`on MTP of the liver and hardly causing side effects such as fatty liver by selectively inhibiting
`the MTP in the small intestine. SOLUTION: The ester compound represented by general formula
`(1) [wherein, R<SP>1</SP>and R<SP>2</SP>are each a hydrogen atom or an aryl group or the
`like which may be substituted; X is -COO- or -CON(R<SP>10</SP>)-; R<SP>3</SP>and
`R<SP>4</SP>are each a hydrogen atom, a 1-6C alkyl group, a 1-6C alkoxy group or the like;
`R<SP>5</SP>, R<SP>6</SP>and R<SP>7</SP>are each a hydrogen atom, a 1-6C alkyl group,
`a 1-6C alkoxy group or the like; R<SP>8</SP>and R<SP>9</SP>are the same or different, and
`each a hydrogen atom, a 1-6C alkyl group, -CON(R<SP>18</SP>) (R<SP>19</SP>, -
`COO(R<SP>20</SP>) or the like; ring A, ring B and ring C are the same or different and each
`an aryl ring, a heterocycle residue or the like; Alk<SP>1</SP>and Alk<SP>2</SP>are the same
`or different and each an alkanediyl or the like; and l and m are each 0 or an integer of 1-3), a
`prodrug or a pharmaceutically acceptable salt thereof is provided. ;COPYRIGHT: (C)2004,JPO
`
`
`
`1 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`2 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`3 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`4 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`5 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`6 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`7 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`8 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`9 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`10 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`11 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`12 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`13 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`14 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`15 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`16 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`17 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`18 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`19 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`20 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`21 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`22 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`23 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`24 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`25 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`26 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`27 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`28 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`29 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`30 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`31 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`32 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`33 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`34 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`35 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`36 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`37 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`38 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`39 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`40 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`41 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`42 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`43 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`44 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`45 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`46 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`47 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`48 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`49 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`50 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`51 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`52 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`53 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`54 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`55 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`56 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`57 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`58 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`59 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`60 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`61 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`62 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`63 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`64 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`65 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`66 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`67 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`68 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`69 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`70 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`71 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`72 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`73 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`74 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`75 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`76 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`77 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`78 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`79 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`80 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`81 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`82 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`83 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`84 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`85 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`86 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`87 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`88 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`89 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`90 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`91 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`92 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`93 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`94 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`95 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`96 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`97 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`98 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`99 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`100 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`101 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`102 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`103 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`104 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`105 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`106 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`107 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`108 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`109 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`110 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`111 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`112 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`113 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`114 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`115 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`116 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`117 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`118 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`119 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`120 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`121 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`122 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`123 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`124 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`125 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`126 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`127 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`128 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`129 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`130 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`131 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`132 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`133 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`134 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`135 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`136 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`137 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`138 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`139 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`140 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`141 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`142 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`143 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`144 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`145 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`146 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`147 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`148 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`149 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`150 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`151 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`152 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`153 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`154 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`155 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`156 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`157 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`158 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`159 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`160 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`161 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`162 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`163 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`164 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`165 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`166 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`167 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`168 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`169 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`170 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`171 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`172 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`173 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`174 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`175 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`176 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`177 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`178 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`179 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`180 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`181 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`182 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`183 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`184 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`185 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`186 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`187 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`188 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`189 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`190 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`191 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`192 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`193 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`194 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`195 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`196 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`197 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`198 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`199 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`200 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`201 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`202 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`203 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`204 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`205 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`206 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`207 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`208 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`209 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`210 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`211 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`212 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`213 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`214 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`215 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`216 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`217 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`218 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`219 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`220 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`221 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`222 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`223 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`224 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`225 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`226 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`227 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`228 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`229 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`230 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`231 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`232 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`233 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
`
`
`
`234 of 234
`
`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836