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`SOLID MEDICINAL PREPARATION IMPROVED IN SOLUBILITY AND STABILITY
`AND PROCESS FOR PRODUCING THE SAME
`
`Inventor:
`
`Publication number: W02006046623
`2006-05-04
`Publication date:
`YAMANE SHOGO (JP); YAMANE HIROFUMI (JP);
`SUNAMI MASAKI (JP)
`JAPAN TOBACCO INC (JP); YAMANE SHOGO (JP);.
`YAMANE HIROFUMI (JP); SUNAMI MASAKI (JP)
`
`Applicant:
`
`Classification:
`- international:
`
`A61K47102; A61K9114; A61K9/20; A61K311225;
`A61K45/00; A61K47104; A61K47130; A61K47132;
`A61K47/36; A61K47/38; A61K47/42; A61P3/04;
`A61P3106; A61P3/10; A61P9110; A61P9112;
`A61 P43/00; C07C237130; A61 K9/14; A61 K9/20;
`A61K31/21; A61K45/00; A61K47/02; A61K47/30;
`A61K47/32; A61K47/36; A61K47/38; A61K47/42;
`A61P3/00; A61P9/00; A61P43/00; C07C237/00;
`A61 K9/16K2; A61 K9/00M18D; A61 K9/16H2;
`A61 K9/16H68; A61 K9/16H6F; A61 K9/16K;
`A61K9/20H6B; A61K9/20H6F2; A61K31/225
`Application number: W02005JP19744 20051020
`Priority number(s): JP20040310254 20041025; US20040631894P
`20041130
`
`- European:
`
`Also published as:
`
`CA2582767 (A 1)
`AU2005297923 (A 1)
`
`I EP1806149 (A1)
`I JP57206612
`
`Cited documents:
`
`JP5097682
`. JP2001172180
`. . JP2003321424
`JP2003509505
`more>>
`
`Report a data error here
`
`Abstract of W02006046623
`A solid medicinal preparation to which improved solubility has been imparted, while maintaining
`preparation stability, by taking a formulation contrivance on a sparingly water-soluble chemical substance
`as an active ingredient for the medicine. The solid preparation comprises a sparingly water-soluble
`chemical substance as an active ingredient, a water-soluble polymer, and an inorganic porous substance
`and has improved water solubility. It is characterized in that (1) the sparingly water-soluble chemical
`substance forms a solid dispersion together with the water-soluble polymer, (2) the water-soluble polymer
`as a component of the solid dispersion is in the form of fine pieces, and (3) the fine pieces of the water(cid:173)
`soluble polymer are held on the surface of the inorganic porous substance in the state of being adsorbed
`on and/or adherent to the surface. The solid preparation can be produced by dissolving a sparingly water(cid:173)
`soluble chemical substance as an active ingredient and a water-soluble polymer in an organic solvent,
`mixing the resultant solution with an inorganic porous substance with stirring, subsequently granulating
`the mixture, and then drying the granules.
`
`Data supplied from the esp@cenet database - Worldwide
`
`http://v3.espacenet.com/textdoc?DB=EPODOC&IDX=W02006046623&F=O
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`10/14/2007
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`(54) Title: SOLID MEDICINAL PREPARATION IMPROVED IN SOLUBILITY AND Sf ABILITY AND PROCESS FOR PR():.
`DUCING TIIE SAME
`
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