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VIMOVO® (Naproxen And Esomeprazole Magnesium) Tablets | Horizon Pharma
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`Page 1 of 4
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`(cid:204)(cid:204)
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`Navigation
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`NASDAQ:HZNP 27.62 (-1.77) 05.08.15 4:15 PM ET
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`VIMOVO (naproxen and esomeprazole magnesium)
`®
`Tablets
`The Smarter Naproxen Due to Added Gastroprotection
`VIMOVO (naproxen and esomeprazole magnesium) delayed-release tablets 375 mg/20 mg
`and 500 mg/20 mg are a proprietary, single-tablet combination of the nonsteroidal anti-
`inflammatory drug (NSAID) naproxen and immediate-release esomeprazole, a stomach acid
`–reducing proton pump inhibitor (PPI). Naproxen has proven anti-inflammatory and analgesic
`properties, and esomeprazole magnesium reduces the stomach acid–secretion that can
`cause gastric ulceration. With the combination of naproxen and esomeprazole magnesium
`into a single product, VIMOVO decreases the risk of gastric gastrointestinal (GI) ulcers while
`reducing pain and inflammation from osteoarthritis (OA), rheumatoid arthritis (RA) and
`ankylosing spondylitis.
`
`http://www.horizonpharma.com/vimovo/
`
`5/9/2015
`
`

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`VIMOVO® (Naproxen And Esomeprazole Magnesium) Tablets | Horizon Pharma
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`Page 2 of 4
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`Indications and Usage
`VIMOVO is approved to relieve the signs and symptoms of osteoarthritis, rheumatoid arthritis,
`and ankylosing spondylitis and to decrease the risk of stomach (gastric) ulcers in patients at
`risk of developing stomach ulcers from treatment with NSAIDs. VIMOVO is not recommended
`as a starting treatment for relief of acute pain. Controlled studies do not extend beyond 6
`months.
`
`Important Safety Information
`• Nonsteroidal anti-inflammatory drugs (NSAIDs), including naproxen, a
`component of VIMOVO, may increase the chance of a heart attack or stroke,
`which can be fatal. This chance increases with longer use and in people who
`have heart disease or risk factors for heart disease.
`• VIMOVO should not be used before or after a type of heart surgery called
`coronary artery bypass graft (CABG).
`• NSAID-containing medications like VIMOVO may increase the chance of
`stomach and intestinal problems, such as bleeding or an ulcer. These problems
`can happen without warning and can lead to death. Older patients may have a
`greater chance of developing these problems.
`
`VIMOVO is not right for everyone, including patients who have had an asthma attack, hives,
`or other allergic reaction with aspirin or any other NSAID medicine, patients who are allergic
`to any of the ingredients in VIMOVO, or women in late stages of pregnancy.
`
`Serious allergic reactions, including skin reactions, can occur without warning and can be life-
`threatening; discontinue use of VIMOVO at the first appearance of a skin rash, or if you
`develop sudden wheezing; swelling of the lips, tongue or throat; fainting; or problems
`swallowing.
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`http://www.horizonpharma.com/vimovo/
`
`5/9/2015
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`

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`VIMOVO® (Naproxen And Esomeprazole Magnesium) Tablets | Horizon Pharma
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`Page 3 of 4
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`VIMOVO should be used at the lowest dose and for the shortest amount of time as directed
`by your health care provider.
`
`Tell your health care provider right away if you develop signs of active bleeding from any
`source.
`
`VIMOVO can lead to onset of new hypertension or worsening of existing high blood pressure,
`either of which may contribute to an increased risk of a heart attack or stroke.
`
`Speak with your health care provider before starting VIMOVO if you
`
`• Have a history of ulcers or bleeding in the stomach or intestines
`• Have heart problems, high blood pressure, or are taking high blood pressure medications
`• Have kidney or liver problems
`
`Tell your doctor about all of the medicines you take, prescription and non-prescription drugs,
`including clopidogrel, vitamins and herbal supplements. VIMOVO may affect how other
`medicines work and other medicines may affect how VIMOVO works.
`
`VIMOVO may increase your risk of getting severe diarrhea. Call your doctor right away if you
`have watery stool, stomach pain, and fever that does not go away.
`
`Talk to your health care provider about your risk for bone fractures and developing low levels
`of magnesium if you take VIMOVO for a long period of time.
`
`Talk to your health care provider about your risk for developing low levels of magnesium if
`you take VIMOVO for a long period of time.
`
`The most common side effects of VIMOVO include: inflammation of the lining of the stomach,
`indigestion, diarrhea, stomach ulcers, abdominal pain, and nausea.
`
`For more information on VIMOVO, please see the Medication Guide and Full Prescribing
`Information.
`
`Products:
`
`OVERVIEW
`ACTIMMUNE
`®
`BUPHENYL
`®
`
`http://www.horizonpharma.com/vimovo/
`
`5/9/2015
`
`

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`VIMOVO® (Naproxen And Esomeprazole Magnesium) Tablets | Horizon Pharma
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`Page 4 of 4
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`DUEXIS
`®
`PENNSAID
`®
`RAVICTI
`®
`RAYOS
`®
`VIMOVO
`®
`
`Click here to learn more about VIMOVO (naproxen and esomeprazole magnesium) Tablets including full
`prescribing information and boxed warning.
`
`Related Links
`• Osteoarthritis
`• Rheumatoid Arthritis
`• Ankylosing Spondylitis
`• Patient Resources
`
`Privacy Policy
`Legal Notice
`All Rights Reserved ©2015 Horizon Pharma plc
`HOME
`PRODUCTS
`PATIENTS
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`http://www.horizonpharma.com/vimovo/
`
`5/9/2015

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