ILLUSTRATED
`
`n's
`MEDICAL
`DICTIONARY
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`.
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`·'
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`24TH EDITION
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`Ia. WILLIAMS & WILKINS
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`~Baltimore/London.
`
`Dr. Reddy's Laboratories, Ltd., et al.
`v.
`Galderma Laboratories, Inc.
`IPR2015-
`Exhibit 1047
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`Exh. 1047
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`Copyright ©, 1982
`Williams & Wilkins
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`428 East Preston Street
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`Baltimore, MD 21202, U.S.A.
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`Copyright © by William Woodland Company: 1911, 1st ed.; 1912, 2nd ed.; 1914, 3rd ed.; 1916, 4th ed.; 1918, 5th
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`ed.; 1920, 6th ed.; 1922, 7th ed.; 1924, 8th ed.; 1926, 9th ed.; 1928, 10th ed.; 1930, 11th ed.
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`Copyright © by Williams &_ Wilkins: 1933, 12th ed.; 1935, 13th ed.; 1939, 14th ed.; 1942, 15th ed.; 1946; 16th ed.;
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`l949,_1_7th ed.; 1953, ‘18th'ed.; 1957, 19th ed.; 1961, 20th ed.; 1966, 21st ed.; 1972, 22nd ed.; 1976, 23rd ed.
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`All rights reserved. This book is protected by copyright. No part of this bookrmay be reproduced in any form
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`or by any means, including photocopying, or utilized by any information storage and retrieval system without
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`written permission from the copyright owner.
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`Made in the United States ofAmerica
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`English Language Co-editions
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`Asian 1967, 1972, 1976
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`Indian 1967, 1973
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`Taiwan 1972, 1978
`Translated Editions
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`Greek 1976
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`Indian 1977
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`Japanese 1977
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`Portuguese 1976
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`Spanish (in press)
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`Library of Congress Cataloging in Publication Data
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`Stedman, Thomas Lathrop, 1863-1938.
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`Stedman’s Medical dictionary. -
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`1. Medicine—Dictionaries. I. Title. II. Title: Medical dictionary. [DNLM: 1. Dictionaries, Medical. W 13
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`S812m]
`610'.3‘21
`R121.S8 1982
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`ISBN 0-683-07915-8
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`81-3021
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`AACR2
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`Composed and printed at the
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`Waverly Press, Inc.
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`Mt. Royal and Guilford Aves.
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`Baltimore, MD 21202, U.S.A.
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`Exh. 1047
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`papilliform
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`1023
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`papuiovesicie
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`—
`papillo’matous. Relating to a papilloma.
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`Papillo’mavirus. A genus of viruses (family Papovaviri-
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`dae) containing DNA (molecular weight
`5 X 106),
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`including the papilloma and warts viruses of man and
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`other animals. Virions are about 55 nm in diameter.
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`Papillon, M. M. See P.-Lefévre syndrome.
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`Papillon-Léage. See P.-L. and Psaume syndrome.
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`papilloretinitis
`(pap’i-lo-ret-i-ni‘tis). Retinopapillitis;
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`papillitis with extension of the inflammation to neighbor-
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`ing parts of the retina.
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`tome, inci-
`papillotomy (pa-pil-lot’o-mi) [papilla + G.
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`sion ]. An incision into the major duodenal papilla.
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`papillula, pl. papillulae (pa-pi1‘u-lah, -le) [Mod. L. dim.
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`of L. papilla]. A small papilla.
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`Papin, Denis, French physicist, 1647-1714. See P.’s digest-
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`er.
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`+
`Papovaviridae
`(pa-po’va-vir'T-de)
`[pa(pilloma)
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`po(lyoma) + va(cuolating) ]. A family of small, antigeni-
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`cally distinct viruses that replicate in nuclei of infected
`cells; most have oncogenic properties. Virions are 45 to 55
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`nm in diameter, nonenveloped, and ether-resistant; capsids
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`are icosahedral with 72 capsomeres, and they contain
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`double-stranded DNA (molecular weight 3 to 5' X 106).
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`The family comprises
`the genera Papillomavirus and
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`Polyomavirus.
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`papovavirus (pi-po’v5_-vi'rus). Any virus of the family
`Papovaviridae.
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`PAPP. Abbreviation for p- aminopropiophenone.
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`Pappenheim, Artur, German physician, 1870-1916. See
`P.’s stain, Unna-P. stain.
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`‘V
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`pap’pose, pap’pous [G. pappos, down]. Downy.
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`pap'pus
`[G. pappos. down]. The first downy growthof
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`beard.
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`PAPS. Abbreviation for adenosine 3’-phosphate '5‘-phos-
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`phosulfate.
`V
`~
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`papula, pl. pap’ulae (pap’u-lah) [L. ]. Papule.
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`pap'ular. Relating to papules.
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`g
`papulaftion. The formation of papules.
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`papule (pap’fil)' [ L. papula. pimple]. Papula; a small, cir-
`cumscribed, solid elevation on only skin. growth;
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`Celsus’ p.’s,
`lichen agrius.
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`‘ follicular p., a papular lesion arising about a hair follicle;
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`not specific for any condition.
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`moist p., mucous p.,
`condylbma la_tum.
`split p.’s, p.’s at commissures of the mouth seen in some
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`cases of secondary syphilis.
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`papuliferous
`[papule +' L: fero,
`to bear]. Having
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`papules.
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`papulo- _ [L. papula, papule ]. Combining form denoting
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`papule.
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`papuloerythematous (pap’u-lo-Er-Y-them‘a-tus,
`-the’m2'i-
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`tus). Denoting an eruption of papules on an erythematous
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`surface.
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`‘‘
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`pap’ulopus’tular. Denoting an eruption composed of
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`- papules and pustules.
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`pap'ulopus'tule. A small semisolid skin elevation which
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`rapidly evolves into a pustule.
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`The occurrence of numerous widespread
`papulo’sis.
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`papules.
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`a chronic papular and ulcerative
`lymphomatoid p.,
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`variant of pityriasis lichenoides et varioliformis acuta
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`characterized by dermalrvasculitis with heavy perivascular
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`infiltrations by atypical mononuclear cells suggestive of a
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`lymphoma; it is usually benign.
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`' malignant atrophic p., Degos’ or- Kiihlmeier-Degos
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`disease; a cutaneovisceral
`syndrome characterized by
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`pathognomonic umbilicated porcelain-white papules with
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`elevated telangiectatic annular borders. followed'by the
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`developmengof intestinal ulcers which perforate, causing
`peritonitis; arterioles in the lesions are occluded by
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`endothelial proliferation; it leads to progressive neurologi-
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`cal disability and death.
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`papulosquamous (pap’u-lo-skwa'mus)
`[papulo- » + L.
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`. squamosus, scaly (squamous) ]. Denoting an eruption
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`composed of both papules and scales.
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`pap'uloves’icle. A small semisolid skin elevation which
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`evolves into a blister.
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`papil'liform. Resembling or shaped like a papilla.
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`papillitis (pap’i—li’tis) [papilla + G. suffix -itis, inflamma-
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`tion ]. Inflammation of the optic disk or renal papilla.
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`renal papillary necrosis.
`necrotizing p.,
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`papillo- [ L. papilla, q. v. ]. Combining form denoting papil-
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`la, papillary.
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`papilloadenocystoma (p5-pil'o-ad-é-no-sis-to’mah). A be-
`nign epithelial neoplasm characterized by glands or gland-
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`structures,
`formation of
`cysts,
`and finger-like
`like
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`projections of neoplastic cells covering a core of fibrous
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`connective tissue.
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`papillocarcinoma (pa-pil’o-kar-si-no’mah) [papilla + G.
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`karkimima, cancer].
`1. A papilloma that has become
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`is characterized by
`malignant. 2. A carcinoma that
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`finger-like projections of neoplastic cells in
`papillary,
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`association with cores of fibrous stroma as a supporting
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`structure.
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`papilloma (pap-T-lo’mah) [papilla + G. suffix -oma. tu-
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`mor ]. Papillary tumor; villoma; a circumscribed benign
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`epithelial tumor projecting from the surrounding surface;
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`more precisely, a benign epithelial neoplasm consisting of
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`villous or arborescent outgrowths of fibrovascular stroma
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`covered by neoplastic cells.
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`p. acumina’tum,
`condyloma acuminatum.
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`p. canalic’ulum, a papillomatous benign tumor arising
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`V
`within the duct of a gland.
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`canine oral p., warts affecting mucous membranes of
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`young dogs, caused by a papillomavirus.
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`p. diffu’sum, widespread occurrence of p.’s.
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`duct p.,
`intraductal p.
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`p. du’rum,
`hard p.; a wart, corn, or cutaneous horn.
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`fibroepithelial p.,
`skin tag.
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`hard 1)., p. durum.
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`Hopmann’s p., Hopmann’s polyp; a papillomatous
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`overgrowth of the nasal mucous membrane.
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`infectious p. of cattle, cattle warts; single or multiple
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`- rough nodules on the skin and mucous membranes caused
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`by a papillomavirus;
`in young cattle, which are most
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`susceptible. they are most numerous on the head, neck. and
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`shoulders; in cows they usually affect the udder and teats.
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`p. inguina’le trop’icum,
`a cutaneous eruption, occurring
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`in Colombia, characterized by numerous slender pink
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`vegetations in, the inguinal. region.
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`intracystic p.,
`a p. growing within a cystic adenoma,
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`filling the cavity with a mass of branching epithelial
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`processes.
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`intraductal p., duct p.; a small, often impalpable, benign
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`p. arising in a lactiferous duct and frequently causing
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`bleeding from the nipple.
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`p. mol'le,
`soft, p.
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`a papillomatous
`p. neuropath'icum or neurot’icum,
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`eruption or growth following the course of a nerve.
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`rabbit p.,
`see Shope p.
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`rabbit oral p., a virus disease of rabbits characterized by
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`nodules located usually on the lower surface of the tongue,
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`but never on the skin as in Shope p.
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`Shope p., a common wart of the wild cottontail rabbit of
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`North America. caused by a papillomavirus.
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`soft p., p. molle; (l) a p. with only a thin layer of horny
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`epithelium; (2) any small soft growth; e.g., a soft mole or
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`nevus.
`a
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`V
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`transitional cell p., a benign papillary tumor of transi-
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`tional epithelium; in the urinary tract it is called transition-
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`al cell carcinoma (q. v.), grade 1, because of the likelihood
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`of its recurrence.
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`p. vene’reum, condyloma acuminatum.
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`villous p.,
`villous tumor; a p. composed of slender.
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`finger-like excrescences occurring in the bladder or large
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`intestine. or from the choroid plexus of
`the cerebral
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`ventricles; villous p.’s of the colon are usually sessile and
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`frequently become malignant.
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`zymotic p., yaws.
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`papillomatosis (pap’i-lo-ma-to’sis). 1. The development of
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`numerous papillomas. 2. Papillary projections of
`the
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`epidermis forming a microscopically undulating surface.
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`subareolar duct p.,
`adenoma of the nipple; a benign
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`tumor which may clinically resemble Paget’s disease, but
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`which is a papillary or solid growth of columnar and
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`myoepithelial cells producing a florid pseudoinfiltrative
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`pattern.
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`V
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`Exh. 1047
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`pus
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`1175
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`pyeloplasty
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`'
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`pus [ L. ]. A fluid product of inflammation, consisting of
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`3 liquid (liquor puris) Containing leukocytes (p. corpuscles)
`and the debris of dead cells and tissue elements liquefied
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`leuko-
`by the proteolytic and histolytic enzymes (e.g.,
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`protease) that are elaborated by polymorphonuclear leuko-
`cytes..
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`blue p., p. tinged with pyocyanin, a product of Pseudomo-
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`mzs aerugmosa.
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`cheesy p., a very thick almost solid p. resulting from the
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`absorption of the liquor puris.
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`.
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`curdy p., p. containing flakes of caseous matter.
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`green 11.. blue p. when, as sometimes happens, it has more
`of a green hue.
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`ichorous 1)., thin p. containing shreds of sloughing tissue,
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`and sometimes of aifetid odor.
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`laudable p., a term formerly used when suppuration was
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`considered a desirable stage in wound healing.
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`sanious p.,
`ichorous p. stained with blood.
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`pustula (pus’tu-lah) [L. ]. Pustule.
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`pustulant (pus’tu’-lant). l. Causing a pustular eruption. 2.
`An agent producing pustules.
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`pustular (pus’tu-lar). Relating to or marked by pustules.
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`pustulation (pus'tu-la’shun). The fonnation or the pres-
`ence of pustules.
`V
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`pustule (pus'tfil) [L. pustula]. A small circumscribed ele-
`vation of the skin, containing purulent material.
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`malignant p., cutaneous anthrax.
`‘
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`postmortem p., an ulcer. on the knuckle usually, resulting
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`from infection during a dissection or the performance of an
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`autopsy.
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`an epidermal p. formed by
`spongiform p. of Kogoj,
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`infiltration of neutrophils into necrotic epidermis in which
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`the cell walls persist as a spongelike network; seen in
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`.
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`pustular psoriasis.
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`pustuliform (pus'tu-li'-form). Having the appearance of a
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`pustule.
`_
`’
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`pustulocrustaceous (pus’tu-lo-krus-ta’shus). Marked by
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`pustules crusted with dry pus.
`"
`'
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`pustulosis (pus-tu-lo'sis) [ L. pustula, pustule.. + G. suffix’
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`-osis, condition ]. 1. An eruption of pustules. 2. Te
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`occasionally used to designate acropustulosis.
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`p. vaccin’iformis acu’ta,
`eczema herpeticum.
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`putamen (pu-ta’men) [ L. that which falls off in pruning, fr.
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`puto, to prune] [ NA]. The outer, larger, and darker gray
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`of the three portions into which the nucleus lentiformis is
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`divided by laminae of white fibers; it is connected with the‘
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`caudate nucleus by intervening bands of gray substance
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`that penetrate the internal capsule. Its histological struc-
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`ture is similar to that. of the caudate nucleus with which
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`together it composes ‘the striatum. See alsocorpus striatum;
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`nucleus lentiformis.
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`Putnam,
`James J., Boston neurologist,‘ 1846—19:l8. See
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`_P.-Dana syndrome.
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`putrefaction (pu’tri-fak’shun)A [L. putre-facio, pp. -factius,
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`to make rotten ]. Decay (2); decomposition or rotting, the
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`breakdown of organic matter usually by bacterial action,
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`resulting in the formation of other substances of less
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`complex constitution with the evolution of ammonia or its"
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`derivatives and hydrogen sulfide; characterized usually by
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`the presence of toxic or malodorous products.
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`putrefactive (pu'tri-fak'tiv). Relating to or causing,pu-
`trefaction.
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`putrefy ,(pu’tri-fi). To cause to become, or to become,
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`putrid.
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`putrefying (pu’tri-fi’ing). UndergoingVputrefaction,
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`putrescence (pu-tres’ens). The state of putrefaction.
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`putrescent (pu-tres'ent) [L. putreseo, to grow rotten, fr.
`puter. rotten ]. Denoting. or in the process of, putrefaction.
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`putrescine (pu-tres’En). .A poisonous amine (polyamine),
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`1,4-diaminobutane, NH2(CHz)4NH2,
`formed from the
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`amino acid, arginine, during putrefaction.
`.V
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`pu'trid [L. putridus]. 1. In a state of putrefaction.
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`Denoting putrefaction.
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`Putti, Vittorio, Italian surgeon,
`l880—l940. See P.-Platt
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`operation, procedure.
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`PUVA. Abbreviation for oral administration of gsoralen
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`and subsequent exposure to long wavelength ultraviolet
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`light (uv-a); used to treat psoriasis.
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`PVP. Abbreviation for polyvinylpyrrolidone.
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`PWIVI. Abbreviation for pokeweed mitogen.
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`pyarthrosis (pi-ar-thro’sis) [G. pyon, pus, + arthrésis, a
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`jointing]. Suppurative arthritis.
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`pycno-. For words so beginning, see under pykno-.
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`pyel-. See pyelo-.
`'7
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`pyelectasis, pyelectasia (pi-E-1ek’ta-sis, pi-E-lek-ta'zT-ah)
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`[pyel- + G. ektasis. extension]. Dilation of the pelvis of
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`the kidney.
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`pyelit’ic. Relating topyelitis.
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`pyelitis (pi-E-li’tis) [ pyel-‘ + G. suffix -itis, inflammation ].
`1. Inflammation of the renal pelvis. 2. Obsolescent term for
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`pyelonephritis.
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`I
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`pyelo-, pyel- [G. pyelos, trough, tub, vat (pe1vis).,PYEL ].
`Combining‘ forms denoting pelvis, usually the renal
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`pelvis.
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`pyelocaliceal (pi’é-lo-kal’i’-se’al). Pyelocalyceal; relating to
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`7.
`the renal pelvis and calices.
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`pyelocaliectasis (pi’e-lo-kal‘T-ek't§-sis). ' Calicectasis.
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`py’elocal’yce’al. Pyelocaliceal.
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`pyelocystitis (pi-E-lo-sis-ti'tis) [pyelo- + G. kystis, blad-
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`der, + suffix -iris. inflammation]. Inflammation of. the
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`renal pelvis and the bladder. ,
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`‘-
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`pyelofluoroscopy (pi’E-lo-flfir-os'ko-pi)
`[pyelo- + L.
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`skopea‘,
`to flow, + G.
`to view ]. Fluoroscopic
`fluo.
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`examination of the renal pelves. usually with a contrast
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`medium.
`‘
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`py'elogram.
`A roentgenogram of the renal pelvis and
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`ureter.
`.
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`to
`[pyelo- + G. graphfi,
`pyelography (pi'E-log’ra-fi)
`write]. Pelviureterography;
`pyeloureterogi-aphy;‘ ure-
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`teropyelography;
`the kidney and
`radiologic study ‘of
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`renal collecting system, usually performed with the aid of
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`a contrast agent.
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`antegrade p., antegrade urography in which the contrast
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`medium is injected into the renal calices or.~pelvis.
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`pyelolithotomy (pi’é-lo-li-thot’o-mi) [pyelo- + G. Iithos.
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`Stone: + tome". incision]. Pelvilithotomy.‘
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`pyelolymphatic (pi'é-lo-lim-fat’ik). Pertaining to the lym-
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`phatics of the renal pelvis.
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`pyelonephritis (pi’E-lo-ne-fri’tis) [pyelo- + ‘G. nephros,
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`kidney, + suffix -itis,
`inflammation ]. Nephropyelitis;
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`inflammation of the renal parenchyma, calyces, and pelvis,
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`particularly due to local bacterial infection:
`=
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`acute p., acute inflammation of the renal parenchyma and
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`pelvis characterized by small cortical abscesses and yellow-
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`ish streaks in the medulla due to pus in the collecting
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`tubules and interstitial tissue.
`—
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`—
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`ascending p., p. due to bacterial infection from the lower
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`urinary tract, particularly by reflux of infected urine.
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`bacillary p. of cattle, a specific, necrotizing inflammation
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`of the kidney pelvis and ureters of cattle,-caused by
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`infection with Corynebacterium renale.
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`chronic 1).,
`chronic inflammation of. the renal paren-
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`chymay and pelvis resulting from bacterial infection,-chap
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`acterized by calyceal deformities and overl.ying large flat
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`renal scars with patchy distribution.
`_
`f
`‘I
`,
`_
`xanthogranulomatous p., a chronic inflammatory condi-_
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`tion diffusely involving the entire'kidney and usually
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`resulting in a grossly enlarged and functionless kidney
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`which can grossly resemble a neoplasm or tuberculosis;
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`it
`histologically,
`is characterized by an inflammatory
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`reaction with numerous lipid-laden,
`foamy histiocytes
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`mixed with lymphocytes and plasma cells to form multiple
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`granulomas.
`H‘
`‘
`.-
`.
`_.
`-
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`pyelonephrosis '(pi’E-lo-ne-fro’sis) [pyelo- + G. nephros,
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`kidney, + suffix -osis, condition].
`1 Any disease of the
`pelvis of the kidney.
`3
`'-
`-
`i
`"
`1
`'
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`pyeloplasty (pi’é-lo-plas-ti) [pyelo- + G. pIass6, to’fas’h-
`ion ]. Aplastic or reconstructive operation on the kidney
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`pelvis to correct an obstruction.
`'
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`capsular flap p., a reconstructive procedure for correction’
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`of uteropelvic obstruction, whereby a flap of renal capsule
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`is swung down from the renal hilus to enlarge an
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`obstructed intrarenal pelvis and ._upper ureter; used to
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`-correct situations involving loss of renal pelvic tissue which
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`preclude the use of renal pelvis for-.the reconstruction. .
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`Exh. 1047