`
`PROTOCOL NUMBER:
`
`109-HV-101
`
`STUDY PHASE:
`
`1
`
`14 Cambridge Center
`Cambridge. MA 02142, USA
`TEL: 1-617-679-2000
`FAX: 1-617-679-3518
`
`5200 Research Place
`San Diego, CA 92122
`TEL: 1-858-401-8500
`FAX: 1-858401-8750
`
`Thames House
`Foundation Park
`Maidenhead. Berkshire SL6 auo
`United Kingdom
`TEL: 44-1628-501000
`FAX: 44-1628-501010
`
`PROTOCOL TITLE:
`
`A Single-Center, Randomized, Blinded, Plaeebo- and
`Active-Controlled Study to Evaluate the QTc Interval
`Prolongation Potential of BG000l2 When Administered to
`Healthy Volunteers
`
`DATE:
`
`29 June 2006
`Version 1
`FINAL
`
`I approve this document in accordance with Biogen lace‘:
`cument policies end procedures.
`
`/ carman Bozlc. vies President. Clinical Tn'a| Drug Safety.
`Dmg safety and Risk Management, Biogen ldee Inc.
`
`°
`
`Date
`
`05 J7/CZ 2/0G_
`
`The information contained herein may not be used. disclosed, or published without the written consent of Biogen Idec Inc.
`I
`
`CONFIDENTIAL
`
`Page 1 of 43
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`281
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`Biogen Exhibit 2308
`Coalition v. Biogen
`IPR2015—01993
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