Cleveland Clinic announces its top 10 medical innovations of the year
`Brie Zeltner, The Plain Dealer By Brie Zeltner, The Plain Dealer
`Follow on Twitter
`on November 03, 2010 at 6:30 AM, updated November 03, 2010 at 10:53 AM
`CLEVELAND, Ohio — A radioactive dye that can detect and
`highlight brain plaques that signal Alzheimer's disease is the
`medical innovation of the year, chosen from more than 90
`candidates by physicians at the Cleveland Clinic.
`
`The top 10 medical innovations for 2011, to be announced
`this morning at the Clinic's eighth annual Innovation
`Summit, includes groundbreaking drugs for cancer, hepatitis
`and multiple sclerosis, as well as technical innovations like
`incision-less bariatric surgery.
`
`The Summit, in its third and final day today, was expected to
`draw more than 1,000 health care leaders from across the
`country to discuss innovations in treating obesity and
`diabetes.
`
`View full size
`The Cleveland Clinic's top 10 medical innovations for 2011 were
`announced today, and include breakthroughs in Alzheimer's diagnosis,
`cancer therapy, and weight loss surgery.
`
`Tracy Boulian, The Plain Dealer
`
`In the spring, more than 60 physicians at the Cleveland Clinic
`nominated innovations they felt would change the face of medicine. Since then, they narrowed the field several times, focusing
`on drugs and devices that could show a significant potential for patient benefit or improved health care delivery, a high
`probability of success and good quality data to support its nomination.
`
`Nominees must have Food and Drug Administration approval, or a great chance of approval by early 2011.
`
`Here are the Top 10:
`
`1. Molecular imaging biomarker for early detection of Alzheimer's Disease: A new brain imaging compound called AV-
`45 will soon make it possible to detect the very earliest stages of the brain damage caused by Alzheimer s, and is expected to
`become the dominant way to diagnose the disease.
`
`2. Targeted T-cell antibody for metastatic melanoma: A new anti-cancer drug, ipilimumab, allows the body s own immune
`system to more effectively fight cancer. It was given priority review by the FDA after it improved the survival rates of patients
`with previously treated advanced melanoma.
`
`3. First cancer vaccine approved by the FDA: Provenge (Sipuleucel-T), the first cancer vaccine to show a survival benefit,
`is a prostate cancer treatment that works by stimulating the immune system. Its April approval means it will likely be available
`for use earlier in the treatment process.
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`Biogen Exhibit 2067
`Coalition v. Biogen
`IPR2015-01993
`
`

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`4. Jupiter Study: Statins for healthy individuals: Through a large international study, researchers have found that
`cholesterol-lowering drugs called statins drastically cut the risk of heart disease and death for people with normal levels of
`cholesterol but elevated levels of inflammation.
`
`5. Hepatitis C protease inhibiting drugs: Two drugs awaiting approval, boceprevir and telaprevir, were developed
`specifically to target the hepatitis C virus and have shown a vast improvement over the cure rates of existing treatments.
`
`6. Telehealth monitoring for individuals with heart failure: An implantable, miniature, permanent monitor that can
`measure and communicate daily pulmonary artery pressure, as well as in-home devices that record and send real-time weight,
`blood pressure and heart rate data are allowing for closer monitoring of costly medical conditions, potentially reducing
`hospitalization.
`
`7. Endoscopic weight-loss procedure: Transoral Gastroplasty (TOGA). An incision-less option for bariatric surgery, TOGA
`uses two flexible endoscopes to pass instruments through the mouth, reducing the size of the stomach to a small pouch.
`
`8. Exhaled nitric oxide (NO) breath analysis for diagnosing asthma: A hand-held diagnostic testing device that allows
`precision and accuracy in diagnosing and managing asthma, the device measures levels of exhaled nitric oxide, a gas produced
`by cells in the lungs during inflammation.
`
`9. Oral disease modifying treatment for multiple sclerosis: Fingolimod, approved this year by the FDA, is the first oral
`treatment available to MS patients, a major breakthrough in treatment that reduced attacks and brain lesions in clinical trials.
`
`10. Capsule endoscopy for diagnosis of pediatric GI disorders: A safe and painless alternative to endoscopic imaging and
`X-rays, the pill-sized capsule takes hundreds of pictures and short video clips of the inside of the digestive tract and transmits
`them to a data recorder during transit.
`
`Go to clevelandclinic.org/innovations for more information on the summit and the Clinic's top 10.
`
`© 2016 cleveland.com. All rights reserved.
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