`
`si9ma-aldrich. com
`
`SAFETY DATA SHEET
`Version 3. 10
`Revision Date 11 /24/2015
`Print Date 02108/2016
`
`1. PRODUCT AND COMPANY IDENTIFICATION
`
`1.1
`
`Product identifiers
`Product name
`
`ASTM® 05134 Qualitative Reference Naphtha
`Standard
`
`Product Number
`Brand
`
`48265-U
`Supelco
`
`1.2
`
`Relevant identified uses of the s ubstance or mixture and uses advised aga inst
`
`Identified uses
`
`Laboratory chemicals, Synthesis of substances
`
`1.3
`
`Details of the supplier of the safety data sheet
`
`Company
`
`Telephone
`Fax
`
`Sigma-Aldrich
`3050 Spruce Street
`SAINT LOUIS MO 63103
`USA
`+ 1 800-325-5832
`+ 1 800-325-5052
`
`1.4
`
`Emergency telephone number
`
`Emergency Phone #
`
`(314) 776-6555
`
`2. HAZARDS IDENTIFICATION
`
`2.1
`
`Classification of the substance or mixture
`
`GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
`Flammable liquids (Category 1 ), H224
`Germ cell mutagenicity (Category 1 B), H340
`Carcinogenicity (Category 1 A), H350
`Aspiration hazard (Category 1 ), H304
`
`For the full text of the H-Statements mentioned in this Section, see Section 16.
`
`2.2 GHS Label elements, including preca utionary statements
`
`Pictogram
`
`Signal word
`
`Danger
`
`Hazard statement(s)
`H224
`H304
`H340
`H350
`
`Precautionary statement(s)
`P201
`P202
`
`P210
`P233
`Supelco - 48265-U
`
`Extremely flammable liquid and vapour.
`May be fatal if swallowed and enters airways.
`May cause genetic defects.
`May cause cancer.
`
`EXHIBIT NO. 1-3_
`K
`Obtain special instructions before use.
`Do not handle until all safety precautions have been read and ~-----~-'
`understood.
`Keep away from heal/sparks/open flames/hot surfaces. No smoking.
`Keep container tightly closed.
`
`Page 1 of 9
`
`CFAD v. Anacor, IPR2015-01776, CFAD EXHIBIT 1067 - Page 1 of 9
`
`
`
`P240
`P241
`P242
`P243
`P280
`
`P301 + P310
`
`P303 + P361 + P353
`
`P308 + P313
`P331
`P370 + P378
`
`P403 + P235
`P405
`P501
`
`Ground/bond container and receiving eq uipment.
`Use explosion-proof electrical/ ventilating/ lighting/ equipment.
`Use on ly non-sparking tools.
`Take precautionary measures against static discharge.
`Wear protective gloves/ protective clothing/ eye protection/ face
`protection.
`IF SWALLOWED: Immediately call a POISON CENTER or doctor/
`physician.
`IF ON SKIN (or hair): Remove/ Take off immediately all contaminated
`clothing. Rinse skin with water/ shower.
`IF exposed or concerned: Get medical advice/ attention.
`Do NOT induce vomiting.
`In case of fire: Use dry sand, dry chemical or alcohol-resistant foam for
`extinction.
`Store in a well-ventilated place. Keep cool.
`Store locked up.
`Dispose of contents/ container to an approved waste disposal plant.
`
`2.3
`
`Hazards not otherwise classified (HNOC) or not covered by GHS - none
`
`3. COMPOSITION/INFORMATION ON INGREDIENTS
`
`3.2 Mixtures
`
`
`d azar ous componen s
`H
`t
`Component
`
`Low boiling point naphtha A complex
`CAS-No.
`64741-42-0
`EC-No.
`265-042-6
`Index-No.
`649-265-00-X
`
`Classification
`
`Concentration
`
`Care. 1 B; Asp. Tox. 1; H304,
`H350
`
`>= 90 - <= 100
`O/o
`
`Benzene
`Flam. Liq. 2; Skin lrril. 2; Eye
`71-43-2
`CAS-No.
`200-753-7
`lrrit. 2A; Muta. 1 B; Care. 1 A;
`EC-No.
`STOT RE 1; Asp. Tox. 1;
`601-020-00-8
`Index-No.
`Registration number 01-2119447106-44-XXXX Aquatic Acute 3; Aquatic
`Chronic 3; H225, H304, H315,
`H319, H340, H350, H372,
`H41 2
`For the full text of the H-Statements mentioned in this Section, see Section 16.
`
`>= 0.1 - < 1 %
`
`4. FIRST AID MEASURES
`
`4.1
`
`Description of first aid measures
`
`General advice
`Consult a physician. Show this safety data sheet to the doctor in attendance.Move out of dangerous area.
`
`If inhaled
`If breathed in, move person into fresh air. If not breathing, give artificial respiration . Consult a physician.
`
`In case of skin contact
`Wash off with soap and plenty of water. Consult a physician.
`
`In case of eye contact
`Flush eyes with water as a precaution.
`
`If swallowed
`Do NOT induce vomiting. Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a
`physician.
`
`4.2 Most important symptoms and effects, both acute and delayed
`The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11
`
`Supelco - 48265-U
`
`Page 2 of 9
`
`CFAD v. Anacor, IPR2015-01776, CFAD EXHIBIT 1067 - Page 2 of 9
`
`
`
`4.3
`
`Indication of any immediate medical attention and specia l treatment needed
`No data available
`
`5. FIREFIGHTING MEASURES
`
`5.1
`
`Extinguishing media
`
`Suitable extinguishing media
`Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
`
`Special hazards arising from the substance or mixture
`Nature of decomposition products not known.
`
`Advice for firefighters
`Wear self-contained breathing apparatus for firefighting if necessary.
`
`Further information
`Use water spray to cool unopened containers.
`
`5.2
`
`5.3
`
`5.4
`
`6. ACCIDENT AL RELEASE MEASURES
`
`6.1
`
`Personal precautions , protective equipment and emergency procedures
`Use personal protective equipment. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Remove all
`sources of ignition. Evacuate personnel to safe areas. Beware of vapours accumulating to form explosive
`concentrations. Vapours can accumulate in low areas.
`For personal protection see section 8.
`
`6.2
`
`Environmental precautions
`Prevent further leakage or spillage if safe to do so. Do not let product enter drains.
`
`6.3 Methods and materials for containment and cleaning up
`Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and place in
`container for disposal according to local regulations (see section 13).
`
`6.4
`
`Reference to o ther sections
`For disposal see section 13.
`
`7. HANDLING AND STORAGE
`
`7.1
`
`7.2
`
`7.3
`
`Precautions for safe handling
`Avoid contact with skin and eyes. Avoid inhalation of vapour or mist.
`Use explosion-proof equipment.Keep away from sources of ignition - No smoking.Take measures to prevent the build
`up of electrostatic charge.
`For precautions see section 2.2.
`
`Conditions for safe storage, including any incompatibilities
`Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully
`resealed and kept upright to prevent leakage.
`
`Specific end use(s)
`Apart from the uses mentioned in section 1 .2 no other specific uses are stipulated
`
`8. EXPOSURE CONTROLS/PERSONAL PROTECTION
`
`8.1
`
`Basis
`
`USA. Occupational Exposure Limits
`(OSHA) - Table Z-1 Limits for Air
`Contaminants
`
`Control parameters
`c
`"th
`omponen s w1
`wor :p ace con ro parame ers
`k I
`I
`t
`Component
`GAS-No.
`Value
`Control
`parameters
`500.000000
`ppm
`2,000.000000
`mq/m3
`The value in mg/m3 is approximate.
`TWA
`0.5 ppm
`USA. ACG IH Threshold Limit Values
`(TLV)
`
`Low boiling point
`naphtha A complex
`
`64741-42-0 TWA
`
`Benzene
`
`Remarks
`71-43-2
`
`Supelco - 48265-U
`
`Page 3 of 9
`
`Leukemia
`
`CFAD v. Anacor, IPR2015-01776, CFAD EXHIBIT 1067 - Page 3 of 9
`
`
`
`Substances for which there is a Biological Exposure Index or Indices
`(see BEi® section)
`Confirmed human carcinogen
`Danqer of cutaneous absorption
`STEL
`12.5 ppm
`
`I USA. ACGIH Threshold Limit Values
`
`{TLV)
`
`Leukemia
`Substances for which there is a Biological Exposure Index or Indices
`(see BEi® section)
`Confirmed human carcinogen
`Danqer of cutaneous absorption
`I USA. Occupational Exposure Limits
`TWA
`110 ppm
`(OSHA) - Table Z-2
`
`Z37.40-1969
`CEIL
`125 ppm
`
`Z37.40-1 969
`Peak
`150 ppm
`
`I USA. Occupational Exposure Limits
`
`(OSHA) - Table Z-2
`
`I USA. Occupational Exposure Limits
`
`{OSHA) - Table Z-2
`
`Z37. 40-1969
`See 1910.1028. See Table Z-2 for the limits applicable in the
`operations or sectors excluded in 1910. 1028
`The final benzene standard in 1910.1028 applies to all occupational
`exposures to benzene except some subsegments of industry where
`exposures are consistently under the action level (i.e .. distribution
`and sale of fuels, sealed containers and pipelines, coke production,
`oil and gas drilling and production, natural gas processing, and the
`percentage exclusion for liquid mixtures); for the excepted
`subseqments, the benzene limits in Table Z-2 apply.
`TWA
`
`I USA. NIOSH Recommended
`
`I 0.1 ppm
`
`Exposure Limits
`Potential Occupational Carcinogen
`See Appendix A
`ST
`11 ppm
`
`I USA. NIOSH Recommended
`
`Exposure Limits
`Potential Occupational Carcinogen
`See Appendix A
`
`Benzene
`
`71-43-2
`
`Remarks
`
`Value
`
`Biological
`s ecimen
`
`Basis
`
`In urine
`
`ACG IH - Biological
`0.0300
`S-
`Phenylmerca mg/g
`Exposure Indices
`(BEi)
`pturic acid
`End of shift {As soon as possible after exposure ceases)
`t,t-Muconic
`0.5000
`In urine
`ACGIH - Biological
`acid
`mg/g
`Exposure Indices
`(BEi)
`End of shift (As soon as possible after exposure ceases)
`
`8.2
`
`Exposure controls
`
`Appropriate engineering controls
`Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of
`workday.
`
`Person al protective equipment
`
`Eye/face protection
`Face shield and safety glasses Use equipment for eye protection tested and approved under appropriate
`government standards such as NIOSH (US) or EN 166(EU).
`
`Supelco - 48265-U
`
`Page 4 of 9
`
`CFAD v. Anacor, IPR2015-01776, CFAD EXHIBIT 1067 - Page 4 of 9
`
`
`
`Skin protection
`Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without
`touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after
`use in accordance with applicable laws and good laboratory practices. Wash and dry hands.
`Body Protection
`Complete suit protecting against chemicals, Flame retardant antistatic protective clothing., The type of
`protective equipment must be selected according to the concentration and amount of the dangerous substance
`at the specific workplace.
`
`Respiratory protection
`Where risk assessment shows air-purifying respirators are appropriate use a full-face respirator with multi(cid:173)
`purpose combination (US) or type AXBEK (EN 14387) respirator cartridges as a backup to engineering
`controls. If the respirator is the sole means of protection, use a full-face supplied air respirator. Use respirators
`and components tested and approved under appropriate government standards such as NIOSH (US) or CEN
`(EU).
`Control of environmental exposure
`Prevent further leakage or spillage if safe to do so. Do not let product enter drains.
`
`9. PHYSICAL AND CHEMICAL PROPERTIES
`
`9.1
`
`Information on basic physical and chemical properties
`
`a) Appearance
`
`b) Odour
`c) Odour Threshold
`d) pH
`e) Melting point/freezing
`point
`
`f)
`
`Initial boiling point and
`boiling range
`
`Form: clear, liquid
`Colour: colourless
`No data available
`No data available
`
`No data available
`No data available
`
`-16 °C (3 °F) at 1,013 hPa (760 mmHg)
`
`g) Flash point
`h) Evaporation rate
`
`21 °C (70 °F)
`No data available
`
`Flammability (solid, gas) No data available
`i)
`j) Upper/lower
`No data available
`flammability or
`explosive limits
`k) Vapour pressure
`I) Vapour density
`
`667 hPa (500 mmHg) at 25 °C (77 °F)
`No data available
`
`m) Relative density
`n) Water solubility
`o) Partition coefficient: n-
`octanol/water
`p) Auto-ignition
`temperature
`q) Decomposition
`temperature
`r) Viscosity
`
`s) Explosive properties
`t) Oxidizing properties
`
`No data available
`No data available
`
`No data available
`
`No data available
`
`No data available
`
`No data available
`
`No data available
`No data available
`
`9.2 Other safety information
`No data available
`Supelco - 48265-U
`
`Page 5 of 9
`
`CFAD v. Anacor, IPR2015-01776, CFAD EXHIBIT 1067 - Page 5 of 9
`
`
`
`10. STABILITY AND REACTIVITY
`
`10.1 Reactivity
`No data available
`
`10.2 Chemical stability
`Stable under recommended storage conditions.
`
`10.3 Possibility of hazardous reactions
`Vapours may form explosive mixture with air.
`
`10.4 Conditions to avoid
`Heat, flames and sparks. Extremes of temperature and direct sunlight.
`
`10.5
`
`Incompatible materials
`Bases, Strong oxidizing agents, acids, Halogens, Metallic salts
`
`10.6 Hazardous decomposition products
`Other decomposition products - No data available
`In the event of fire: see section 5
`
`11 . TOXICOLOGICAL INFORMATION
`
`11 .1
`
`Information on toxicological effects
`
`Acute toxicity
`Inhalation: No data available
`
`Dermal: No data available
`
`No data available
`
`Skin corrosion/irritation
`No data available
`
`Serious eye damage/eye irritation
`No data available
`
`Respiratory or skin sensitisation
`No data available
`
`Germ cell mutagenicity
`No data available
`
`Carcinogenicity
`
`IARC:
`
`IARC:
`
`NTP:
`
`1 - Group 1: Carcinogenic to humans (Benzene)
`
`2B - Group 2B: Possibly carcinogenic to humans (Low boiling point naphtha A complex)
`
`Known to be human carcinogen (Benzene)
`
`OSHA:
`
`OSHA specifically regulated carcinogen (Benzene)
`
`Reproductive toxicity
`No data available
`No data available
`
`Specific target organ toxicity - single exposure
`No data available
`
`Specific target organ toxicity - repeated exposure
`No data available
`
`Aspiration hazard
`No data available
`
`Additional Information
`RTECS: Not available
`
`Supelco - 48265-U
`
`Page 6 of 9
`
`CFAD v. Anacor, IPR2015-01776, CFAD EXHIBIT 1067 - Page 6 of 9
`
`
`
`narcosis, Inhalation of high concentrations of benzene may have an initial stimulatory effect on the central nervous
`system characterized by exhilaration, nervous excitation and/or giddiness, depression, drowsiness, or fatigue. The
`victim may experience tightness in the chest, breathlessness, and loss of consciousness. Tremors, convulsions, and
`death due to respiratory paralysis or circulatory collapse can occur in a few minutes to several hours following severe
`exposures. Aspiration of small amounts of liquid immediately causes pulmonary edema and hemorrhage of pulmonary
`tissue. Direct skin contact may cause erythema. Repeated or prolonged skin contact may result in drying, scaling
`dermatitis, or development of secondary skin infections. The chief target organ is the hematopoietic system. Bleeding
`from the nose, gums, or mucous membranes and the development of purpuric spots, pancytopenia, leukopenia,
`thrombocytopenia, aplastic anemia, and leukemia may occur as the condition progresses. The bone marrow may
`appear normal, aplastic or hyperplastic, and may not correlate with peripheral blood-forming tissues. The onset of
`effects of prolonged benzene exposure may be delayed for many months or years after the actual exposure has
`ceased.
`
`Stomach - Irregularities - Based on Human Evidence
`Stomach - Irregularities - Based on Human Evidence (Benzene)
`
`12. ECOLOGICAL INFORMATION
`
`12.1 Toxicity
`No data available
`
`12.2 Persistence and degradability
`No data available
`
`12.3 Bioaccumulative potential
`No data available
`
`12.4 Mobility in soi l
`No data available
`
`12.5 Results of PBT and vPvB assessment
`PBT/vPvB assessment not available as chemical safety assessment not required/not conducted
`
`12.6 Other adverse effects
`No data available
`
`13. DISPOSAL CONSIDERATIONS
`
`13.1 Waste treatment methods
`
`Product
`Burn in a chemical incinerator equipped with an afterburner and scrubber but exert extra care in igniting as this
`material 1s highly flammable. Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a
`licensed professional waste disposal service to dispose of this material.
`
`Contaminated packaging
`Dispose of as unused product.
`
`14. TRANSPORT INFORMATION
`
`DOT (US)
`Packing group: I
`Class: 3
`UN number: 1993
`Proper shipping name: Flammable liquids, n.o.s. (Benzene)
`Reportable Quantity (RO): 2000 lbs
`
`Poison Inhalation Hazard: No
`
`IMDG
`UN number: 1993
`Packing group: I
`Class: 3
`Proper shipping name: FLAMMABLE LIQUID, N.O.S. (Benzene)
`
`IATA
`Packing group: I
`Class: 3
`UN number: 1993
`Proper shipping name: Flammable liquid, n.o.s. (Benzene)
`
`EMS-No: F-E, S-E
`
`Supelco - 48265·U
`
`Page 7 of 9
`
`CFAD v. Anacor, IPR2015-01776, CFAD EXHIBIT 1067 - Page 7 of 9
`
`
`
`15. REGULATORY INFORMATION
`
`SARA 302 Components
`No chemicals in this material are subject to the reporting requirements of SARA Title Ill, Section 302.
`
`SARA 313 Components
`The following components are subject to reporting levels established by SARA T itle Ill, Section 313:
`CAS-No.
`Revision Date
`71-43-2
`2007-07-01
`
`Benzene
`
`SARA 311/312 Hazards
`Fire Hazard, Chronic Health Hazard
`
`Massachusetts Right To Know Components
`
`Benzene
`
`Pennsylvania Right To Know Components
`
`Low boiling point naphtha A complex
`Benzene
`
`New Jersey Right To Know Components
`
`Low boiling point naphtha A complex
`Benzene
`
`California Prop. 65 Components
`WARNING! This product contains a chemical known to the
`State of California to cause cancer.
`Benzene
`
`CAS-No.
`71-43-2
`
`CAS-No.
`64741-42-0
`71-43-2
`
`CAS-No.
`64741-42-0
`71-43-2
`
`CAS-No.
`71-43-2
`
`Revision Date
`2007-07-01
`
`Revision Date
`2009-07-17
`2007-07-01
`
`Revision Date
`2009-07-17
`2007-07-01
`
`Revision Date
`2009-02-01
`
`WARNING: This product contains a chemical known to the
`State of California to cause birth defects or other reproductive
`harm.
`Benzene
`
`CAS-No.
`71 -43-2
`
`Revision Date
`2009-02-01
`
`16. OTHER INFORMATION
`
`Full text of H-Statements referred to under sections 2 and 3.
`
`Aquatic Acute
`Aquatic Chronic
`Asp. Tox.
`Care.
`Eye lrrit.
`Flam. Liq.
`H224
`H225
`H304
`H315
`H319
`H340
`H350
`H372
`H412
`Muta.
`Skin lrrit.
`STOT RE
`
`Acute aquatic toxicity
`Chronic aquatic toxicity
`Aspiration hazard
`Carcinogenicity
`Eye irritation
`Flammable liquids
`Extremely flammable liquid and vapour.
`Highly flammable liquid and vapour.
`May be fatal 1f swallowed and enters airways.
`Causes skin irritation.
`Causes serious eye irritation.
`May cause genetic defects.
`May cause cancer.
`Causes damage to organs through prolonged or repeated exposure.
`Harmful to aquatic life with long lasting effects.
`Germ cell mutagenicity
`Skin irritation
`Specific target organ toxicity - repeated exposure
`
`Supelco - 48265-U
`
`Page 8 of 9
`
`CFAD v. Anacor, IPR2015-01776, CFAD EXHIBIT 1067 - Page 8 of 9
`
`
`
`HMIS Rating
`Health hazard:
`Chronic Health Hazard:
`Flammability:
`Physical Hazard
`
`NFPA Rating
`Health hazard:
`Fire Hazard:
`Reactivity Hazard:
`
`0
`
`4
`0
`
`O
`4
`0
`
`Further information
`Copyright 2015 Sigma-Aldrich Co. LLC. License granted to make unlimited paper copies for internal use only.
`The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a
`guide. The information in this document is based on the present state of our knowledge and is applicable to the
`product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the
`product. Sigma-Aldrich Corporation and its Affiliates shall not be held liable for any damage resulting from handling
`or from contact with the above product. See www.sigma-aldrich.com and/or the reverse side of invoice or packing
`slip for additional terms and conditions of sale.
`
`Preparation Information
`Sigma-Aldrich Corporation
`Product Safety - Americas Region
`1-800-521-8956
`
`Version: 3.10
`
`Revision Date: 11 /24/2015
`
`Print Date: 02/08/2016
`
`Supelco - 48265-U
`
`Page 9 or 9
`
`CFAD v. Anacor, IPR2015-01776, CFAD EXHIBIT 1067 - Page 9 of 9