throbber
PROBLEM TO BE SOLVED: To provide a new remedy for hyperlipemia substantially acting
`on MTP of the liver and hardly causing side effects such as fatty liver by selectively inhibiting
`the MTP in the small intestine. SOLUTION: The ester compound represented by general formula
`(1) [wherein, R<SP>1</SP>and R<SP>2</SP>are each a hydrogen atom or an aryl group or the
`like which may be substituted; X is -COO- or -CON(R<SP>10</SP>)-; R<SP>3</SP>and
`R<SP>4</SP>are each a hydrogen atom, a 1-6C alkyl group, a 1-6C alkoxy group or the like;
`R<SP>5</SP>, R<SP>6</SP>and R<SP>7</SP>are each a hydrogen atom, a 1-6C alkyl group,
`a 1-6C alkoxy group or the like; R<SP>8</SP>and R<SP>9</SP>are the same or different, and
`each a hydrogen atom, a 1-6C alkyl group, -CON(R<SP>18</SP>) (R<SP>19</SP>, -
`COO(R<SP>20</SP>) or the like; ring A, ring B and ring C are the same or different and each
`an aryl ring, a heterocycle residue or the like; Alk<SP>1</SP>and Alk<SP>2</SP>are the same
`or different and each an alkanediyl or the like; and l and m are each 0 or an integer of 1-3), a
`prodrug or a pharmaceutically acceptable salt thereof is provided. ;COPYRIGHT: (C)2004,JPO
`
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`IPR2015-01836
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`IPR2015-01836
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`IPR2015-01836
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`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836
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`PENN EX. 2260
`CFAD V. UPENN
`IPR2015-01836

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