Curriculum Vitae
`
`
`
`Date Prepared:
`September 1, 2015
`Name:
`John Weyl Winkelman
`Office Address: Massachusetts General Hospital
`Sleep Disorders Clinical Research Program
`1 Bowdoin Square, 9th floor
`Boston, MA 02114
`12 Field Road
`Lexington, MA 02421
`617-643-9101
`jwwinkelman@partners.org
`617-643-6050
`Philadelphia, PA
`
`Home Address:
`
`Work Phone:
`Work Email:
`Work FAX:
`Place of Birth:
`
`
`Psychobiology
`
`Psychobiology
`
`Medicine
`
`Williams College, Williamstown,
`MA
`Harvard University, Cambridge,
`MA
`Harvard Medical School
`
`Education
`
`09/74-06/78 B.A.
`
`09/79-06/83 Ph.D.
`
`09/83-06/87 M.D.
`
`
`Postdoctoral Training
`
`07/87-07/88
`Intern
`
`Mt. Zion Hospital and Medical
`Center, San Francisco, CA
`Massachusetts General Hospital
`Massachusetts General Hospital
`
`Massachusetts General Hospital
`
`Internal Medicine
`
`Psychiatry
`07/88-07/90 Resident
`07/90-07/91 Chief Resident Clinical
`Psychopharmacology Unit
`Neurology (Sleep
`Medicine)
`
`07/91-07/92 Clinical
`Fellow
`
`
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`
`
`Faculty Academic Appointments
`
`1986-1987
`Lecturer
`
`
`
`1991-1996
`
`Instructor
`
`1996-2000
`
`Instructor
`
`2000-2007 Assistant Professor
`
`Associate Professor
`
`
`
`2008-
`present
`
`Appointments at Hospitals/Affiliated Institutions
`07/91-07/99 Clinical Assistant
`Psychiatry
`
`Psychology
`
`Psychiatry
`
`Medicine
`
`Psychiatry
`
`Psychiatry
`
`Harvard Graduate School of Arts and
`Sciences
`Harvard Medical School
`
`Harvard Medical School
`
`Harvard Medical School
`
`Harvard Medical School
`
`Massachusetts General Hospital
`
`07/91-07/00 Assistant Physician
`
`Psychiatry
`
`McLean Hospital, Belmont MA
`
`07/96-
`
`Associate Physician Medicine
`
`Brigham and Women’s Hospital
`
`Psychiatrist
`
`07/06–
`
`09/13-02/15 Associate
`Psychiatrist
`
`Psychiatrist
`
`02/15-
`
`Psychiatry
`
`Psychiatry
`
`Brigham and Women’s Hospital
`
`Massachusetts General Hospital
`
`Psychiatry
`
`Massachusetts General Hospital
`
`Major Administrative Leadership Positions
`
`Local
`1986-1987
`
`Course Director, Psychobiology
`
`1998-present Course Co-Director, Clinical Sleep Disorders, 4th
`year elective
`Symposium Organizer, Physiological Markers in
`Psychiatry, Clinical Psychopharmacology Unit
`Medical Director, Sleep Disorders Center and Sleep
`Research Program
`Course Director, Organic Mental Disorders, PGY 2
`Psychiatry and Neurology Residents
`Symposium Director, Harvard Psychiatry Day, All
`residents and child fellows in Harvard-affiliated
`psychiatry programs
`Associate Clinical Director, Sleep Disorders Service Brigham and Women’s Hospital
`Course Director, Diagnosis and Treatment of Sleep
`Brigham and Women’s Hospital
`
`Harvard University Faculty of Arts
`and Sciences
`Harvard Medical School
`
`Massachusetts General Hospital
`
`McLean Hospital
`
`McLean Hospital
`
`Harvard Medical School
`
`1990-1991
`
`1991-1996
`
`1995-1996
`
`1996
`
`1996-2006
`1997, 1999
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`Brigham and Women’s Hospital,
`Newton/Brighton, MA
`Brigham and Women’s Hospital
`Brigham and Women’s Hospital
`Harvard Medical School
`
`Stressa, Italy (Boehringer-
`Ingelheim)
`
`Massachusetts General Hospital
`Massachusetts General Hospital
`Harvard Medical School
`
`Partners Healthcare
`Brigham and Women’s Hospital
` Harvard Medical School
`
`Commonwealth of Massachusetts,
`Dept. of Mental Health
`Tufts Evidence-based Practice
`Center, Agency for Healthcare
`Research and Quality, Boston, MA
`
`International Restless Legs
`Syndrome Study Group
`
`1999-2013
`
`Disorders
`Medical Director, Sleep Health Center
`
`Course Director, Sleep Medicine: 2001
`Course Director, Advances in Sleep Medicine
`Symposium organizer, Update on Diagnosis and
`Pathophysiology of Restless Legs Syndrome,
`Division of Sleep Medicine
`
`2001
`2002
`2008
`
`
`
`International
`2005
`
`Chair, Scientific Committee, Fourth International
`Scientific Symposium on Parkinson’s Disease and
`Restless Legs Syndrome
`Committee Service
`Local
`1989-1993
`
`1989-1991
`
`1997
`
`
`
`2005-2006
`
`2006-2012
`2014-
`
`Regional
`2003-2005
`
`
`2009-2010 Key Informant Panel, Sleep Apnea Diagnosis and
`
`Treatment
`
`
`
`
`
`
`Psychiatry Residency Selection Committee
`Psychiatry Residency Training Committee
`Mental Status Examination Committee for Medical
`School Psychiatric Education
`Consultant, Pharmacy and Therapeutics Committee
`Sleep Fellowship Selection Committee
`Associate Preceptor, Training Program in Sleep,
`Circadian, and Respiratory Neurobiology
`
`Psychopharmacology Work Group
`
`
`
`Executive Committee
`
`
`International
`2007-2010,
`2010-2015
`
`Professional Societies
`
`
`2004-2007
`Chair, Nosology Committee
`
`
`American Academy of Sleep
`Medicine
`Chair, Movement Disorders and Parasomnias Section American Academy of Sleep
`Medicine
`American Academy of Neurology,
`St. Paul, MN
`American Academy of Sleep
`Medicine
`Movement Disorders Society
`
`Chair, Practice Parameter for the Treatment of
`Restless Legs Syndrome
`Member, Scoring Manual Committee
`
`Member, Restless Legs Syndrome Evidence-Based
`Treatment Committee
`
`2006-2008
`
`2007-
`present
`2011-
`
`2014-
`
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`
`American Psychiatric Association
`
`
`
`
`Editorial Activities
`
`Ad hoc Reviewer
`
`American Journal of Kidney Diseases
`American Journal of Medicine
`Annals of Neurology
`Archives of Internal Medicine
`British Medical Journal
`Clinical Neurophysiology
`CNS Drugs
`CNS Spectrums
`European Journal of Neurology
`Expert Opinion in Pharmacotherapy
`General Hospital Psychiatry
`Human Brain Mapping
`International Journal of Sleep Disorders
`Journal of the American Medical Association (JAMA)
`Journal of the American Society of Nephrology
`Journal of Attention Disorders
`Journal of Biological Rhythms
`Journal of Clinical Psychiatry
`Journal of Clinical Sleep Medicine
`Journal of Clinical Psychopharmacology
`Journal of Sleep Research
`Journal of Psychosomatic Research
`Journal Watch Neurology
`Lancet
`Lancet Neurology
`Medical Letter
`Movement Disorders
`Nature Genetics
`Neurology
`New England Journal of Medicine (NEJM)
`PLOS ONE
`Psychological Medicine
`Psychosomatic Medicine
`Psychosomatics
`Sleep
`Sleep Medicine
`Sleep Medicine Reviews
`Stroke
`Other Editorial Roles
`1999
` Advisor, text revision to DSM-IVR
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
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`
`2005-present
`2005-2007
`2005-2007
`
`Editorial Board Member
` Advisor, revision to scoring manual
`Editorial Board Member
`
`2006-present
`2006-2011
`
`Editorial Board Member
`Editor
`
`2007-present Associate Editor
`2012
`Advisor, DSM-5
`Honors and Prizes
`
`1978
`Phi Beta Kappa, Sigma XI, Highest Honors in
`Psychology
`Tuition scholarship and teaching stipend
`Tuition scholarship and teaching stipend
`Outstanding Resident Award
`Movement Disorders Section Investigator
`Award
`BRI Fund to Sustain Research Excellence
`
`1979-1980
`1980-1983
`1989
`2007
`
`2011-2012
`
`
`Report of Funded and Unfunded Projects
`Funding Information
`
`Past Funded Projects
`
`Sleep Medicine
`American Academy of Sleep Medicine
`International Journal of Sleep and
`Wakefulness
`CNS Drugs
`RLS Scientific Bulletin, Restless Legs
`Syndrome Foundation
`Sleep
`American Psychiatric Association
`
`Williams College
`
`Harvard Graduate School
`National Science Foundation
`National Institute of Mental Health
`American Academy of Sleep Medicine
`
`Biomedical Research Institute, Brigham
`and Women's Hospital
`
`1996-2001
`
`
`
`
`Sleep Academic Award
`NHLBI#HL-96-006 (to BWH)
`Co-PI (with J. Woodrow Weiss MD)
`The major goal of the grant was to plan and institute methods for introduction of courses
`related to sleep medicine into the Harvard Medical School curriculum.
`2000-2007 Circadian Rhythms of Neuropathic Pain
`
`Pfizer Inc. (to BWH)
`
`PI, Investigator Initiated, Total Costs: $114,700
`
`The major goal of the study was to use the forced desynchrony protocol to define the
`independent roles of circadian rhythms and homeostatic drive in diabetic peripheral
`neuropathy pain severity.
`2003-2004 Randomized Double-Blind, Placebo-Controlled Dose-Response Study of the Efficacy
`and Safety of Sumanirole in Patients with Idiopathic Restless Legs Syndrome
`Pharmacia, Phase II trial (to SHC)
`PI, Total Costs: $144,699
`The major goal of the study was to test the efficacy and safety of the dopamine agonist
`sumanirole in the treatment of restless legs syndrome.
`
`
`
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`
`
`2003-2005 A Double-blind Crossover Trial of Levetiracetam (Keppra) and Placebo in the treatment
`of Restless Legs Syndrome
`UCB Pharma (to SHC)
`PI, Investigator initiated, Total Costs: $362,500
`The major goal of the study was to test the efficacy and safety of the levetiracetam in the
`treatment of restless legs syndrome.
`2004-2005 A Randomized, Double-blind, Placebo- controlled, Parallel Group Clinical Trial
`Comparing Fixed Doses of 0.25 mg, 0.50 mg, and 0.75 mg Pramipexole (Mirapex)
`Administered Orally to Investigate the Safety and Efficacy in Patients with Idiopathic
`Restless Legs Syndrome for 12 weeks.
`Boehringer Ingelheim Pharmaceuticals Inc., Phase III trial (to SHC)
`PI, National Coordinating Investigator, Total Costs: $55,984
`The major goal of the study was to test the efficacy and safety of the dopamine agonist
`pramipexole in the treatment of restless legs syndrome.
`2004-2005 A 12 week, Double-blind, Placebo-controlled, Twice Daily Dosing Study to Assess the
`Efficacy and Safety of Ropinirole in Patients Suffering from Restless Legs Syndrome
`Requiring Extended Treatment Coverage.
`GlaxoSmithKline, Phase IV trial (to SHC)
`PI, Total Costs: $147,969
`The major goal of the study was to test the efficacy and safety of the dopamine agonist
`ropinirole in the treatment of restless legs syndrome.
`A 12 Week, Double-blind, Placebo-controlled Study to Asses the Tolerability, Efficacy,
`and Safety of Ropinirole Dosed PRN in Subjects with Restless Legs Syndrome who
`Respond to Open-Label Treatment with Ropinirole
`GlaxoSmithKline, Phase IV trial (to SHC)
`PI, Total Costs: $15,290
`The major goal of the study was to test the efficacy and safety of the dopamine agonist
`ropinirole in the treatment of patients with intermittent restless legs syndrome.
`2005-2006 A Multi-Center, Randomized, Double Blind, Placebo-Controlled, Five Arm Parallel
`Group Trial to Investigate the Efficacy and Safety of Four Different Transdermal Doses
`of Rotigotine in Subjects with Idiopathic Restless Legs Syndrome
`Schwarz Biosciences, Phase II trial (to SHC)
`PI, Total Costs: $177,133
`The major goal of the study was to test the efficacy and safety of the dopamine agonist
`rotigotine in the treatment of restless legs syndrome.
`2006-2007 A 12-Week, Multi-Center, Double-blind, Placebo-Controlled, Parallel Group Flexible
`Dose Polysomnography Study of Ropinirole Controlled Release for Restless Legs
`Syndrome
`GlaxoSmithKline, Phase II trial (to SHC)
`PI, Total Costs: $45,307
`The major goal of the study was to test the efficacy, effects on polysomnography, and
`safety of the dopamine agonist ropinirole in the treatment of restless legs syndrome.
`2006-2007 A Phase IV Randomized, Double-blind, Active and Placebo Controlled, 6 Week Trial to
`
`2005
`
`
`
`
`
`
`
`
`
`
`
`
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`
`
`
`2005-2008
`
`Investigate the Efficacy and Safety of a Starting (and Fixed) Dose of .25 mg
`Pramipexole (Mirapex) in Patients with Idiopathic Restless Legs Syndrome
`Boehringer Inhelheim Pharmaceuticals, Phase IV trial (to SHC)
`PI, National Coordinating Investigator, Total Costs: $57,529
`The major goal of the study was to test the efficacy and safety of the dopamine agonist
`pramipexole in the treatment of restless legs syndrome.
`The Effects of Eszopiclone Treatment (3 mg for two months) to Counteract the Adverse
`Metabolic Consequences of Primary Insomnia
`Sepracor (to BWH)
`PI, Investigator Initiated, Total Costs: $506,610
`The major goal of the study was to test the relationship of two-month treatment response
`to eszopiclone or placebo to changes in glucose tolerance as assessed by IVGTT. The
`secondary aim was to test whether there were identifiable changes in brain transmitters
`and metabolites as assessed by magnetic resonance spectroscopy or in hippocampal
`morphology as assessed by MRI in patients with primary insomnia.
`2009 - 2010 A Polysomnography Study of GSK 1838262 (XP13512) Extended Release Tablets
`Versus Placebo in the Treatment of Restless Legs Syndrome (RLS) and Associated
`Sleep Disturbance
`GlaxoSmithKline (to SHC)
`PI, Total Costs: $290,392
`
`
`
`
`
`
`
`
`
`
`
`The major goal of this study was to test the efficacy and safety of XP13512 in the
`treatment of restless legs syndrome
`2011-2012 A Randomized, Double-blind, Placebo-controlled, Parallel Group Study to Determine
`the Safety and Efficacy of IPX 159 in the Treatment of Moderate to Severe Restless
`Legs Syndrome (RLS)
`Impax Pharmaceuticals (to SHC)
`PI, Total Costs: $80,567
`The major goal of the study was to test the efficacy and safety of IPX1159 in the
`treatment of Restless Legs Syndrome
`2012-2013 A Multi-Center, Randomized, Double-Blind, Placebo-Controlled, Parallel Group,
`Polysomnograpy Study to Investigate Safety and Efficacy of Rotigotine Transdermal
`Patch in Patients with Restless Legs Syndrome and End-Stage Renal Disease Requiring
`Hemodialysis
`UCB Pharma (to SHC)
`International Coordinating Investigator, PI, Total Costs: $12,278
`The major goal of the study was to test the efficacy and safety of rotigotine in the
`treatment of restless legs syndrome in ESRD
`2012-2013 A Phase 3B, Double-Blind, Randomized, Placebo-Controlled Study of Rotigotine and its
`Effect on All-Day Functioning and Quality of Life in Subjects with Moderate to Severe
`Idiopathic Restless Legs Syndrome
`UCB Pharma (to SHC)
`PI, Total Costs: $235,497
`The major goal of the study was to test the efficacy and safety of rotigotine in the
`
`
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`2009-2014
`
`
`
`
`
`2013
`
`treatment of restless legs syndrome
`Thalamic and Anterior Cingulate Cortex GABA and Glutamate in Restless Legs
`Syndrome: A 1-HMRS study
`GSK (to SHC)
`PI, Investigator Initiated, Total Direct Costs: $222,500
`The major goal of this study is to determine if abnormalities exist in RLS in levels of the
`major inhibitory and excitatory neurotransmitters in key pain modulating pathways.
`Butrans for Treatment of Restless Legs Syndrome
`Purdue (to MGH)
`PI, Investigator initiated, Total Costs (terminated study): $18,421
`The major goal of the study was to test the efficacy and safety of butrans in the treatment
`of restless legs syndrome
`
`
`Past Unfunded Projects
`2009-2011 A 1H-MRS Study of Altered Regional Brain GABA in Insomnia
`
`PI, Investigator Initiated
`
`The major goal of the study was to test whether there were identifiable changes in brain
`transmitters and metabolites as assessed by magnetic resonance spectroscopy or in voxel-
`based morphology/diffusion tensor imaging as assessed by MRI in patients with primary
`insomnia and major depressive disorder.
`Current funded projects
`2012-2017 Cortical GABA in MDD and Primary Insomnia with Magnetic Resonance Spectroscopy
`
`NIMH 1RO1MH095792-01A1 (to MGH)
`
`PI, Total Direct Costs: $1,557,081
`
`The principal objective of this study is to evaluate regional neurochemical alterations in
`primary insomnia and MDD using 1H-MRS in order to determine whether GABA
`abnormalities in MDD are related to insomnia or the mood state.
`Restless Legs Syndrome and Cardiovascular Control
`UCB Pharma, investigator initiated (to BWH)
`PI, Total Direct Costs: $113, 050
`The goal of this study is to determine if patients with restless legs syndrome exhibit
`autonomic dysfunction compared with age-matched health controls.
`A method to switch from oral dopamine agonists to rotigotine in patients with restless
`legs syndrome
`UCB Pharma, investigator initiated (to MGH)
`PI, Total Direct Costs: $186,401
`The goal of this study is to determine the optimal algorithm for switching patients with
`restless legs syndrome from oral dopaminergic agents to transdermal rotigotine.
`Efficacy of the SENSUS Pain Management System in the treatment of RLS: an open-
`label trial
`Neurometrix, Inc., investigator initiated (to MGH)
`PI, Total Direct Costs: $56,935
`The primary objective of this study is to determine whether the SENSUS device is an
`effective and safe treatment for RLS.
`
`
`2012-
`
`
`
`2014-
`
`
`
`2014-
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`Current Unfunded Projects
`
`2007 -
`Genetic Associations of Restless Legs Syndrome and Periodic Limb Movements of Sleep
`
`PI, Investigator Initiated
`
`The major goal of this study is to determine if there are genotypic determinants of
`phenotypic variations in restless legs syndrome.
`A Randomized, Double-Blind, Placebo-Controlled, Parallel Group Study to Determine the
`Efficacy and Safety of Topiramate in the Treatment of Sleep Related Eating Disorder
`(SRED)
`PI, Investigator Initiated
`The major goal of the study is to test the efficacy and safety of topiramate in the treatment
`of sleep-related eating disorder.
`
`
`2008-
`
`
`
`
`
`
`Report of Local Teaching and Training
`Teaching of Students in Courses
`1986-1987
`Psychobiology
`Harvard undergraduates
`
`1994-1999 Mental Status Examination
`2nd year medical students
`
`Harvard University, Faculty of Arts and
`Sciences, 18 lectures
`
`Harvard Medical School
`2 hrs contact/yr
`
`Formal Teaching of Residents, Clinical Fellows and Research Fellows (post-docs)
`No presentations below were sponsored by outside entities
`
`
`1991-1995
`
`
`1996
`
`
`1994
`
`
`1996
`
`1996-
`present
`
`Sleep Disorders
`Psychiatry residents
`Sleep Disorders
`Psychiatry residents
`Sleep Disorders in Primary Care
`Primary Care residents
`Sleep Disorders
`Internal Medicine residents
`Psychiatric Aspects of Sleep Disorders
`Psychiatry residents, Medical psychiatry
`fellows
`Sleep Disorders in Women
`1997
`Internal Medicine residents
`
`Insomnia in Primary Care
`1997-2005
`Primary Care residents
`
`Sleep Disorders and Chronic Pain
`1997
`Pain fellows
`
`1998-2007 Neuropsychiatry of Sleep Disorders
`Psychiatry residents
`
`Psychopharmacology of Sleep Disorders
`
`McLean Hospital
`One hour lecture
`Brigham and Women’s Hospital
`One hour lecture
`Massachusetts General Hospital
`One hour lecture
`Brigham and Women’s Hospital
`One hour lecture
`Harvard-Longwood Psychiatry Residency
`
`Brigham and Women’s Hospital
`One hour lecture
`Brigham and Women’s Hospital
`One hour lecture
`Brigham and Women’s Hospital
`One hour lecture
`Massachusetts General Hospital/McLean
`hospital Psychiatry Residency
`One hour lecture
`Massachusetts General Hospital
`
`
`1998-2007
`
`
`
`
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`
`2003-2005
`
`2003-2013
`
`
`2009-
`present
`
`
`
`1997-2013
`
`Psychiatry residents
`Insomnia
`Neurology fellows
`Psychiatric Medications and Illness: Effects
`on Sleep; Sleep related Movement
`Disorders, Psychopharmacology of
`Insomnia
`BWH Sleep fellows
`
`2003-2005 Non-Respiratory Sleep Disorders
`Harvard Pulmonary Critical Care Fellows
`
`Advances in RLS Treatment, Medication
`Effects on Sleep, Psychiatric Sleep
`Medicine
`Sleep Medicine fellows
`Neurobiology of Sleep,
`2013-
`Psychopharmacology of Sleep Disorders,
`present
`Psychiatry residents
`
`
`
`Clinical Supervisory and Training Responsibilities
`1992-1996 McLean Hospital sleep clinic and sleep
`laboratory, Psychiatry residents
`Brigham and Women’s Hospital sleep clinic
`and sleep laboratory, Sleep fellows
`Massachusetts General Hospital sleep
`clinic, Brigham and Women's Hospital
`Internal Medicine/Primary care residents
`
`One hour lecture
`Brigham and Women’s Hospital
`One hour lecture
`Brigham and Women’s Hospital
`Three One hour lectures
`
`Three one hour lectures
`Brigham and Women’s Hospital,
`Massachusetts General Hosptial
`One hour lecture
`Beth Israel Deaconess Hospital,
`Three one hour lectures
`
`Massachusetts General Hospital
`
`Nine one-hour lectures
`
`
`4 hours per week
`
`2-4 fellows per year, 4-6 hours per week
`
`1 resident per week, 20 weeks per year, 4-8
`hours per week each
`
`2013-present
`
`
`
`
`Formally Supervised Trainees and Faculty
`1997-1998 David Slamowitz, MD/private practice sleep medicine, Denver CO
`Clinical supervision resulting in independent clinical sleep laboratory and practice
`Robert Fogel, MD/Merck Pharmaceuticals
`1998-2000
`Clinical and academic supervision resulting in 3 chapters
`
`Chang-Kook Yang, MD/ Department of Psychiatry, University or Busan, Korea
`2004-2006
`Research supervision resulting in the publication of 6 manuscripts/chapters
`
`2008-2010 David Plante, MD/ Assistant Professor in Psychiatry, University of Wisconsin, Madison
`Research supervision resulting in the publication of 9 manuscripts/chapters and 1 edited
`book; Livingston Award from Department of Psychiatry, Massachusetts General Hospital;
`American Sleep Medicine Foundation fellowship, American Academy of Sleep Medicine
`2011-2012 Wei-Chin Lin, MD / Taipei Veterans General Hospital, Taipei, Taiwan
`Research supervision resulting in the publication of 1 manuscript and 2 in preparation
`Sayaka Aritake-Okada, PhD/ Assistant Professor, Sports Psychiatry and Neuroscience
`Lab, Faculty of Sport Sciences, Waseda University, Japan
`Research supervision resulting in publication of 1 manuscript and 2 manuscripts in
`preparation
`
`2011-2013
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`
`Psychiatric Sleep Disorders,
`Narcolepsy, Parasomnias
`
`2011-
`
`
`
`
`1995-1997
`
`1996
`
`
`
`Susan Mackie, MD/ Instructor in Medicine, Brigham and Women’s Hospital
`Research supervision resulting in 3 chapters submitted and one investigator-initiated grant
`
`Formal Teaching of Peers (e.g., CME and other continuing education courses)
`No presentations below were sponsored by outside entities.
`Geriatric Psychiatry Massachusetts General Hospital,
`
`1994
`Sleep and Insomnia in the
`Elderly
`Harvard Medical School
`
`1995
`Restless Legs Syndrome in
`Brigham and Women’s Hospital,
`ESRD
`Harvard Medical School
`Review of Sleep Disorders
`McLean Hospital, Harvard
`Medical School
`Brigham and Women’s Hospital,
`Harvard Medical School
`
`Renal Dialysis
`
`Psychiatry
`
`Diagnosis and
`Treatment of Sleep
`Disorders
`Psychopharmacology Massachusetts General Hospital,
`Harvard Medical School
`
`Psychopharmacology of
`Sleep Disorders
`
`1996-1997,
`2000-2006,
`2013-2014
`1996, 2002 Differential Diagnosis and
`Treatment of Insomnia,
`Depressive disorders
`Sleep Disorders
`
`1997, 2003
`
`2000
`
`Sleep Disorders
`
`2000, 2003
`
`Sleep Medicine
`
`Primary Medicine
`Today
`
`Office Practice of
`Primary Medicine
`Primary Care for
`Subspecialists
`Intensive Review of
`Neurology
`Pri-Med
`
`Pri-Med, Harvard Medical
`School, San Jose, CA
`
`Pri-Med, Harvard Medical
`School
`Brigham and Women’s Hospital,
`Harvard Medical School
`Brigham and Women’s Hospital,
`Harvard Medical School
`Harvard Medical School,
`Chicago, IL
`Brigham and Women’s Hospital,
`Harvard Medical School
`
`Harvard Medical School
`McLean Hospital, Harvard
`Medical School
`Brigham and Women’s Hospital,
`Harvard Medical School
`
`Brigham and Women’s Hospital,
`Harvard Medical School
`
`Harvard Medical School
`Massachusetts General Hospital,
`Harvard Medical School
`
`2003
`
`2003-2010
`
`2004
`2004-2008,
`2010-2015
`2002-2006,
`2009
`
`2006-2010
`
`2006
`2007
`
`2010-2015
`
`Major Depression, Excessive
`Daytime Sleepiness
`Sleep Disorders
`
`Update in General
`Internal Medicine for
`Sub-specialists
`Major Depression, Insomnia Pri-Med
`Psychiatry
`Sleep Disorders for
`Psychiatrists
`Sleep Disorders
`
`Primary Care Internal
`Medicine, Principles
`and Practice
`Office Practice of
`Primary Care
`Medicine
`Insomnia and Its Treatments Pri-Med
`Sleep Disorders and Anxiety Anxiety Disorders:
`Cognitive Behavioral
`Therapy and
`Pharmacotherapy
`Treatment Approaches
`Psychopharmacology: Massachusetts Mental Health
`
`Sleep Disorders
`
`Treatment of Sleep
`
`PAR1004
`IPR of U.S. Patent No. 8,772,306
`Page 11 of 31
`
`

`
`2011
`
`2011
`
`2011
`
`2014
`
`2014
`
`Disorders
`
`A Master Class
`
`Assessment and Treatment
`of Insomnia in Depressed
`Patients
`Sleep disorders
`
`Difficult to Treat
`Depression
`
`Lifestyle Medicine
`
`Center/Beth Israel Deaconess
`Medical Center, Harvard Medical
`School
`Massachusetts General Hospital
`Psychiatry Academy, Harvard
`Medical School
`Harvard Medical School
`
`Persistent insomnia in
`treated Major Depression:
`sleep disorder or mood
`disorder?
`
`Insomnia and Major
`Depression
`Periodic Limb Movements
`of Sleep and Restless Legs
`Syndrome
`
`Difficult to Treat
`Depression
`
`Psychiatry Academy,
`Massachusetts General Hospital
`
`Depression, Anxiety
`and Stress in 2014
`Sleep! – A CME
`Course for Physicians
`
`McLean Hospital, Harvard
`Medical School
`Harvard Medical School
`
`Psychiatry Grand Rounds Beth
`Israel Deaconess Hospital,
`Boston, MA
`Psychiatry Grand Rounds,
`Massachusetts General Hospital
`McLean Hospital Grand Rounds
`Psychiatry Grand Rounds
`Brockton Veterans Association
`Hospital, Brockton, MA
`Behavioral Neurology Grand
`Rounds, Brigham and Women’s
`Hospital
`Pulmonary Grand Rounds,
`Massachusetts General Hospital
`Psychopharmacology Grand
`Rounds, McLean Hospital
`Psychiatry Grand Rounds,
`Brigham and Women’s Hospital
`Renal Grand Rounds, Brigham
`and Women’s Hospital
`Sleep Medicine Grand Rounds,
`Brigham and Women’s Hospital
`Psychiatry Grand Rounds,
`Cambridge Hospital, Cambridge
`
`
`Local Invited Presentations
`No presentations below were sponsored by outside entities.
`
`1991
`Sleep Disorders
`
`Differential Diagnosis of Insomnia
`
`New Directions in Sleep Disorders
`Review of Sleep Disorders
`
`Restless Legs Syndrome
`
`Sleep Disorders: Beyond Sleep Apnea
`
`Antidepressants and Sleep
`
`Sleep Related Eating Disorder
`
`Sleep Disorders in Renal Failure
`
`Restless Legs Syndrome
`
`Sleep in the Psychiatric Patient
`
`
`
`1992
`
`1993
`1994
`
`1995
`
`1996
`
`1996
`
`1997
`
`1997
`
`1997
`
`1997
`
`
`
`PAR1004
`IPR of U.S. Patent No. 8,772,306
`Page 12 of 31
`
`

`
`1997
`1997
`
`1998
`
`1998
`
`1998
`
`1999
`
`2000
`
`2002
`
`2002
`
`2003
`2003
`
`2004
`
`2005
`2006
`2006
`
`2007
`
`2007
`
`2008
`
`2009
`
`2010
`
`2011
`
`2011
`
`2012
`
`2013
`
`Sleep Disorders
`Differential Diagnosis of Sleep Disorders in the
`Psychiatric Patient
`Sleep Disorders in Psychiatric Patients
`
`Sleep in the Psychiatric Patient
`
`A Case of Restless Legs Syndrome and Sprue
`
`Sleep Disorders
`
`Sleep Related Eating Disorder
`
`Sleep Disturbance in Diabetes
`
`Insomnia Diagnosis and Treatment
`
`Excessive Daytime Sleepiness
`Psychopharmacology of Sleep Disorders
`
`Differential Diagnosis and Treatment of Insomnia
`
`Advances in Restless Legs Syndrome
`Psychopharmacology of Sleep Disorders
`Parasomnias
`
`Differential Diagnosis and Treatment of Insomnia
`
`Insomnia
`
`Sleep Disorders
`
`Epidemiology, Diagnosis, and Correlates of RLS
`
`What We Can Learn about Depressive disorders from
`the Study of Insomnia
`RLS in Adults and Children
`
`Sleep Disorders in College Students
`
`Sleep Medicine for Psychiatrists
`
`Sleep Medicine for Psychiatrists
`
`MA
`McLean Hospital Grand Rounds
`Psychopharmacology Grand
`Rounds, McLean Hospital
`Massachusetts Mental Health
`Center Grand Rounds, Boston,
`MA
`Department of Psychiatry Grand
`Rounds, Cambridge Hospital
`Medicine Grand Rounds,
`Brigham and Women’s Hospital
`Rheumatology Grand Rounds,
`Brigham and Women’s Hospital
`Endocrinology Grand Rounds,
`Brigham and Women’s Hospital
`Joslin Diabetes Center Grand
`Rounds, Boston MA
`Psychiatry Grand Rounds,
`Massachusetts General Hospital
`McLean Hospital Grand Rounds
`Psychopharmacology Grand
`Rounds, Cambridge Hospital
`Psychiatry Grand Rounds, Beth
`Israel Deaconess Hospital
`McLean Hospital Grand Rounds
`McLean Hospital Grand Rounds
`Medicine Grand Rounds,
`Faulkner Hospital, Jamaica Plain,
`MA
`Psychiatry Grand Rounds, Mt.
`Auburn Hospital, Cambridge MA
`Partners Physician Day, Boston
`MA
`Internal Medicine Grand Rounds,
`Mt. Auburn Hospital
`Sleep Medicine Grand Rounds,
`Brigham and Women’s Hospital
`Psychiatry Grand Rounds,
`Massachusetts General Hospital
`Sleep Medicine Grand Rounds,
`Children's Hospital
`Mental Health Grand Rounds,
`Harvard University Health
`Service
`Psychiatry Grand Rounds,
`Massachusetts General Hospital
`Psychiatry Grand Rounds, St
`Elizabeth's Hospital, Brighton,
`
`PAR1004
`IPR of U.S. Patent No. 8,772,306
`Page 13 of 31
`
`

`
`Psychiatric Sleep Medicine
`
`Sleep Disorders in the Oncology Context
`
`Sleep Disorders in Palliative Care
`
`Multimodal Imaging in Insomnia and Restless Legs
`Syndrome
`
`MA
`Psychiatry Grand Rounds, Mt.
`Auburn Hospital, Cambridge, MA
`Mental Health Grand Rounds,
`Dana Farber Cancer Institute
`Palliative Care Grand Rounds,
`Massachusetts General Hospital
`McLean Imaging Center speaker
`series, McLean Hospital
`
`Sleep Disorders
`
`
`Report of Regional, National and International Invited Teaching and
`Presentations
`Invited Presentations and Courses
`Regional
`Those presentations below sponsored by outside entities are so noted and the sponsor is identified in
`parentheses.
`
`1992
`
`Psychiatry Grand Rounds, Lahey Clinic,
`Tufts University School of Medicine,
`Burlington MA
`Massachusetts Psychiatric Society, Fall
`Scientific Program, Newton, MA
`Psychiatry Grand Rounds, St. Elizabeth’s
`Hospital, Tufts University School of
`Medicine
`Psychiatry Grand Rounds, Boston Veterans
`Administration Hospital, Boston University
`School of Medicine & Harvard Medical
`School, Boston, MA
`Sleep Disorders in Psychiatric Perspective Boston University School of Medicine,
`University Hospital Grand Rounds, Boston
`MA
`Massachusetts Institute of Technology
`Health Service, Grand Rounds, Cambridge
`MA
`Solomon Carter Fuller Hospital Grand
`Rounds, Boston University School of
`Medicine, Boston, MA
`Medicine Grand Rounds, Central Maine
`Medical Center, Portland, ME (Eli Lilly)
`Bedford Veterans Association Hospital
`Grand Rounds, Boston University School of
`Medicine, Bedford, MA (Eli Lilly)
`Carney Hospital Medical Grand Rounds,
`Tufts University School of Medicine,
`Dorchester, MA
`Nutrition Grand Rounds, New England
`
`The Treatment of Sleep Disorders
`
`Sleep Disorders
`
`Differential Diagnosis of Insomnia
`
`Sleep Related Eating Disorder
`
`Sleep Disorders,
`
`Differential Diagnosis and Treatment of
`Insomnia
`Psychopharmacology of Sleep Disorders
`
`Sleep Disorders
`
`Sleep Related Eating Disorder
`
`2013
`
`2013
`
`2013
`
`2015
`
`
`
`1992
`
`1993
`
`1994
`
`1994
`
`1995
`
`1998
`
`1999
`
`1999
`
`2000
`
`2001
`
`
`
`PAR1004
`IPR of U.S. Patent No. 8,772,306
`Page 14 of 31
`
`

`
`Medical Center, Tufts University School of
`Medicine, Boston, MA
`Internal Medicine Grand Rounds, Shattuck
`Hospital, Boston, MA
`
`Evaluation and Management of Excessive
`Daytime Sleepiness in the Psychiatric
`Patient
`Sleep Disorders
`
`Insomnia in the Psychiatric Patient
`
`Restless Legs Syndrome
`
`Mood Disorders and Sleep
`
`Sleep Disorders
`
`Sleep Disorders
`
`Sleep Disorders
`
`Sleep and its Relationship to Psychiatric
`Disorders
`
`Advances in Restless Legs Syndrome
`
`Restless Legs Syndrome
`
`Baystate Medical Center Grand Rounds,
`Springfield, MA
`Massachusetts Psychiatric Society, Annual
`Psychopharmacology Conference
`Medicine Grand Rounds, Faulkner Hospital,
`Tufts University School of Medicine,
`Jamaica Plain, MA
`Sleep Disorders and the Psychiatric Patient Psychiatry Grand Rounds, Boston
`University School of Medicine, Boston
`Medical Center, Boston, MA
`Psychiatry Grand Rounds, St. Elizabeth’s
`Hospital, Boston, MA
`Psychiatry Grand Rounds, Shattuck
`Hospital, Boston, MA
`Restless Legs Syndrome for the Psychiatrist Psychiatry Grand Rounds, St. Elizabeth’s
`Hospital, Boston, MA (Boehringer-
`Ingelheim)
`Annual Peter Mencher Memorial Grand
`Rounds, Department of Medicine,
`Winchester Hospital, Winchester, MA
`Internal Medicine Grand Rounds, Lahey
`Clinic, Burlington, MA
`Keynote speaker, American Psychiatric
`Nursing Association annual meeting,
`Cambridge, MA
`Psychiatry Grand Rounds, Tufts Medical
`Center, Boston, MA
`Medicine Grand Rounds, New England
`Baptist Hospital, Boston, MA
`Psychiatry Grand Rounds, North Shore
`Medical Center, Salem MA
`Medicine Grand Rounds, Lowell General
`Hospital, Lowell, MA
`Neurology Grand Rounds, Boston
`University School of Medicine, Boston, MA
`Mini-residency in Dental Sleep Medicine,
`Tufts University Boston, MA
`Massachusetts Sleep Society, Newton, MA
`
`What the psychiatrist