STEADYMED vs UNITED THERAPEUTICS CORPORATIONSTEADYMED vs UNITED THERAPEUTICS CORPORATION
`
`WILLIAMS, ROBERT on 08/26/2016WILLIAMS, ROBERT on 08/26/2016
`
`Page 1
`
`·1· · · · ·UNITED STATES PATENT AND TRADEMARK OFFICE
`
`·2· · · · ·BEFORE THE PATENT TRIAL AND APPEAL BOARD
`
`·3
`
`·4· · STEADYMED LTD.,
`
`·5· · · · · · ·Petitioner,
`
`·6· · · · ·vs.
`
`·7· · UNITED THERAPEUTICS
`· · · CORPORATION,
`·8
`· · · · · · · ·Patent Owner.
`·9· ·-------------------------------------------
`· · ·Case IPR2016-000006 (Patent 8,497,393)
`10· ·-------------------------------------------
`
`11
`
`12
`
`13
`
`14· · VIDEOTAPED DEPOSITION OF ROBERT M. WILLIAMS, PH.D.
`
`15
`
`16· · · · · · · · · Friday, August 26, 2016
`
`17· · · · · · · · · · · · ·9:30 a.m.
`
`18
`
`19· · · · · · · · · ·12235 El Camino Real
`
`20· · · · · · · · · ·San Diego, California
`
`21
`
`22
`
`23· ·Reported by:
`
`24· ·Harry Alan Palter
`
`
`25· ·CSR No. 7708, Certified LiveNote Reporter
` P.1
`
`UT Ex. 2059
`SteadyMed v. United Therapeutics
`IPR2016-00006
`
`
`Elisa Dreier Reporting Corp., U.S. Legal Support Company (212)557-5558Elisa Dreier Reporting Corp., U.S. Legal Support Company (212)557-5558
`
`950 Third Avenue, New York, NY· 10022950 Third Avenue, New York, NY· 10022
`
`

`
`
`STEADYMED vs UNITED THERAPEUTICS CORPORATIONSTEADYMED vs UNITED THERAPEUTICS CORPORATION
`
`WILLIAMS, ROBERT on 08/26/2016WILLIAMS, ROBERT on 08/26/2016
`
`Page 2
`
`·1· ·APPEARANCES:
`
`·2
`
`·3· ·For Petitioner:
`
`·4
`· · · · · · · ·DLA PIPER LLP (US)
`·5· · · · · · ·BY:· STUART E. POLLACK, ESQ.
`· · · · · · · ·1251 Avenue of the Americas
`·6· · · · · · ·New York, New York 10020-1104
`
`·7
`
`·8· ·-and-
`
`·9
`· · · · · · · ·DLA PIPER LLP (US)
`10· · · · · · ·BY:· MAYA PRAKASH CHOKSI, ESQ.
`· · · · · · · ·33 Arch Street, 26th Floor
`11· · · · · · ·Boston, Massachusetts 02110-1447
`
`12
`
`13
`· · ·For Patent Owner:
`14
`
`15· · · · · · ·WILSON SONSINI GOODRICH & ROSATI
`· · · · · · · ·BY:· KATHERINE D. HASPER, ESQ.
`16· · · · · · ·650 Page Mill Road
`· · · · · · · ·Palo Alto, California 94304-1050
`17
`
`18
`· · ·-and-
`19
`· · · · · · · ·FOLEY & LARDNER LLP
`20· · · · · · ·BY:· STEPHEN B. MAEBIUS, ESQ.
`· · · · · · · ·Washington Harbour
`21· · · · · · ·3000 K Street, N.W., Suite 600
`· · · · · · · ·Washington, D.C. 20007-5109
`22
`
`23
`
`24
`
`25
`
`
` P.2
`
`UT Ex. 2059
`SteadyMed v. United Therapeutics
`IPR2016-00006
`
`
`Elisa Dreier Reporting Corp., U.S. Legal Support Company (212)557-5558Elisa Dreier Reporting Corp., U.S. Legal Support Company (212)557-5558
`
`950 Third Avenue, New York, NY· 10022950 Third Avenue, New York, NY· 10022
`
`YVer1f
`
`

`
`
`STEADYMED vs UNITED THERAPEUTICS CORPORATIONSTEADYMED vs UNITED THERAPEUTICS CORPORATION
`
`WILLIAMS, ROBERT on 08/26/2016WILLIAMS, ROBERT on 08/26/2016
`
`Page 3
`
`·1· ·APPEARANCES:
`
`·2
`
`·3· ·For Patent Owner:
`
`·4
`
`·5· · · · · · ·UNITED THERAPEUTICS CORPORATION
`· · · · · · · ·BY:· SHAUN SNADER, ESQ.
`·6· · · · · · ·1735 Connecticut Avenue, N.W., 2nd Floor
`· · · · · · · ·Washington, D.C. 20009
`·7
`
`·8
`
`·9· ·Videographer:
`
`10· · · · · · ·Kory Ross
`
`11
`
`12
`
`13
`
`14
`
`15
`
`16
`
`17
`
`18
`
`19
`
`20
`
`21
`
`22
`
`23
`
`24
`
`25
`
`
` P.3
`
`UT Ex. 2059
`SteadyMed v. United Therapeutics
`IPR2016-00006
`
`
`Elisa Dreier Reporting Corp., U.S. Legal Support Company (212)557-5558Elisa Dreier Reporting Corp., U.S. Legal Support Company (212)557-5558
`
`950 Third Avenue, New York, NY· 10022950 Third Avenue, New York, NY· 10022
`
`YVer1f
`
`

`
`
`STEADYMED vs UNITED THERAPEUTICS CORPORATIONSTEADYMED vs UNITED THERAPEUTICS CORPORATION
`
`WILLIAMS, ROBERT on 08/26/2016WILLIAMS, ROBERT on 08/26/2016
`
`Page 4
`
`·1· · · · · · · · · · · · · · ·INDEX
`
`·2· · · · · · · · · · · · · · · · · · · · · · · · · · · ·PAGE
`
`·3· · ·APPEARANCES· · · · · · · · · · · · · · · · · · · · · 2
`
`·4
`
`·5
`
`·6· · · · · · · · · · · INDEX TO EXAMINATION
`
`·7
`
`·8· · · · · · · WITNESS:· ROBERT M. WILLIAMS, PH.D.
`
`·9
`
`10· · ·EXAMINATION OF:
`
`11· · ·Robert M. Williams, Ph.D.
`
`12· · · BY MR. POLLACK· · · · · · · · · · · · · · 9, 129, 266
`
`13· · · BY MS. HASPER· · · · · · · · · · · · · · · · · · ·250
`
`14
`
`15
`
`16
`
`17
`
`18
`
`19
`
`20
`
`21
`
`22
`
`23
`
`24
`
`
`25· · · · · · · · ·(cid:129)__________________________(cid:129)
` P.4
`
`UT Ex. 2059
`SteadyMed v. United Therapeutics
`IPR2016-00006
`
`
`Elisa Dreier Reporting Corp., U.S. Legal Support Company (212)557-5558Elisa Dreier Reporting Corp., U.S. Legal Support Company (212)557-5558
`
`950 Third Avenue, New York, NY· 10022950 Third Avenue, New York, NY· 10022
`
`YVer1f
`
`

`
`
`STEADYMED vs UNITED THERAPEUTICS CORPORATIONSTEADYMED vs UNITED THERAPEUTICS CORPORATION
`
`WILLIAMS, ROBERT on 08/26/2016WILLIAMS, ROBERT on 08/26/2016
`
`Page 5
`
`·1· · · · · · · · · · · ·INDEX TO EXHIBITS
`
`·2· · · · · · · · · ·ROBERT M. WILLIAMS, PH.D.
`
`·3· · · SteadyMed Ltd. vs. United Therapeutics Corporation
`
`·4· · · · · · · · · · Friday, August 26, 2016
`
`·5· · · · · · · · Harry Alan Palter, CSR No. 7708
`
`·6
`
`·7· · MARKED· · · · · · DESCRIPTION· · · · · · · · · · · PAGE
`
`·8· · Exhibit 1· · · Petitioner's Notice of· · · · · · · · 11
`· · · · · · · · · · ·Deposition of Robert M.
`·9· · · · · · · · · ·Williams, Ph.D., Pursuant to
`· · · · · · · · · · ·37 C.F.R. Section 42.53
`10
`· · · Exhibit 2· · · Declaration of Robert M.· · · · · · · 25
`11· · · · · · · · · ·Williams, Ph.D., in Support
`· · · · · · · · · · ·of Patent Owner Response to
`12· · · · · · · · · ·Petition
`
`13· · Exhibit 3· · · U.S. Patent No. 8,497,393 B2· · · · · 52
`
`14· · Exhibit 4· · · U.S. Patent No. 6,765,117 B1· · · · · 52
`
`15· · Exhibit 5· · · Appendix A· · · · · · · · · · · · · · 78
`
`16· · Exhibit 6· · · Appendix B· · · · · · · · · · · · · · 78
`
`17· · Exhibit 7· · · Magellan Laboratories· · · · · · · · ·80
`· · · · · · · · · · ·Characterization of the Drug
`18· · · · · · · · · ·Substance UT-15
`
`19· · Exhibit 8· · · Chart of all of the purities· · · · · 82
`· · · · · · · · · · ·and total related impurities
`20· · · · · · · · · ·from the Appendix A,
`· · · · · · · · · · ·Deposition Exhibit 5
`21
`· · · Exhibit 9· · · Chart containing all samples,· · · · ·82
`22· · · · · · · · · ·including the ones from
`· · · · · · · · · · ·Exhibit 2052
`23
`· · · Exhibit 10· · ·Chart containing all samples,· · · · ·85
`24· · · · · · · · · ·not including the ones from
`· · · · · · · · · · ·Exhibit 2052
`25
`
`
` P.5
`
`UT Ex. 2059
`SteadyMed v. United Therapeutics
`IPR2016-00006
`
`
`Elisa Dreier Reporting Corp., U.S. Legal Support Company (212)557-5558Elisa Dreier Reporting Corp., U.S. Legal Support Company (212)557-5558
`
`950 Third Avenue, New York, NY· 10022950 Third Avenue, New York, NY· 10022
`
`YVer1f
`
`

`
`
`STEADYMED vs UNITED THERAPEUTICS CORPORATIONSTEADYMED vs UNITED THERAPEUTICS CORPORATION
`
`WILLIAMS, ROBERT on 08/26/2016WILLIAMS, ROBERT on 08/26/2016
`
`Page 6
`
`·1· · Exhibit 11· · ·UT-15 Injection, Drug· · · · · · · · 103
`· · · · · · · · · · ·Substance, Volume 1.2,
`·2· · · · · · · · · ·Chemistry, Manufacturing and
`· · · · · · · · · · ·Controls, NDA 21-272
`·3
`· · · Exhibit 12· · ·Journal of Organic Chemistry· · · · ·108
`·4· · · · · · · · · ·article: The Intramolecular
`· · · · · · · · · · ·Asymmetric Pauson-Khand
`·5· · · · · · · · · ·Cyclization as a Novel and
`· · · · · · · · · · ·General Stereoselective Route
`·6· · · · · · · · · ·to Benzindene Prostacyclins:
`· · · · · · · · · · ·Synthesis of UT-15
`·7· · · · · · · · · ·(Treprostinil)
`
`·8· · Exhibit 13· · ·Spreadsheet on thumb drive· · · · · ·130
`
`·9· · Exhibit 14· · ·Document dated 1.2.09 from· · · · · ·130
`· · · · · · · · · · ·United Therapeutics re: NDA
`10· · · · · · · · · ·021272/S-010, Remodulin
`· · · · · · · · · · ·Resubmission of Supplemental
`11· · · · · · · · · ·New Drug Application
`
`12· · Exhibit 15· · ·Report by Terence L.· · · · · · · · ·156
`· · · · · · · · · · ·Threlfall: Analysis of
`13· · · · · · · · · ·Organic Polymorphs, A Review
`
`14· · Exhibit 16· · ·World Intellectual Property· · · · · 161
`· · · · · · · · · · ·Organization, Document no. WO
`15· · · · · · · · · ·2005/007081 A2 (aka "Phares
`· · · · · · · · · · ·Reference")
`16
`· · · Exhibit 17· · ·Solid-State Chemistry of· · · · · · ·164
`17· · · · · · · · · ·Drugs, Second Edition, by
`· · · · · · · · · · ·Stephen R. Byrn, Ralph R.
`18· · · · · · · · · ·Pfeiffer, Joseph G. Stowell
`
`19· · Exhibit 18· · ·FDA Guidance for Industry,· · · · · ·174
`· · · · · · · · · · ·ANDAs: Pharmaceutical Solid
`20· · · · · · · · · ·Polymorphism, Chemistry,
`· · · · · · · · · · ·Manufacturing, and Controls
`21· · · · · · · · · ·Information
`
`22· · Exhibit 19· · ·ScienceDirect article:· · · · · · · ·179
`· · · · · · · · · · ·Crystal Modification of
`23· · · · · · · · · ·Dipyridamole Using Different
`· · · · · · · · · · ·Solvents and Crystallization
`24· · · · · · · · · ·Conditions
`
`25
`
`
` P.6
`
`UT Ex. 2059
`SteadyMed v. United Therapeutics
`IPR2016-00006
`
`
`Elisa Dreier Reporting Corp., U.S. Legal Support Company (212)557-5558Elisa Dreier Reporting Corp., U.S. Legal Support Company (212)557-5558
`
`950 Third Avenue, New York, NY· 10022950 Third Avenue, New York, NY· 10022
`
`YVer1f
`
`

`
`
`STEADYMED vs UNITED THERAPEUTICS CORPORATIONSTEADYMED vs UNITED THERAPEUTICS CORPORATION
`
`WILLIAMS, ROBERT on 08/26/2016WILLIAMS, ROBERT on 08/26/2016
`
`Page 7
`
`·1· · Exhibit 20· · ·Declaration of David Walsh· · · · · ·190
`· · · · · · · · · · ·Under 37 C.F.R. 1.132
`·2
`· · · Exhibit 21· · ·United Therapeutics NDA· · · · · · · 211
`·3· · · · · · · · · ·Annual Report, Remodulin
`· · · · · · · · · · ·injection, NDA 21-272, dated
`·4· · · · · · · · · ·7.21.03
`
`·5· · Exhibit 22· · ·Journal of Organic Chemistry· · · · ·220
`· · · · · · · · · · ·article: Synthetic Studies on
`·6· · · · · · · · · ·Et-743. Assembly of the
`· · · · · · · · · · ·Pentacyclic Core and a Formal
`·7· · · · · · · · · ·Total Synthesis
`
`·8· · Exhibit 23· · ·(12) Unexamined Patent· · · · · · · ·245
`· · · · · · · · · · ·Gazette (A) (Japanese version
`·9· · · · · · · · · ·of Kawakami reference)
`
`10· · Exhibit 24· · ·(12) Unexamined Patent· · · · · · · ·245
`· · · · · · · · · · ·Gazette (A) (English version
`11· · · · · · · · · ·of Kawakami reference)
`
`12· · Exhibit 25· · ·Pair of drawings made of the· · · · ·246
`· · · · · · · · · · ·compound in the Kawakami
`13· · · · · · · · · ·reference
`
`14· · Exhibit 26· · ·Corrections to Williams· · · · · · · 251
`· · · · · · · · · · ·Declaration
`15
`
`16
`
`17· · · · · · · · ·(cid:129)__________________________(cid:129)
`
`18
`
`19
`
`20
`
`21
`
`22
`
`23
`
`24
`
`25
`
`
` P.7
`
`UT Ex. 2059
`SteadyMed v. United Therapeutics
`IPR2016-00006
`
`
`Elisa Dreier Reporting Corp., U.S. Legal Support Company (212)557-5558Elisa Dreier Reporting Corp., U.S. Legal Support Company (212)557-5558
`
`950 Third Avenue, New York, NY· 10022950 Third Avenue, New York, NY· 10022
`
`YVer1f
`
`

`
`
`STEADYMED vs UNITED THERAPEUTICS CORPORATIONSTEADYMED vs UNITED THERAPEUTICS CORPORATION
`
`WILLIAMS, ROBERT on 08/26/2016WILLIAMS, ROBERT on 08/26/2016
`
`Page 8
`
`·1· · · · · · · · · ·San Diego, California
`
`·2· · · · · · Friday, August 26, 2016; 9:30 a.m.
`
`·3
`
`·4
`
`·5· · · · · · · THE VIDEOGRAPHER:· Good morning.· We are
`
`·6· ·on the record.· This is the videotaped deposition of
`
`·7· ·Robert M. Williams, Ph.D., in the matter of
`
`·8· ·SteadyMed, Ltd., vs. United Therapeutics
`
`·9· ·Corporation.
`
`10· · · · · · · This deposition is taking place at 12235
`
`11· ·El Camino Real, Suite 200, San Diego, California
`
`12· ·92130, on August 26, 2016, at 9:30 A.M.
`
`13· · · · · · · My name is Kory Ross.· I'm the
`
`14· ·videographer with U.S. Legal Support.· Video and
`
`15· ·audio recording will be taking place unless all
`
`16· ·counsel agree to go off the record.
`
`17· · · · · · · Would all present please identify
`
`18· ·themselves, beginning with the witness.
`
`19· · · · · · · THE WITNESS:· Robert M. Williams.
`
`20· · · · · · · MR. POLLACK:· Stuart E. Pollack, DLA
`
`21· ·Piper, LLP U.S., on behalf of SteadyMed, Ltd., the
`
`22· ·petitioner.· I'm joined with Maya Choksi from the
`
`23· ·same law firm.
`
`24· · · · · · · MS. HASPER:· Katherine Hasper of Wilson,
`
`
`25· ·Sonsini, Goodrich & Rosati, on behalf of United
`UT Ex. 2059
` P.8
`SteadyMed v. United Therapeutics
`IPR2016-00006
`
`
`Elisa Dreier Reporting Corp., U.S. Legal Support Company (212)557-5558Elisa Dreier Reporting Corp., U.S. Legal Support Company (212)557-5558
`
`950 Third Avenue, New York, NY· 10022950 Third Avenue, New York, NY· 10022
`
`YVer1f
`
`

`
`
`STEADYMED vs UNITED THERAPEUTICS CORPORATIONSTEADYMED vs UNITED THERAPEUTICS CORPORATION
`
`WILLIAMS, ROBERT on 08/26/2016WILLIAMS, ROBERT on 08/26/2016
`
`Page 9
`
`·1· ·Therapeutics and the witness.
`
`·2· · · · · · · MR. MAEBIUS:· And Steve Maebius from
`
`·3· ·Foley & Lardner on behalf of patent owner.
`
`·4· · · · · · · THE VIDEOGRAPHER:· Thank you, Counsel.
`
`·5· · · · · · · The certified court reporter is Harry
`
`·6· ·Palter.
`
`·7· · · · · · · Will you please swear in the witness.
`
`·8
`
`·9
`
`10· · · · · · · · ROBERT M. WILLIAMS, PH.D.,
`
`11· ·having been duly administered an oath in accordance
`
`12· ·with the California Code of Civil Procedure
`
`13· ·Section 2094, was examined and testified as follows:
`
`14
`
`15
`
`16· · · · · · · · · · · · EXAMINATION
`
`17· ·BY MR. POLLACK:
`
`18· · · · Q· · ·Good morning, Dr. Williams.
`
`19· · · · A· · ·Good morning, Counselor.
`
`20· · · · Q· · ·Just as a formality to start today, could
`
`21· ·you state your name for the record and your current
`
`22· ·position.
`
`23· · · · A· · ·Robert M. Williams, university
`
`24· ·distinguished professor at Colorado State
`
`25· ·University.
`
`
` P.9
`
`UT Ex. 2059
`SteadyMed v. United Therapeutics
`IPR2016-00006
`
`
`Elisa Dreier Reporting Corp., U.S. Legal Support Company (212)557-5558Elisa Dreier Reporting Corp., U.S. Legal Support Company (212)557-5558
`
`950 Third Avenue, New York, NY· 10022950 Third Avenue, New York, NY· 10022
`
`YVer1f
`
`

`
`
`STEADYMED vs UNITED THERAPEUTICS CORPORATIONSTEADYMED vs UNITED THERAPEUTICS CORPORATION
`
`WILLIAMS, ROBERT on 08/26/2016WILLIAMS, ROBERT on 08/26/2016
`
`Page 10
`
`·1· · · · Q· · ·Okay.· Now, I know you've been deposed
`
`·2· ·before; correct?
`
`·3· · · · A· · ·Yes.
`
`·4· · · · Q· · ·How many times have you been deposed?
`
`·5· · · · A· · ·I don't know the exact number.· It's
`
`·6· ·somewhere around 17, 15 -- 16, 17, somewhere in
`
`·7· ·there.· I lost count, actually.
`
`·8· · · · Q· · ·Okay.· Were all of those patent cases?
`
`·9· · · · A· · ·Yes.
`
`10· · · · Q· · ·And how many of those cases were for
`
`11· ·United Therapeutics?
`
`12· · · · A· · ·Let me see.· Three.· I think this would
`
`13· ·be my third deposition with United Therapeutics.
`
`14· ·But I'd have to -- I can check -- check.· It may be
`
`15· ·three or four.· I don't remember.· I think it's for
`
`16· ·sure three.
`
`17· · · · Q· · ·Okay.· But you understand all the rules
`
`18· ·of depositions at this point?
`
`19· · · · A· · ·Yes.
`
`20· · · · Q· · ·Okay.· And there's no reason today that
`
`21· ·you can't give your best testimony?
`
`22· · · · A· · ·No.
`
`23· · · · Q· · ·All right.
`
`24· · · · · · · MR. POLLACK:· I'm going to mark as
`
`
`25· ·Williams Deposition Exhibit 1 the Petitioner's
`UT Ex. 2059
` P.10
`SteadyMed v. United Therapeutics
`IPR2016-00006
`
`
`Elisa Dreier Reporting Corp., U.S. Legal Support Company (212)557-5558Elisa Dreier Reporting Corp., U.S. Legal Support Company (212)557-5558
`
`950 Third Avenue, New York, NY· 10022950 Third Avenue, New York, NY· 10022
`
`YVer1f
`
`

`
`
`STEADYMED vs UNITED THERAPEUTICS CORPORATIONSTEADYMED vs UNITED THERAPEUTICS CORPORATION
`
`WILLIAMS, ROBERT on 08/26/2016WILLIAMS, ROBERT on 08/26/2016
`
`Page 11
`
`·1· ·Notice of Deposition.
`
`·2· · · · · · · (Exhibit 1 marked)
`
`·3· ·BY MR. POLLACK:
`
`·4· · · · Q· · ·And Dr. Williams, are you here today in
`
`·5· ·response to Petitioner's Notice of Deposition of
`
`·6· ·Robert M. Williams, Ph.D.?
`
`·7· · · · A· · ·Yes, that's my understanding.
`
`·8· · · · Q· · ·So you've done two other depositions for
`
`·9· ·United Therapeutics.· Did both of those cases also
`
`10· ·involve treprostinil?
`
`11· · · · A· · ·Yes.
`
`12· · · · Q· · ·And those were two cases in New Jersey
`
`13· ·involving generic challenges to United Therapeutics
`
`14· ·Remodulin product?
`
`15· · · · A· · ·Yes.
`
`16· · · · Q· · ·Do you remember the names of the two
`
`17· ·defendants in those cases?
`
`18· · · · A· · ·Sandoz in the first case, which went to
`
`19· ·trial, and then Teva.
`
`20· · · · Q· · ·Okay.· And the type of case is still
`
`21· ·ongoing?
`
`22· · · · A· · ·I believe so.
`
`23· · · · Q· · ·Have you submitted an expert report or
`
`24· ·Declaration in the Teva case?
`
`25· · · · A· · ·Yes.
`
`
` P.11
`
`UT Ex. 2059
`SteadyMed v. United Therapeutics
`IPR2016-00006
`
`
`Elisa Dreier Reporting Corp., U.S. Legal Support Company (212)557-5558Elisa Dreier Reporting Corp., U.S. Legal Support Company (212)557-5558
`
`950 Third Avenue, New York, NY· 10022950 Third Avenue, New York, NY· 10022
`
`YVer1f
`
`

`
`
`STEADYMED vs UNITED THERAPEUTICS CORPORATIONSTEADYMED vs UNITED THERAPEUTICS CORPORATION
`
`WILLIAMS, ROBERT on 08/26/2016WILLIAMS, ROBERT on 08/26/2016
`
`Page 12
`
`·1· · · · Q· · ·And have you -- and you've been deposed
`
`·2· ·already in that Teva case?
`
`·3· · · · A· · ·Yes.
`
`·4· · · · Q· · ·Did your expert Declaration or deposition
`
`·5· ·concern the '393 patent at all?
`
`·6· · · · A· · ·Yes.
`
`·7· · · · Q· · ·Okay.· Did you opine on the validity or
`
`·8· ·invalidity of the '393 patent in that case?
`
`·9· · · · A· · ·No.
`
`10· · · · Q· · ·Okay.· What did you opine on?
`
`11· · · · A· · ·Claim construction.
`
`12· · · · Q· · ·Okay.· And what were the issues regarding
`
`13· ·claim construction in that case?
`
`14· · · · · · · MS. HASPER:· Objection.· Relevance.
`
`15· · · · · · · THE WITNESS:· I don't -- I don't recall
`
`16· ·off the top of my head.
`
`17· ·BY MR. POLLACK:
`
`18· · · · Q· · ·Okay.· Were they similar to the claim
`
`19· ·construction issues in the current IPR?
`
`20· · · · A· · ·I believe there was some overlap, yes.
`
`21· · · · Q· · ·Which ones were an overlap?
`
`22· · · · A· · ·Again, I'd have to go back and look at my
`
`23· ·Declaration.
`
`24· · · · Q· · ·You don't recall --
`
`
`25· · · · A· · ·It's -- I don't recall exactly.
` P.12
`
`UT Ex. 2059
`SteadyMed v. United Therapeutics
`IPR2016-00006
`
`
`Elisa Dreier Reporting Corp., U.S. Legal Support Company (212)557-5558Elisa Dreier Reporting Corp., U.S. Legal Support Company (212)557-5558
`
`950 Third Avenue, New York, NY· 10022950 Third Avenue, New York, NY· 10022
`
`YVer1f
`
`

`
`
`STEADYMED vs UNITED THERAPEUTICS CORPORATIONSTEADYMED vs UNITED THERAPEUTICS CORPORATION
`
`WILLIAMS, ROBERT on 08/26/2016WILLIAMS, ROBERT on 08/26/2016
`
`Page 13
`
`·1· · · · Q· · ·Okay.
`
`·2· · · · A· · ·I don't want to give an inaccurate
`
`·3· ·answer.
`
`·4· · · · Q· · ·Absolutely.
`
`·5· · · · · · · Do you recall if there was any discussion
`
`·6· ·of the meaning of the term "product" in the '393
`
`·7· ·case with either -- with Teva?
`
`·8· · · · · · · MS. HASPER:· Objection.· Relevance.
`
`·9· · · · · · · You may answer to the extent it doesn't
`
`10· ·reveal privilege.
`
`11· · · · · · · THE WITNESS:· Again, my -- I haven't
`
`12· ·looked at that material for awhile, so I'm hesitant
`
`13· ·to give an answer right now.
`
`14· ·BY MR. POLLACK:
`
`15· · · · Q· · ·You're not sure?
`
`16· · · · A· · ·I'm not 100 percent sure.
`
`17· · · · Q· · ·Okay.· What about the word "comprising"?
`
`18· ·Was there any issue about the meaning of the word
`
`19· ·"comprising" in the '393 case?
`
`20· · · · · · · MS. HASPER:· Same objection.
`
`21· · · · · · · THE WITNESS:· I'd have to give the same
`
`22· ·answer.· I don't exactly recall.
`
`23· ·BY MR. POLLACK:
`
`24· · · · Q· · ·Well, do you know did you -- whether
`
`
`25· ·there was an issue or not, did you make any comments
`UT Ex. 2059
` P.13
`SteadyMed v. United Therapeutics
`IPR2016-00006
`
`
`Elisa Dreier Reporting Corp., U.S. Legal Support Company (212)557-5558Elisa Dreier Reporting Corp., U.S. Legal Support Company (212)557-5558
`
`950 Third Avenue, New York, NY· 10022950 Third Avenue, New York, NY· 10022
`
`YVer1f
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`

`
`
`STEADYMED vs UNITED THERAPEUTICS CORPORATIONSTEADYMED vs UNITED THERAPEUTICS CORPORATION
`
`WILLIAMS, ROBERT on 08/26/2016WILLIAMS, ROBERT on 08/26/2016
`
`Page 14
`
`·1· ·or provide any opinions regarding the meaning of the
`
`·2· ·word "comprising" in the Teva case?
`
`·3· · · · · · · MS. HASPER:· Same objection.
`
`·4· · · · · · · THE WITNESS:· I didn't hear you,
`
`·5· ·Katherine?
`
`·6· · · · · · · MS. HASPER:· Same objection.
`
`·7· · · · · · · THE WITNESS:· And your question again
`
`·8· ·was?· Did I give --
`
`·9· ·BY MR. POLLACK:
`
`10· · · · Q· · ·Did you give any opinion of any form
`
`11· ·regarding the meaning of the term "comprising" in
`
`12· ·the Teva case regardless of what the -- ultimate
`
`13· ·issue was?
`
`14· · · · A· · ·I'd need to refresh my recollection by
`
`15· ·looking at the Declaration I submitted.
`
`16· · · · Q· · ·You don't recall as you sit here?
`
`17· · · · A· · ·I don't recall.
`
`18· · · · Q· · ·And do you know whether the Declaration
`
`19· ·you submitted, whether it was -- whether it was
`
`20· ·stamped "confidential"?
`
`21· · · · A· · ·I believe so.
`
`22· · · · · · · MR. POLLACK:· Counsel, to the extent it's
`
`23· ·available, we'd like to get a copy of his
`
`24· ·Declaration from the Teva case.
`
`
`25· · · · · · · MS. HASPER:· I'll look into it for you.
`UT Ex. 2059
` P.14
`SteadyMed v. United Therapeutics
`IPR2016-00006
`
`
`Elisa Dreier Reporting Corp., U.S. Legal Support Company (212)557-5558Elisa Dreier Reporting Corp., U.S. Legal Support Company (212)557-5558
`
`950 Third Avenue, New York, NY· 10022950 Third Avenue, New York, NY· 10022
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`YVer1f
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`

`
`
`STEADYMED vs UNITED THERAPEUTICS CORPORATIONSTEADYMED vs UNITED THERAPEUTICS CORPORATION
`
`WILLIAMS, ROBERT on 08/26/2016WILLIAMS, ROBERT on 08/26/2016
`
`Page 15
`
`·1· ·BY MR. POLLACK:
`
`·2· · · · Q· · ·And are you also involved in certain
`
`·3· ·other generic challenges to the Remodulin product,
`
`·4· ·also pending the District of New Jersey?
`
`·5· · · · A· · ·I know that there's a case now that I've
`
`·6· ·been retained for involving Watson Laboratories.
`
`·7· · · · Q· · ·Any others?
`
`·8· · · · · · · MS. HASPER:· Objection.· Privilege.
`
`·9· · · · · · · To the extent that you can answer without
`
`10· ·revealing attorney-client communications or
`
`11· ·confidential information, you may do so.
`
`12· · · · · · · THE WITNESS:· Not that I'm aware of.
`
`13· ·BY MR. POLLACK:
`
`14· · · · Q· · ·Not that you're aware of?· Okay.
`
`15· · · · · · · And in the Watson case, have you
`
`16· ·submitted any opinions or formed any opinions in
`
`17· ·that case?
`
`18· · · · A· · ·Not yet.
`
`19· · · · Q· · ·Not yet?· Do you know what the issues are
`
`20· ·in the Watson case?
`
`21· · · · · · · MS. HASPER:· Again, objection.
`
`22· ·Privilege.
`
`23· · · · · · · I caution the witness not to answer to
`
`24· ·the extent that doing so would reveal privileged
`
`25· ·information.
`
`
` P.15
`
`UT Ex. 2059
`SteadyMed v. United Therapeutics
`IPR2016-00006
`
`
`Elisa Dreier Reporting Corp., U.S. Legal Support Company (212)557-5558Elisa Dreier Reporting Corp., U.S. Legal Support Company (212)557-5558
`
`950 Third Avenue, New York, NY· 10022950 Third Avenue, New York, NY· 10022
`
`YVer1f
`
`

`
`
`STEADYMED vs UNITED THERAPEUTICS CORPORATIONSTEADYMED vs UNITED THERAPEUTICS CORPORATION
`
`WILLIAMS, ROBERT on 08/26/2016WILLIAMS, ROBERT on 08/26/2016
`
`Page 16
`
`·1· · · · · · · THE WITNESS:· That's at a very early
`
`·2· ·stage, so I haven't done any --
`
`·3· ·BY MR. POLLACK:
`
`·4· · · · Q· · ·You haven't done anything?
`
`·5· · · · A· · ·No.
`
`·6· · · · Q· · ·Okay.· About how many hours in total have
`
`·7· ·you worked on cases for United Therapeutics at this
`
`·8· ·point?
`
`·9· · · · · · · MS. HASPER:· Objection.
`
`10· · · · · · · Mr. Pollack, this is -- you're asking
`
`11· ·about how much time he's spent either on his own
`
`12· ·with counsel working on --
`
`13· · · · · · · MR. POLLACK:· Okay.· Stop the speaking
`
`14· ·objections now; all right?
`
`15· · · · · · · MS. HASPER:· I'm trying to explain that
`
`16· ·you're asking a line of questions which assumes --
`
`17· · · · · · · MR. POLLACK:· Okay.· Just -- just say
`
`18· ·your objection.
`
`19· · · · · · · (Indiscernible crosstalk)
`
`20· · · · · · · THE WITNESS:· Excuse me, Counselor?
`
`21· ·BY MR. POLLACK:
`
`22· · · · Q· · ·Yes.· How many hours have you worked on
`
`23· ·cases for United Therapeutics?
`
`24· · · · · · · MS. HASPER:· Objection.· I instruct the
`
`
`25· ·witness not to answer to the extent doing so will
`UT Ex. 2059
` P.16
`SteadyMed v. United Therapeutics
`IPR2016-00006
`
`
`Elisa Dreier Reporting Corp., U.S. Legal Support Company (212)557-5558Elisa Dreier Reporting Corp., U.S. Legal Support Company (212)557-5558
`
`950 Third Avenue, New York, NY· 10022950 Third Avenue, New York, NY· 10022
`
`YVer1f
`
`

`
`
`STEADYMED vs UNITED THERAPEUTICS CORPORATIONSTEADYMED vs UNITED THERAPEUTICS CORPORATION
`
`WILLIAMS, ROBERT on 08/26/2016WILLIAMS, ROBERT on 08/26/2016
`
`Page 17
`
`·1· ·reveal privileged information.
`
`·2· · · · · · · THE WITNESS:· I have no idea.
`
`·3· ·BY MR. POLLACK:
`
`·4· · · · Q· · ·Well, more than a hundred?
`
`·5· · · · · · · MS. HASPER:· Objection.· Privileged.
`
`·6· · · · · · · THE WITNESS:· I don't know.
`
`·7· · · · · · · MR. POLLACK:· Are you instructing him not
`
`·8· ·to answer?
`
`·9· · · · · · · MS. HASPER:· The objection -- so I'm
`
`10· ·going to give you a standing instruction to this
`
`11· ·entire line of questioning, that to the extent
`
`12· ·Mr. Pollack asks you about privileged information,
`
`13· ·including your communications with counsel for
`
`14· ·United Therapeutics, that we request you not answer.
`
`15· · · · · · · MR. POLLACK:· I'm not asking about his
`
`16· ·communications.
`
`17· ·BY MR. POLLACK:
`
`18· · · · Q· · ·About how much income have you received
`
`19· ·so far from United Therapeutics working on their
`
`20· ·cases?
`
`21· · · · · · · MS. HASPER:· Objection.· Relevance.
`
`22· ·Prejudicial.
`
`23· · · · · · · THE WITNESS:· I don't recall.
`
`24· ·BY MR. POLLACK:
`
`
`25· · · · Q· · ·Over $100,000?
` P.17
`
`UT Ex. 2059
`SteadyMed v. United Therapeutics
`IPR2016-00006
`
`
`Elisa Dreier Reporting Corp., U.S. Legal Support Company (212)557-5558Elisa Dreier Reporting Corp., U.S. Legal Support Company (212)557-5558
`
`950 Third Avenue, New York, NY· 10022950 Third Avenue, New York, NY· 10022
`
`YVer1f
`
`

`
`
`STEADYMED vs UNITED THERAPEUTICS CORPORATIONSTEADYMED vs UNITED THERAPEUTICS CORPORATION
`
`WILLIAMS, ROBERT on 08/26/2016WILLIAMS, ROBERT on 08/26/2016
`
`Page 18
`
`·1· · · · · · · MS. HASPER:· Objection.· Relevance.
`
`·2· ·Prejudicial.
`
`·3· · · · · · · THE WITNESS:· I'd have to go look at my
`
`·4· ·invoices.
`
`·5· ·BY MR. POLLACK:
`
`·6· · · · Q· · ·Over $50,000?
`
`·7· · · · · · · MS. HASPER:· Objection.· Relevance.
`
`·8· ·Prejudicial.
`
`·9· · · · · · · THE WITNESS:· Likely.
`
`10· ·BY MR. POLLACK:
`
`11· · · · Q· · ·Likely over 50 -- between 50 and 100?· Is
`
`12· ·that fair?
`
`13· · · · · · · MS. HASPER:· Objection.· Relevance.
`
`14· ·Prejudicial.
`
`15· · · · · · · THE WITNESS:· I don't know.
`
`16· ·BY MR. POLLACK:
`
`17· · · · Q· · ·It could be over hundred?
`
`18· · · · · · · MS. HASPER:· Objection.· Relevance.
`
`19· ·Prejudicial.· Asked and answered.
`
`20· ·BY MR. POLLACK:
`
`21· · · · Q· · ·It could be over a hundred thousand
`
`22· ·dollars?
`
`23· · · · A· · ·I'm thinking I'd have to go look.
`
`24· · · · · · · MS. HASPER:· Objection.· Relevance,
`
`25· ·privilege, asked and answered.
` P.18
`
`UT Ex. 2059
`SteadyMed v. United Therapeutics
`IPR2016-00006
`
`
`Elisa Dreier Reporting Corp., U.S. Legal Support Company (212)557-5558Elisa Dreier Reporting Corp., U.S. Legal Support Company (212)557-5558
`
`950 Third Avenue, New York, NY· 10022950 Third Avenue, New York, NY· 10022
`
`YVer1f
`
`

`
`
`STEADYMED vs UNITED THERAPEUTICS CORPORATIONSTEADYMED vs UNITED THERAPEUTICS CORPORATION
`
`WILLIAMS, ROBERT on 08/26/2016WILLIAMS, ROBERT on 08/26/2016
`
`Page 19
`
`·1· · · · · · · THE WITNESS:· I'd have to look.
`
`·2· ·BY MR. POLLACK:
`
`·3· · · · Q· · ·You'd have to look.
`
`·4· · · · · · · I'm asking if it's possible whether it
`
`·5· ·was over a hundred thousand dollars?
`
`·6· · · · · · · MS. HASPER:· Objection.· Relevance.
`
`·7· ·Privileged.· Asked and answered.
`
`·8· · · · · · · THE WITNESS:· I just remember I've been
`
`·9· ·working on a lot of different cases at the same
`
`10· ·time.
`
`11· ·BY MR. POLLACK:
`
`12· · · · Q· · ·Sure.
`
`13· · · · A· · ·I don't remember.
`
`14· · · · Q· · ·Sure.
`
`15· · · · · · · What's your hourly rate?
`
`16· · · · A· · ·$650 an hour.
`
`17· · · · Q· · ·Okay.· Have you worked over a hundred
`
`18· ·hours on United Therapeutics cases?
`
`19· · · · · · · MS. HASPER:· Same objection.
`
`20· · · · · · · THE WITNESS:· I'd have to give the same
`
`21· ·answer.· I'd have to go back and look at my
`
`22· ·invoices.· I don't -- I don't recall off the top of
`
`23· ·my head.
`
`24· ·BY MR. POLLACK:
`
`
`25· · · · Q· · ·Okay.· What about in this IPR?· About how
`UT Ex. 2059
` P.19
`SteadyMed v. United Therapeutics
`IPR2016-00006
`
`
`Elisa Dreier Reporting Corp., U.S. Legal Support Company (212)557-5558Elisa Dreier Reporting Corp., U.S. Legal Support Company (212)557-5558
`
`950 Third Avenue, New York, NY· 10022950 Third Avenue, New York, NY· 10022
`
`YVer1f
`
`

`
`
`STEADYMED vs UNITED THERAPEUTICS CORPORATIONSTEADYMED vs UNITED THERAPEUTICS CORPORATION
`
`WILLIAMS, ROBERT on 08/26/2016WILLIAMS, ROBERT on 08/26/2016
`
`Page 20
`
`·1· ·many hours have you worked in this IPR?
`
`·2· · · · · · · MS. HASPER:· Same objection.
`
`·3· · · · · · · THE WITNESS:· I don't know.
`
`·4· ·BY MR. POLLACK:
`
`·5· · · · Q· · ·No idea?
`
`·6· · · · A· · ·No.
`
`·7· · · · Q· · ·"No."· More than 40 hours?
`
`·8· · · · · · · MS. HASPER:· Same objection.
`
`·9· · · · · · · THE WITNESS:· Again, I don't want to give
`
`10· ·an inaccurate answer, so I would need to look at my
`
`11· ·invoices.
`
`12· ·BY MR. POLLACK:
`
`13· · · · Q· · ·I understand.· But I'm asking just for an
`
`14· ·approximate answer.· Is it more than 40 hours?
`
`15· · · · · · · MS. HASPER:· Same objection.
`
`16· · · · · · · THE WITNESS:· I don't know.
`
`17· ·BY MR. POLLACK:
`
`18· · · · Q· · ·About how much have you invoiced for in
`
`19· ·this matter?
`
`20· · · · · · · MS. HASPER:· Same objection.
`
`21· · · · · · · THE WITNESS:· Between two and three
`
`22· ·invoices, so I'm not really sure.
`
`23· ·BY MR. POLLACK:
`
`24· · · · Q· · ·Okay.· About how much was this at each
`
`25· ·invoice?
`
`
` P.20
`
`UT Ex. 2059
`SteadyMed v. United Therapeutics
`IPR2016-00006
`
`
`Elisa Dreier Reporting Corp., U.S. Legal Support Company (212)557-5558Elisa Dreier Reporting Corp., U.S. Legal Support Company (212)557-5558
`
`950 Third Avenue, New York, NY· 10022950 Third Avenue, New York, NY· 10022
`
`YVer1f
`
`

`
`
`STEADYMED vs UNITED THERAPEUTICS CORPORATIONSTEADYMED vs UNITED THERAPEUTICS CORPORATION
`
`WILLIAMS, ROBERT on 08/26/2016WILLIAMS, ROBERT on 08/26/2016
`
`Page 21
`
`·1· · · · A· · ·I do not recall.
`
`·2· · · · · · · MS. HASPER:· Same objection.
`
`·3· ·BY MR. POLLACK:
`
`·4· · · · Q· · ·Was each invoice larger than $50,000?
`
`·5· · · · A· · ·No.
`
`·6· · · · · · · MS. HASPER:· Same objection.
`
`·7· ·BY MR. POLLACK:
`
`·8· · · · Q· · ·Were some of the invoices larger than
`
`·9· ·$50,000?
`
`10· · · · A· · ·No, I don't think so.
`
`11· · · · Q· · ·You think all of them were below $50,000?
`
`12· · · · A· · ·Yes.
`
`13· · · · Q· · ·Okay.· And there were about three
`
`14· ·invoices?
`
`15· · · · · · · MS. HASPER:· Same objection.
`
`16· · · · · · · THE WITNESS:· Again, I can't exactly
`
`17· ·recall.
`
`18· ·BY MR. POLLACK:
`
`19· · · · Q· · ·Okay.· Can you give --
`
`20· · · · A· · ·Because I'm working on other matters.
`
`21· ·Completely different matters, not for United
`
`22· ·Therapeutics.· So --
`
`23· · · · Q· · ·Sure.
`
`24· · · · A· · ·I have a very accurate record on my
`
`25· ·computer, but I don't remember.
` P.21
`
`UT Ex. 2059
`SteadyMed v. United Therapeutics
`IPR2016-00006
`
`
`Elisa Dreier Reporting Corp., U.S. Legal Support Company (212)557-5558Elisa Dreier Reporting Corp., U.S. Legal Support Company (212)557-5558
`
`950 Third Avenue, New York, NY· 10022950 Third Avenue, New York, NY· 10022
`
`YVer1f
`
`

`
`
`STEADYMED vs UNITED THERAPEUTICS CORPORATIONSTEADYMED vs UNITED THERAPEUTICS CORPORATION
`
`WILLIAMS, ROBERT on 08/26/2016WILLIAMS, ROBERT on 08/26/2016
`
`Page 22
`
`·1· · · · Q· · ·How many matters are you working on now?
`
`·2· · · · · · · MS. HASPER:· Objection.· Relevance.
`
`·3· · · · · · · THE WITNESS:· Around nine right now.
`
`·4· ·BY MR. POLLACK:
`
`·5· · · · Q· · ·Okay.
`
`·6· · · · A· · ·I'm paid for about nine different
`
`·7· ·matters.
`
`·8· · · · Q· · ·All right.· About how much do you earn a
`
`·9· ·year doing matters?
`
`10· · · · · · · MS. HASPER:· Objection.· Relevance.
`
`11· · · · · · · THE WITNESS:· Which -- what do you mean
`
`12· ·"a year"?· It varies from year to year