Curriculum Vitae
`Daniel James Rader, M.D.
`April 2016
`
`Perelman School of Medicine
`University of Pennsylvania
`11-125 Smilow Center for Translational Research
`3400 Civic Center Blvd
`Philadelphia, PA 19104
`Tel: 215/573-4176
`Fax: 215/573-8606
`E-mail address: rader@mail.med.upenn.edu
`
`
`
`
`
`
`Office Address:
`
`
`
`
`
`
`
`Education:
`
`1981
`1984
`
`Lehigh University, (summa cum laude)
`B.A.
`M.D. Medical College of Pennsylvania (summa cum laude)
`
`
`
`Postgraduate Training and Fellowship Appointments:
`
`
`
`
`
`
`
`
`
`Internship, Internal Medicine, Yale-New Haven Hospital, New Haven, CT
`1984-1985
`Residency, Internal Medicine, Yale-New Haven Hospital, New Haven, CT
`1985-1987
`Chief Resident, Internal Medicine, Yale School of Medicine, New Haven, CT
`1987-1988
`1988-1991 Medical Staff Fellow, Molecular Disease Branch, National Heart, Lung, and
`Blood Institute, National Institutes of Health, Bethesda, MD
`
`
`
`
`Academic Appointments:
`
`
`
`
`
`
`
`
`1991-1993
`1994-2000
`2000-2005
`2006-2014
`
`Staff Scientist, Molecular Disease Branch, NHLBI, NIH
`Assistant Professor of Medicine, University of Pennsylvania School of Medicine
`Associate Professor of Medicine, University of Pennsylvania School of Medicine
`Edward S. Cooper, M.D./Norman Roosevelt and Elizabeth Meriwether McLure
`Professor of Medicine
`2006-present Professor of Pharmacology, University of Pennsylvania School of Medicine
`(Secondary)
`2013-present Professor of Medicine in Genetics, University of Pennsylvania School of
`Medicine (Secondary)
`2014-present Seymour Gray Professor of Molecular Medicine, University of Pennsylvania
`School of Medicine
`
`
`Hospital and Administrative Appointments:
`
`1994-present
`
`
`1996-2005
`
`
`1996-1998
`1998-2006
`2002
`
`
`2002-2008
`
`Director, Preventive Cardiovascular Medicine and Lipid Clinic
`University of Pennsylvania Health System
`Associate Program Director, General Clinical Research Center
`University of Pennsylvania School of Medicine
`Institutional Review Board, University of Pennsylvania
`GCRC Advisory Committee, Children’s Hospital of Philadelphia
`Chair, Experimental Therapeutics Theme Group, Strategic Planning
`Initiative, University of Pennsylvania School of Medicine
`Faculty Advisory Committee, Office of Human Research, Univ. Penn
`
`
`
`
`
`
`
`
`
`
`
`
`1 of 66
`
`PENN EX. 2030
`CFAD V. UPENN
`IPR2015-01835
`
`

`
`Daniel J. Rader, M.D.
`
`
`2003-2012
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`2005-present
`
`
`2005-2006
`
`
`2006-2011
`
`
`2007-2014
`
`2008-2014
`
`2009-2014
`
`2011-present
`
`2013-present
`
`2014-present
`
`2016-present
`
`
`Awards and Honors:
`1979
`1983
`1984
`1995
`1996
`1997
`1999
`2000
`2000
`
`
`
`
`
`2002-present
`2002
`2004
`2005
`
`2005
`
`2005
`
`2005
`
`2007
`2007
`2007
`2009
`
`2009
`
`Page 2
`
`Chair, Advisory Committee, Molecular Diagnostics and Genotyping Core,
`University of Pennsylvania School of Medicine
`Associate Director, Institute for Translational Medicine and Therapeutics
`University of Pennsylvania School of Medicine
`Program Director, General Clinical Research Center
`University of Pennsylvania School of Medicine
`Director, Clinical and Translational Research Center
`Perelman School of Medicine at the University of Pennsylvania
`Bridge Funding Program Committee, Perelman School of Medicine at the
`University of Pennsylvania
`Committee on Appointments and Promotions, Department of Medicine,
`Perelman School of Medicine at the University of Pennsylvania
`Scientific Director, Clinical and Translational Research, Cardivascular
`Institute, Perelman School of Medicine at the University of Pennsylvania
`Chief, Division of Translational Medicine and Human Genetics, Department
`of Medicine, Perelman School of Medicine at the University of Pennsylvania
`Director, PennMedicine BioBank, Perelman School of Medicine at the
`University of Pennsylvania
`Chair, Department of Genetics, Pereleman School of Medicine at the
`Univeristy of Pennsylvania
`Chief, Division of Human Genetics, Department of Pediatrics, Children’s
`Hospital of Philadelphia
`
`Phi Beta Kappa
`Alpha Omega Alpha
`Dean's Award, Medical College of Pennsylvania
`WW Smith Charitable Trust Awardee
`Outstanding Faculty Award, Department of Medicine
`Donald B. Martin Outstanding Teacher Award
`Election to American Society of Clinical Investigation (ASCI)
`Established Investigator, American Heart Association
`Burroughs Wellcome Fund Clinical Scientist Award in Translational
`Research
`Annual listing in “Top Doctors of Philadelphia” (Philadelphia Magazine)
`Doris Duke Charitable Foundation Distinguished Clinical Investigator Award
`Chair, Gordon Conference on Lipid and Lipoprotein Metabolism
`Jeffrey M. Hoeg Award
`for Basic Science and Clinical Research,
`Arteriosclerosis, Thrombosis, and Vascular Biology Council of
`the
`American Heart Association
`8th Annual Gill Heart Institute Award for Outstanding Contributions to
`Cardiovascular Research
`William Osler Patient Oriented Research Award, University of Pennsylvania
`School of Medicine
`Bristol Myers Squibb “Freedom to Discover” Unrestricted Cardiovascular
`Research Award
`International Atherosclerosis Society Distinguished Fellow
`Election to Association of American Physicians (AAP)
`Named Associate Editor, Journal of Clinical Investigation (JCI)
`Dewitt Goodman Lecture, Columbia University
`
`Bondy Lecture, Yale University
`
`
`
`
`
`2 of 66
`
`PENN EX. 2030
`CFAD V. UPENN
`IPR2015-01835
`
`

`
`Daniel J. Rader, M.D.
`
`
`MERIT (Merthod to Extend Research in Time) Award from the NIH-NHLBI
`Banting Lecture, University of Toronto
`Election to the Institute of Medicine, now the National Academy of Medicine
`American Heart Association’s Clinical Research Prize
`
`Page 3
`
`2009
`2010
`2011
`2012
`
`National Scientific Committees and Peer Review:
`
`
` National American Heart Association Lipoproteins and Lipid Metabolism Research Study
`Committee, Member, 1990-1994
`American Heart Association Southeastern Pennsylvania Affiliate Grant Review Committee,
`Reviewer, 1995-1997
`Executive Committee, Arteriosclerosis Thrombosis and Vascular Biology Council, American Heart
`Association, 1999-2002
` General Clinical Research Center, Site Visitor on competing renewals, 1997-2005
`
`Program Projects, NHLBI, NIH, Ad hoc reviewer, 1996-present
`
`Program Chair, Arteriosclerosis Thrombosis and Vascular Biology Council, American Heart
`Association Scientific Sessions, November 2001
`Vice-Chair, Gordon Conference on Lipid and Lipoprotein Metabolism, Meriden, New Hampshire,
`June, 2002
`Program Co-chair, AHA ATVB meeting, May 8-10, 2003
`
` Chair, Gordon Conference on Lipid and Lipoprotein Metabolism, Meriden, New Hampshire, June,
`2004
` Chair, Research Committee, American Heart Association Pennsylvania-Delaware Affiliate, 2004-
`2005
`Scientific Advisory Board, Stanley Sarnoff Foundation for Cardiovascular Research, 2001-2008
`Board of External Experts, National Heart Lung and Blood Institute, National Institutes of Health,
`2008-present
`Board, Deuel Conference, 2010-present
`
` Chair, Deuel Conference, 2013
` Co-Chair, Gordon Conference on Atherosclerosis, 2013
` Co-Chair, Familial Hypercholesterolemia Summit, 2014/2015/2016
`
`Editorial and Peer Review Activity:
`
`
`
`
`
`
`
`
`
`
`
`
`
`1999-present Editorial Board, Trends in Molecular Medicine
`2000-present Editorial Board, Arteriosclerosis, Thrombosis, and Vascular Biology
`2001-present Editorial Board, American Journal of Physiology (Endocrinology and Metabolism)
`2002-present Editorial Board, Circulation
`2002-present Editorial Board, Circulation Research
`2005-present Editorial Board, Journal of Lipid Research
`2007-2012
`Associate Editor, Journal of Clinical Investigation
`2012-present Deputy Editor, Arteriosclerosis Thrombosis and Vascular Biology
`Reviewer, American Journal of Cardiology
`Reviewer, Arteriosclerosis, Thrombosis, and Vascular Biology
`Reviewer, Atherosclerosis
`Reviewer, Biochemica Biophysica Acta--Lipid Metabolism
`Reviewer, Cell Metabolism
`Reviewer, Circulation
`Reviewer, Circulation Research
`Reviewer, Clinical Chemistry
`Reviewer, Diabetes
`Reviewer, Diabetes Care
`
`
`
`
`
`3 of 66
`
`PENN EX. 2030
`CFAD V. UPENN
`IPR2015-01835
`
`

`
`Daniel J. Rader, M.D.
`
`
`Page 4
`
`Reviewer, Journal of Clinical Investigation
`Reviewer, Journal of Lipid Research
`Reviewer, Metabolism
`Reviewer, Molecular and Cell Biology
`Reviewer, Nature
`Reviewer, Nature Cell Bioloby
`Reviewer, Nature Genetics
`Reviewer, Nature Medicine
`Reviewer, New England Journal of Medicine
`Reviewer, Proceedings of the National Academy of Sciences
`Reviewer, Science
`Reviewer, Science Translational Medicine
`
`
`Teaching and Education
`
`1.
`2.
`
`3.
`
`4.
`
`5.
`6.
`7.
`
`8.
`
`Outpatient Attending, Preventive Cardiovascular Medicine and Lipid Clinic; 1994-present
`Lecturer, Medical Student Curriculum 2000, Cardiovascular Block, University of Pennsylvania
`School of Medicine; 2-4 lectures per year; 1996-present
`Lecturer, Medical Student Curriculum 2000, Genetics Block, University of Pennsylvania School
`of Medicine; 1 lecture per year; 2009-present
`Unit Coordinator, Molecular Basis of Gene Therapy, CAMB 610; 2 months per year; 1997-
`present
`Lecturer, Introduction to Patient Oriented Research Course, 1999-2006
`Lecturer, Clinical Investigator Toolbox Course, Department of Medicine 2006-present
`Lecturer, CAMB 550/Genetic Principles, University of Pennsylvania School of Medicine, 2015-
`present
`Lecturer, Preventive Cardiology Fellows, University of Pennsylvania School of Medicine, 2009-
`present
`
`
`Active NIH and Foundation Grant Support (not including industry-sponsored research)
`
`
`
`
`
`
`Grant/sponsor
`
`
`
`
`R37 HL055323 (Rader)
`
`
`
`
`NHLBI
`
`
`"HDL Metabolism: Influence of Extracellular Lipases"
`
`
`
`UL1TR 0000003 (FitzGerald)
`
`
`NIH, NHGRI
`
`
`
`"Institutional Clinical and Translational Science Award"
`
`
`
`
`
`
`
`U01 HG006398 (Rader)
`
`
`NIH, NHGRI
`“iPS-derived hepatocytes for interrogation of lipid phenotypes associated with GWAS lipid loci”
`
`R01 HL109489 (Rader)
`
`
`
`
`NIH, NHLBI
`“Interrogation of novel pathways regulating VLDL production and plasma lipids”
`
`
`
`
`
`
`R01 HL111398 (Rader)
`
`NIH, NHLBI
`“Discovery and Validation of Novel Loci Associated with HDL Function”
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`Dates
`04/01/14-03/31/19
`
`
`09/01/06-06/30/16
`
`
`
`
`07/01/11-06/30/16
`
`08/01/11-07/31/16
`
`01/01/12-11/30/16
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`4 of 66
`
`PENN EX. 2030
`CFAD V. UPENN
`IPR2015-01835
`
`

`
`Daniel J. Rader, M.D.
`
`
`
`
`1R01 HL111293 (Gelfand)
`NIH, NHLBI
`“A trial to determine the effect of psoriasis treatment on cardiometabolic disease”
`
`
`R01 HL122843-01A1 (Saleheen/Rader)
`
`NIH/NHLBI
`
`
`
`
`“Molecular mechanisms linking the CXCL12 pathway to atherosclerosis”
`
`P01 HL059407 (Wilson)
`NIH, NHLBI
`
`AAV Gene Therapy for Lipid Disorders
`‘Project 2 – Optimizing Liver-Directed Gene Therapy for Inherited Dyslipidemia (Project Leader:
`Rader)”
`
`10CVD03 (Rader)
`Leducq
`“Molecular Mechanisms of Novel Genes Associated with Plasma Lipids and Cardiovascular Disease”
`
`15GPSGC24470098 (Rader)
`American Heart Association
`“Interrogation of the Plasma Proteome for the Development of New Biomarkers and Therapeutic
`Targets for Cardiovascular Disease”
`
`Selected Lectures by Invitation (since Jan 2005 only)
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`Page 5
`
`02/01/12-01/31/17
`
`02/01/2015-01/31/19
`
`07/01/15 – 06/30/20
`
`
`
`
`
`
`
`
`
`01/01/11-12/31/16
`
`07/01/15-06/30/19
`
`
`2005
`Medical Grand Rounds, Washington University, St. Louis, MO
`Deuel Conference on Lipids, Dana Point, CA
`Research Symposium Keynote Address, Lankenau Hospital, Wynnewood, PA
`Himmelfarb Lectureship, Sinai Hospital of Baltimore, Baltimore, MD
`Keystone Symposium, Whistler, BC
`Cardiology Grand Rounds, Johns Hopkins Hospital, Baltimore, MD
`Endocrine Grand Rounds, Beth Israel Deaconess Medical Center, Boston, MA
`Gordon Research Conference on Atherosclerosis, Meriden, NH
`2nd International Symposium on Triglycerides and HDL” – New York, NY
`Gill Heart Research Day, University of Kentucky, Lexington, KY
`Jefferson Kynett CV Conference – Thomas Jefferson University – Philadelphia, PA
`ACC Cardiovascular Symposium – NYC
`
`
`2006
`Rockefeller University Hospital – NYC
`Cardiology Grand Rounds, New York University Medical School – NYC
`Keystone Symposium – Keystone, CO
`American Diabetes Association Conference – Washington, DC
`Thomas Jefferson University Translational Symposium – Philadelphia, PA
`Temple University Lecture Series – Philadelphia, PA
`Gordon Conference on Lipoprotein Metabolism – Mt Holyoke, MA
`Metabolic Syndrome Symposium – Boston, MA
`National Lipid Association Masters Summit Conference – AHA Scientific Sessions – Chicago, IL
`AHA Scientific Sessions – Chicago, IL
`Cooper University Hospital – Camden, NJ
`
`
`
`
`
`5 of 66
`
`PENN EX. 2030
`CFAD V. UPENN
`IPR2015-01835
`
`

`
`Daniel J. Rader, M.D.
`
`
`Page 6
`
`
`
`2007
`Endocrinology Grand Rounds, Temple University Hospital – Philadelphia, PA
`ACC Scientific Sessions – New Orleans, LA
`Society for Vascular Medicine and Biology Annual Scientific Sessions – Baltimore, MD
`European Lipoprotein Club – Tutzing, Germany
`DALM Meeting – New York, NY
`Cardiology Grand Rounds, Yale University School of Medicine – New Haven, CT
`Gill Heart Institute, University of Kentucky – Lexington, KY
`ACC Cardiovascular Symposium – New York, NY
`
`
`2008
`Cardiology Grand Rounds, Massachusetts General Hospital – Boston, MA
`Albert Einstein College of Medicine – New York, NY
`Temple University School of Medicine – Philadelphia, PA
`Gordon Conference on Lipid and Lipoprotein Metabolism, Waterville Valley, NH
`Tufts Molecular Cardiology Research Institute, Woods Hole, MA
`Ottawa Heart Institute, Ottawa, Ontario
`Cardiology Grand Rounds, Montreal Heart Institute, Montreal, Quebec
`Cardiology Grand Rounds, McGill University, Montreal, Quebec
`Citywide Endocrinology Grand Rounds, University of Toronto, Toronto, Ontario
`Invited speaker, 10th Anniversary Scientific Meeting of the Doris Duke Charitable Foundation
`National Lipid Association, AHA Conference – New Orleans, LA
`
`
`2009
`Cardiology and Internal Medicine Grand Rounds, UT Southwestern, Dallas
`Keynote Speaker, Vanderbilt University Cardiovascular Research Day – Nashville, TN
`Cardiology Grand Rounds, Brigham & Women’s Hospital – Boston, MA
`Cardiology Grand Rounds, Boston Medical Center – Boston, MA
`Cardiometabolic Health Congress – Boston, MA
`Bondy Lecture, Medical Grand Rounds, Yale University – New Haven, CT
`Dewitt Goodman Lecture, Medical Grand Rounds, Columbia University, New York, NY
`
`
`2010
`Children’s Hospital Oakland Research Institute – Oakland, CA
`Cardiology Grand Rounds, Stanford University – Palo Alto, CA
`Drexel University College of Medicine – Philadelphia, PA
`Temple University School of Medicine – Philadelphia, PA
`Keystone Symposium – Banff, Canada
`Deuel Conference on Lipids – Dana Point, CA
`Banting Lecture, University of Toronto – Toronto, Canada
`Gordon Research Conference – Waterville Valley, NH
`Accelerating Proof of Concept Conference – Philadelphia, PA
`Johns Hopkins University – Baltimore, MD
`Cardiometabolic Health Congress – Boston, MA
`AHA Symposium– Chicago, IL
`ACC/NYCVS Symposium – New York, NY
`
`
`2011
`NURSA Meeting – Bethesda, MD
`Medicine Grand Rounds, NYU – New York, NY
`ATVB Meeting – Chicago, IL
`
`
`
`
`
`6 of 66
`
`PENN EX. 2030
`CFAD V. UPENN
`IPR2015-01835
`
`

`
`Page 7
`
`Daniel J. Rader, M.D.
`
`
`BIDMC Cardiology Grand Rounds – Boston, MA
`St. Francis Hospital – Hartford, CT
`HDL Summit – New York, NY
`Gordon Conference – Newport, RI
`Keynote speaker, Karolinska Institute Cardiovascular Retreat
`Cardiology Grand Rounds, University of Massachusetts
`Robert Jeresaty Cardiovascular Symposium, Hartford, CT
`Guest Speaker, Ernst Klenk Symposium in Molecular Medicine – Cologne, Germany
`AHA Symposium– Orlando, FL
`Plenary Speaker, American College of Rheumatology - Chicago, IL
`
`2012
`Keystone Symposium – Santa Fe, NM
`Medicine Grand Rounds, Washington University – St. Louis, MO
`University of Michigan – Ann Arbor, MI
`Nature Colloquium on Human Genetics – Boston, MA
`Scandinavian Atherosclerosis Conference – Denmark
`Medicine Grand Rounds, Columbia University – New York, NY
`Mayo Clinic – Rochester, MN
`ADA Meeting – Philadelphia, PA
`Gordon Conference – Watervalley Hill, NH
`Drexel University College of Medicine - Philadelphia, PA
`AHA Symposium – Los Angeles, CA
`CVRC Symposium – University of Virginia
`Inflammation and Atherosclerosis Symposium – Munich, Germany
`
`2013
`Keystone Symposium – Lake Tahoe, CA
`Deuel Conference – Silverado, Napa, CA
`Cleveland Clinic – Cleveland, OH
`ATVB Meeting – Lake Buena Vista, FL
`NYU Symposium – New York City, NY
`University of Colorado – Denver, CO
`ASGCT 16th Annual Meeting – Salt Lake City, UT
`National Lipid Association Meeting – Las Vegas, NV
`New York Lipid Club Lecture Club – NYC, NY
`Atherosclerosis Gordon Conference – Stowe, VT
`British Atherosclerosis Society Autumn Meeting – Cambridge, UK
`Hartford Hospital CV Symposium – Hartford, CT
`CHOP Symposium – Philadelphia, PA
`CHOP Mid-Atlantic Micro/ncRNA Mini-Symposium – Philadelphia, PA
`IDOM & IFI Joint Symposium – Philadelphia, PA
`
`2014
`Vascular Biology Seminar at Harvard – Boston, MA
`2014 Caskey Lecture, University of South Carolina - Columbia, SC
`Medical University of South Carolina - Charleston, SC
`Deuel Conference - San Diego, CA
`IVB/MHI Symposium – University of North Carolina – Chapel Hill, NC
`AHA Heart Science Forum - Philadelphia, PA
`McGill University – Royal Victoria Hospital – Montreal, Canada
`Gordon Conference – Watervalley Hill, NH
`
`
`
`
`
`7 of 66
`
`PENN EX. 2030
`CFAD V. UPENN
`IPR2015-01835
`
`

`
`Page 8
`
`Daniel J. Rader, M.D.
`
`
`
`2015
`Diabetes and Metabolism Seminar – University of Washington – Seattle, WA
`ISA – Amsterdam, Netherlands
`Keystone Symposia – Copenhagen, Denmark
`John Hopkins CVD Research Retreat – Baltimore, MD
`Cardiac Regeneration Meeting – Venice, Italy
`Mendelian Randomization Conference – Bristol, England
`University of Leicester – Leicester, England
`
`2016
`Cardeza Foundation for Hematologic Research – Philadelphia, PA
`Harvard School of Public Health, Boston MA
`Kroc Lectureship, Univ of Alabama Birmingham
`Yale Endowed Lectureship - New Haven, CT
`Gordon Conference - Waterville Valley, NH
`
`
`Bibliography
`
`Peer-Reviewed Original Scientific Publications
`
`
`3.
`
`4.
`
`6.
`
`1. Sparks CE, Rader DJ, Marsh JB. Metabolism of two forms of apolipoprotein B of VLDL by rat
`liver. J Lipid Res. 1983 Feb;24(2):156-66. PMID: 6833892
`2. Schaeffer JR, Rader DJ, Gregg RE, Fairwell T, Zech LA, Kindt MR, Benson MD, Brewer HB
`Jr. In vivo protein metabolism utilizing stable isotopes and mass spectrometry: a new
`approach to the study of mutant proteins in humans. Trans Assoc Am Physicians.
`1990;103:187-94. PMID: 2132530
`Lohse P, Kindt MR, Rader DJ, Brewer HB Jr. Genetic polymorphism of human plasma
`apolipoprotein A-IV is due to nucleotide substitutions in the apolipoprotein A-IV gene. J Biol
`Chem. 1990 Jun 15;265(17):10061-4. PMID: 2351649
`Lohse P, Kindt MR, Rader DJ, Brewer HB Jr. Human plasma apolipoproteins A-IV-0 and A-
`IV-3: Molecular basis for two rare variants of apolipoprotein A-IV-1. J Biol Chem. 1990 Jul
`25;265(21):12734-9. PMID: 1973689
`5. Charnas LR, Bernardini I, Rader DJ, Hoeg JM, Gahl WA. Clinical and laboratory findings in
`the oculocerebrorenal sydrome of Lowe, with special reference to growth and renal function.
`N Engl J Med. 1991 May 9;324(19):1318-25. PMID: 2017228
`Lohse P, Kindt MR, Rader DJ, Brewer HB Jr. Three genetic variants of human plasma
`apolipoprotein A-IV. J Biol Chem. 1991 Jul 25;266(21):13513-8. PMID: 1677358
`7. Rader DJ, Castro G, Zech LA, Fruchart JC, Brewer HB Jr. Metabolism of apolipoprotein A-I
`in high density lipoprotein particles LpA-I and LpA-I,A-II. J Lipid Res. 1991 Nov;32(11):1849-
`59. PMID: 1770304
`8. Novotny WF, Brown SG, Miletich JP, Rader DJ, Broze GJ Jr. Plasma antigen levels of the
`lipoprotein associated coagulation inhibitor in patient samples. Blood. 1991 Jul 15;78(2):387-
`93. PMID: 2070076
`9. Rader DJ, Gregg RE, Meng MS, Schaefer JR, Zech LA, Benson MD, Brewer HB Jr. In vivo
`metabolism of a mutant apolipoprotein, apoA-IIowa, associated with
`hypoalphalipoproteinemia and hereditary systemic amyloidosis. J Lipid Res. 1992
`May;33(5):755-63. PMID: 1619367
`
`10. Lohse P, Rader DJ, Brewer HB Jr. Heterozygosity for apolipoprotein E-4Philadelphia(Glu13--
`--Lys, Arg145----Cys) is associated with incomplete dominance of type III
`hyperlipoproteinemia. J Biol Chem. 1992 Jul 5;267(19):13642-6. PMID: 1352296
`
`
`
`
`
`8 of 66
`
`PENN EX. 2030
`CFAD V. UPENN
`IPR2015-01835
`
`

`
`Daniel J. Rader, M.D.
`
`
`Page 9
`
`11. Schaefer JR, Rader DJ, Ikewaki K, Fairwell T, Zech LA, Kindt MR, Davignon J, Gregg RE,
`Brewer HB Jr. In vivo metabolism of apolipoprotein A-I in a patient with homozygous familial
`hypercholesterolemia. Arterioscler Thromb. 1992 Jul;12(7):843-8. PMID: 1616910
`12. Mautner SL, Sanchez JA, Rader DJ, Mautner GC, Ferrans VJ, Fredrickson DS, Brewer HB
`Jr, Roberts WC. The heart in Tangier disease: Severe coronary atherosclerosis with near
`absence of high-density lipoprotein cholesterol. Am J Clin Pathol. 1992 Aug;98(2):191-8.
`PMID: 1380771
`13. Reblin T, Rader DJ, Beisiegel U, Greten H, Brewer HB Jr. Correlation of apolipoprotein(a)
`Isoproteins with Lp(a) density and distribution in fasting plasma. Atherosclerosis. 1992
`Jun;94(2-3):223-32. PMID: 1385958
`14. Shibusawa Y, Ito Y, Ikewaki K, Rader DJ, Brewer HB Jr. Counter-current chromatography of
`lipoproteins with a polymer phase system using the cross-axis synchronous coil planet
`centrifuge. J Chromatogr. 1992 Apr 3;596(1):118-22. PMID: 1522174
`15. Weiss JS, Rodrigues M, Kruth HS, Rajagopalan S, Rader DJ, Kachadoorian H. Panstromal
`Schnyder's Corneal Dystrophy. Ultrastructural and histochemical studies. Ophthalmology.
`1992 Jul;99(7):1072-81. PMID: 1495786
`16. Wetterau JR, Aggerbeck LP, Bouma ME, Eisenberg C, Munck A, Hermier M, Schmitz J, Gay
`G, Rader DJ, Gregg RE. Absence of microsomal triglyceride transfer protein in individuals
`with abetalipoproteinemia. Science. 1992 Nov 6;258(5084):999-1001. PMID: 1439810
`17. Benvenga S, Cahnmann HJ, Rader DJ, Kindt M, Robbins J. Thyroxine binding to the
`apolipoproteins of high-density lipoproteins HDL2 and HDL3. Endocrinology. 1992
`Dec;131(6):2805-11. PMID: 1446618
`18. Klein HG, Lohse P, Duverger N, Albers JJ, Rader DJ, Zech LA, Santamarina-Fojo S, Brewer
`HB Jr. Two different allelic mutations in the lecithin:cholesterol acyltransferase (LCAT) gene
`resulting in classic LCAT deficiency: LCAT (tyr83-->stop) and LCAT (tyr156-->asn). J Lipid
`Res. 1993 Jan;34(1):49-58. PMID: 8445342
`19. Rader DJ, Cain W, Zech LA, Usher D, Brewer HB Jr. Variation in Lp(a) concentrations
`among individuals with the same apo(a) isoform is determined by the rate of Lp(a) production.
`J Clin Invest. 1993 Feb;91(2):443-7. PMID: 8432853
`20. Rader DJ, Schaefer JR, Lohse P, Verges B, Kindt M, Zech LA, Steinmetz A, Brewer HB Jr.
`Rapid in vivo transport and catabolism of human apolipoprotein A-IV-1 and slower catabolism
`of the apoA-IV-2 isoprotein. J Clin Invest. 1993 Aug;92(2):1009-17. PMID: 8349786
`21. Wanner C, Rader DJ, Bartens W, Kraemer J, Brewer HB Jr, Schollmeyer P, Wieland H.
`Elevated plasma lipoprotein(a) in patients with the nephrotic syndrome. Ann Intern Med. 1993
`Aug 15;119(4):263-9. PMID: 8328733
`22. Emmerich J, Verges B, Tauveron I, Rader DJ, Santamarina-Fojo S, Schaefer J, Ayault-Jarrier
`M, Thieblot P, Brewer HB Jr. Familial high density lipoprotein deficiency due to marked
`hypercatabolism of normal apolipoprotein A-I. Arterioscler Thromb. 1993 Sep;13(9):1299-306.
`PMID: 8364014
`23. Sharp D, Blinderman L, Combs KA, Kienzle B, Ricci B, Wagner-Smith K, Gil CM, Turck CW,
`Bouma ME, Rader DJ, Aggerbeck LP, Gregg RE, Gordon DA, Wetterau JR. Cloning and
`gene defects in microsomal triglyceride transfer protein associated with abetalipoproteinemia.
`Nature. 1993 Sep 2;365(6441):65-9. PMID: 8361539
`24. Rader DJ, Schaefer JR, Lohse P, Ikewaki K, Thomas F, Harris WA, Zech LA, Dujovne CA,
`Brewer HB Jr. Increased production of apolipoprotein A-I associated with elevated levels of
`high density lipoproteins and apolipoprotein A-I in a patient with familial
`hyperalphalipoproteinemia. Metabolism. 1993 Nov;42(11):1429-34. PMID: 8231838
`Ikewaki K, Rader DJ, Sakamoto T, Nishiwaki M, Wakimoto N, Schaefer J, Ishikawa T,
`Fairwell T, Zech L, Nakamura H, Nagano M, Brewer HB Jr. Delayed catabolism of high
`density lipoprotein apolipoproteins A-I and A-II in human cholesteryl ester transfer protein
`deficiency. J Clin Invest. 1993 Oct;92(4):1650-8. PMID: 8408618
`
`25.
`
`
`
`
`
`9 of 66
`
`PENN EX. 2030
`CFAD V. UPENN
`IPR2015-01835
`
`

`
`Daniel J. Rader, M.D.
`
`
`26.
`
`Page 10
`
`Ikewaki K, Rader DJ, Schaefer J, Fairwell T, Zech LA, Brewer HB Jr. Evaluation of apoA-I
`kinetics in humans using simultaneous endogenous stable isotope and exogenous radiotracer
`labeling methods. J Lipid Res. 1993 Dec;34(12):2207-15. PMID: 8301239
`27. Rader DJ, Ikewaki K, Duverger N, Feuerstein I, Zech LA, Connor W, Brewer HB Jr. Markedly
`decreased plasma high density lipoprotein levels without premature coronary atherosclerosis
`caused by rapid catabolism of apolipoproteins A-I and A-II. J Clin Invest. 1994 Jan;93(1):321-
`30. PMID: 8282802
`28. Duchateau P, Rader DJ, Duverger N, Theret N, De Geitere C, Brewer HB Jr, Fruchart JC,
`Castro G. Tangier disease: isolation and characterization of LpA-I, LpA-I:A-II, LpA-II, and
`LpA-IV particles from plasma. Biochim Biophys Acta. 1993 Aug 4;1182(1):30-6. PMID:
`8347683
`29. Duverges N, Rader DJ, Duchateau P, Fruchart JC, Castro G, Brewer HB Jr. Biochemical
`characterization of the three major subclasses of lipoprotein A-I (LpA-I) preparatively isolated
`from human plasma. Biochemistry. 1993 Nov 23;32(46):12372-9. PMID: 8241125
`30. Rader DJ, Ikewaki K, Duverger N, Schmidt H, Pritchard H, Frohlich J, Clerc M, Dumon MF,
`Fairwell T, Zech L, Santamarino-Fojo S, Brewer HB Jr. Markedly accelerated catabolism of
`apolipoprotein A-II and high density lipoproteins containing apoA-II in classic LCAT deficiency
`and fish-eye disease. J Clin Invest. Jan 1994; 93(1): 321–330. PMCID: PMC293770
`31. Sack M, Rader DJ, Cannon RO III. Oestrogen and inhibition of oxidation of low-density
`lipoproteins in postmenopausal women. Lancet. 1994 Jan 29;343(8892):269-70. PMID:
`7905101
`32. Usher DC, Swanson C, Rader DJ, Krämer J, Brewer HB Jr. A comparison of Lp(a) levels in
`fresh and frozen plasma using ELISAs with either anti-apo(a) or anti-apoB reporting
`antibodies. Chem Phys Lipids. 1994 Jan;67-68:243-8. PMID: 8187219
`33. Rader DJ, Cain W, Ikewaki K, Talley G, Zech LA, Usher D, Brewer HB Jr. The inverse
`association of plasma lipoprotein(a) concentrations with apolipoprotein(a) isoform size is not
`due to differences in Lp(a) catabolism but to differences in production rate. J Clin Invest.
`1994 Jun;93(6):2758-63. PMID: 8201014
`34. Traber MG, Rader DJ, Acuff R, Brewer HB Jr., Kayden HJ. Discrimination between RRR-
`and all racemic-alpha-tocopherols labeled with deuterium by patients with
`abetalipoproteinemia. Atherosclerosis. 1994 Jul;108(1):27-37. PMID: 7980705
`35. Bartens W, Rader DJ, Talley G, Brewer HB Jr. Decreased plasma levels of lipoprotein(a) in
`patients with hypertriglyceridemia. Atherosclerosis. 1994 Aug;108(2):149-7. PMID: 7980714
`36. Duverger N, Rader DJ, Brewer HB Jr. Distribution of subclasses of human HDL containing
`apolipoprotein A-I without apolipoprotein A-II (LpA-I) in normolipidemic men and women.
`Arterioscler Thromb. 1994 Oct;14(10):1594-9. PMID: 7918309
`Ikewaki K, Rader DJ, Zech LA, Brewer HB Jr. In vivo metabolism of apolipoproteins A-I and
`E in patients with abetalipoproteinemia: implications for the roles of apolipoproteins B and E in
`HDL metabolism. J Lipid Res. 1994 Oct;35(10):1809-19. PMID: 7852858
`38. Benvenga S, Cahnmann HJ, Rader DJ, Kindt M, Facchiano A, Robbins J. Thyroid hormone
`binding to isolated human apolipoproteins A-II, C-I, C-II, and C-III: homology in thyroxine
`binding sites. Thyroid. 1994 Fall;4(3):261-7. PMID: 7833661
`39. Verges B, Rader DJ, Schaefer J, Zech L, Kindt M, Fairwell T, Gambert P, Brewer HB Jr. In
`vivo metabolism of apolipoprotein A-IV in severe hypertriglyceridemia: a combined radiotracer
`and stable isotope study. J Lipid Res. 1994 Dec;35(12):2280-91. PMID: 7897325
`40. Gorin MB, Paul TO, Rader DJ. Angioid streaks associated with abetalipoproteinemia.
`Ophthalmic Genet. 1994 Sep-Dec;15(3-4):151-9. PMID: 7749670
`41. Gilligan D, Sack M, Guetta V, Casino P, Quyyumi A, Rader DJ, Panza J, Cannon RO III. The
`effect of antioxidant vitamins on low-density lipoprotein oxidation and impaired endothelium-
`dependent vasodilatation in patients with hypercholesterolemia. J Am Coll Cardiol. 1994
`Dec;24(7):1611-7. PMID: 7963105
`
`37.
`
`
`
`
`
`10 of 66
`
`PENN EX. 2030
`CFAD V. UPENN
`IPR2015-01835
`
`

`
`Daniel J. Rader, M.D.
`
`
`Page 11
`
`42. Duverger N, Rader DJ, Ikewaki K, Nishiwaki M, Sakamoto T, Ishikawa T, Nagano M,
`Nakamura H, Brewer HB Jr. Characterization of high-density apolipoprotein particles A-I and
`A-I:A-II isolated from humans with cholesteryl ester transfer protein deficiency. Eur J
`Biochem. 1995 Jan 15;227(1-2):123-9. PMID: 7851377
`43. Skarlatos S, Duverger N, Rader DJ, Kruth H. Cholesterol efflux from human monocyte-
`derived macrophages in the presence of LpA-I:A-II. Biochim Biophys Acta. 1995 Jan
`25;1270(1):19-25. PMID: 7827131
`44. Rader DJ, Mann WA, Cain W, Kraft HG, Usher D, Zech LA, Hoeg JM, Davignon J, Lupien P,
`Grossman M, Wilson JM, Brewer HB Jr. The LDL receptor is not required for normal
`catabolism of Lp(a) in humans. J Clin Invest. 1995 Mar;95(3):1403-8. PMCID: PMC441483
`Ikewaki K, Zech L, Kindt M, Brewer HB Jr, Rader DJ. Apolipoprotein A-II production rate is a
`major factor regulating the distribution of apolipoprotein A-I among HDL subclasses LpA-I and
`LpA-I:A-II in normolipidemic humans. Arterioscler Thromb Vasc Biol. 1995 Mar;15(3):306-12.
`PMID: 7749839
`46. Ricci B, Sharp D, O'Rourke E, Kienzle B, Blinderman L, Gordon D, Smith-Monroy C,
`Robinson G, Gregg R, Rader DJ, Wetterau J. A 30 amino acid truncation of the microsomal
`triglyceride transfer protein large subunit disrupts its interaction with protein disulfide
`isomerase and causes abetalipoproteinemia. J Biol Chem. 1995 Jun 16;270(24):14281-5.
`PMID: 7782284
`47. Bartens W, Rader DJ, Talley G, Kindt M, Brewer HB Jr. Lipoprotein(a) in patients with
`combined hyperlipidemia: effect of triglycerides. Eur J Clin Invest. 1995 Sep;25(9):647-53.
`48. PMID: 7498237
`49. Aguie G, Rader DJ, Clavey V, Traber M, Torpier G, Kayden H, Fruchart JC, Brewer HB Jr,
`Castro G. Lipoproteins containing apolipoprotein B isolated from patients with
`abetalipoproteinemia: identification and characterization. Atherosclerosis. 1995
`Dec;118(2):183-91. PMID: 8770313
`Ikewaki K, Nishiwaki M, Sakamoto T, Ishikawa T, Fairwell T, Zech L, Nagano M, Nakamura
`H, Brewer HB Jr, Rader DJ. Increased catabolic rate of low density lipoproteins in humans
`with cholesteryl ester transfer protein deficiency. J Clin Invest. 1995 Sep;96(3):1573-81.
`PMID: 7657828
`51. Grossman M, Rader DJ, Muller D, Kolansky D, Kozarsky K, Clark BJ, Stein E, Lupien P,
`Brewer HB Jr, Raper S, Wilson JM. A pilot study of ex vivo gene therapy for homozygous
`familial hypercholesterolemia. Nat Med. 1995 Nov;1(11):1148-54. PMID: 7584986
`52. Jamieson D, Usher D, Rader DJ, Lavi E. Apolipoprotein(a) deposition in atherosclerotic
`plaques of cerebral vessels: a potential role for endothelial cells in lesion formation. Am J
`Pathol. 1995 Dec;147(6):1567-74. PMID: 7495281
`53. Raper SE, Grossman M, Rader DJ, Thoene JG, Clark BJ, Kolansky DM, Muller D, Wilson
`JM. Safety and feasibility of liver-directed ex vivo gene therapy for homozygous familial
`hypercholesterolemia. Ann Surg. 1996 Feb;223(2):116-26. PMID: 8597504
`Ikewaki K, Zech L, Brewer HB Jr, Rader DJ. ApoA-II kinetics in humans using endogenous
`labeling with stable isotopes: slower turnover of apoA-II compared with