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`Lice-nsecl patent:
`The ddRN.Ai md'Inuiogypa'ten13 exclusivelyliterised fi'uu11 (SIRE! offer broad proteclcicln for the rneltho-d of
`gern-elafirlg hairpin RNA rn-cllecules from DNA nuns:.rL|n5 tnsilennegaws of inIe1'EL
`
`Commonly referrecltn-as 1he'Graharn' and '\I'u'aterl1a:.Ise" patent 1'an1i|ie5. ‘fl1e:e patems have been granted in
`a range ufjurisdictions irrciusding the US, Eurupe,Japan, Australia, China and Korea.
`\I'i"IIh fiiing dates in I998
`and 1999. respectiveI3r.tl1e Grraharn and ‘uI'u'aierhuuse pacenls den1-clnstlamih-e early eslahlishinent CIFRNAI
`ted1na|og.I in a rangeufapplicariuns including human thelapeulilfi. pfuaridingflersinefis pmgrams in
`de-we-loprnem a onmpefirive edge B-eniteu: oundnuatupurslie ap1:um.rn:i1:ie5 for idenu'f)rI'ng imprcrvemenlstcl
`line dd|iNJ-'~i platfcxrn techrK:l4og,- relafingto human 1i1erapeufi1'_=c CEREI is a Benitec shareholder.
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`Patenc Summary
`
`Ben rrec Patent:
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`Licensed Panerns
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`3-,.ade_,.,3..|E
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`In adfiiicrn In I3|R0‘spatenls. Benitec has also licensed the European patem e5I3teofGa|apagos NV relalirlg
`to Rhlnflli techrmlagr. This patent. with filingdate in 2|X}2. provides additional pru-tecliorl for RNN ten:|'InuPog|{in
`Europe, widn subiicensing righlrlto Benitec inthae field ofhurnan IhE13pEI.llil3.
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`iiata-at-'I'II:le
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`Patent lain.
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`Stalin
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`US6,573,099
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`GeneticEDHEULDEIE
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`target gene{GraharrI
`patent family]
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`CSIRO
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`{field}
`granted Bjune 2003:
`{Ex1:|usiIne.
`irrevu-cable license Reexamination Cerfificate
`_
`for human
`[‘|..|S90.'ElO9lJ'9E] Issued 8 MarI:I1
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`GrahampaIerrrl'a.rni!}I member: View
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`Granted
`WOI999[|:£E129 CSIRO
`Control clfgene
`U5 EBDETBBE. E1 E377-"4. 775192597-".
`exa:-rasi-on {Graham [15 March
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`family patent]
`1599].
`ifTE\l'tH3biE license 30418670, ED531119, 84315217,
`for human
`9029527"). A.usI.r.alia. Canada.
`‘rl1erapeLI1:i3)
`Eumpe{underopposi1:ion]. UK.
`Hang Kong, lndiajapan. Korea»
`Mexico, Newzealand, Singqn-ore,
`S<:||.rth Africa
`Pending
`US. Brazil. Eumpeiapan. Mexico
`
`Granted
`Methuds and means W0l599|l1l53lJ5O CSIRO
`US. Austraiia. China. Europe.
`forohlaining
`{7 April 1959]
`Exclusive.
`modified
`irrevocable license Hewiealanscl
`phenotypes
`for human
`Pending
`[Waterhouse patent
`fl1erapeLm'G]
`U5.-Canada. Europe. Japan
`family]-
`
`SJRNA Icnuciou-Ln:
`assay method and
`EDl'|StI'|.lCI5
`
`EP ‘I44-4346
`(29 August
`2002}
`
`Granted
`Europe
`
`Ga|apagcrs'N\a"
`{Non4axI:lusiIre
`litEl'kSE for human
`therapeutits and
`cliagnostilsj
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`Meflwudsfur
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`agen-I3
`[Lungcarsuer]
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`WOZDDBIOEBU NewSnu'l:l1
`[5 llnl-arch 21108]
`lnncrvations
`{Exclusiine license
`for human
`Iherapeufit: and
`diagraostirsi
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`Granted
`Austraiia. China. Hang Kong,
`Singapore
`Pending
`Canada. China. Europe. Hang
`Kong. lslael, India.japaan, US
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`e»nm>enmecm CSHL EXHIBIT 2003 5 I,
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`BENITEC V. CSHL
`|PR2016-00016
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`In
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`@2015 All |_liglIlsRa5lerved.B-enitec Biopharmaunmau
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