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`

`
`
`
`Edited for the British Pharmacological Society bl’
`
`R. S. Stacey (Secretary)
`W. D. M. Paton (Chairman)
`P. A. Nasmyth (Press Editor)
`Jennifer Maclagan (Assistant Press Editor)
`
`N. Ambache
`R. B. Barlow
`J. M. Barnes
`J. W. Black
`W. C. Bowman
`P. B. Bradley
`S. Brenner (co—opted)
`A. W. Cuthbert
`C. T. Dollery
`W. S. Feldberg
`L. G. Goodwin
`D. F. Hawkins (co-opted)
`F. Hobbiger
`J. R. Hodges
`
`D. B. Hope
`H. W. Kosterlitz
`J. Maddox
`J. F. Mitchell
`J. L. Mongar
`M. W. Parkes
`Mary Pickford
`H. P. Rang
`H. O. Schild
`D. F. Sharman
`Hannah Steinberg
`F. M. Sullivan
`J. R. Vane
`Marthe Vogt
`
`Editorial assistance is pro rided by the stafi" of Nature
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`
`Manuscripts (two copies) should be sent to Professor R. S. Stacey, St. ThomaS’5
`Hospital Medical School, London S.E.l. Authors should consult the sugg6Sti0"S
`inside the back cover.
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`Copyright © 1970 by the British Journal ofPharmacology. All rights of repf0d”°tiOn
`are reserved in respect of all papers, articles,
`illustrations, etc., published in ms
`journal in all countries of the world.
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`CFAD v. Anacor, IPR2015-01776 ANACOR EX. 2116 - 2/12
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`

`
`CONTENTS
`
`VOLUME 40
`
`No. 1
`
`SEPTEMBER 1970
`
`page
`
`23
`
`37
`
`45
`
`57
`
`68
`
`78
`
`86
`
`92
`
`102
`
`ll?)
`
`I24
`
`Systematic Pharmacology
`-
`: b
`tl
`'
`*
`'
`CALLINGHAM, B. A. and SHARMAN, D. F.
`The concentration of catechola
`ram
`mules In K’
`of the domestic fowl (Ga/lu.s' clornesticus).
`(SP2, M)
`3
`BANEIUEE. U-, F§LDBERG_.
`a“d GEORGIEV, V. P. Microinjections of tubocurarine, leptazoi
`strychnine and picrotoxm into the cerebral cortex of anaesthetized cats.
`(SP2, DM2)
`FELDEERG, W. and GEORGIEV, V. P.
`Central effects of picrotoxin
`hen acti
`f‘
`liquor spaces in anaesthetized cats.
`(SP2)
`W
`mg
`[Om the
`IAaSbI'IbF'i?:'D,(€fi3?.§I'1d BUNN, D. R. G.
`The effect of Arvin on reticulo-endothelial activity in
`Autopharmacology
`
`BRIMBLECOMBE, R. W. and EVERETT, SALLY D. Actions of some choliner
`fast-twitch and slow-twitch skeletal muscle of the cat.
`(API, SP3)
`BRIMBLECOMBE, R. W. and EVERETT, SALLY D.
`Actions of sarin on t‘
`t-t
`"t h '
`.
`twitch skeletal muscles of the cat and protective action by anticholinergigsdrxgls? (;:'1]>(i,sé%V§'
`MARSHALL,
`I. G.
`A comparison between the blocking actions of ?.~(4-phenylpiperidin )
`cyclohcxanol (AH 5183) and its N-methyl quaternary analogue (AH 5954).‘
`(AP1, SP3’ DMC1’;
`]t3il(-;)l:Ti/tnC§1[.1l~2I1IéS(t.;r1.(;tiCZ::tél{(:i,ogS.IDEA???)MELCHIORRI, P.
`The effects of caerulem on insulin sec;-e_
`Pharmacokinetics
`
`gic antagonists on
`
`SHARK/\Wl, M.
`Effects of morphine and pentobarbitone on acetylcholine s
`ynthesis by rat
`cerebral cortex.
`(PK2, SP2, APl)
`t"
`'
`'
`'
`-
`‘
`-
`-
`.
`'
`.
`.
`'
`f th
`A
`e an inociceptive actions of chollnomimettc and morphme_
`1IiR(Eesc()1t:£l;S'D (DM2eosnl;g§1rison o
`(DM2, SP3)
`WATSON, P. J. Drug receptor sites in the rabbit saphenous nerve.
`
`Psychopharmacology
`
`SH1LL1~ro, ELIZABETH E.
`behaviour of mice.
`(PP)
`
`A method for investigating the effects of drugs on the exploratory
`
`Toxicology
`NATOFF, I. L. and REIFF, B. Quantitative studies of th
`toxicity of organophosphates in rats.
`(CP, DM2)
`
`ff
`t
`f
`t
`‘ t
`e e ec 0 an agoms S on the acme
`
`Proceedings of the British Pharmacological Society, Dublin,
`8-10 July, 1970
`
`l35P
`
`1361’
`
`1381’
`
`1391’
`
`1411’
`
`1421’
`
`143!’
`
`l44P
`
`l45P
`
`Inhibition of brain cholinesterase activity after the injection of organophospho
`REIFF, B.
`compounds in the rat
`HOPKIN, JUDY M. and NEAL, M. J.
`rat spinal cord slices
`Dooor-:rT, N. S., SPENCER, P. S. J. and TURNER, T. A. R.
`ouabain administered intracerebrally to conscious mice
`MARLEY,
`and SELLER, T. J.
`Some effects of muscarine on the central nervous system of
`chickens
`
`ms
`The release of “C—glycine from electrically stimulated
`
`The pharmacological eflectg of
`
`Some effects of nicotine on the central nervous system of
`
`MARLEY, E. and SELLER, T. J.
`chickens
`The effect of adrenaline on 5-hydroxyindole concentrations in the hypo-
`GORDON, A. E.
`thalamus and thalamus of rat
`MAJOR, C. T. and PLEUVRY, BARBARA J.
`phine and the sympathomimetic drugs
`MELDRUM, B. S. and NAQUET, R.
`Effects of psiloeybin, dimethyltryptamine and various
`lysergic acid derivatives on photxcally-tnduced epilepsy in the baboon (Papio papia)
`PICKETT, R. D. Acute toxicity of heroin, alone and in combination with cocaine or quinine
`
`A comparison of the analgesia produced by mo;--
`
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`page
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`1531’
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`155?
`
`l57P
`1581’
`
`l59P
`l60P
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`l6lP
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`1621’
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`l63P
`1641’
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`l66P
`l67P
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`1721’
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`VOLUME 40
`
`NO. 1 (continued)
`
`The effect Of propranolol on the human and canine
`
`TURNER, P. Alprenolol and propranolol in hyperthyroid tachycardia
`COLTART, D. J.
`A comparison of the effects of‘ propranolol and practolol on the exercise
`tolerance in angina pectoris
`COLTART, D. J. and MELDRUM, S. J.
`transtnembrane action potential
`MURNAGHAN, M. F.
`Comparative effectiveness of lignocaine, quinidine, propranolol and
`procainamide as antifibrillatory agents
`DAS, P. K. and PARRATT, J. R. Myocardial effects of phentolamine
`FOb(.E.).c_\RrY, M., GILL, D., HILL, P. and PETTIT, J. Cardiovascular effects of pentazocine in
`ra
`its
`ALPS, B. J., JOHNSON, E. S. and WILSON, A. B. Cardiovascular actions of Wy 21901, a new
`hypotensive and anti-arrhythmic agent
`ALI>s, B. J., HILL, MADELINE, JOHNSON, E. S. and WILSON, A. B.
`properties of Wy 21901
`WESTON, A..H.
`Changes in the amounts Of high-energy phosphate compounds associated
`with the actions Of‘ phenylephrine and isoprenaline on smooth and cardiac muscle
`FARMER, J. B. and LEVY, G. P.
`Interaction of isoprenaline and /9’-adrenoceptor blocking
`drugs on intestinal smooth muscle
`COUPAR, l. M. and TURNER, P.
`in isolated human smooth muscle
`MOTTRAM, D. R.
`Binding sites for 2-haloalkylamines
`RAND, M. J. and VARMA, B.
`Effects of McN-A—343 On responses induced by sympathetic
`nerve stimulation in the rabbit isolated ear artery
`WILSON, J .
`The uptake of adrenergic neurone blocking drugs
`BUTTERWORTH, K. R. and RANDALL, M. J.
`The 6f'i'6CtS.Of a- and /3-adrenoceptor blocking
`agents 011 the responses of the rat uterus to catecholammes throughout the oestrous cycle
`BAMFORD, D. S., PERCIVAL, R. C. and TOTHILL, A. U.
`Raspberry leaf tea: a new aspect to
`an old problem
`The effect of the interval between elec-
`KOSTERLITZ, H. W. and WATERFIELD, ANGELA A.
`trical stimuli On the acetylcholine output of the myenteric plexus-longitudinal muscle prep-
`aration Of the guinea-pig ileum
`POSNER, J.
`The release of prostaglandin E2 from the bovine iris
`HENMAN, F. D., MOLE, K. H. and SHEPHERD, D. M.
`Effects of decarborane on gastric
`secretion in the Shay rat
`The use of neuromuscular blocking agents to
`BUCKETT, W. R. and FRISK-HOLMBERG, M.
`investigate receptor structure requirements for histamine release
`Eymg, P,
`The Schultz-Dale reaction in bovine pulmonary smooth muscles
`WHITTINGTON, HILARY. Effects of azathioprine and phenylbutazone in rat adjuvant arthritis
`BYWATER, R. J.
`Some effects of Esclzeric/zia co/i enterotoxin on fluid and electrolyte trans-
`fer in calf small intestine
`The origin of ascorbic acid Stored in the leucocytes
`LOH, H. S. and WILSON, C. W. M.
`ODUMOSU, A. and WILSON, C. W. M. The growth maintaining activity and intestinal absorp-
`tion of ascorbic acid in guiflea-Pigs
`Liver damage and excretion of bivalent Sulphur after
`BUTLER, W. H. and MAGOS, L.
`exposure to carbon disulphide in fed and fasted rats with and without phenobarbitone pre-
`treatment
`_
`_
`SUMMERS, R_ J_
`Effects of pargylme on body temperature and on hypothalamic levels of
`Inonoamines in the rabbit (T)’f’
`I
`_
`.
`TONKS, R. S.
`Effect of amylobarbttone, dextro-amphetamine and a mixture of these on
`performance and learning in man (T)
`.
`DANIEL, M., GIFFARD, F. and SANFORD, J.
`The effects Of acepromazme and methyl-
`amphetamine on the performance of the ridden horse (T).
`V
`_
`'
`AUSTIN, FRANCIS H.
`A study of the sympathomimetic effects of phencyclidine hydro-
`chloride (T)
`BILLINGHAM, M. E. J., GAUGAS, J. M. and ROBINSON, B. V.
`erties of anti-lymphocytic Serum (T)
`BILLINGHAM, M. E. J., GORDON, A. H. and ROBINSON, B. V.
`inflammation by the liver (T)
`
`Autonomic blocking
`
`Relative affinities of some a-adrenoceptor blocking drugs
`
`The anti-inflammatory prop-
`
`Synthesis of an inhibitor of
`
`WT), Abstract by title only.
`
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`

`
`VOLUME 40
`
`No. 2
`
`OCTOBER 1970
`
`Page
`
`175
`
`219
`
`227
`
`237
`
`249
`
`257
`
`268
`
`275
`
`294
`
`310
`
`317
`326
`
`334
`
`342
`
`Systematic Pharmacology
`AYITEY-SMITH, E. and VARMA, D. R. An assessment of the role of the sympathetic nervous
`system in experimental hypertension using normal and immunosympathectomized rats.
`(SP1, API)
`AYITEY-SMITH, E. and VARMA, D. R. Mechanism of the hypotensive action of rnethyldopa in
`normal. and immunosympathectomized rats.
`(_SPl, DMI)
`BRADLEY, P. B. and CANDY, J. M.
`Iontophoretic release of acetylcholine, noradrenaline,
`5-hydroxytryptamine and D-lysergic acid diethylamide from micropipettes.
`(SP2, PK3, DM1)
`BOAKES, R. J., BRADLEY, P. B., BRIGGS, I. and DRAY, A. Antagonism of 5-hydroxytryptamine
`by LSD 25 in the central nervous system: a possible neuronal basis for the actions of LSD 25.
`(SP2, DMl, DM2)
`MCCULLOUGH, DEBORAH 0., MILBERG, JANE N. and ROBINSON, S. M. A central site for the
`hypothermic eilects of (—l—)—amphetamine sulphate and p-hydroxyamphetamine hydrobromide
`in mice.
`(SP2)
`_
`DODDS, M. G. and FOORD, R. D. Enhancement by potent diuretics of renal tubular necrosis
`induced by cephaloridine.
`(SP3, DM2, TX)
`DHAWAN, B. N. and SI-IARMA, J. N. Facilitation of the flexor reflex in the cat by intrathecal
`injection of catecholamines.
`(SP2, API, DM2)
`
`Autopharmacology
`
`DE LA LANDE, I. S., HILL, B. D., .lELLE’I'I‘, L. B. and MCNEIL, J. M. The role of monoamine
`oxidase in the response of the isolated central artery of the rabbit ear to tyramme. (AP1, PKI,
`SP1)
`GILLESPIE, J. S., MACLAREN, A. and POLLocI<, D. A method of stimulating difierent segments
`of the autonomic outflow from the spinal column to various organs in the pithed cat and rat.
`(API)
`APPEL, W. C. and VINCENZI, F. F. Effects of hemicholinium and bretylium on the release of
`autonomic transmitters in the isolated sino-atrial node.
`(API, SP1, PK3)
`KOSTERLITZ, H. W., Lens, G. M. and WALLIS, D. I. Synaptic potentials recorded by the
`sucrose-gap method from the rabbit superior cervical ganglion.
`(API)
`LEME, J. GARCIA, HAMAMURA, L. and ROCHA E SILVA, M. ElTect of anti-proteases and hexa-
`dimethrine bromide on the release of a bradykinin-like substance during heating (46" C)
`of rat paws.
`(AP2)
`MITCHELL, R. G. and PORTER, J. F. Histamine and granulocytes in the umbilical cord blood
`of infants at birth.
`(AP2, CP)
`(AP2, PK2)
`NAKANO, J. Metabolism of prostaglandin E, in dog kidneys.
`NUSTAD, K. and RUBIN, I. Subcellular localization of renin and kininogenase in the rat kidney.
`(AP2)
`BARRACLOUGH, M. A. and JONES. N. F. Effects of adenosine 3’,5’-monophosphate on renal
`function in the rabbit.
`(AP3, SP3)
`BISSET, G. W., CLARK, BARBARA J., KRI«:J€’:t, 1., PoLA<“:EI<, I. and RUDINGER, J. Some pharma-
`cological properties of a synthetic oxytocin analogue [1-N-carbamoyl-hemicystine-2-O-
`Inethyltyrosine]-oxytocin (carbamoyl-methyloxytocin), an antagonist
`to the neurohypo-
`physial hormones.
`(AP3, DM2)
`
`361
`
`Psycltopharmacology
`Al-l'l‘l3E, LnsA and SHILLITO, ELIZABETH. The effect of benzodiazepines and atropine on explor-
`atory behaviour and motor activity of mice.
`(PP)
`
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`Page
`
`373
`
`382
`
`396
`
`406
`
`418
`
`426
`
`437
`
`446
`
`461
`
`468
`
`508
`
`522
`
`524
`
`526
`
`528
`
`531
`
`534
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`VOLUME 40
`
`No. 3
`
`NOVEMBER 1970
`
`Systematic Pharmacology
`A. M. and CARTER, J. Comparative chronotropic activity of B-adrenoceptive
`BARRETT,
`antagonists.
`(SP1, APl, DM2)
`to glucagon, ouabain and noradrenaline.
`SPILKER, B.
`Comparison of the inotropic response
`(SP1)
`DOWNEY, J. A. and FREWIN, D. B. The efizagtjfif ethyl alcohol and chlorpromazine on the
`response of the hand blood vessels to cold.
`MOLENAAR, P. C. and POLAK, R. L. Stimulation by atropine of acetylcholine release and
`synthesis in cortical slices from rat brain.
`(SP2, API, DMI)
`Autopharmacology
`EY, T. A. Effects of chronic metaraminol treatment on the sympa-
`d adrenal demedullated rats kept in warm or cold environments.
`
`JOHNSON, G. E. and PUGSL
`thetic activity of intact an
`(API, PK1)
`RICIA A. and SCHNEIDER, R. The effects of “autonomic drugs" on villous move-
`HOOPER, PA-r
`’
`merit in the small intestine of the pigeon.
`(API, SP3, DM2)
`BOWERY, N. G._, LEWI_s, G. P. and MATTHEWS, J. The relationship between functional vaso-
`dilatation in adipose tissue and prostaglandin.
`(AP2, SP1)
`LEWIS, G. P. and _WINsEY, N. J. P. The action of pharmacologically active substances on the
`flow and composition of cat hind limb lymph.
`(AP2, SP1)
`Pharmacokinetics
`I. and PLETSCHER, A. Distribution and metabolism of L-3-0-
`BARTHOLINI, G., KURUMA,
`methyldopa in rats.
`(PKI, PK2, SP2)
`of 5-hydroxytryptamine in the pul-
`ALABASTER, VALERIE A. and BAKHLE, Y. S. Removal
`monary circulation of rat isolated lungs.
`(PK2)
`Drug Mechanisms
`REID, W. D. Turnover rate of brain 5-hydroxytryptamine increased by D-amphetamine.
`(DMI, PK2)
`BURGEN, A. S. V. and SPERO, L. The efiects of calcium and magnesium on the response of
`(DM2)
`intestinal smooth muscle to drugs.
`Influence of pH on the inhibitory action
`ANTONIO, A., ROCHA E SILVA, M. and YAsi-iUDA, Y.
`of local anaesthetics on smooth muscle contraction.
`of drugs through stationary water layers
`CUTHBERT, A.‘W. and DUNANT, YvEs. Diffusion
`(DMl, DM2)
`as the rate limiting process in their action at membrane receptors.
`SHORT COMMUNICATIONS
`BOULLIN, D. J., MCMAHON, E. M. and O’BRiEN, R. A. Uptake of dopamine by platel
`(PK3)
`D. Positive correlation between initial pupil
`HORLINGTON, M. and ROBSON,
`BURNS, J.,
`_
`bbits and to carbachol in man.
`diameter and amplitude of
`miotic response to pilocarpine in ra
`(API, PM)
`_
`. and SPILKER, B. A.
`Inotropic effects of thyroxine and related compounds
`.BAiRD, J. R. C
`_
`on guinea-pig left atria in vivo.
`(AP3, SP1)
`IvERsEN, L. L. and SALT, P. J.
`Inhibition of catecholamine Uptake; by steroids in the isolated
`rat heart.
`(API, PK3» SP1)
`d neostigmine on acetylcholine responses of isolated ileum.
`EDGE, N. D.
`pP2 of eserine an
`(DM2, PM)
`_
`_
`YLES, SUSAN and SCHOLEIELD, P. C. Cardio-selective 3 adrenoceptor blockade
`ADAM, K. R., Bo
`_
`and the coronary circulation.
`(SP, AP, DM2)
`
`ets in viva.
`
`Proceedings of th
`
`e British Pharmacological Society, London,
`9-11 September, 1970
`Commum'can'ons
`d METCALFE, S. M. Metabolic inhibition in primary cell cultures by
`METCALFE, J. C. an
`lipid-soluble molecules
`D, G. P. Destruction of chlorpromazine during
`CURRY, S. H., D’MELLo, A. and MOUL
`absorption by rat intestine in vitro
`_
`.
`ROBSON, R. D. Reflex and other vascular changes inlanaesthetized dogs after B'adr€rl0C6pt0r
`o
`antagonism with alprenolol, bunolol and proprano
`V
`'
`.
`'
`_
`LEWIS, G. P. and WAWRETSCHEK, W. A. The kinin-forming system in rabbit hind limb lymph
`after thermal injury
`_
`ble existence of different
`types of
`MEYER, P., PAPADIMITRIOU, A. and WoRcEL, M. Possi
`angiotensin 11 receptors
`_
`GODFRAIND, T. Angiotensin auto-potentiation
`Blockade of the efl'ects of valyl-5-angio-
`MEYER, P., PAPADIMITRIOU, A. and WORCEL, M.
`_
`.
`tensinamide II, oxytocin, noradrenaline, 5-hydfoxytfyptamlne and acetl/1Ch011I16 by 811311-
`Cydine CFAD V. Anacor, |PR201 5-01 776 ANACOR EX. 2116 - 6/12
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`
`VOLUME 40
`
`No. 3 (continued)
`
`flag?
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`571 P
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`BRASH, A. R. and CU'I‘HBIZRT, A. W. The effects of saponins on the transporting epithelium
`of isolated frog skin
`lg/lICil~{/\L, F. Platelet aggregation by very low intensity acoustical energy and its inhibition
`y ( rugs
`SMITH, J. B. and WILLIs, A. L. Formation and release of prostaglandins by Platelets in
`response to thrombin
`A
`PALMER, M. A., PIPER, PRISCILLA J. and VANE, J. R. Release of vaso-active substances
`from lungs by injection of particles
`HoD(iL's, J. R. and lVll'I'Cl-lLl-JY, SUSAN. A comparison of the effects of betamethasone and
`tetracosactrin on hypothalamo-pituitary-adrenal activity in the rat
`_
`ODUMOSU, A. and WILSON, C. W. M. The relationship between ascorbic acid concentrations
`and cortisol production during the development of scurvy in the Eumea-1913
`BERRY, CYNTHIA F. and COTTRELL, G. A.
`Isolation of dense-cored granules from the neuro-
`secretory system of the vena cava of the small octopod, E/£‘(/ONE cirrosa
`ARMSTRONG, J. M. and BOURA, A. L. A. Relative susceptibility of Peripheral 5>’mP3-lhetlc
`nerves to adrenergic neurone blockade by bethanidine
`_
`ADAMS, P. R., CASH, H. C. and QUILLIAM, J.
`I’. Extrinsic and intrinsic acetylcholine and
`barbiturate effects on frog skeletal muscle
`GREENI3L'Ro, R., KOSTERLITZ, H. W. and WATERI-IELD, ANGELA A. The efTects of hexa-
`methonium, morphine and adrenaline on the output of acetylcholine from the myenteric
`plexus-longitudinal muscle preparation of the ileum
`KNOLL, J. and VIzI, E. S. Presynaptic inhibition of acetylcholine release by endogenous
`and exogenous noradrenaline at high rate of stimulation
`l-IUGI-IES, J. The detection and assay of noradrenaline released from isolated tissues during
`intramural nerve stimulation
`AMBACHE, N. and ZAR, M. A300. Motor transmission in the vas deferens:
`action of noradrenaline
`DRAPER, J. G. and TOTHILL, ANNE U. Adrenaline uptake mechanisms in the rat uterus
`MCKIERNAN, J. M., MUIR, T. C. and POLLOCK, D.
`Changes in the r6SD0_T1SiV€f1€SS Of the
`colon and vas deferens to nerve stimulation and injected transmitters in the pithed rat follow-
`ing chronic morphine treatment
`BRowN, D. A. and SCHOLFIELD, C. N. Potentials in isolated rat superior cervical ganglia
`produced by nicotine
`KERKUT, G. A., RALPH, K. L., WALKER, R. J. and WOODRUFI-‘, G. N. The effect of drug
`pretreatment on synaptic activity in Helix brain
`MOIR, A. T. B. and YATES, C. M. Actions of phenelzine on the interactions of the meta-
`bolism of tryptophan and dopamine in brain
`SIMMONDS, M. A. and URETSKY, N. J. Acute hypotliermic response of the rat to intra-
`ventricular injection of 6-hydroxydopamine
`BLACK, J. W., PARSONS, M. E. and THOMPSON, M. Comparative assays using gastric acid
`secretion: a simple application of non-linear curve fitting (T) T
`D‘AuRIAc, ANGLES G., MEYER, P., OSBORNE, M. J. and WORCEL, M.
`traction of angiotensin II in coronary and renal circulations (T)
`AIKEN, J. W. and VANE, J. R. Conversion of angiotensin I to angiotensin II in isolated
`strips of arterial smooth muscle (T)
`DAVILA, D. and KHAIRALLAH, P. A. Angiotensin effect on biosynthesis of noradrenaline (T)
`BEGENT, NIcoLA and BoRN, G. V. R. A method for measuring the effectiveness of drugs on
`platelet thrombus formation in viva (T)
`
`Mechanism of ex-
`
`the inhibitory
`
`Clinical Pliarmacology Section
`Lon, H. S. and WILSON, C. W. M. The relationship between leucocyte ascorbic acid and
`plasma iron
`KELMAN, G. R. and KENNEDY, B. R. Cardiovascular effects of pancuronium in anaesthetized
`man
`
`CLARKE, R. S. J., DUNDEE, J. W. and LOAN, W. B. The use of post-operative vomiting as a
`means of evaluating anti-emetics
`BusiiMAN, J. A., HOPE, C. E. and PAYNE, J. P. A method for inducing stress for the assess-
`ment of drugs in man
`CARTER, S. J., HOPE, C. E. and PAYNE, J. P. The effect of ingested alcohol on hand blood
`flow in resting man
`GIL-RODRIGUEZ, J. A., PAYNE, J. P. and PoI'rER, D. R. Some cardiovascular effects of
`intravenous atropine in patients anaesthetized with halothane
`MA'I’HlAS, J. A. and PAYNE, J. P. Practolol in the management of cardiac dysrhythmias in
`patients anaesthetized with halothane
`AELLIG, W. H., PRICIIARD, B. N. C. and SCALES, B. Blood levels of practolol following
`intravenous administration
`
`HODGL‘, R. L. and ROBINSON, S. M. Vascular actions of clonidine in man
`
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`
`Page
`
`VOLUME 40
`
`No. 3 (continued)
`
`574P
`
`COLLIER, J. G., NACHEV, CH. and ROBINSON, B. F. A new method for studying the pharma-
`cology of the superficial veins in conscious man
`575P AYERS, A. B., DAVIES, B. N. and WITHRINGTON, P. G. The responses of the isolated perfused
`spleen of man to sympathetic nerve stimulation, catecholamines and polypeptides
`576P HILLIER, K. and KARIM, S. M. M. The human isolated cervix: a study of its spontaneous
`motility and responsiveness to drugs
`577P PHILLIPS, SUSAN J., RICHENS, A. and SHAND, D. G. A method for studying spinal pharma-
`cology in man
`.MAWER, G. E. and SIMoNs, P. J. The influence of dose on the
`578? BALASUERAMANIAM, K.,
`distribution and elimination of amylobarbitone in healthy subjects
`5791’ MAWER, G. W., MILLER, N. E. and_ TURNEERG, L. A. Preliminary observations on the
`elimination of amylobarbitone by patients with chronic liver disease
`SSOP O’MALLEY, K. and STEVENSON, I. H.
`Increased half-life of antipyrine in women taking oral
`contraceptives (T)
`580P GosLINcs, W. R. 0., MATTIE, H. and NAUTA, E. H. The absorption and elimination of
`cloxacillin in patients on chronic intermittent haemodialysis (T)
`580P FOLB, P. I. The effects of steroid and of immunosuppressive drug therapy on lymphocyte
`stimulation by Caiidida antigens (T)
`Denioizrtratibris
`
`he responses of the guinea-pig isolated heart
`
`588P
`
`58lP PALMER, M. A., PIPER, PRIscILLA J. and VANE, J. R. The release of rabbit aorta contracting
`substance (RCS) from chopped lung and its antagonism by anti-inflammatory drugs
`582P ALABASTER, VALERIE A. and BAKHLE, Y. S. The release of biologically active substances
`from isolated lungs by 5-hydroxytryptamine and tryptamine
`S83P WILLIS, A. L.
`Simplified thin-layer chromatography of prostaglandins in biological extracts
`584P ARENSON, M. S., EccLEs, R. and WILsoN, H. The Vidian nerve and the sphenopalatine
`ganglion in relation to lacrimation in the cat
`585P HADHAZY, P. The effect of isoprenaline on t
`to vagal stimulation and to acetylcholine
`586P KERKUT, G. A., NEWTON, LYNNE C., PITMAN, R. M., WALKER, R. J. and WOODRUFF, G. N.
`Acetylcholinc receptors of invertebrate neurones
`’nation of the junction between the myenteric
`588P GABELLA, G. Electron microscopical exami
`_
`plexus and the longitudinal muscle of the guinea-pig ileum
`ARMITAGE, A. K., GRANT, C. A., LEE, P. N., SELLERS, C. M. and WILSON, A. Measurement
`and printout of average heart-rate using digital techniques
`hine in the rat using a sub-
`589P GOODE, P. G. The induction of physical dependence to morp
`cutaneously implanted reservoir
`590P BUCKLEY, G. A. and HEADING, CI-IRIsTI_NE E. Tolerance to neostigmine
`59lP BUCKLEY, G. A. and HEATON, J. Simultaneous determination of choline acetylase and
`cholinesterase activity
`592P BEGENT, NICOLA and BORN, G. V. R. Determination of the iontophoretic release of adeno-
`sine diphosphate fi'om micropipettes
`593P
`RICHENS, A, and ROWE, D. J. F‘.
`Interaction between anticonvulsant drugs and vitamin D
`JENNIFER A. C. Pharmacologically active substances in malignant ascites fluid
`595P SYKES,
`596P DAVIES, D. DENISON and MATHIAS, J. A. A method for the determination of residual
`quantities of halothane in blood
`597P G1I,—Ro1)I{1Gu12z, J. A., HILL, D. W. and LUNDBERG, S. The measurement of renal blood
`flow during anaesthesia by means of a single-shot urineless technique with 1311-hippuran
`598P HILL, D. W., MABLE, S. E. R., PAYNE, J. P. and WORSLEY, R. A three-channel telephone
`data link for the transmission of physiological variables
`599P HOPE, C. E. and WILCOCK, A. H. An improved method of measuring drug-induced peri-
`pheral vascular responses in conscious man
`D. A. and TURNER, P. Comparison of atropine and (—)-
`600P BAGS]-IAW, H., CHAMBERLAIN,
`hyoscyamine on heart rate in man
`6OIP CLARKE, R. S. J. and DUNDEE, J.
`anti-emetics
`602P BEGENT, NICOLA and BORN, G. V. R. A method for measuring the effectiveness of drugs
`on platelet thrombus formation in viva (T)
`he dog and their detection
`602P WILLIAMS, K. I. The release of neurohypophyseal hormones in t
`using the blood-bathed organ technique (T)
`602P AIKEN, J. W. A method for comparing the sensitivity to chemical stimuli of adrenergic
`and cholinergic neurones in the cat stellate ganglion (T)
`F. A rapid morphological change of blood platelets as a
`6021’ BORN, G. V. R. and MICHAL,
`pharmacological test system
`f rapid morphological changes of blood platelets (T)
`602P MACFARLANE, D. E. Demonstration o
`602P WRIGHT, HELEN PAYLING. Autoradiographical studies of aortic endothelium in guinea-pig (T)
`
`W. A class experiment to investigate the side-eifects of
`
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`
`VOLUME 40
`
`No. 3 (continued)
`
`C. B. Aggregation and the release of active sub‘
`
`The distribution of 1251-polyvinyl pyrrolidone
`
`toic membrane of the chick embryo (T)
`
`page
`6031’
`
`603]’
`
`6031’
`
`6031’
`603?
`
`603P
`603P
`6031’
`
`603P
`
`6031’
`
`603P
`603P
`
`JUENGJAROEN, KANCHANA and MILLS, D.
`stances in platelets of different species (T)
`MILLS, D. C. B. and SMITH, J. B. The effect of inhibitors of platelet 3’,5’-AMP phospho-
`diesterase on platelet aggregation (T)
`GOLDMAN, EPHRAT and YOULTEN, L. J. F.
`(PVP) after intravenous injections in rats (T)
`AMEACHE, N. and ZAR,
`M. A300. Effects of noradrenaline on the guinea-pig vas deferens (T)
`BURRAGE, KAREN and
`HELLMANN, K. Screening compounds for inhibition of tumour cell
`dissemination (T)
`TUCKER, DEREK. Cell culture of the chorioallan
`DUKE, D. I. Teratology of anticancer drugs (T)
`BURRAGE, KAREN
`, KELLMANN, K. and SALSBURY, A. J.
`Inhibition of malignant metastases
`by ICRF 159 (T)
`JAMES, SALLY. Effect of antilymphocytic serum on spontaneous dissemination of tumour
`cells (T)
`CHAVES-CHAVAI§RIA, R., PAYNE, J. P.
`and PowELL, J. W. A system for the determination of
`liquid-gas partition coefficients using gas chromatography (T)
`MORRISON, P. C. A. A dual-beam alcohol vapour analyser (T)
`COLLIER, J. G., NACHEV,
`.
`CH. and ROBINSON, B. F. A new method for quantitating the effect
`of vaso-active drugs on superficial veins in conscious man (T)
`T (T). Abstract by title only
`
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`page
`
`605
`
`617
`
`630
`
`639
`
`659
`
`668
`
`689
`
`702
`
`721
`
`732
`
`740
`
`747
`
`759
`
`VOLUME 40
`
`No.4
`
`DECEMBER 1970
`
`Systematic Pharmacology
`GELLER, R. G., GOVIER, W. C., PisANo, J. J., TANIMURA, T. and VAN CLINESCHMIDT, B.
`The action of ranatensin, a new polypeptide from amphibian skin, on the blood pressure of
`experimental animals.
`(SP I)
`BROADLEY, K. J. An analysis of the coronary vascular responses to catecholamines, using a
`modified Langendorff heart preparation.
`(SP1, AP1)
`SIMMONDS, M. A. and URETSKY, N. J. Central effects of 6-hydroxydopamine on the body
`temperature of the rat.
`(SP2, PK3, DMI)
`MARLEY, E. and STEPHENSON, J. D. Effects of catecholamines infused into the brain of young
`chickens.
`(SP2, DMZ)
`HOYLAND, VALERIE J., SHILLITO, ELIZABETH E. and Voor, MARTHE.
`phenylalanine on the behaviour of cats.
`(SP2, PP)
`BURNsToci<, G., CAMPBELL, G., SATCHELL, D. and SMYTHE, ANNE. Evidence that adenosine
`_trip_hosphate or a related nucleotide is the transmitter substance released by non-adrenergic
`inhibitory nerves in the gut.
`(SP3, AP2)
`
`The effect of parachloro-
`
`Autopharmacology
`GULATI. 0. ll, PARIKH, H. M., RINGE, S. Y. and Sl-IERLEKAR, M. L. An investigation of
`a-inethyl amino-acids and their derivatives on isolated tissue preparations.
`(AP1)
`B_0ADLE—Bl_BE_R, MARQARET C., HUGHES, J. and ROTH, R. H. Acceleration of noradrenaline
`b|0SYnth€S151"
`the guinea-pig vas deferens by potassium.
`(AP1, PK2, PK3)
`MELDOLESI, J. Effect of caerulein on protein synthesis and secretion in the guinea-pig
`pancreas.
`(AP2, DMI)
`_l-l0DGi:s, J. R. and MITCHLEY, SUSAN. Recovery of hypothalamo-pituitary-adrenal function
`in the rat after prolonged treatment with betamethasone.
`(AP3)
`Hoi)oEs, J. R. and HoTsToN, R. T. Ascorbic acid deficiency and pituitary adrenocortical
`activity in the guinea-pig.
`(AP3)
`COVILLE, P. F. and TELEORD, J. M. The effect of thyroid hormones on the action of some
`centrally acting drugs.
`(AP3, SP2)
`Investigations into the mechanism of the antifertility
`KENDI-E,
`and TELEORD, J. M.
`action of minimal doses of megestrol acetate in the rabbit.
`(AP3, SP3)
`Pharmacokinetics
`
`775
`
`790
`
`800
`
`814
`
`827
`
`836
`
`847
`
`866
`
`871
`
`881
`884
`
`887
`
`and PEci<, A. W. The relationship between the level of cholinesterase in plasma
`HOBBIGER.
`and the 3.00011 Of suxamethonium in animals.
`(PK2, PKI)
`B5‘-la IJNDA J-’ IVERSEN. L. L. and URETSKY, N. J. Time course of the effects of 6-hydroxy‘
`cI])(f(p3a,rn];[115I lo)n catecholamine-containing neurones in rat hypothalamus and striatum.
`(PK2,
`I-OIZOU, L- A- Uptake of monoainines into central neurones and the blood-brain barrier
`in the infant rat.
`(PK3, SP2, AP1)
`Drug Mechanisms
`inhibitors on frog sartorius
`KIRSTEN, E. B. and KUPERMAN, A. S. Effects of sulphydryl
`muscle: p-chloromelcuflbenzolc acid and p-chloromercuribenzenesulphonic acid. (DMI, SP3)
`KIRSTEN, E. B. and KUPERMAN, A. S. Eff
`t
`f
`1 h d
`l' h'b'
`f
`t
`'
`cle:
`Nfithylnqaleimidel
`(DML SP3)
`ec so su p y ry in i
`itors on rog sar orius mus
`
`Psychopharmacology
`LAVERTY, R. and TAYLOR, K. M. Effects of intraventricular 2,4,5-trihydroxyphenylethyl-
`amine (6-hydroxydopamine) on rat behaviour and brain catecholainine metabolism.
`(PP,
`SP2, AP1 )
`Toxicology
`EVANS, M. H. Two toxins from a poisonous sample of mussels Mytilus edulis.
`Pharmacometrics
`
`(TX)
`
`COTTRELL, G. A., PowELL, B. and STANTON, M. A simple method for measuring a picogram
`of acetylcholine using the clam (Mya arenaria) heart.
`(PM, AP1)
`
`Chemotherapy
`AMBROGI, V., ARTINI, D., DE CARNERI, I., CAsTELL1N0, S., DRADI, E., LOGEMANN, W., MEiN-
`ARDI, G., Di SOMMA, M. and TosoLiNi, G. Studies on the antibacterial and antifungal prop-
`erties of 1,4-naphthoquinones.
`(CT, DMI)
`
`SHORT COMMUNICATIONS
`
`CURTis, D. R., FELIX, D. and MCLELLAN, H. GABA and hippocampal inhibition. (SP2, DM2)
`DAY, M. D. and OWEN, D. A. A. Role of noradrenaline in the acute pressor response to
`angiotensin in conscious cats.
`(AP1)
`Index to Volume 40
`
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`
`164p
`
`Proceedings of the
`
`procaine (2><l0-4 g/ml) or by transmural stimulation at 10 Hz and 0-3 ms for up
`to 60 s or by storage at 4° C for 48 h.
`Incubation with amyl
`Release of the material was related to sphincter tone.
`nitrite, 2,4-dinitrophenol, Ca2+ free Krebs solution, anoxia or stimulation with high
`pulse widths for long periods reduced tone and inhibited release of the active material.
`Output increased as tone increased after first mounting the tissue.
`
`Estimates of prostaglandin content of the bovine iris give a very low level. The
`results,
`therefore, suggest that release of the prostaglandin-like substance in the
`present experiments is not a passive process.
`REFERENCES
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`AMBACHE, N. (1959). Further studies on the preparation, purification and nature of irin. J. .PliysioI.,
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