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`AGENT ENHANCING UPID-LOEWRING EFFECT
`
`Page I of I
`
`Inventor:
`
`Publication number: W02005051382
`2005-06-09
`Publication date:
`MORITANI HIROSHI (JP); SUGA AKIRA (JP); MIURA
`MASANORI (JP); KUBOTA HIDEKI (JP); SASUGA
`OAISUKE (JP)
`YAMANOUCHI PHARMA CO LTD (JP); MORITANI
`HIROSHI (JP); SUGA AKIRA (JP); MIURA MASANORI
`(JP); KUBOTA HIDEKI (JP); SASUGA DAISUKE (JP)
`
`Applicant:
`
`Cited documents:
`
`I JP2002155080
`
`W00071502
`JP10036349
`"'""
`JP8225526
`-
`_ JP2002155083
`more>>
`
`Classification:
`- International:
`
`A61K31/366; A61K31/40; A61K31/403; A61K311437;
`A61K31/438; C07D405110; C07D471/04; A61K31/366;
`A61K31/40; A61K31/403; A61K31/4353; A61K31/438;
`C07D405/00; C07D471/00; (IPC1-7): A61K31/438;
`C07D405/10; C070471/04; C07D519/00; A61K31/403;
`A61K31/366; A61K31/40; A61K31/437; A61K45/00
`A61K31/366; A61K31/40; A61K31/403; A61K31/437;
`A61K31/438; C070405/10; C07D471/04
`Application number: W02004JP17899 20041125
`Priority number(s): JP20030398273 20031128
`
`- European:
`
`Report a data error here
`
`Abstract of W02005051382
`It is intended to provide a drug which has an excellent effect of inhibiting the secretion of apoB-related
`lipoproteins and enhances the lipid-lowering effect of another lipid-lowering agent, i.e., an agent
`enhancing lipid-lowering effect. It is found out that a derivative having tetrahydropyran represented by the
`following general formula (I): (I) wherein each symbol is as defined in the description; has a potent activity
`of inhibiting the secretion of apoB-related lipoproteins and can enhance the lipid-lowering effect of another
`lipid-lowering agent, when used together with such an agent. When used together with another lipid(cid:173)
`lowering agent, the above drug ls useful as an agent enhancing lipid-lowering effect for familial
`hypercholesterolemia and a remedy for intractable hyperlipemia with the coincidence of diabetes.
`
`Data supplied from the esp@cenet database - Worldwide
`
`http://v3.espacenet.com/textdoc?DB=EPODOC&JDX=W02005051382&F=O
`
`10114/2007
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`(54) Title: AGl:.'NT ENHANCING LIPID-LOEWRJNG EFFECT
`
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`(57) Abstract: It is intended to provide a drug which has an exc:ellent effect of
`inhibiting the seeretion ofapoB-related lipoproteins and enhances the lipid-low(cid:173)
`ering effect of another lipid-lowering agent, i.e., an agent enhancing lipid-low(cid:173)
`ering effect. It is found out that a derivative having tetrahydropynm represented
`by the following general fonnula (I): (I) wherein each s)tmbol i~ as defined in
`the description; has a potent activity of inhibiting the secretion of apoB-relaled
`lipoproteins and can enhance the lipid-lowering effect of.aoother lipid-lowering
`agent, when used together with such an agenL When used together with another
`lipid-lowering agent. the above drug is useful as an agent Cnhancing lipid-lower(cid:173)
`ing effect for familial hypercholesterolemia and a remedy for intractable h~
`lipemia with the coincidence of diabetes.
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`PENN EX. 2172
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`WO 2005/051382
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`PENN EX. 2172
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`PENN EX. 2172
`CFAD V. UPENN
`IPR2015-01836
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`

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`WO 2005/051382
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`10 of 46
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`PENN EX. 2172
`CFAD V. UPENN
`IPR2015-01836
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`

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`WO 2005/051382
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`PENN EX. 2172
`CFAD V. UPENN
`IPR2015-01836
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`WO 2005/051382
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`PENN EX. 2172
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`WO .2005/051382
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`PENN EX. 2172
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`WO 2005/051382
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`PENN EX. 2172
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`PENN EX. 2172
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`PENN EX. 2172
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`PENN EX. 2172
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`WO 2005/051382
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