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`Sawai Ex 1005
`Page 789 of 4322
`
`

`

`16
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`Sawai Ex 1005
`Page 790 of 4322
`
`

`

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`Sawai Ex 1005
`Page 791 of 4322
`
`

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`Sawai Ex 1005
`Page 792 of 4322
`
`

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`Sawai Ex 1005
`Page 793 of 4322
`
`

`

`V
`
`DFfr?
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`
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`
`of HMG-CoA reductase.
`200 yl of microsomal suspension and they showed no significant.inhibition
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`inhibition also and is indicated in the results. Buffer A, and DMA
`
`Compactin in DMA at various concentrations was assayed for
`
`were also assayed by adding 10 yl of each to
`
`reductase activity.
`
`plus 10 yl of drug dilution were assayed for HMG-CoA
`experiment. 200 yl Aliquots of microsomal suspension ( .97 - l.llmg/ml)
`in Buffer A with 10 mM DTT and frozen at -80"C until thawed and used for
`
`Microsomes were prepared from male Spraque-Dawley rats (l63 q
`
`)
`
`results.
`Dilution of each compound gave the concentrations indicated in the
`
`Sawai Ex 1005
`Page 794 of 4322
`
`

`

`4
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`
`Sawai Ex 1005
`Page 795 of 4322
`
`

`

`CS
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`6/13/85
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`8) 63-550(RN 26083)
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`
`6)
`
`Sawai Ex 1005
`Page 796 of 4322
`
`

`

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`
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`
`Sawai Ex 1005
`Page 797 of 4322
`
`

`

`C/^
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`
`Sawai Ex 1005
`Page 798 of 4322
`
`

`

`1
`10
`/ 60
`
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`
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`
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`
`•
`
`Sawai Ex 1005
`Page 799 of 4322
`
`

`

`Ko
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`6
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`24) 62-320/Na-4(23531) 6/24/85
`
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`23) Compactln (24291) 6/24/85
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`6/19/85
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`22) 63-565(RN 26128)
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`
`Sawai Ex 1005
`Page 800 of 4322
`
`

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`-C
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`28) 63-560(RN 26107)
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`6/24/85
`
`26) 63-567(RN 26149)
`
`Sawai Ex 1005
`Page 801 of 4322
`
`

`

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`1
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`32) 63-556.(RN 26093) 6/26/05
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`31) 62-320/Na-4(23531) 6/26/05
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`Sawai Ex 1005
`Page 802 of 4322
`
`

`

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`of IIMG-CoA reductase.
`200 pi of microsomal suspension and they showed no significant inhibition
`
`inhibition also and is Indicated in the results. Buffer A, and DMA
`
`Compactin in DMA at various concentrations was assayed for
`
`were also assayed by adding 10 pi of each to
`
`reductase activity.
`
`plus 10 pi of drug dilution were assayed for IIMG-CoA
`experiment. 200 pi Aliquots of microsomal suspension ( o.9l
`mg/ml)
`1n Buffer A with 10 mM OTT and frozen at -80- C until thawed and used for
`
`)
`
`Microsomes were prepared from male Spraaue-Dawley rats ( 150 q
`
`Sawai Ex 1005
`Page 803 of 4322
`
`

`

`2
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`Sawai Ex 1005
`Page 804 of 4322
`
`

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`Sawai Ex 1005
`Page 805 of 4322
`
`

`

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`Sawai Ex 1005
`
`Page 806 of 4322
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`Sawai Ex 1005
`Page 806 of 4322
`
`

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`u falu
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`of HMG-CoA reductase.
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`Inhibition also and is Indicated in the results. Buffer A, and DMA
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`Compactln 1n DMA at various concentrations was assayed for
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`experiment. 200 vil AHquots of microsomal suspension ( 0.96
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`1n Buffer A with 10 mM DTT and frozen at -80flC until thawed and used for
`
`Microsomes were prepared from rfiale Spraque-Dawley rats ( 150.g }
`
`Sawai Ex 1005
`Page 807 of 4322
`
`

`

`(S-s
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`14
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`Sawai Ex 1005
`Page 808 of 4322
`
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`Sawai Ex 1005
`Page 809 of 4322
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`Sawai Ex 1005
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`Page 810 of 4322
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`Sawai Ex 1005
`Page 810 of 4322
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`Page 811 of 4322
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`Sawai Ex 1005
`Page 811 of 4322
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`Page 813 of 4322
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`Sawai Ex 1005
`Page 814 of 4322
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`Sawai Ex 1005
`Page 815 of 4322
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`Page 816 of 4322
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`Sawai Ex 1005
`Page 817 of 4322
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`Sawai Ex 1005
`Page 818 of 4322
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`Sawai Ex 1005
`Page 819 of 4322
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`Sawai Ex 1005
`Page 820 of 4322
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