Sam Pleasure | UCSF Medical Center
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`https://www.ucsfhealth.org/cgi-bin/expertDetail.cgi?doctorid=26957
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`Home > Doctors > Sam Pleasure
`
`Sam Pleasure, Ph.D., M.D.
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`Neurologist and epilepsy specialist
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`Dr. Samuel J. Pleasure is a neurologist and neuroscientist specializing in the care of epilepsy patients. In his research, he studies how early brain
`development is disturbed leading to structural brain lesions that cause epilepsy in many patients. He has published numerous scientific papers in
`this area and serves as an ad hoc reviewer for many scientific journals. Pleasure earned his medical degree and doctorate in neuroscience from
`the University of Pennsylvania. At UCSF, he completed a residency in neurology and served as chief resident for one year, followed by a research
`fellowship in neuroscience. Pleasure joined the faculty at UCSF as assistant professor in residence and the Robert and Elinor Aird Endowed Chair
`of Neurology in 2000. He is a member of the American Neurological Association, the American Academy of Neurology, American Epilepsy Society,
`Society for Neuroscience, Society for Developmental Biology and Cajal Club. He is a John Merck Scholar in the Biology of Developmental
`Disabilities in Children and is board certified by the American Board of Psychiatry and Neurology.
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`Clinics
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`Multiple Sclerosis Center
`1500 Owens St., Suite 320
`San Francisco, CA 94158
`Phone: (415) 353-2069
`Fax: (415) 353-2633
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`Hours: Monday to Friday
`7:30 a.m. – 6:00 p.m.
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`Conditions & Treatments
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`Epilepsy
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`More about Sam Pleasure
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`Education
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`University of Pennsylvania School of Medicine 1993
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`Residencies
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`UCSF Medical Center, Neurology 1997
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`Selected Research and Publications
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`Bonney S, Harrison-Uy S, Mishra S, MacPherson AM, Choe Y, Li D, Jaminet SC, Fruttiger M, Pleasure SJ, Siegenthaler JA. Diverse
`Functions of Retinoic Acid in Brain Vascular Development. J Neurosci. 2016 Jul 20; 36(29):7786-801.
`Cocas LA, Fernandez G, Barch M, Doll J, Zamora Diaz I, Pleasure SJ. Cell Type-Specific Circuit Mapping Reveals the Presynaptic
`Connectivity of Developing Cortical Circuits. J Neurosci. 2016 Mar 16; 36(11):3378-90.
`Choe Y, Pleasure SJ, Mira H. Control of Adult Neurogenesis by Short-Range Morphogenic-Signaling Molecules. Cold Spring Harb Perspect
`Biol. 2015; 8(3).
`Choe Y, Huynh T, Pleasure SJ. Epithelial cells supply Sonic Hedgehog to the perinatal dentate gyrus via transport by platelets. Elife. 2015; 4.
`Yabut OR, Fernandez G, Huynh T, Yoon K, Pleasure SJ. Suppressor of Fused Is Critical for Maintenance of Neuronal Progenitor Identity
`during Corticogenesis. Cell Rep. 2015 Sep 29; 12(12):2021-34.
`Yabut O, Pleasure SJ, Yoon K. A Notch above Sonic Hedgehog. Dev Cell. 2015 May 26; 33(4):371-2.
`Choe Y, Huynh T, Pleasure SJ. Migration of oligodendrocyte progenitor cells is controlled by transforming growth factor
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` family proteins
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`Biogen Exhibit 2385
`Coalition v. Biogen
`IPR2015-01993
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`Sam Pleasure | UCSF Medical Center
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`https://www.ucsfhealth.org/cgi-bin/expertDetail.cgi?doctorid=26957
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`during corticogenesis. J Neurosci. 2014 Nov 5; 34(45):14973-83.
`Berberoglu MA, Dong Z, Li G, Zheng J, Trejo Martinez Ldel C, Peng J, Wagle M, Reichholf B, Petritsch C, Li H, Pleasure SJ, Guo S.
`Heterogeneously expressed fezf2 patterns gradient Notch activity in balancing the quiescence, proliferation, and differentiation of adult
`neural stem cells. J Neurosci. 2014 Oct 15; 34(42):13911-23.
`Orosco LA, Ross AP, Cates SL, Scott SE, Wu D, Sohn J, Pleasure D, Pleasure SJ, Adamopoulos IE, Zarbalis KS. Loss of Wdfy3 in mice
`alters cerebral cortical neurogenesis reflecting aspects of the autism pathology. Nat Commun. 2014; 5:4692.
`Cocas L, Pleasure SJ. Wrong place, wrong time: ectopic progenitors cause cortical heterotopias. Nat Neurosci. 2014 Jul; 17(7):894-5.
`Yabut O, Pleasure SJ. The quintessence of quiescence. Neuron. 2014 May 7; 82(3):501-3.
`Choe Y, Zarbalis KS, Pleasure SJ. Neural crest-derived mesenchymal cells require Wnt signaling for their development and drive
`invagination of the telencephalic midline. PLoS One. 2014; 9(2):e86025.
`nchez-Alca
`Yang S, Edman LC, S
`n O, Arenas E.
`n P, Pleasure SJ, Villaescusa JC, Mar
`iz JA, Fritz N, Bonilla S, Hecht J, Uhl
`Cxcl12/Cxcr4 signaling controls the migration and process orientation of A9-A10 dopaminergic neurons. Development. 2013 Nov;
`140(22):4554-64.
`Li G, Pleasure SJ. The development of hippocampal cellular assemblies. Wiley Interdiscip Rev Dev Biol. 2014 Mar-Apr; 3(2):165-77.
`Berger JR, Choi D, Kaminski HJ, Gordon MF, Hurko O, D'Cruz O, Pleasure SJ, Feldman EL. Importance and hurdles to drug discovery for
`neurological disease. Ann Neurol. 2013 Sep; 74(3):441-6.
`jcicki P, Mostowska A, Davidson B,
`Ross AP, Mansilla MA, Choe Y, Helminski S, Sturm R, Maute RL, May SR, Hozyasz KK, W
`Adamopoulos IE, Pleasure SJ, Murray JC, Zarbalis KS. A mutation in mouse Pak1ip1 causes orofacial clefting while human PAK1IP1 maps
`to 6p24 translocation breaking points associated with orofacial clefting. PLoS One. 2013; 8(7):e69333.
`Siegenthaler JA, Choe Y, Patterson KP, Hsieh I, Li D, Jaminet SC, Daneman R, Kume T, Huang EJ, Pleasure SJ. Foxc1 is required by
`pericytes during fetal brain angiogenesis. Biol Open. 2013 Jul 15; 2(7):647-59.
`ndez G, Pleasure SJ. The ventral hippocampus is the embryonic origin for adult neural stem cells in the dentate gyrus.
`Li G, Fang L, Fern
`Neuron. 2013 May 22; 78(4):658-72.
`Choe Y, Kozlova A, Graf D, Pleasure SJ. Bone morphogenic protein signaling is a major determinant of dentate development. J Neurosci.
`2013 Apr 17; 33(16):6766-75.
`Harrison-Uy SJ, Siegenthaler JA, Faedo A, Rubenstein JL, Pleasure SJ. CoupTFI interacts with retinoic acid signaling during cortical
`development. PLoS One. 2013; 8(3):e58219.
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`Publications are derived from MEDLINE/PubMed and provided by UCSF Profiles, a service of the Clinical & Translational Science Institute (CTSI)
`at UCSF. Researchers can make corrections and additions to their publications by logging on to UCSF Profiles.
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