Contact Time on Water Induced Hemolysis,” PDA J. Pharm. Sci. Technol., 50, 223-226
`(1996).
`
`137. Lee, Y.C., Myrdal, P.B., and Yalkowsky, S.H., "Aqueous Functional Group Activity Coefficients
`(AQUAFAC) 4: A