[)t~~c~ 1~;~~.~c~ts ~7f' :~1~~~~ix•iri ~3r~ Cx~~~tr~~ ~'r°t>`t~t~;l~rt~ir~~ 4~~~c
`tE~~r~.~clt i~tuca~s~~i [~~,~t~r~,
`11f3. 7'~i(;~t F;~, i~,ii t'rw~~~ `~1C1; and tt,i,~ F ~Idr+gait, ~7[~
``~la~;t~si €
`
`~_
`~
`~
`l ~tiE~'.~.I~.
`it ttlt~ t~.~~ (. T'
`ut. ,~, I
`
`I
`
`~
`
`i
`
`_
`
`_[''I.l
``.
`
`_ ~
`
`_
`~ , ~,,._.
`,~~~,
`_,.,
`
`'I'r t-- N. Ii~C~?V l.`i~Lf 1t (~{I ~T
`~'. ~`~ tlh~:Il~Y ~ ' 'Cdt!{1C
`r~yl.i,. it ~,ll..~ rn
`..;.;1 ~
`~
`~~~
`,,,
`~ r ~„a'i
`~
`>t t ai
`~-~~~.
`u.~~tir.~l
`
`~
`
`~I _
`
`_,_,1
`
`~ - ..,
`~
`ir.~ .. _ . ~
`i ~
`
`_
`r ~ ~~
`
`i
`
`~~1 taz,
`c:
`.~~.,_;._i ; .i,c.~~
`
`~
`
`~~.
`
`~
`
`r ~,t .~~. p . , i~~ctl
`
`. ~
`
`~
`
`_
`
`1. , r~
`~~-...~~.
`.u:
`
`~
`~,~~. .
`
`~ ..ir~ary
`c a~~~~
`
`~._ .~:~~
`
`.:t,
`
`i
`
`_
`
`~
`
`~t
`
`-
`
`~
`
`i ~~~ ,.
`
`~
`
`i..~,i
`„ri
`
`~ri~~, i~~sw~, ~Ea~ci
`'aye'. rs
`~ l
`
`r.
`
`,ii~_:i
`
`:i:~..
`
`,I_,,,~fl .~.. ,..
`
`i,.
`
`~nl~s
`
`1
`
`I 1,11 -'I
`
`ii'
`
`:`.: I~
`..
`I~~'.. ~,. i. I~~
`
`i:lt', ~.]('t' .. ~."I~.4
`
`~' :k'~r~Ci
`
`i, i_
`
`I
`
`I
`
`~6i~1[1l:
`
`7s~ ~C~ 9
`
`~7
`
`i
`
`i s
`
`~
`
`l~ .. ~r ; ,rr
`
`r~v~tt-
`
`Mf ~l~ject~ve, T'c~ deter~riir~e if a drse of as~rtr n exists
`t3a~f mi~t~I ir~hiit~it throrsat~ex~~<-tl~pert~pn't pt3ketet
`function ~~ithc:ui ca~~sin~ g::esErc eriuca~~1 ihjurv, +he
`~tud3~Ci €h~ e~#~ct~trt av,~~e~ r:~e~ e of d~i5€sat '.,
`,. ~'
`mgrs to 26~)s~ rr~c~,°dJ tin , .sir c juice pr ~ .,r,dur.=,
`;FG~~ end PCFz~ti~ ran ~er~~m thrornbpxanQ ~x ;c~ ~~
`stomach rn;~casai inj«~y a~ refl~ctec~ by ~astr~~e juicy
`h~meglobn an~4 [7hfF~ c~ncerntr~t~br~~,
`~ ~7e~tc7nt ~A r~t~d~ami~~d. ~I~cmtso-~t~~itrc~i~~i study.
`Settirrq, i~es~arch I~sbrarakory rat ~ "l~terans fi;tf~irs
`41"I£'ff6C~~ ~4}(1~6(.
`P;~rticlnz~r~~s' t 6 hea#thy vpiunt~}ors i5 mon 7~~1 11
`Y`!d)YtQIT1.
`~ lnterv~r~fr~n: ~n i~~ first p<~rt cat t~~ ssudy, aolun[e~r~
`rec~iued p4acet~~', ~s~fr~,<1, 324 mgrd; 13RQ m~tc3; car
`2~t70 ~~~,~Ic~ Iar 2 ciay~. Ir; the sacd~sd part vo~crn~eors
`received ptacvt~C,, ~s~i.in, 3 m~r'ci, tL~ n3~;d~ 3t? mqd; ~r
`4k rr~c~s''~ fc~r Q ~lap~s_
`Measurerrients: gastric {~ cry F~~~~ ~nc~ f~G~ .,, he-
`rr,~~lr~b€r~ arsd aNA cc~~c~ntrati~ns;, gastric juicy vr~i-
`um~ end acidity, and serur~~ salicyl~te ~nc~ tt-vrarr~b~x-
`an~ C~7 cas~cefetrations.
`~ ~:1 sis~~ far
`NeS~rrts: in file dirst pit, sigr~iticant
`~e ~rrss-
`~apprc~ximat~iy ~9G~1 inhit~it ott ~f c~as is
`k~gl~n~lin out~~~t ~~r~5 c~t~served writs daiky ~ ,,,irr~ dg~cs
`s! 32a 2a <6~74 mc}. Fitr~~°~~~v~r. a si~nificar7t increase try
`gastric ;~.isr~ r»r~eoglobin ouEput acc~rr~ci only witP~
`Tti00 rr7c~ `c1. Ir the ~ecanc~ ~~rt. signit~c~nt inhit~ tir~r~
`Qap~r~x~rnct~r,, ~,,~~q'r ~f ~ast~ia PG~,,~4siput~,v~s r:.:~~eU
`~a~ z~ ,~ qty ,~;~ rir c~~s~ a~ 3tJ ~~a<~. ~r~we~ as~r;r ~, d~ cs
`~i~I tint e _see P~a~x e~utpstt si~n,fiC~n4~y, aittaou~;+~
`kha~~e cios~~; u~~ sign~ticant[y r~d~~c,~ ~~>~urn th€c~n~t~ux-
`an~ E3~ ire class-~elafe~ rv~~ns~~r.
`Cc7nck;sic~r,s: A~~~r n care vign {icon#ly r~tl4ace ser~r~-i
`tt7rramt~oxz~r~~ F3;, <~t ~lc~sc,s cri 3 mc~?c~ or t~7 rnr~,'~i, which
`area ~igraif€~ ~rnty t~c~lot~~ tl~a thr~st~e~ici vc~s~ fur sign f~-
`c~n# e~~tr :- c?ro^t~yl~ne~sri ir7hit~itc~r, and <sc~tc ste~rn-
`~ecft r~7,~t_~~s~~= :~;urya
`
`I,
`
`~
`!:~. i'. ~
`
`~
`
`_
`
`~.~ u~._~, .,I~~ ~_,
`..~ I'. .~f
`.,
`
`~
`
`~i
`~~'
`~: ~
`
`i-~,i
`
`i
`
`~ ..
`
`..._
`.~...
`
`~
`
`-, ~
`
`~,
`
`i
`
`_
`~c~
`_.i ~~ is
`
`~
`
`_
`
`i~
`c. ~G
`i
`
`_.
`
`~
`i,,~r i
`.,
`c~......
`~: r~ ,,..
`
`~I pr,~~s-
`~~~~,.
`i..- ifl ~C)f'Iii Eli
`,:i n
`Sri, it
`~ tie (csz
`•~,,~~I
`_.
`~~, iai '~u-
`_
`it:.~-~ .J r~_~}~,
`
`?~i c I". ~
`~.iir.~,..~..
`
`i
`
`~
`.
`
`~.'~r
`_
`
`i
`
`;nit ,
`
`Div'. I'~' ~,
`~i
`.._.
`~~-.iii
`_„ I,~
`~ iilE;: tl~,l ,
`~~
`
`I~ i.~c.•-
`
`~.i,, ~n~.;_
`
`lid
`
`t Es ill
`
`_, ~,
`
`i
`
`i
`
`11~~~~. 1[It' ~~ .
`
`~,
`
`~
`
`,.. .. ..~
`
`.~.
`
`_~.i
`
`;I
`4 4'~~i
`
`to ~ I
`
`~,
`
`_.
`
`I
`
`1~C1)I C)i~~
`
`l I~ ~~~hy
`.~ ,~ ,,~Ii~:lccl '~
`
`i
`
`1;~, ~ ;r.l ~ ye;~r~
`_
`....
`_„ -~rit. Ali rc,~~<,ni.ni^. h,s<; ,t
`
`6K~}
`
`l E:Is'~7i!Ca
`
`~~c;~t
`
`i n~t~F~ ~tf l.nenf.;,
`
`,~
`
`b>;ur~;c' i'~~
`
`.tisira;4~er s
`
`6o~vnlo.ided 1'~rom: http://finunls.org/ by t~ Reprints llcslc l.~scr on 06/2t/20IG
`
`Page 1 of 6
`
`Patent Owner Ex. 2023
`CFAD v. Pozen
`PR2015-01718
`
`

`
`~7
`ff--
`
`~. ~r ~.:
`,. I
`
`i
`
`~
`..
`
`_. ~~
`_.
`
`Diu. , r, ~
`,ci.
`I.
`
`vc~f ~r,~ch ss tlia
`'Iti tics ~l~ "ti i,
`
`._ i ~., ~•I.
`
`nii _
`
`_i_ ~f
`
`i~ ~
`
`..~
`
`ilt fifi.f
`
`i
`
`~~~
`
`_.
`
`~ ~
`
`~ „
`
`I~
`
`..._
`
`.. '.lir
`
`..._ . l~ ...,. I
`
`r 1~~;.~
`
`r Chi i
`
`~ :, .. ~~;
`
`,~,~
`
`~,~~..~.
`
`~
`
`_ .,
`
`r„~~ .
`
`~~~~
`
`r
`
`~~:~~,~~ . ,;.,,
`~~
`~
`n ~us~_~~
`__;u,.~
`i .-._
`i
`u,f :..:.'t. ~,.
`u~'c
`~~~...
`
`,,,
`
`,,,~.:
`
`,.~
`
`I~
`
`~~
`
`~~ __
`
`.. c
`...
`[ ~.'1 r
`
`. _
`._,..
`.t: at
`
`~~~ F~f:~, .
`,~f,~.,~7~~s
`~
`xn~_
`,I that
`,, 4tr.
`.,~h. r, ~..a
`i
`
`_
`Lr li i
`. ny ...l
`h
`..
`
`t .
`i
`
`.,-
`_.., i.
`
`,.,.
`..
`
`_.~i..
`_,i .. [~~~
`
`..
`N,~ i..~
`
`_i
`~ i i
`~, ,i...
`
`i _.
`
`F.
`
`~~.1 i.~l. ni
`i.
`~,. 'i;_,
`
`r
`
`,.
`
`I p
`_
`
`:.~, si Sff:f ..,... r.R
`
`C,7~7stric .ft3ic~ 5t{rn~3~s =rc1 ~E,cr~~in,~~~~.~r't
`__ .,n
`~~I.. -_ .",z.id~~st~~at
`
`ri
`
`!„ ~ ~t E.~i.h 1~n'~indi g;-.,,, c~e ~.an
`
`i
`
`ii
`
`..'s p tl~ IIt[ 9~t71 ~1f ali: .
`
`:,:i' I
`
`.-
`
`~.!1
`
`'il
`
`~.. I'.
`
`ii
`
`~r
`
`i
`~ .. ii.l
`~
`
`_
`
`i'~,:'.
`
`_...
`,.
`i, ~
`''I- '. ~,",.
`t
`..,f ~'~_.
`1~~
`
`Ire-.
`, '. 1Y .
`.._~
`fit"
`
`~{
`__ ~
`_~~ilB ~ ~Y
`111. ~.,:5
`1 ~.,,
`_, !'I'.i, -Ek.
`
`;~ f ~rI'. 1'.li Ili "I ~Cti ~': '.I'i:
`
`I.I
`
`~ f r`'.. III '~i~ ~ ~}U{i~}41x
`
`.~ I
`
`i.. ..~ ~_ ill ~'
`
`.~Ii.'..
`
`... ~I
`
`II
`
`..
`
`_i (.''~+.
`
`I
`
`,r.
`
`r '.~
`
`._
`
`~.
`
`~ C:.
`
`.III: ~._
`
`.,. ~l:[:.i
`
`II I1fl
`
`i
`
`I.
`
`'.. i...,
`
`. i~,';~
`
`'~
`
`I
`
`~~.
`
`i
`i.
`
`i
`
`..
`
`i~~,.
`~.
`
`~.
`
`_
`
`~., ~ti~.,u
`
`~~
`
`i
`
`.'h.
`
`it
`
`_ ~~iicl
`
`,.
`
`~ i_
`
`.f
`',
`Itlt~
`
`i
`
`,~
`~
`~~.~i
`i~_.i
`
`~~~.
`~,_
`._ ._
`
`I
`
`_.,
`
`I
`
`iin.
`..
`
`Jr, .,
`i'.'
`
`li
`~I
`I
`
`_
`
`~,itl
`_.~,~,i
`.r..,
`~ ,
`,.
`
`i
`
`_
`
`~ ..,.
`
`~.e~~~[c:
`
`s-~'~
`
`,,:
`~
`~
`~
`~ ~
`!, ..f
`. ~.
`~~~4 cell rta; - -~~~.
`
`t , ,.:s.
`~
`~ d3
`rr,~l4-asc~
`
`I
`
`t
`
`i i r,.,
`
`~ rUt~tetl: nt ! ~ ,i,' eSf~ ~1ic rr.~
`
`ti~iiltimc~ 1;"~t
`
`iA~rim~x~rt ~
`
`'T 8$
`
`Downloaded From: http://xnnals.ornl b~~ t~ Reprints Deslc User un U6/2U2UIG
`
`Page 2 of 6
`
`Patent Owner Ex. 2023
`CFAD v. Pozen
`IPR2015-01718
`
`

`
`[~'4 =~
`
`~.
`
`— ~ ~r
`
`__—
`
`____
`
`_-~.,.
`
`--
`
`_.
`
`_ ~
`
`-~
`
`~~
`
`.n.r~ a ,
`
`i, .. ~ 1 12a ~f r~ph~':kL~ `t;If~~are; 'eta,^, I7 ~gs?, C;tr -
`f';~, .,,slurs °~r1,i5 v,~es~ c~nsidnt~~E'~ ::i4ticall~~
`
`fa~•~ust.
`
`lyart s
`
`~ct3ti
`
`r.n~
`
`~;~[i'
`
`IG+~ cls ti. to
`
`~'G~u~ (1.'-..
`
`I', ,ii
`
`~
`
`~
`
`~i
`
`....;r ~',1i~..I ~. .~..
`
`.~:~~I: i
`c I'~'~l
`~
`
`~..~~ ~
`r
`
`t
`
`~
`~[~
`~
`~,i..
`~I, .,~, _
`
`~i ~.
`~ i.'
`.c.
`
`i;
`~
`
`f. ~
`r
`
`_
`
`_
`
`~~
`
`i~ ,, ~
`i.
`
`~i
`
`~,.~_
`~II '~
`
`fl~~ i
`
`.r;r~d I id
`~
`i i(:~i~
`
`~ iCl
`I
`:I ti~,it3t
`
`~f
`
`~
`
`_~
`i~l
`~, _
`I~
`i _.,,
`
`c.Uic_,rr#I~~ _~fi: _.I ttl~dfrt
`~ri _ .r~cl ti~tt•
`,~_,.
`i
`i~ ~.. ! in
`;I_ ~ . _
`_ .
`ii
`,.i
`jttir~_
`~
`~f~
`
`i
`
`i
`
`.,...
`~_
`
`„~ ~
`:tit.
`it
`
`~
`r :_
`i.
`
`~
`
`i -.
`i
`
`~
`
`~
`
`~
`
`~l
`L '.
`I~ ~ _
`~,i~
`i
`~
`1
`
`~
`
`~
`
`i,~ ~~
`~"
`I'~ ~
`
`_.
`,
`~1 i~.~.i~_
`
`ti
`~
`
`~_i.. ~ . I~ ~i~
`~,
`
`ii i i
`
`t~F
`
`~
`
`.,i , . ,
`. ~'
`~~i: , :~
`_ _ `.~ a .. _..;~I}~
`i ~i i~ tv~rc
`,~t~ie j~~l,. ~ _ .~ nhii~ ~ ~n
`
`! ' i
`
`_
`
`l iti
`
`t
`
`~
`
`r /n• ~
`
`~
`
`~
`
`!urrsc Its ;v~irEiE~rr :~
`
`Downloaded from: http:l/~un.ils.org/ by a Repriufs Desk User on U(>/2120L(
`
`Page 3 of 6
`
`Patent Owner Ex. 2023
`CFAD v. Pozen
`IPR2015-01718
`
`

`
`i't'Y'II";'r._i'1 ~t El C~
`Ott ~•i r~~
`C.
`
`I~;".I: I:'t'
`~
`~u~_
`.z
`
`-`l~ f _ .I.= [`-,.
`~ ,r-~~3 ,
`
`~,~ .,.
`ss~~trtc ~
`
`~
`
`._. .~.~i ~ ,.
`_~ x~tz,
`
`~, i
`
`~i~
`
`i
`
`~. -~;1
`
`~
`
`':1~_;:r~
`
`cif 9,7c :7~ai~, in ~lcaats,
`
`"~.L. ,c ..~-urrt
`I~~~ _~.> d
`~
`_~
`_ ~~., _.
`~
`~~t r.'
`I
`i
`_-. <
`r
`l7t .zl
`, 1~.,.i.nk ~ snY~~i, w. .,,.
`
`_
`
`.. ~
`~I
`
`.~:i;7t~.! 1 _~ ~:ar t~..;~
`~,-
`_._,.. ~~_.,~v.
`~~u~,.
`~~,- ,~~iri~~
`i._~_i _~_ c::.
`i~'~,~.
`
`r3a~
`~
`ri~~
`j~~
`_ ~~I
`r,~~~ ,~~,
`
`i~, ~,!
`~
`~~ .. ~,~'
`,i
`~r~
`
`I
`
`_ ._.
`~
`~~
`r ;~ t.
`~I.~-_
`
`r
`
`~ .
`_
`r~:
`_~.~.ry_
`F i,_ ..
`~~si~~
`I
`~ c _e7j tt~~. i _ ~.v~er
`
`i4. C!., i I' ~_ ,~.
`
`~ ~.. i ~ e~,
`
`r', .. ~~ft
`
`Ciaang~ ~ i;i ~.ist
`ja:i c h.. ~ ~, i~~~~;:i cir [air, ~, c ~~,~;~~
`t:s~r;s uk 2~t3tF~u[~ ~ti~, ~, ,~_~~rv;til > F~;ure ~, P:,t~~rar dN~t
`~rtd r,'cCjr!}, Cyast ~ jt~ .,~ 4`i~l;t~a~e ~~c~di~~r, ~r,~ ..cap, ~i~t-
`~+ioC >verc i?.,C =;~ ' ~s'_t ~rf~~t4c# hY ,sr,yv ~,~~=~rin c1a~~~.
`
`~
`
`,_ ~.,..~~' t ~ . _ , , '';+,~~~irdis ~~it S~~~urn 7"IiruttthnYGrsie
`., i~~,. f ~:iE:, Clut(5U~ IF'att~ l ~Y1t4 2
`,,
`~
`C t i::,,.r_~ ,
`
`f ,_~,.r=; .,kts~pa;
`ii.~ un 4~~r~i i
`
`tiic .'~ ~ .~i_t.~~l i ~.(~.ii,i;~~r}' ~:~FeGts
`t ,~r; ~~~:~n~ , I.~,~'. ~sr,c3 ~e~lfie.
`
`~x
`
`~
`
`~.
`
`,_~, ::~
`f
`
`~
`
`~
`
`,~ r ~
`I'
`
`-.rig ~j3uce P(~E
`r, ~ 1.(71. ~ a
`
`its
`
`~'~~~1.
`
`I h~ .,~,~,i~ir, J,;~~ ;a c r~~tuce:i ~cr;arr
`
`~ - - ~ :}
`i 7 ~,~:''=r _
`
`~ r, .., ~
`... . ~
`~, ~lit1 r ~,~ r
`
`- ~entately `Grp ~_l,
`~t o ~,
`~ ~9C 7r~ icir~h.:i in't~
`
`ni4ctissi~~n
`
`i ~, ii
`itit Ylr ~1r
`,tS~7lr1Tt c
`~~ctlt>t7 .:~~(S ai7
`f~.
`c jt:r~• i,~ he:~.lthp ,zd.~kt ~ L;~k~e1'~,
`5tam~~sTt r
`-:,,~~~ ~ ,ir~t . ~.~~~;; .t~,~~l~~„;n
`t)tf,cr isi~~
`,,,~~ rias _
`~_
`~, ~~it~.
`,1 ~(.:.
`3 ,'L15[it ~.~kR[j311 Qil~7'~t -~~~(?
`c k7$I~ ~-~C
`:~r
`~ti :,n;"rra ~e~;~ratic~st i1a F~~~ .:~~~~; i ~~
`~~t~:t,~~.~ r. ~
`.,,:~,.. ~i;~ ~rstd C?~'r,A ec~nten:s are
`a:~~l t;~ ~~ ~ ,rr ~
`._ ~_ ~,~_ .. ~~: ,;, ~rr2a4t7 r~aaccsyaal i~j~iry i7, ~,
`~cnsiilti~~~.
`Sl6i.ab'. ~ITT.i.~~7T Flkh ~bllP~41 '7I P.i ;~r~I L'
`(C _~
`1 '.'r ,J l?
`~~ t. c! nn~ir~ ~>~C~ ut ~n~, ~~ sert:.~ ~~~ i:h
`.;;~~ :~;-
`inn: °
`;.s ra;~~~~ irry~a ~v<S Cc~ ZbCi~> mg, 4vhe~ +: °;g.
`piriei
`
`E t 'sa~V 1 ~
`
`i
`
`rP~v
`
`€>)' Jrr( r~,al htc~.lrcirt€'
`
`~ .tntt e?'
`
`...
`
`:S
`
`1$7
`
`Dotivuloaded l~rmn: I~ttp://annals.org/ by a Reprints Dell. User ou 0(121/201(,
`
`Page 4 of 6
`
`Patent Owner Ex. 2023
`(FAD v. Pozen
`IPR2015-01718
`
`

`
`_—r, _
`
`_ m .__~ ,.fir=r~ ~~
`
`~, ~. G -_I ~~.
`
`(`~_F
`
`,u11
`
`~
`
`,..
`
`_
`
`~~~I,._
`
`, ~
`
`~,_. ~
`
`~~~am
`
`t
`
`~C~,
`
`-
`
`i
`
`li~ ,r~
`
`I
`
`~ .~ Pi ~I_ ~~ i
`
`~,i~~ ~a~.: S
`
`,..
`
`..
`
`a
`
`_...
`
`i
`
`i i~
`,~~ i ,_ i ~ i ~.-~., - .r ,.,
`
`,
`
`...
`
`:~~, ul:~~~j
`
`.. ~. ~'.
`
`._~ -i.i',~~,. 'u
`
`it ~ .. ~.
`
`_ -,t"~
`
`i
`
`f
`
`<<
`
`5 i
`
`~
`
`~
`
`:'n _..
`
`i
`
`.._~. i.
`
`_.i'. .i ~I:iJ~:
`
`.
`
`~)~,i -I.. i, t, :i~. ~~il It.: ,_~1~if. i~S ,i~~ r~i i
`l~lk.!E7'r
`f} r:~::~L~.~,., n~ U. ,:
`:,u i~ J
`i ._i~~t'I~F. ~iit~~ut~.
`~.
`_.
`~,i
`r
`
`_
`
`..
`
`_
`
`_
`
`_ _
`
`._...
`
`I:I
`
`_.
`
`! _
`
`.,~ i~:i~_~_
`
`F' .t
`
`l ! I~~s
`
`,-
`
`~.
`
`R
`
`I I
`
`cl; ~,
`
`t I':C lil
`
`i_r~J;~.i
`
`c,ii
`~. .~~.
`
`~
`
`f _
`
`I Lt C~ !P .! ~JI
`
`1
`
`It7l HJ[i
`
`t',t CPs'ti
`
`.tl
`
`I~~i ~l~'. '.
`
`.~_~ :I ~i
`
`.I. ~iil.l I
`
`~._~~~ _~
`tiEtt~•i _
`4'Y €`
`_, i; 17L~{ `S:OTI ih ~{~i!
`r ~}~r~"..~
`~ dflE Ce3~~G'CiC 111i,i~ 4;' CS': 41~
`
`._,t'.I •,...~
`
`~~
`
`'.
`
`_. ~1 ~
`
`iI
`
`~..~.
`
`'.. -i
`
`.,
`
`..
`
`~
`
`I
`
`l"
`,i
`
`~. iI
`
`~
`
`_..
`
`~
`
`f1 U.~i l_I '.
`.. I,
`
`,~
`
`.. ,,, S'I, ~.. ~~
`
`.',lti f: 1C I t1C""_..1; .... -r l~t ifl
`
`rr~.ic;4a~'
`iric r ,.,i ~
`
`n~ ,. -.~ ' i
`-r
`~
`ir; :~.~,i i~_
`
`~~~~_i..
`
`I
`
`~
`
`,_
`
`i
`
`t
`
`r:~
`
`~. ~~
`
`~~
`i~
`
`tad
`
`_
`
`~
`
`~_
`
`! ~~a:il=•ai ka~° tart
`~~ ~ r. ~fcc~tr~e~~
`
`C
`
`.... r. .I.
`
`"'1',
`
`I,..
`
`-..I i .. ', I,.'.
`
`1.1 'll ''.1\~
`
`I'~!'. .'f
`~
`lEll al,l'~.-.'
`m:i~~c~, ,l ~ _~I -. . r,
`~
`i _
`a"(;E~_
`
`.I i, J'~... `. ~
`.~.!_~~.
`i
`~ ~~ r:n i
`
`~ I..'
`.~
`
`~
`L ,I ~'. .I'1 , .1. '..:\IT~14
`~? ~
`~ ,~_ ~ i i:n .., , i. ~~
`is
`~~
`~
`i_
`._,
`
`i
`
`y~~t,~:te"~,
`
`a~,tiu,-
`
`~
`
`,
`
`_ate.li,.,i
`
`~F _i„~ f :i,~_i
`
`~
`,_
`~:i, . r.
`
`i
`
`.~i~~,
`
`~
`
`i ,r ~ i
`
`i
`~ ... .i~.
`
`-~ i s
`.__I ~
`i~i~.°~._:~t t.f•,l~ ~~e~
`
`~,
`
`_
`
`~ i ' i~
`
`~
`
`,_
`
`•c•i~l eittt~~u: tai ht~a€ll ~ ~i~,iti<ut
`
`~.i~tti ~.
`
`~
`
`~
`
`i. . ~~~ ir.~~isti~
`
`_.
`
`f
`
`,-~~ fCt .it ,l i:,"~ ~J ~. ~'fi I.~`;, "tf II`.. i
`
`.. ,'~-:I
`
`~ ttl.
`
`i'~
`
`i.
`
`~11~ lilt Ill(". ~.-'. [O CI77CJ~~ C. ~iIL~t}V L', ~.~~il fll:l't-
`
`~1'E' 6E ~u•'r~
`.h4 fir_. rani: ~~
`_.
`•,~§tti ds. h
`
`i ~l.tL [I
`
`~.,.
`
`.._. 15 I'~. ~~:'i',
`,. _. ~
`~'. ,~.: ~
`~_~,I
`~, ~.
`_,.
`i~
`
`'r . r~~
`
`r
`
`,la r' i~[)ti~ iR
`is ..~3F,.,,~
`"
`~. ,I. ,.
`
`I'-. ~
`:i
`~.r ,.
`~. ~. ~
`~, ~.i
`
`t.~.t
`>i_ Ikt c~tlS S- i
`i .,, ..
`~. "<k (i C~
`'~i r ~ ~i_~, ..,iuntz•o;s E, ~ti i~~:c~~.'
`~-r f~~r I,
`~ ~~i. ' n~.:€ ct ~) i to ~~,.,r~.S
`_ ,.~ i~,
`~
`rn.q
`,rii7.
`
`I
`
`~
`
`,. ,. f
`
`_..
`
`-. ?~i ..
`
`,i
`
`,il .c ~i. ~._
`
`ii~.l
`
`~
`
`_ ., u.`... f
`
`rF '-
`
`ir;i'i ~r~
`
`_.~
`
`ui .~_i
`
`~
`
`_.I
`
`i~r ~~'. i, ~, ~,
`
`~
`
`~~~l c~i n
`
`~[3 Zr i
`I
`iII;C:. ~ ._
`.~, ..
`
`....
`f.~_
`,_
`- , ~
`., ,.
`i ~.[
`
`I
`
`_
`I ~~ I
`..~ i
`
`_
`
`_
`
`_
`
`,~i~ll I !_
`
`'1 '..f: :lip.
`;I;~' ~'I -
`tl
`,.. -.1
`
`I
`
`i
`
`i
`
`i
`
`1.~
`
`.. r~
`
`,Ii. J,A
`
`~ ___l_
`i I
`1 _ ',I
`1
`.~ri C~._' i. li
`I'i':li:
`
`I
`
`~. DTI ~'§ i.~~t~ +iii ..' ~',
`~(~I ~\' ..'I~~\'.I f. 'if ', _'\
`V. it ~~.
`I
`~,{~,':
`_,..
`., ~,i
`i, l~'
`
`~i'i li~i r ,.-. in~~
`
`rII
`~
`
`_
`,~I. it
`
`~.
`
`~ J
`
`E;
`
`,.i~~,,, r
`
`.. ~
`
`~
`
`~, _.
`.,.
`
`~I~. '~~
`
`i
`t~
`
`,e~~~_, i~
`'1: -.
`1 i
`.~;r.~ ~
`
`I'i ~~
`
`..~ I
`i..,
`_~VFi.,~sill 4'. ~~f;
`r i .~ .. L~,I~~,~
`~~:i ri°c ~Ihti€ I~~si
`iu~ist ~v~;:; r,c1t n '~ ~ , ,
`
`~n~ .. ~~
`~f ~.
`~. ~~~
`r,i i~:l
`~
`it i
`i. -,~._
`
`~I~ .'I'
`S~I.i
`_
`i st~~stm
`~
`ll
`~
`l
`
`~~II
`1
`1~1;-'
`n. ~ : I
`i
`i
`~
`
`..
`i ;ar,
`i
`
`~ ~ ~
`
``~'~~
`
`~_ ,~„ '~
`
`..
`
`_
`
`II -. il.
`
`..r~. l'.
`
`r....
`
`~'t"..
`
`F
`
`'.I.
`
`I ~
`
`~
`
`i
`
`~
`
`,~ I~. ,`. is
`
`.'f.I'T4
`
`~i
`
`~
`
`~
`
`~
`
`Ali.
`~i1.i.Efr
`
`i
`
`I~.
`
`~~ i
`
`~r .
`
`~
`
`i~~in
`
`~.~
`I
`
`i
`
`n ~_
`
`,t
`~
`~ i~..
`
`~.I
`
`,~i ,. i~: i
`
`~
`~ i,~
`~
`
`~
`
`i ,
`i
`
`~r~,
`sir, ~
`~
`~
`'i:f
`~~_ 1~.
`~ ,~~~r,'~
`fl~r~~_~
`~i
`~~~~~ ~~~, :lire
`i~:. l , Ei'~,.<< It
`
`r
`
`i
`
`I
`
`f~~° 7l4>~ Y ' I ~ I
`~'
`~k,~z fii~ i:aic~
`~i 13C r'?~ (Ctli~...i '. If
`
`V
`
`I, I~.~
`
`III".
`
`i. _
`~; , ~~~~
`,I'~(r~'.
`
`I- J~..",
`~~ . ~:~ i
`i~l
`~
`
`_
`
`..
`- .,
`~
`
`i
`
`I
`
`i
`
`r. ii, ~, s
`? tr , sl, ntaY
`~..
`I -.
`~i~S71C1-1,
`r pl~~~4cict fisn~.ti~~n. .i:,~
`~: .,._in:~ d~~: ~ i
`iti,isi
`I~x) 4'S, Si'~)t ,~ 1~iTt ~fJl~ ,t 1[?4,';'k~F C1t~ 1'v :i..~~~:11
`rt ti LF~i: tt` ~:l r'. I',
`
`I
`~~
`
`~
`
`E$8
`
`I 1 .. ,;,ark
`
``a~s.l
`
`, iu,i,~7s .3j` f,:a ~,._,.
`
`~ ,
`
`- ~'nlufu,i i'lI ~ I'~urnkaer .~
`
`I)o~viiloatled drum: http://annals.o~'~ril by a Reprints DCslc User on OG/21/2bIG
`
`Page 5 of 6
`
`Patent Owner Ex. 2023
`CFAD v. Pozen
`IPR2015-01718
`
`

`
`ir: ~n
`r.i
`z r ~..i.~.', ~.~ i-~
`
`a
`
`I. n'- ! ~~~~
`~.~~,_ ~.I.~~
`i ~.. ,.!tit 4u i'
`
`~ ~,~
`i I~:i:~:iiti-
`
`i
`
`~
`
`~i
`
`i, _
`
`t~
`
`~~
`
`I. f<~~., c, 111. tP~: ~. ~, lil .
`
`i~.
`
`~,
`
`I
`
`ii c I.~z
`
`~,..,
`
`~.
`
`.. ~
`
`~
`
`i
`
`~ _
`
`~
`
`'~;~9
`
`Do~~~nloaded from: htgrNanntilsorgl Vy.i Reprints Dcsk User on 06/2t/207G
`
`Page 6 of 6
`
`Patent Owner Ex. 2023
`CFAD v. Pozen
`IPR2015-01718