GLU
`VAL
`GLN
`LEU
`Ieu
`GLU
`SER
`GLY
`GLY
`GLV
`u
`
`dfu
`GLU
`VAL
`VAL
`em GLN
`LEU
`LEU
`VAL
`VAL
`GLU
`GLU
`SER
`SER
`GLY
`GLY
`GLY
`GLY
`GLY
`GLY
`
`s'L'u
`GLU
`VAL
`VAL
`em GLN
`Leu
`LEU
`VAL
`VAL
`GLU
`GLU
`SEH
`SER
`GLY
`GLY
`GLY
`GLY
`GLY
`ala
`
`is}
`VAL
`GLN
`Leu
`VAL
`GLU
`SER
`GLY
`GLY
`GLY
`
`$15
`VAL
`GLN
`LEU
`leu
`GLU
`SER
`GLY
`GLY
`GLY
`
`G—l-_U
`GLU
`GLU
`VAL
`VAL
`VAL
`em em GLN
`LEU
`LEU
`Leu
`Ieu
`VAL
`VAL
`GLU
`GLU
`GLU
`SEH
`SEFI
`SEFI
`GLY
`GLY
`GLY
`GLY
`GLY
`GLY
`GLY
`GLY
`GLY
`eu
`eu
`L
`Te
`L
`n
`L
`L
`ER
`LEU
`u
`n
`s
`A
`sen
`e
`Y
`Fl
`I
`
`GLN
`GLY
`55!:
`LEU
`
`L
`LV
`Sen
`LEU
`
`GL
`Pno
`G
`
`Ft
`LEU
`
`R
`
`
`G-|:U
`VAL
`GLN
`LEU
`VAL
`GLU
`SER
`GLY
`GLY
`GLY
`
`LN
`LY
`
`5
`LEU
`ARG
`LEU
`sen
`cVs
`ALA
`ALA
`sen
`e
`LY
`
`GAL-U
`VAL
`GTLN
`LEU
`VAL
`GLU
`SEH
`GLY
`GLY
`GLY
`
`sen
`LEU
`
`sen
`H
`L
`H
`
`'
`
`G_L-U
`VAL
`GLN
`LEU
`VAL
`GLU
`SEFI
`GLY
`GLV
`GLY
`u
`
`C~‘.-l-_-U
`VAL
`GLN
`LEU
`VAL
`asp
`SER
`GLY
`GLY
`GLY
`
`GLU
`VAL
`GLN
`LEU
`leu
`GLU
`SER
`GLY
`GLY
`GLY
`u
`
`GT.-U
`VAL
`GL
`Leu
`Ieu
`GLU
`SEFI
`GLY
`GLY
`GLY
`u
`
`GL
`GL
`sen
`LEU
`
`V
`A
`AL
`sen
`H
`GLY
`H
`
`SE
`LEU
`‘
`'
`
`-
`sen
`
`T
`
`L
`SEF!
`LEU
`Fl
`
`- LA
`sen
`e
`Lv
`
`.
`
`H
`LEU
`
`A
`A
`sen
`
`_
`
`‘
`
`G-I-_-U
`VAL
`GLN
`LEU
`VAL
`GLU
`SER
`GLY
`GLY
`GLY
`LEU
`VAL
`GLN
`PR0
`GLY
`GLY
`SEE
`LEU
`ARE
`LEU
`sen
`cvs
`ALA
`ALA
`sen
`e
`Y
`H
`e
`R
`"
`L
`T
`n
`TVn
`TYFI Asx
`sen
`Tnn
`AsN
`ALA
`TYH
`VAL MET MET MET
`Tvn
`ASN
`VAL
`
`GLU
`sLu
`GI
`GLU
`GLU
`VAL
`VAL
`V)
`VAL
`VAL
`am GLN
`am an
`GLN
`LEU
`LEU
`Leu
`LE
`LEU
`VAL
`VAL
`VAL
`V!
`VAL
`GLX
`GLU
`GLX
`GI
`GLU
`SEH
`SEE
`SER
`SE
`lhr
`GLY
`GLY
`GLY
`Gl
`GLY
`GLY
`GLY
`GLY
`GI
`GLY
`GLY
`GLY
`GLY
`as
`GLY
`LEU
`LEU
`LEU
`LE
`LEU
`VAL
`VAL
`VAL
`VA
`ile
`Tys
`lys
`LN
`GLX
`Gl
`GLN
`Pno
`Pno
`Pno
`PF
`Pno
`GLY
`GLY
`LY
`GLY
`Gl
`GLY
`GLY
`GLY
`LY
`GLV
`a:
`GLY
`sen
`sen
`EH
`sen
`se
`sen
`LEU
`LEU
`LEU
`LEU
`LE
`LEU
`ARG AHG
`ARG
`ARG ARG
`AF
`LEU
`LEU
`LEU
`LEU
`LEU
`LE
`sen
`sen
`sen
`sen
`gly
`se
`cvs
`CYS
`cvs
`cvs
`cvs
`cx
`ALA
`ALA
`ALA
`ALA
`ALA
`Al
`ALA
`ALA
`ALA
`ALA
`ALA
`AL
`sen
`sen
`sen
`sen
`sen
`SE
`5
`e
`P
`PH
`P e
`P
`Y"
`V
`vs; GL;
`GhY
`at
`2
`THR
`THE’
`BE
`e
`PHE
`Val
`Pr
`Vghe
`SER
`n«
`THn
`Asx
`GL
`Tvn
`HIS
`T\
`VAL
`sen
`5
`MET MET
`Ml
`Asx
`HI
`
`A
`T
`ALA
`sen
`THn
`TnP
`ALA
`sen
`Ans MET MET
`PHe
`LVs
`sen
`
`TVn
`
`
`
`TFIP
`VAL
`AHG
`
`TnP
`VAL
`AFIG
`
`I:
`1Tn'P
`VAL
`Pno
`
`VAL
`VAL
`ARG Ans
`
`VAL
`ARG
`
`VAL
`ARG
`
`VAL
`ARG
`
`VAL
`Ans
`
`VAL
`Ans
`
`III
`III
`TnP
`TnP
`VAL
`VAL
`ARG AFIG
`-
`
`II
`TnP
`VAL
`-—
`
`sen
`THF
`VAL
`ARG
`
`_II
`TF
`LE
`AF
`GTGI
`PF
`en
`I
`(L;
`Pr:3:
`Tr
`VA
`::ILT}
`T:
`
`A:GT
`G‘
`St
`V:L!
`T‘
`AK
`A:
`5:
`V.
`L‘
`G
`Ar
`PrAV
`ll
`3|
`
`A3A)
`G\L.
`TI
`LI
`T‘
`L!
`G
`LI
`A:
`ll
`LI
`
`MET
`ASN
`GLY
`LEU
`
`AL
`PH
`A
`0
`GLU
`GLU
`ASP
`ASP
`ALA
`ALA
`THn
`THn
`VAL
`VAL
`TYR
`Tvn
`TVn
`Tvn
`cvs
`CY5
`ALA
`ALA
`ARG Ans
`THR
`Pno
`SEA
`VAL
`Pno
`sen
`ALA
`Leu
`ALA
`ALA
`VAL
`sen
`ASP
`LEU
`GLY
`‘ma Tap
`...
`Tvn
`...
`LEU
`...
`Tyfi
`FHE
`av
`SE“ 6“
`ALA
`sen
`VAL
`VAL
`GLY
`GLY
`Tn? ’fi»
`(,‘.|_V
`GLV
`GLN
`GLN
`W N,
`Lem
`LEU
`VAL
`THR
`
`ALA
`GLU
`ASP
`
`AL
`A
`GLU
`ASP
`ALA
`THR
`VAL
`VAL
`TVR
`TYH
`TYR
`Tvn
`cvs
`cvs
`ALA
`ALA
`ARG Ans
`’ ”
`
`i
`
`_
`
`
`ALA
`ALA
`LA
`“L”
`GLU
`GLU
`~
`ELL:
`ASP AsP
`Asx AsP
`ALA
`ALA
`ALA
`ALA
`THn
`THn
`THn
`Tun
`LEU
`VAL
`VAL
`LEU
`Tvn
`Tvn
`TVn
`Tvn
`TVH
`TVn
`TVn
`Tvn
`cvs
`cvsx
`cVs
`cvs
`ALA
`ALA
`ALA
`ALA
`Ans
`ARG ARG
`LVs
`sen
`ALA
`LYS
`LVTSF
`VAL
`GLY
`VAL
`THn
`Pno
`sen
`ALA
`TYR
`ALA
`VAL
`VAL
`TYR
`ALA
`sen
`TVn
`PHe
`Pno
`PHe
`THR
`p1-{E
`._
`...
`PHE
`._
`HEALTH
`RTMENT
`H e
`Q5
`A
`.Hosmnv|u||nnmuc|:uu|r~|:e
`VAL
`GLY
`'
`-
`GLY
`’TVh"‘1'fiI5"""""" "'“FfiE“"""'
`TRP
`'
`'
`GLY
`GLN GLNP®I'c Health %i5‘"°e
`THE Rfluofifillnslututesfim Health
`LYS
`LEU
`Lew
`LEU
`VAL
`VAL
`VAL
`VAL
`VAL
`QFE
`sen
`THn
`THn
`TH»:
`
`
`
`...
`
`’"’
`
`
`
`ALA
`VAL
`ALA
`PRO
`GLX
`GLU
`GLU
`GLU
`VAL Asx
`ASP
`AsP
`ALA
`ALA
`ALA
`ALA
`sen
`THn
`THn
`THR
`lLE
`VAL
`VAL
`VAL
`TYR
`TVn
`Tvn
`Tyn
`TYH
`TYR
`Tvn
`TYR
`cvs
`cvs
`cvs
`Cvs
`ALA
`ALA
`ALA
`ALA
`7Ane_7 ARG Ane__iAf§V
`1:: at 2::
`:22
`Pno
`VAL
`GLY
`LEU
`GLY
`sen
`Pno
`GLY
`GLV
`THn
`Tvn
`Pno
`sen
`VAL
`THn
`sen
`ALA
`PRO cvs
`THFI
`SEFI
`W
`PHE
`VAL
`_
`—
`“*5
`ME’
`—
`ALA
`ASP
`ASP
`HIS
`,,,,vAL VLL
`GLY
`GLY
`GLY
`TnP
`TnP
`TRP
`GLY
`MY GLY
`GLN
`GLN
`GLN
`W W. W
`Leu
`Pno
`Leu
`VNL
`VAL
`VAL
`sea
`THR
`THE
`
`
`
`._
`
`...
`
`AFC?
`ALA
`GLX
`GLU
`AsP Asx
`ALA
`GLY
`THn
`GLY
`VAL
`VAL
`TVn
`Tvn
`TVH
`Tvn
`CYS
`CYS
`ALA
`VAL
`Ans
`sen
`‘:25
`5%’:
`ALA
`ALA
`ALA
`Ans
`Leu
`-—»
`---
`-~-
`---
`--
`PHE
`
`GLY
`GLY
`Lvs
`pm
`ma
`VAL
`§FR
`THE
`
`3:
`<3
`A:
`AV
`Tl
`PI
`T‘
`T‘
`r:
`A:
`L‘
`<2
`u
`TI
`A:
`<3
`A:
`T|
`PI
`~
`-
`—
`—
`A
`,,E
`G
`T1
`a
`§
`A.
`L:
`V
`S
`10
`
`_
`
`Sanofi/Regeneron Ex. 1029, pg 902
`
`W
`
`‘T
`T
`
`LEUI 39)
`
`SER[ 96)
`GLYL99}
`GLV( 99)
`
`Pno( 98)
`GLY
`SEW: 951
`_LEU[9B:
`AFl(3( 95)
`
`cvs
`ALA( 95)
`sem 97)
`PHE( 971
`am 95)
`[
`
`'
`
`'
`
`?"rnP
`mm; 95;
`IGL~:s5J
`_PRO(95)
`GLY
`
`-
`
`LYSL95)
`LEU195)
`Tr-IF
`VAL{95)
`
`L
`
`I
`EARG
`‘Prue
`
`ITLE
`Sen
`
`ARG
`
`'Y'r'H
`,
`T
`Tw=_T(g5;
`7
`‘
`
`YR
`vnq 96}
`Y5
`
`5
`
`_
`;
`
`Lane
`‘
`‘
`=
`V
`E
`LV
`L:
`VAL
`EFF!
`
`Sanofi/Regeneron Ex. 1029, pg 902
`
`

`
`
`
`
`
`SEQUENCES OF PROTEINS OF
`IMMUNOLOGICAL INTEREST
`
`Elvin A. Kabat, Tai Te Wu, Howard Bilofsky.
`Margaret Reid—Hiller, and Harold Perry
`(1983)
`
`Page;
`
`20
`
`Epxjatg
`
`Position -1 of 1M5'CL (precursor heavy chains) should be Phe.
`Pau and Paul are the same protein.
`
`m5
`
`65;
`
`65?
`
`26
`27
`
`66;
`
`67;
`
`111;
`
`23
`
`168;
`168;
`
`30
`35
`
`10K26—12A1
`and
`The antibody speoificities for 1OKMfl—7A1
`light chains) should by anti—p—azobenzene arsonate.
`and 5175.
`SAPC178 and SAPC176 (mouse lambda light chains) should be named as S178
`
`(mouse
`
`kappa
`
`light
`lambda
`References for HOPC1, J698, H2061, S176, and H2020 (mouse
`chains)
`should be Weigert, M., Cesari, I.M., Yonkovich, S.J. & Cobn. M.
`(1970) Nature, 228. 1DH5-10N7.
`
`be
`should
`(mouse lambda light chains)
`References for H3159 and MOPCS11
`2112-2116.
`Cesari;
`I.M. & weigert,
`H.
`(1973) Proc. Natl. Acad. Sci. U.S.A., 70.
`
`sequenced
`chains) were
`light
`lambda
`(mouse
`S178
`and
`J558. XS1DH.
`completely. while HOPC1,
`J698, H2061. S176, H2020. W3159. and HOPC511
`compositions.
`(mouse lambda
`light
`chains) were
`analyzed by
`amino
`acid sequence
`and MAB-13
`There is an additional reference to TEPC952
`light
`chains)
`i.e., Elliott,
`E.W., Jr.. Steiner, L.A.
`(1981) Fed. Proc., 40. 1098.
`
`lambda
`(mouse
`A Eisen, H. N.
`
`"The order of
`The statement in the notes of mouse lambda light chains,
`the
`genes has been determined as V1—J3-C3—J1-C1-V2-J2-C2-JR-CA." should
`J2-C2—JH—CH."
`be
`replaced by
`“There
`are
`two
`linkage groups:
`J3-C3-J1—C1
`and
`
`Positions 13 and 1A of CAM (human heavy chain subgroup
`Gln and Lys respectively.
`
`III)
`
`should be
`
`Position 171 of SA3'CL (light constant chain) should be Asn.
`Se?
`be
`Positions 1u2 and 143 of MOFC315 (light constant chain)
`should
`and Gly respectively. based on the translation from nucleotide sequences
`(flothwell. A.L.M., Paskind, M., Roth. M.,
`Imanishi-Kari. T., Rajewsky,
`K.
`A Baltimore, D.
`(1982) Nature, 298, 380-382; wu, G.E., Govindi. N.,
`Hozumi. N. & Murialdo, H.
`(1982) Nucl. Acids Res.,
`I0, 3831-38A3).
`chain)
`have
`Positions 258 and 263
`of MOPC173
`(heavy
`constant
`revised by the authors to Pro and Val respectively.
`The position numbering for the codons of
`light
`chain variable
`Sh°U1d read as 95. 95A. 953. 95C, 95D, 95E. 95F. 95. and 97.
`
`region
`
`been
`
`185;
`
`52
`
`2A6;
`
`
`
`The human kappa J-segments (Hieter, P.A., Maizel, J.V., Jr. & Leder,
`(1982) J. Biol. Chem.. 257, 1516-1522) are as follows:
`11
`J2
`J3
`J5
`TRP
`LEU
`PHE
`TGG
`TAG
`TTC
`CTC
`THR
`THR
`THE
`ACG
`ACT
`ACT
`ACT
`PHE
`PHE
`TTC
`TTT
`TIC PHE
`TTC
`GLY
`GGC
`GGC
`GGC
`GLY
`GGC GL!
`GLN
`GAA
`GAG
`CCT
`PRO
`GGA GLY
`GLY
`GGG
`GGG
`GGG
`GLY
`GGG
`GLY
`THR
`ACC
`ACC
`ACC
`THR
`ACC
`THE
`LYS
`AAG
`AAG
`AAA
`LYS
`AAG
`LYS
`VAL
`GTE
`CTG
`GTG
`VAL
`GTG
`VAL
`GAA GLU
`GAG
`GAT ASP
`GAG
`GLU
`ATC
`ILE
`ATC
`ATC
`ILE
`ATC
`ILE
`AAA
`LYS
`AAA
`AAA
`LYS
`AAA
`LYS
`CGT
`ARG
`CGT
`CGT
`ARG
`CGT
`ARG
`
`96
`97
`98
`99
`100
`101
`102
`103
`ION
`105
`106
`107
`10B
`
`TYR
`THR
`PHE
`GLY
`GLN
`GLY
`THR
`LYS
`LEU
`GLU
`ILE
`LXS
`AHG
`
`
`
`
`P.
`
`ii
`ILE
`ATC
`THR
`ACC
`PHE
`TTC
`GGC GLY
`CAA GLN
`GGG
`GLY
`ACA
`THE
`CGA
`ARG
`CTG
`LEU
`GAG
`GLU
`ATT
`ILE
`AAA
`LYS
`CGT
`ARG
`
`Sanofi/Regeneron Ex. 1029. P9 903
`
`Sanofi/Regeneron Ex. 1029, pg 903
`
`

`
`SEQUENCES OF
`
`PROTEINS o|=
`
`IMMUNOLOGICAL
`INTEREST .\
`
`Tabulation and Analysis of
`Amino Acid and Nucleic Acid Sequences of
`Precursors, V-Regions, C-Regions, J-Chain,
`
`l5’2—Microglobulins, Major Histocompatibility Antigens,
`Thy-1, Complement, C-Reactive Protein, Thymopoietin,
`Post-gamma Globulin, and a2-Macroglobulin
`
`1 983
`
`Elvin A. Kabat*, Tai Te wuT , Howard Bi/ofsky 1,
`Margaret Fleid-Milleri, and Harold Perryi
`
`*Depts. of Microbiology, Human Genetics and Development, and Neurology, Cancer Centerl
`Institute of Cancer Research, College of Physicians and Surgeons, Columbia University, New
`York, NY 10032 and the National Institute of Allergy and Infectious Diseases, Bethesda, MD
`20205
`
`TDepts. of Biochemistry, Molecular Biology, and Cell Biology, and Engineering Sciences and
`Applied Mathematics, Northwestern University, Evanston, IL 60201 and the Cancer Center,
`Northwestern University Medical School, Chicago, IL 60611
`i Bolt Beranek and Newman lnc., Cambridge, MA 02238
`
`The collection and maintenance of this data base is sponsored through Contract N01-RR-8-2118
`by the following components of the National Institutes of Health, Bethesda, MD 20205:
`Division of Research Resources
`National Cancer Institute
`National Institute of Allergy and Infectious Diseases
`National Institute of Arthritis, Diabetes, Digestive and Kidney Diseases
`National Institute of General Medical Sciences
`
`U.S. DEPARTMENT OF HEALTH
`AND HUMAN SERVICES
`Public Health Service
`National Institutes of Health
`
`(1933)
`
`THE HEALTH SCIENCES LIBRARY
`._-.....-.1-..--run: n-m nu-Tn-nDu'rA TMVTR
`
`Sanofi/Regeneron Ex. 1029, pg 904
`
`Sanofi/Regeneron Ex. 1029, pg 904
`
`

`
`Our listing of sequences will be kept up to date. Investigators are invited to send additional
`sequence data when accepted for publication. Send two copies of the manuscript together with
`a letter of acceptance from a journal to:
`Dr. E.A. Kabat
`National Institutes of Health
`Building 4, Room 337
`9000 Rockville Pike
`Bethesda, Maryland 20205
`
`If a computer tape is available, please send it to facilitate entering sequences.
`when published, three reprints should be provided.
`
`If any published sequences have been overlooked or if any errors are found, please bring them to
`our attention.
`"
`
`Sanofi/Regeneron Ex. 1029, pg 905
`
`Sanofi/Regeneron Ex. 1029, pg 905
`
`

`
`245
`
`11
`11
`
`12
`L6
`
`13
`12
`
`14
`L7
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`,,,
`_ _
`_
`_
`_ _
`- _
`, -
`_ ,
`_
`_
`-
`-
`— ,
`---
`
`GAA GAG
`ATA CTG
`___ ___
`AAA AAA
`CGT CGT ———
`
`___
`
`___
`
`___
`
`___
`
`CDDONS OF VARIABLE REGION LIGHT CHAINS
`15
`10
`9
`8
`T
`6
`1
`2
`3
`4
`5
`PKAPPA
`Hmm HKIU2 MCIPC MOPC MOPC MOPC 1<2A MPC MOFG s1u7
`(11)-24
`41
`21
`157
`149
`11 was
`a
`(K2)
`GGA
`,,,
`,,,
`,,
`,,,
`,,, ,,,
`-,,
`___ ___ ___ ___ ___
`,,,
`.,,
`ATT
`ATC
`ATT
`ATT
`ATC ATC ATT ATC AAT ATC ATG ATG ATC
`ATG
`ATG
`GAO
`GAG
`AAG
`GA1
`GAG GAG GAG
`GAG GAA GAG GAG GAG GAG
`GAG
`GAC
`GTG
`CA6
`GTA
`GTG
`CAG CAG GTG CAG GTG AAG AAG TTG TTG
`CA6
`CAG
`ATG
`ATG
`ATG
`ATA
`ATG ATG CTG ATG GTO ATG ATG CTG CTG
`ATG
`ATS
`ACO
`AC5
`ACC
`ACC
`ACT ACT ACC ACO
`ACO ACC ACC ACT ACT
`ACC
`ACC
`GAG
`CAG
`cAA
`GAG
`DAG GAG cAA
`me me GAG
`GAG
`CAG
`1c1
`1121 m1
`1G1
`GA1
`1c1 1c1 1G1
`TCT 1c1 1c1
`1c1
`GAG
`cc1
`ccA CCC
`GAA
`GGA GGA GGG
`ccA GOA CCA
`cGA
`AAA
`TCC
`TCC
`AAA
`CTC
`GCC GCC GGT
`TCT GGG GGG
`TCC
`11G
`TCA Am 11::
`1cc
`1cc
`1cc 1cc 1c1
`1cc A1c A1c
`ATG
`CTG
`CTG
`TTA
`ATG
`AAT
`CTA CTA TTG
`ATG CTC-i CTG
`TCC
`TCT
`TC-T
`TCT
`TCC
`CCT
`TCT
`TCT GOT
`TAT TCT TCT
`AGA
`GGA
`GGA Gcc
`A1G
`GTC
`GcA GGA G1G
`GCA G1G G1G
`TCA
`TCT
`TCT
`TCT
`TCA
`ACT
`TCT
`TCT TCT
`TCT AGT AGT
`GTA
`GTA
`GTA
`CTG
`GTA
`TCT
`GTG GTG CTA
`CTA CCA CCA
`GGA
`GGA
`GGA
`GGA
`GGA
`GGA
`GG1 GG1 GGG
`GGA GGA GGA
`GAC
`GAG
`GAO
`GAA
`GAG
`GAA
`GAA GAA GAG
`GAG GAA GAA
`AGG
`AGA
`AGA
`AGA
`AGG
`1Ac
`AG1 AG1 AGG
`AGA AGA AGA
`GTC
`GTC G1c
`GTC
`G11: G11
`GTC G1c Gcc
`GTO GTO GTC
`AGG
`Acc
`Acc
`AG1 Acc
`1cc
`ACC ACC AGG
`AG1 AG1 AG1
`no no c1c
`TTG
`A1c
`A1G Am A1A
`Am 119 11c A1c
`ACT
`ACT
`ACT
`TCG
`ACA ACA TCC
`ACT TCC TCC
`ACC
`1G1
`use
`191
`1Gc
`1G1
`1G1 1Gc
`1Gc 1Gc 1Gc
`1Gc
`CGG
`GGG
`GGG
`GGA GGA AGA
`AAG AGG AGG
`AAG
`GGG
`GCC
`GCA
`GCA GGA GCC
`GCG GCC GCC
`GCC
`AGG
`AGT
`AGT
`AGT AGT AGT
`AGT AGT AGT
`AGT
`—-v—
`———
`___ AGT
`--- ——— ---
`———
`GAG
`GAG
`CAG
`GGG GGG GAA
`CAG CAG CAG
`GAG
`___ ___ ___
`___.
`___
`-.,
`,,,
`GAC AGC AGO
`G1G
`A11 A11 A11
`AGT
`AA1 GGG GGG
`AG1
`AGG AGA ACA
`ACT
`TAT AGC AGC
`G1G
`11A A1-A A1A
`AGc GAG GAG Gcc
`1GG 1GG 1GG
`1GG
`11c 1A1 1A1
`1A1
`GAG CAG CAG
`GAG
`GAG CAA CAA
`CAG
`AAA AGA AGA
`AAA
`CCA ACA ACA
`CCA
`GGG AAT AAT
`GGG
`GG1 GG1
`GAA
`TCT TCT
`TCT
`CCA CCA
`CGT
`AGG AGG
`AAA
`G11 CTT
`c1A
`c1c c1c
`c1G
`A1A A1A A11
`AAG AAG
`1A1
`AA1 1A1
`1cG
`GGT GG1
`GGA
`TCT TCT
`TCO
`GAG GAG
`TAG
`1cc 1G1
`GGG
`
`o
`2
`1
`3
`4
`5
`a
`7
`a
`9
`1o
`11
`I2
`13
`1-1
`15
`1s
`17
`1e
`19
`20
`21
`22
`23
`24
`25
`26
`5;,‘
`ZTB
`27C
`271:
`27:
`27F
`28
`29
`so
`31
`32
`as
`34
`as
`35
`37
`38
`39
`40
`41
`42
`43
`44
`45
`45
`47
`413
`as
`so
`51
`52
`53
`54
`55
`55
`57
`5a
`55
`so
`s1
`62
`S3
`s4
`s5
`as
`s7
`sa
`53
`7n
`71
`72
`73
`74
`75
`TS
`77
`7a
`79
`so
`e1
`52
`B3
`54
`B5
`BS
`57
`as
`as
`90
`91
`92
`93
`94
`95
`96
`97
`97A
`973
`970
`9713
`97E
`97F
`sa
`99
`1oo
`101
`102
`103
`104
`105
`106
`1oeA
`107
`103
`
`F
`R
`'
`
`C
`D
`R
`1
`
`F
`A
`2
`
`C
`D
`R
`2
`
`F
`H
`3
`
`C
`D
`H
`3
`
`F
`Fl
`4
`
`TAT
`G11
`1c
`1GG
`1A1
`CAA
`CAG
`AAA
`CCA
`GAG
`GAA
`TCT
`CCT
`AAA
`(:10
`11A
`A11
`1Ac
`GGG
`Gcc
`TCC
`AAG
`GGG
`1Ac
`ACT
`GGG
`G1c
`con
`GA1
`GGG
`11c
`ACA
`GG1
`AG1
`GGA
`TCT
`GGA
`AcA
`GA1
`11c
`ACT
`CTG
`Acc
`ATT
`AGT
`AGT
`G1G
`GAA
`GCT
`GAA
`GAC
`GTT
`GGA
`GAT
`TAT
`cm
`1G1
`GGA
`GAG
`GG1
`TAC
`AGG
`TAT
`COG
`1Ac
`Ace
`.._.
`
`
`
`--,
`11:;
`GGA
`GGG
`GGG
`ACC
`AAG
`CTG
`GAA
`ATA
`_,_
`AAA
`,,,
`
`---
`
`-,,
`
`CGT
`
`‘
`1
`1
`
`.
`J!
`1
`"
`I
`,‘
`.
`
`21
`20
`19
`15
`17
`16
`s43 MOPC pun
`1Gsoa
`lG13
`I699
`315
`-13
`LAMBDA LAMBDA LAMBDA
`___
`___
`___
`___
`___
`GGT GGT
`GGT
`GCT
`GGT
`GAG GAG
`GAG
`GAG
`GAG
`GTT GTT
`GTT
`GTT
`GTT
`GTG GT6
`GTG
`GTG
`GTG
`ACT ACT
`ACT
`ACT
`ACT
`GAG cAG
`GAG
`cAG
`GAG
`GAA GAA
`GAA
`GAA
`GAA
`1c1 TCT 1c1
`1G1
`1c1
`11:1
`GCA GGA GGA
`GGA
`GGA
`GGA
`,,,
`,,,
`,,,
`-,,
`,,,
`-.,
`CTC CTC CTC
`CTC
`CTC
`OTC
`AGC AGE AGE
`ACC
`ACC
`ACC
`AGA AGA AcA
`AGA
`ACA
`AGA
`TCA TCA TCA
`TCA
`TCA
`TCA
`CCT CCT
`CCT
`CGT
`CCT
`CGT
`GGT GG1 GG1
`GG1
`GG1
`GG1
`GAA GGA GAA
`GAA
`GGA
`GAA
`AGA AGA AGA
`AGA
`AGA
`AGA
`G1G G1G G1G
`G1G
`GTC
`G1G
`AGA A1A AGA
`AGA
`A1A
`AGA
`c1c c1c
`c1G
`c1c
`c1c
`c1c
`ACT ACT ACT
`ACT
`ACT
`ACT
`1G1
`1G1
`TGT
`1G1
`1G1
`1G1
`CGC GGG GGG
`cGc
`GGG
`CGC
`TCA TCA TCA
`TCA
`TCA
`TCA
`AGT
`AGT
`AGT
`AGT
`AGT
`AGT
`---
`---
`---
`———
`---
`---
`ACT ACT
`ACT
`ACT
`ACT
`ACT
`___
`___
`___
`———
`___
`___
`___
`___
`_-_
`___
`___
`___
`GGG GGG ___
`GGG
`GGG
`GGG
`GG1 GCT GCT
`GGT
`GG1
`GGT
`GTT GTT
`GTT
`GTT
`GTT
`ACA ACA
`ACA
`ACA
`ACA
`ACT AG1
`AG1
`ACT
`AG1
`AG1 AG1
`AG1
`AG1
`GG1
`AAG AAG
`AAc
`AAG
`AAG
`TAT
`TAT
`TAT
`TAT
`TAT
`___
`GGG Gcc
`Gcc
`Gcc
`Gcc
`-
`AAG
`AAG
`AAc
`AAG
`AAc
`1GG 1GG _
`1GG
`1GG
`TGG
`GTC A1c
`—
`GTC
`G11
`G11:
`CAA CAA —
`CAA
`CAA
`CAA
`GAA GAA ---
`GAA
`GAA
`GAA
`AAA AAA ___
`AAA
`AAA
`AAA
`CCA CCA , ,
`CCA
`CCA
`CCA
`GAT GAT
`-
`_
`GAT
`GAT
`GAT
`GA1
`cA1 , ,
`cA1
`GA1
`GA1
`TTA TTA — _
`TTA
`TTA
`TTA
`TTC TTC - _
`TTC
`TTC
`TTC
`ACT ACT
`V7
`-
`ACT
`ACT
`ACT
`GG1 GG1
`- _
`GG1
`GG1
`GG1
`G1A
`c1A
`G1A on on , ,
`A1A
`A1A
`A1A
`A1A A1c
`___
`GGT
`GGT
`GG1
`GG1 GG1
`_ _
`GG1
`GGT
`GG1
`GG1 GG1
`-
`-
`Acc
`Acc
`AGG
`Acc AGG _ _
`AAC
`AGO
`AAC
`AAC AGO — —
`AAG
`AAC
`AAC
`AAC AAG — -
`GGA
`GGA
`GGA
`GGA GGA
`GG1
`GG1
`GG1
`GG1 GG1
`GGA
`GGA
`.ccA CCA GGA —,—
`GG1
`GG1
`GG1
`GG1 GG1
`G11
`G11
`G11
`G11 G11
`GG1
`cc1
`CCT
`cc1 cc1 , ,
`Gcc
`G1c
`Gcc
`Gcc G1c
`, ,
`AGA
`AGA
`AGA
`AGA AGA - -
`11c
`11c
`11c
`11c 11c
`_ _
`TCA
`TCA
`TCA
`TCA TCA _ _
`GGG
`GGG
`GGG
`GGC GGG , —
`1cc
`Tcc
`1cc
`1cc 1cc
`_ _
`G1G
`c1G
`c1G
`G1G G1G _ _
`A11
`A11
`A11
`A11 A11
`_ —
`GGA
`GGA
`GGA
`GGA GGA , ,
`GAG
`GAG
`GAG
`GAG GAG — —
`AAG
`AAG
`AAG
`AAG AAG — —
`GGT
`GG1
`GGT
`GG1 GG1
`,
`Gcc
`Gcc
`Gcc
`Gcc Gcc
`, _
`CTC
`CTC
`CTC
`CTC C-TC
`- —
`Acc
`Ace
`Acc
`AGO Acc
`— —
`ATG
`ATC
`ATC
`ATC ATC — —
`ACA
`ACA
`ACA
`ACA ACA — —
`GGG
`GGG
`GGG
`GGG GGG , ,
`GOA
`GGA
`GCA
`ACA GGA , —
`GAG
`GAG
`GAG
`GAG CAG
`AG1
`AG1
`ACT
`AG1 AG1
`GAG
`GAG
`GAG
`GAG GAG
`GAT
`GAT
`GAT
`GAT GAT
`GAG
`GAT
`GAG
`GAG (SAT
`GGA
`GcA GGA
`ATA
`ATG ATG
`TAT
`TAT
`TAT
`11c
`11c 11c
`1G1
`1G1
`TGT
`GG1
`GG1 GG1
`c1A
`G1A on
`1GG
`1GG ___
`TAG
`TTC
`,
`AGG
`AGA ---
`AAG
`AAC
`CAT
`CAT
`1GG
`111
`G1G
`G11
`,,,
`,,,
`
`
`
`
`
`——,
`11c
`GG1
`GGA
`GGA
`AGC
`AAA
`CTG
`AG1
`GTC
`c1A
`GGT
`___
`
`---
`11c
`GG1
`GGA
`GGT
`ACG
`AAA
`CTG
`AG1
`GTC
`c1A
`GGG
`_-..
`
`_-_
`
`___
`
`___
`
`___
`
`
`
`
`Sanofi/Regeneron Ex. 1029, pg 906
`
`Sanofi/Regeneron Ex. 1029, pg 906
`
`

`
`247
`
`SOURCE: CODONS OF VARIABLE REGION LIGHT CHAINS
`1) HK101: HUMAN FOETAL LIVER
`2) HK102: HUMAN FOETAL LIVER
`3) MOPC41: MOUSE ADULT
`4) IAOPGI1: MOUSE MRNA FROM MOPC21
`5)
`|lOPC1G7: MOUSE ADULT
`6) IlOP0149(|(2): MOUSE EMBFIYD E: PLASMOCYTOMA
`7) KZA: MOUSE EMBRYO
`B) MPC11: MOUSE PLASMACYTDMA
`9) HOPC173B: MOUSE PLASMACVTOMA
`10) 5107!: MOUSE EMERYO
`11) T1: MOUSE ADULT
`12) LE: MOUSE ADULT LIVER
`15) T2: MOUSE ADULT, ABNORMAL J OMITTED
`14) L7: MOUSE ADULT LIVER
`15) PKAPPA(11)21: MOUSE MRNA FHDM MPC11
`15)
`IGBSLIHBDA: MOUSE EMBRVO
`17) IG1€ILAllIDA: MOUSE EMBRYO
`1B)
`IGBOSLAIIBDA: MOUSE ADULT
`19) S43: MOUSE ADULT
`20) MOPG315: MOUSE ADULT
`21) PLAI-13: MOUSE ADULT
`REFERENCE: CODONS OF VARIABLE REGION LIGHT CHAINS
`1) HI(1lI1: EENTLEY,D.L & RABB|TTS.T.H. (1960) NATURE.2BB.730-733.
`2) HK1|l2: EENTLEY,D.L E RABBITTS.
`
`(1550) NATURE,28B,750-733.
`3) MOPCO1:
`SEIDMAN.J.G..MAX,E.E.
`Eu LEDEFLF. (1975) NATURE,IElJ,37C|—375.
`A) MOPCZI:
`FONG.K..LE|,A. E SALSER,W.
`(19713) BIOCHEM.BIOPHYS.FIES.COMMUN..90.8S2-8417 HAML‘IN.P.H.,GA|T,M.J.
`RES.,9.44B5-4494.
`5)
`|IOPC187:
`JOHO,R.,WE|SSMAN.I.L..EAFILY.F..COLE,J. 5 HOOD.L. (1550) PROC.NAT.ACAD.SCI.USA.77,11%-1110.
`6)
`IAOPC149(K2): NISHl0KA.Y. Ex LEDER.P. (1930) J. BlOL.CHEM..255.36S1-3694,
`7) KZA: NISHIOKA,Y.
`«E LEDEFLP. (1980) J.BIOL.CHEM:.255,3E91-3694.
`B) MPC11:
`SElDMAN.J.G. & LEDER.P. (1980) NATURE,2B5,779-783.
`9) MOPCWIB: MAX.E.E.,SEIDMAN..J.G.,MlLLER,H. & LEDEF.P. (1980) CELL.21.7E|3~799.
`10) 51073: KWAN,S.P..MAX.E.E..SElDMAN,J.G.,LEDER,F. E SCHARFF.M.D. (1581) CELL,26,57-66.
`11) T1: ALTENBUFIGER,W.,STElNMETZ,M_ K ZACHAU,H.G.
`(1950) NATUHE,2B7,fl|5v3U7_.
`12) L6:
`PECH.M..HOCHTL.J..SCHNELLH. & ZACHAU,H.G.
`(1961) NATUFIE.291.66B—57D.
`13) T2: ALTENBURGER,W..STEINMEI'Z.M. A ZACHAU.H.G.
`(1980) NATURE.287,60G-607.
`14) L1:
`PECH,M.,HOCHTL.J‘.SGHNELL.H.
`In ZACHAU.H.G.
`(1981) NATURE.291,66&-570.
`15) PKIFPA(11)24:
`F|ABBITTS,T.H.,HAMLYN,P.H. 5 MA1'THY5SENS,G.
`(1950) CAN.J.B|OCHEM.,56,175-1B7.
`16)
`IGDSLANBDA: BEFlNARD.0..H0ZUMI,N. & TONEGAWA.S.
`(1973) CELL.15.11S3-1144.
`17) IG13LAMBDA: TONEGAWA.S..MAXAM,A.M..TlZARD.R..BERNARD,D. A GlLBERT.W. (1978) PROC.NAT.ACAD.SC|.USA,75,14B5—1489.
`
`15) IGBOSLAHBDA: BERNARD,
`I,HDZUM|,
`. Eu TONEGAWAS.
`(1975) cELL,15,1133-1144.
`19) S43: BOTHWELLA.L.M.,PASKlND.M..RETH.M.,IMANISHI-KARl,T.1RA.lEWSKY,K. E. EALTlMORE,D. (1992) NATURE.29fl,3BD-382.
`20) MOPC315: EOTHWELLA.LM..PASKlND,M.,RETH.M.,lMANlSHI~KAR|.T..RAJEWSKY.K. & BALTIMDFIE.D. (1962) NATURE.2m.SBO—382.
`21) PLAI-13: EDTHWELLA.LM.,PASK|ND,M.,SCHWARTZ.R.C..SONENSHE|N.G,E..GEFl'ER.M.L & BALT|MDRE.D‘ (1931) NATUI-1E,29D.S5—S7.
`
`1!: M|LSTE|N,C. (1981) NUGLACIDS
`
`
`
`_._,._.....-.,1....
`
`Sanofi/Regeneron Ex. 1029, pg 907
`
`Sanofi/Regeneron Ex. 1029, pg 907
`
`

`
`248
`
`6
`SP1
`-HL
`
`5
`H11
`
`TAT
`CTT
`CAA
`ATG
`AAG
`AGG
`GTG
`AGA
`GAG
`GGG
`
`AAG
`AGG
`GTG
`AGA
`GAG
`GGG
`
`GODONS OF VARIABLE REGION HEAVY CHAINS
`1
`2
`3
`4
`LAMBDA LAMBDA LAMBDA HG3
`VH26
`VH52
`\/H32
`-..
`GAG
`GTG
`CAG
`GTG
`TTG
`GAG
`TGT
`GGG
`GGA
`GGG
`TTG
`GTA
`CAG
`CCT
`GGG
`GGG
`TCC
`GTG
`AGA
`CTC
`TGG
`TGT
`GGA
`GCC
`TCT
`GGA
`TTG
`AGG
`TTT
`AGC
`AGG
`TAT
`3%
`AGG
`___
`TGG
`GTG
`GGG
`GAG
`GGT
`CCA
`GGG
`AAG
`GGG
`CTG
`GAG
`TGG
`GTG
`TGA
`GGT
`T
`AET
`u-—
`___
`GGT
`AGT
`GGT
`GGT
`AGG
`AGA
`TAG
`TAG
`GGA
`GAG
`Tcc
`GTG
`AAG
`GGG
`CGG
`TTG
`Acc
`ATG
`TCA
`AGA
`GAG
`AAT
`TGG
`AAG
`AAG
`ACG
`CTG
`TAT
`GTG
`CAA
`ATG
`AAG
`AGG
`GTG
`AGA
`GAG
`GGG
`GAG
`ACG
`
`U
`1
`2
`3
`4
`5
`s
`7
`2
`9
`1o
`11
`12
`13
`14
`15
`15
`17
`113
`1s
`20
`21
`22
`2:1
`24
`25
`2a
`27
`2a
`29
`30
`a1
`32
`33
`33;‘
`353
`36
`37
`an
`39
`40
`41
`42
`43
`44
`45
`4s
`47
`as
`49
`so
`5
`5%
`52c
`53
`54
`55
`53
`57
`as
`59
`50
`s1
`a2
`as
`54
`55
`ss
`s7
`53
`s9
`70
`71
`72
`73
`T4
`75
`76
`77
`78
`79
`30
`81
`s2
`a2A
`eza
`a2G
`as
`B5
`a4
`as
`E17
`as
`as
`so
`91
`92
`93
`94
`
`F
`Fl
`1
`
`R 1
`
`3
`
`E
`2
`
`3
`R
`2
`
`F
`R
`3
`
`
`
`.—-
`
`32
`97
`95
`59
`1
`1ggA
`:32:
`19.33
`100F
`100G
`1ooH
`1
`J
`1&|
`100K
`101
`102
`10:1
`104
`105
`106
`107
`109
`H39
`11::
`111
`112
`113
`
`c
`B
`3
`
`F
`R
`4
`
`TGG TGG
`GGG
`GGG
`GGA GGA
`GGG GGG
`AGG Acc
`ACG ACG
`GTG GTC
`Acc AGG
`GTG GTG
`TCG TCC
`TGA TGA
`
`-__
`
`___
`
`-__ .__
`
`12
`11
`10
`9
`7
`8
`MOPC
`MCPC MOPC HPC MOPC
`3
`141
`S03
`67
`75
`4
`1
`1
`1
`1 07
`ADULT EMBHYO
`._-
`.__
`-__
`___
`.__
`.__
`.1._
`GAG
`GAG
`GAG GAG GAA GAG GAG
`GAG
`GTG GTG GTG GTG GTG
`GTG
`GTA
`GTA
`CAG CAG ATG AAG AAG
`AAG
`CAG
`CAG
`GTG GTG GTG GTG GTG
`GTG
`GTG
`GTG
`GTG GTG GTG GTG GTG
`GTG
`AAG
`AAG
`GAG GAG GAG GAA GAA
`GAA GAG
`GAG
`GAG
`TCT TGG TGT TCT
`TCT
`TGT TGT
`TGA
`TGA
`GGG GGG GGG GGA GGA
`GGA GGA
`GGA
`GGA
`GCT GGA GGA GGA GGA
`GGA GGA
`CCT
`CCT
`GAG GGG GGG GGG
`GGG
`GGG GGG
`GGG
`GGG
`GTG TTA TTA TTG TTG
`TTG‘! TTG GTG
`GTG
`AAG GTT GTG GTA GTA
`GTA GTG GTG
`GTG
`AAG GAG AAG CAG CAG
`CAG CAA
`GCG
`GGG
`CCT CCT CCT GGT GGT
`GGT GGT
`CCC
`GGG
`GGG GGG GGA GGG GGG
`GGG GGA
`TCA
`TEA
`GCC GGG GGG GGT GGT
`GGT GGA
`CAG
`CAG
`TC-A TCC TCC TCT
`TCT
`TCT
`TCC
`AGC
`AGG
`GTG GTG CTG GTG GTG
`CTG ATG
`GTG
`GTG
`AAG AGA AAA AGA
`AGA
`AGA AAA
`TCC
`TCC
`GTT CTC CTC CTC CTC
`CTC CTC ATC
`ATC
`TGG TGG TGG TGG TGG
`TGG TGG
`AGA
`AGA
`TGG TGT TGT TGT
`TGT
`TGT
`TGT
`TGG
`TGG
`AAG GGA GGA GGA GGA
`GGA GTT
`AGG
`AGG
`GCA GCC GCC ACT ACT
`ACT GCC GTC
`GTC
`TCT TCT TCT TCT TCT
`TCT
`TCT
`TCA
`TCA
`GGA GGA GGA GGG GGG
`GGG GGA
`GGA
`GGG
`TAG TTG TTC TTG TTG
`TTG TTG TTG
`TTG
`AGG AGG AGT AGG
`AGG
`AGG AGT
`TGA
`TGA
`TTC TTC TTC TTC TTC
`TTC TTC
`TTA
`TTA
`AAC AGT AGT AGT
`AGT
`AGT
`AGT
`ACC
`ACC
`AGG AGG AGG GAT GAT
`GAT AAG
`GGG
`GGG
`TAC TAC TAT TTG TTC
`TTC TAC
`TAT
`TAT
`ATG ATG ATG ATG AT
`ATG AT
`T
`TAT TGG 6°“ T” “E T“ Tag
`593
`2?}
`GAG GAG TGT GAG GAG
`GAG AAG
`AAG
`AAG
`Z: :: I: :: :::
`::: T" ::
`2::
`TGG TGG TGG TGG TGG
`TGG
`TGG
`TGG
`GTG GTG GTT GTG GTG
`GTC
`GTT
`GTT
`GGA GGG GGG GGG GGG
`GGG
`GGG
`GGG
`GAG GAA
`GAG GAG
`GAG
`GAG
`GAG
`GCC GGT
`GGT GGT
`AGT
`GGT
`ccT
`OCT CCA
`CCA CCA
`CCA
`CCA
`CCA
`GGA GGG
`GGG GGG
`GGG
`GGA
`GGA
`GAA AAG
`AAG AAG
`AAG
`AAG
`AAG
`GGG GGG
`AGA AGA
`AGA
`GGT
`GGT
`CTT GTG
`CTG CTG
`CTG
`CTG
`CTG
`GAG GTG
`GAG GAG
`GAG
`GAG
`GAG
`TGG TGG
`TGG TGG
`TGG
`TGG
`TGG
`ATG GTG
`ATT ATT
`ATT
`CTG
`GTG
`GGA TGA
`GGT GGT
`GGT
`GGA
`GGA
`ATA GGT
`GGA GGA
`GGA
`ACG
`ATG
`AAG AAT
`AGA AGA
`AGA
`TGG
`TG
`‘T° ‘TT
`‘GT ‘GT
`‘GT
`AT‘
`‘T3
`——— ———
`AAA AA
`AAA
`
`___
`___
`_....
`___
`GGT GGT
`GGT
`CCT AGT
`AAG AA‘;
`AGT
`GGT
`GGT
`AGT GAT
`AAT AAT
`CAT
`AAT
`GAT
`GGT GGG
`GAT AAA
`GAT
`GGT AGT
`TAT TAT
`TAT
`GGA
`GGA
`AGG AGG
`AGA AGA
`AGA
`AGG
`AGG
`AGA AGA
`AGA AGA
`AGA
`AGA
`AGA
`AGG AGG
`GAG GAA
`GAA
`GAG
`GAG
`TAG TAG
`TAG TAG
`TAG
`TAT
`TAT
`GGA GGG
`AGT AGT
`AGT
`AAT
`AAT
`GAG GAG
`GGA GGA
`GGA
`TGA
`TCA
`AAG TGG
`TGT TGT
`TGT
`AGT
`GGT
`TTG GTG
`GTG GTG
`GTG
`GTG
`GTG
`GAG AAG
`AAG AAG
`AAG
`AAA
`AAA
`GGG GGC
`GGT GGT
`GGT
`TGG
`TGG
`AGA GGA
`GGG GGG
`GGG
`AGA
`AGA
`GTG TTG
`TTC TTC
`TTG
`GTG
`GTG
`AGG Acc
`ATG ATG
`ATG
`AGG
`AGG
`ATG ATG
`GTG GTG
`GTG
`ATG
`ATG
`ACC TCC
`TCC TCC
`TCC
`ACC
`AGC
`AGG AGA
`AGA AGA
`AGA
`AAG
`AAG
`GAG GAG
`GAG GAG
`GAG
`GAG
`GAG
`ACG AAC
`ACT ACT
`ACA
`AAC
`AAC
`TGG GGG
`TGG TGG
`TGG
`TGG
`TCC
`ACG AAG
`CAA GAA
`CAA
`AAG
`AAG
`AGG AAG
`AGG AGG
`AGT
`AGG
`AGG
`ACA AGG
`ATC ATC
`GTC
`GAA
`CAA
`GTG GTG
`CTC OTC
`CTD
`GTT
`GTT
`TAG TAT
`TAG TAG
`TAG
`TTG
`TTC
`ATG GTG
`GTT CTT
`CTT
`TTA
`TTA
`GAG CAA
`CAG CAG
`CAG
`AAA
`AAA
`GTG ATG
`ATG ATG
`ATG
`ATG
`ATG
`AGG AAG
`AAT AAT
`AAT
`AAG
`AAG
`AGG AGT
`GGG GGG
`GGG
`AGT
`AGT
`GTG GTG
`GTG GTG
`GTG
`GTG
`GTG
`AGA AGA
`AGA AGA
`AGA
`GAA
`GAA
`GAG GAG
`GAG GAG
`GAG
`GAT
`GAT
`TGT GGG
`GGT GGT
`GGT
`AGT
`AGT
`GAG GAG
`GAG
`GAG
`GAG
`ACT ACT
`ACT
`ACA
`AGA
`GGG GGG
`GGG
`GGG
`ATT ATT
`AGT
`AGG
`TAT
`TAT
`TAT
`TAG
`TAG TAC
`TAG
`TAG
`TGT
`TGT
`TGT
`TGT
`GGA GGA
`Gcc
`AGA AGA
`AGG
`___
`___
`TGA
`GAT AAT
`GTC
`TAC TAC
`ATT
`TAG TAG
`TAT
`GGT GGT
`TAC
`GGT
`TAO
`22;
`AAA
`GAG
`TAG
`TTC
`AGT
`,7,
`TTG
`___
`___
`___
`GAG
`GAT GAC
`TAG
`GTG TAG
`TGG TGG TGG
`GGG GGG
`GGT
`GGA GAA GAA
`GGG GGG
`GGA
`AGG
`AGG Acc
`ACG ACT
`TCA
`GTC CTC
`GTG
`AGG AGA ACT
`GTG GTG
`GTG
`TGG TGG
`TGG
`TGA TGA TGA
`
`I3
`J
`53
`5
`
`19
`23
`
`2D
`3'
`
`21
`102
`
`1E
`17
`22
`16
`15
`14
`PCH
`MPC B1-8 S43 MOFC 155
`105
`11
`21
`-
`1
`——r ——— ——— ——— ———
`———
`——— ———
`GAG GAG GAG GAT GAG GAG GAG GAT GAG
`GTC GTC GTG GTG GTC GTC GTC GTC GTG
`CAG CAA GAA CAG GAA GAA GAA GAA CAG
`GTG CTG CTA GTG GTG GTG GTG GTG GTG
`GAG GAG GAG GTG GAG GAG GAG GAG GAG
`GAG GAG GAG GAG GAG GAG GAG GAG GAA
`TCT GGT GGT
`TGT CCT GGT GGT CCT TOT
`GGA GGG GGG GGG GGG GGG GGG GGG GGA
`GGT GCT GCT GGA GCT ACT GCT GCT CCT
`GAG GAG GAG GGG GAG GAA GAG GAG GAG
`GTG CTT TTT
`TTA GTT GTG GTG GTG GTG
`GTA GTG GTG GTG GTG GTG GTG GTG GTG
`AGA AAG AAG CAG AAG AAG AGG AAG AAG
`CCT ccT CCT GGT GGT GGT GGT GGT GGT
`GGG GGG GGG GGA GGG GGG GGG GGG GGG
`ACT GCT GCT GGG GCT GCT TCT GCT GCT
`TCA TCA TCA TCC TCA TCA TCA TCA TGA
`GTG GTG GTG GGG GTG GTG GTG GTG GTG
`AAG AAG AAG AAA AAG AAG AAG AAG AAG
`ATG C-TG CTG CTC CTG CTG CTG GTG ATA
`Tcc TGG TGG TGG TCC TCC TGG TGG TGG
`TGG TGG TGG TGT
`TGG TGG TGG TGG TGG
`AAG AAG AAG
`GGA AAG AAG AAG AAG AAG
`GCT GCT GCT GCC GGT GCT GCT GCT GOT
`GCT TCT TCT
`TCT TCT TCT TCT TCT TCT
`GGA GGG GGG GGA GGG GGG GGG GGG GGG
`TAG TAG TAG TTG TAG TAG TAG TAG TAT
`ACC AGG AGG AGT Acc AGG AGG AGG Acc
`TTC TTC TTC TTC TTC TTC TTC TTC TTC
`ACT ACC ACC AGT ACC ACC ACC ACC ACA
`AAG AGG AGG AGG AGG AGG AGG AGG AGG
`TAC THC TAC TTT
`TAC TAG TAC TAC TAC
`11?? H2 H3 5% HS {$2 ITTGT ITS TTT
`GGT GAG GAG GAG GAG GAG GAT GAG GAG
`:: Z: :: Z: Z: Z: :: I: Z:
`TGG TGG TGG TGG TGG TGG TGG TGG TGG
`GTA GTG GTG GTT GTG GTG GTG GTG GTG
`AAG AAG AAG GGT AAG AAG AAG AAG AAG
`GAG GAG GAG GAG GAG GAG GAG GAG GAG
`AGG AGG AGG GGT AGG AGG AGG AGG AGG
`CCT CCT CCT CCA CCT CCT CCT CCT CCT
`GGA GGA GGA GAG GGA GGA GGA GGG GGA
`GAT GGA GGA AAG GGA GAA GAA GAA GAG
`GGG GGG GGG GGG GGG GGG GGG GGG GGG
`GTT CTT CTT CTG CTT CTT CTT CTT CTT
`GAG GAG GAG GAG GAG GAG GAA GAG GAG
`TGG TGG TGG TGG TGG TGG TGG TGG TGG
`ATT ATT ATT GTG ATT ATT ATT ATT ATT
`GGA GGA GGA GGA GGA GGA GGT GGA GGA
`GAT AGG AGG TAG AGG AAT AAG AGG TAT
`T
`A
`‘T5 ET? EH AH EAT AH #715 3}? TH
`——— ——— —--
`———
`--- ——— ——— ——— ———
`___ -__ -__
`___
`___ ___ ___ ___ -__
`CUT CCT CCT AGT CCT CC-T CC-T CCT OCT
`GGA AAT AAT GGC AAT GGG TCT TCT AGA
`GGT AGT AGT AGT AGT AAT GAT GAT GAT
`GGG GGT GGT AGT GGT GGT AGT AGT GGT
`TTT GGT GGT AGG GGT GGT GAA GAT AGT
`AGT AGT AGT GTG AGT AGT AGT AGT AGT
`AAG AAG AGG GAG AAG AAG GAG AAG AAT
`TAG TAG TAG TAT
`TAG TAG TAG TAG TAG
`AAT AAT AAT GCA AAT AAT AAT AAT AAT
`GAG GAG GAG GAG GAG GAG GAA GAA GAG
`AAT AAG GAG AGA AAG AAG AAG AAG AAG
`TTG TTG TTG GTG TTC TTC TTC TTC TTG
`AAG AAG AGG AAG AAG AAG AAG AAG AAG
`GGG AGG AGG GGG AGG AGG GAG GGG GGG
`AAG AAG AAG GGA AAG AAG AAG AAG AAG
`GGG GGG GGG TTG GGG GTG GGG GGG GGG
`AGA AGA AGA AGG
`AGA AGA AGA AGA AGA
`GTG GTG GTG ATG GTG GTG TTG TTG GTG
`ACT ACT ACT
`TCA ACT ACT ACT ACT ACT
`GCA GTA ATA AGA GTA GTA GTA GTA GCA
`GAG GAG GAG GAG GAG GAG GAG GAG GAG
`ACA AAA AAA AAT ACA AAA AAA AAA AGA
`TCC GGG GGG GGG
`TGG Tcc TGG TCC TCC
`TCC TCC TCC AAG TCC TCC TCC TCC TCC
`AGG AGG AGG AAG
`AGG AGG AGG AGG AGG
`ACA ACA ACA ACC ACA ACA AGA ACA ACA
`GCC GGG GGG CTG GCC GCC GGG GCC GCC
`TAG TAG TAG TAG TTG TAG TAG TAG TAG TAG
`ATG ATG ATG ATG CTG ATG ACG ATG ATG ATG
`GAG CAG CA6 CAG CAA CAG CAG GAG CAG CAG
`GTG GTG GTG GTG ATG GTG GTG GTG GTG GTG
`AAG AGG AGG AGG
`AGG
`AGG AGG AGG AGG AGG
`AGG AGG AGG AGG AGT
`AGG AGG AGG AGG AGG
`GTG GTG GTG GTG GTA GTG GTG GTG GTG GTG
`AGA AGA AGA AGA
`AGA AGA AGA AGA AGA
`GAG GAG GA
`A
`TGT TCT TC; go;
`GAG GAG GAG GAG
`GAG GAG GAG GAG GAG
`TCT TCT TCT TCT
`TCC TCT TCT TCT TCT
`GGG
`GGG GGG GGG GGG GGA
`GTG
`GTG GTG GTG GTG GTC
`TAT
`GAT TAT TAT TAT TAT
`TAT
`TAT TAT TAC TAG TTG
`TGT
`TGT TGT TGT TGT TGT
`GGA
`AGA
`
`
`
`
`
`_ _
`: I
`- _
`— —
`_ _
`_
`-
`— —
`———
`
`
`
`
`
`
`
`CTG
`GGA
`GGG
`——
`-—-
`
`
`
`———
`——— ———
`———
`_—;
`GAT GAC GAG GAO GAG
`GTG TGG TAG TAG TAG
`TGG TGG TGG TGG TGG
`GGG GGG GGG GGG GGT
`GGA GAA GAA GAA GAA
`GGG GGG GGG GGG GGA
`AGG AGG Acc AGG AGG
`ACG ACT ACT ACT
`TCA
`GTC OTC CTG CTC GTC
`AGG AGA AGA AGA AGG
`GTG GTG GTG GTG GTG
`TGG TGG TGG TGG TGG
`TGA TGA TGA TGA TGA -__ —— ——— -—— ——-
`
`Sanofi/Regeneron Ex. 1029, pg 908
`
`J
`
`
`
`___
`
`___
`
`___
`
`
`
`Sanofi/Regeneron Ex. 1029, pg 908
`
`

`
`as
`PMU3
`
`
`GAG
`TGA
`GTG
`AAG
`GAG
`TCC
`GAG
`GGA
`GGT
`GTG
`TTC
`AAG
`CCA
`ATG
`GAT
`A00
`CTG
`AGA
`CTC
`ACC
`TGG
`ACA
`GTG
`TCT
`GGA
`TTC
`Toe
`CTG
`AGT
`TCT
`TAT
`GGG
`GTG
`AAC
`77-
`-.-
`TGG
`GT0
`CGG
`
`Sanofi/Regeneron Ex. 1029, pg 909
`
`249
`
`35
`BGL1
`
`31
`V
`
`32
`V3
`
`
`
`
`
`
`
`
`7 7
`— 7
`— -
`_ _
`— —
`— —
`_
`_
`7
`7
`—
`—
`
`7--
`
`_
`— A
`— —
`
`— —
`7 —
`7 7
`— —
`———
`
`
`
`
`———
`
`——— ——— ——— ———
`
`7...
`
`.7.
`
`._-
`
`-7
`
`DODDNS OF VARIABLE REGION HEAVY CHAINS (conrd)
`as
`zs
`24
`25
`25
`27
`23
`29
`30
`37
`as
`34
`MG
`PGH
`PGH
`V1
`V11
`V13
`186-2
`145
`V10
`9367 VH441
`SP
`101
`105A 1085
`CHI-1»
`T15
`———
`———
`- 7 777
`-77
`7
`7
`7
`7
`7
`777
`7
`7
`u
`
`
`
`GAG
`GAG GAA GAG GAG GAG GAG GAG GAG GAG GAG GAG GAG GAG GAG
`1
`GTG
`GT0 GTG GTG GTG GTG GTC GTC GTG GTG GTG GTG GTG GTT GTT
`2
`AAG
`GAG CAG AAG AAG AAG GAA CAA AAG AAG AAG GAG AAG GAG GAG
`3
`CTT
`CTT CTG CTG GTG CTG CTG GTG CTG CTG CTG CTG CTG CTG CTT
`4
`CTC
`GAG GAG GTG GTG ATG GAG GAG GTG GTG GTG AAG GTG GAG GAG
`5
`GAG
`GAG CAG GAA GAG GAG GAG GAG GAA GAA GAG GAG GAA GAG GAG
`6
`TCT
`TCA TCA TCT TGT TCT COT OCT TCT TCT TGT TCA TCT TCT
`TCT
`7
`GGA
`GGA GGA GGA GGA GGA GGG GGG GGA GGA GGA GGA GGA GGG GGA
`5
`GGT
`CCT GGT GGA GGA GGA GCT GCT GGA GGA GGA GGT GGA CCT GGT
`9
`GGC
`GAG GAG GGG GGG GGG GAG GAG GGG GGG GGG GGG GGG GAG GAG
`10
`GTG GTG TTG TTG TTG CTT GTT TTG TTG TTG GTG TTG GTG CTG GTG
`11
`GTG GTG GTA GTA GTA GTG GTG GTA GTA GTA GTG GTA GTG GTG
`GTG
`12
`AAA AAG CAG GAG CAG AAG AAG GAG CAG CAG GAG GAG AGG AGG
`GAG
`13
`COT CCT GCT CCT COT CCT CCT CCT CCT CCT GCC OCT CCT GCT
`COT
`14
`GGG GGG GGG GGG GGG GGG GGG GGG GGG GGG TGA GGG GGG GGG
`GGA
`15
`Gcc GCT GGT GGT GGT GGT GGT GGT GGT GGT GAG GGT GTG TGG
`GGA
`16
`TCA TCA TGT TCT TC-T TCA TGA TCT TCT TCT AGC GTCT
`TC-A TCA TCC
`17
`GTG GTG CTG CTG CTG GTG GTG CTG CTG CTG CTG CTG GTG GTG
`CTG
`18
`AAG AAG AGA AGA AGA AAG AAG AGA AGA AGA TCC AGA AAG AAG
`AAA
`19
`ATA ATA CTC CTC CTC CTG GTG CTG CTC OTC ATC OTC ATT ATG
`CTC
`20
`TCC ACC TCC TCC TCC TCC TCC TCC TCC TCC ACC TCC TCC TCC
`TCC
`21
`TGC TGC TGT TGT TGT TGG AGG TGT TGT TGT TGC TGT TGC TGG
`TGT
`22
`AAG AAG GGA GGA GAA AAG AAG GCA GGA GGA ACA GGA AAG AAG
`GOA
`23
`GCT GOT ACT ACT GCT GCT GOT AGT AGT TCT GTG AGT GGT GGT
`GGG
`24
`TOT TCT TCT TGT TGT TCT TGT TGT TGT TCT TGT TCT TCC TCT
`TGA
`25
`GGA GAT GGG GGG GGA GGG GGG GGG GGG GGG GGT GGG GGC GGA
`GGA
`26
`TAC TAC TTG TTC TTC TAG TAG TTC TTG TTC TTC TTG TAC TAT
`TTC
`27
`AGA TcA AGG AGG ACG AGG ACC AGG ACO AGG TGA AGG AGA AGA
`GAT
`28
`TTC TTG TTG TTG TTG TTC TTG TTG TTG TTG TTA TTC TTC TTG
`TTT
`29
`ACT ACT AGT ACT ACT AGG ACC AGT AGT ACT AGT AGT AGT
`AGA
`AGT
`an
`GAC GGC GAT GAT GAT AGC AGG GAT GAT GAT ACC GAT GAT
`AGG
`AGA
`31
`TAC TAO TTC TAC TAG TAC TAC TTC TTC TAG TAT TTC TAT
`TAC
`TAG
`32
`AAG ATC TAG TAC TAG TGG TGG TAG TAG TAG GGT TAC GCT GGT
`TGG
`33
`ATG ATG ATG ATG ATG ATG ATG ATG ATG ATG GTA ATG ATG ATA
`ATG
`:34
`CAC AAC GAG AGC AGC CAC CAC GAG GAG AAC AAC GAG CAO AAC
`AGT
`35
`777
`777
`777 777 777
`-77 777 777 777 777 777 777
`777
`7——
`777
`35A
`..-
`--— --- .-- -7-
`———
`--- -7- 7--
`.._-
`._-
`.--
`..--
`77-
`.._-
`353
`TGG TGG TGG TGG TGG TGG TGG TGG TGG TGG TGG TGG TGG TGG
`TGG
`36
`GTG GTG GTG GTC GTG GTG GTG GTG GTG GTG GTT GTG GTG GTG
`GTG
`37
`AAG AAG CGG CGC CGG AAG AAG CGG CGG GAG CGG CGC AAG AAA
`CGG
`3!
`GAG GAG GAG GAG GAG GAG GAG CAG GAG GGG CAG GAG
`39
`AGG AGG GGT GGT GGT AGG AGG GGT GGT GGT TGT GGT
`Au
`CAT CAT CCA CCA CGG CCT CCT CCA CCA CCA CCA CCA
`41
`GGA GGA GGG GGA AGG GGA GGA GGG GGG GGG GGA GGG
`42
`AAG AAG AAG AAG AAG CGA CGA AAG AAG AAG AAG AAG
`43
`AGC AGO AGA GGA GOA GGG GGG AGA AGA GGA GGT AGA
`44
`CTT CTT CTG CTT COT CTT CTT CTG CTG CTT CTG CTG
`45
`GAG GAA GAG GAG GAG GAG GAG GAG GAG GAG GAG GAG
`46
`TGG TGG TGG TGG TGG TGG TGG TGG TGG TAG TGG TGG
`47
`ATT ATT ATT TTG TTG ATT ATT ATT ATT TTG CTG ATT
`41$
`GGA GGA GCT GGT GCT GGA GGA GGT GCT GGT GGA GCT
`49
`TAT GAA GGA TTT TTG AGG AGG GGA GGA TTG GTG GGA
`50
`ATT ATT AGT ATT ATT ATT ATT AGT AGT ATT ATA AGT
`51
`TAT AAT AGA AGA AGA GAT GAT AGA AGA AGA TGG AGA
`52
`52A GGT GGT AAG AAG AAG CCT CCT AAG AAO AAG AGT AAG
`52B ..- 7.. AAA AAA AAA 7--
`--_ AAA
`AAA GGT AAA
`52C
`777
`777 GGT GGT GGT
`.77
`777 GCT
`GCT GGA GGT
`53
`TAC TAG AAT AAT AAT AAT AAT AAT
`AAT AGG AAT
`54
`AAT AAT GAT GGT GGG AGT AGT GAT
`GGT AGG GAT
`55
`GGT GGT TAT TAC TAT GGT GGT TAT
`TAC GAG TAT
`56
`GGT GGT ACA AGA AGA GGT GGT AGA
`ATA TAT AGA
`57
`ACT ACT AGA AGA AGA ACT ACT AGA
`AGA AAT AGA
`58
`GGG AGG GAG GAG GAG AAG AAG GAG
`GAG GGA GAG
`59
`TAC TAC TAC TAC TAT TAG TAG TAG
`TAG GGT TAG
`so
`AAG AAG AGT AGT AGT AAT AAT AGT
`AGT TTG AGT
`61
`GAG GAG GGA GGA GGA GAG GAG GGA
`GGA ATA GGA
`62
`AAG AAG TCT TCT TCT AAG AAG TCT
`TGT TGG TCT
`63
`TTC TTC GTG GTG GTIT TTC TTC GTG
`ATG AGA GTG
`54
`AAG AAG AAG AAG AAG AAG AAG AAG
`AAG GTG AAG
`E5
`AGC GGG GGT GGT GGT AGO AGC GGT
`GGT AAC GGT
`66
`AAG AAG CGG CGG CGG AAG AAG CGG
`CGG ATC CGG
`S7
`GOO GOO TTC TTC TTC (300 (300 TTC
`TTC AGG TTC
`6B
`AGA ACA ATG AGC ACC ACA ACA ATC
`ACC AAG ATC
`59
`TTG TTG GTG ATG ATG CTG GTG GTG
`ATG GAC GTG
`70
`ACT ACT TCC TCC TCC ACT ACT TCC
`TCC AAT TCC
`71
`GTA GTA AGA AGA AGA GTA GTA AGA
`AGA TCC AGA
`72
`GAG GAG GAG GAT GAT GAG GAG GAG
`GAT AAG GAG
`78
`AAT ACA ACT AAT AAT AAA AAA ACT
`AAT AGG ACT
`74
`Too Tcc Tcc TGG TGT GGG CGG TCC
`TCC GAA TGG
`75
`TGG TGG GAA GAA GAA TGG TCC GAA
`GAA GTT GAA
`76
`AGG AGG AGG AGG AAG AGG AGG AGG
`AGG TTC AGG
`T7
`ACA ACA ATC ATC ATC ACA ACA ATC
`ATC TTT ATC
`7B
`(500 GGG CTG OTC CTC GGG GCC CTC
`CTO AAA CTG
`79
`TAC TAO TAC TAT TAT TAG TAC TAO
`TAT ATG TAG
`30
`ATG ATG CTT CTT CTT ATG ATG CTT
`GTT AAG GTT
`81
`GAG GAG GAG CAA GAA GAG DAG GAG
`GAA AGT GAG
`B2
`CTC CTC ATG ATG ATG CTC OTC ATG
`ATG CTG ATG
`a2A AGG GAG AAT AAG AAG AGG AGG AAT
`AAG GAA AAT
`B2B AGG AGG GCC AGG AGG AGG AGG GGG
`AGA TGT GCC
`B20 CTG GTG GTG GTG CTG CTG CTG GTG
`GTG AAT CTG
`K3
`AGA AGA AGA AGA AGA AGA AGA AGA
`AGG GAG AGA
`84
`TCT TCT GCT GCT GCT TCT TCT GCT
`#
`AGA GCT
`B5
`GAG GAG GAG GAG GAG GAG GAG GAG
`GAG GCC GAG
`as
`GAG GAG GAG GAC GCC GAG GAG GAG
`GAG ATA GAG
`EI7
`TCT TCT ACT AGT AGT TCT TGT ACT
`AGT TAT ACT
`35
`GCA TTG GCC GCC GCC GGG GCG GCC
`GCC TAG GCC
`59
`GTC GTC ATT ACT ACT GTC GTC ATT
`ACT TGT ATT
`90
`TAT TAT TAT TAT TAT TAT TAT TAT
`TAT GGG TAT
`91
`TAC TAO TAC TAC TAC TAT TAG TAC
`TAG AGA TAC
`92
`TGT TGT TGT TGT TGT TGT TGT TGT
`TGT AGG TGT
`93
`GGA GOA GOA GOA GOA
`GGA GAG GCA
`94
`AGA AAA AGA
`AGA
`AGA TAG AGA
`95
`GAT
`GAT
`GAT GTT GAT
`96
`AGT
`97
`AGG
`93
`TAC
`99
`GAC
`100
`CCG
`100A
`TTT
`1003
`777
`_
`
`100E
`7
`——-
`100F
`—
`-77
`10lJG 7
`7-7
`1OOH
`7
`1OD|
`-
`-77
`100.]
`7
`---
`10OK
`—
`--—
`101
`GCT
`102
`TAC
`106
`TGG
`1D4
`GGG
`105
`GAA
`106
`GGG
`107
`ACT
`105
`GTG
`109
`GT0
`110
`ACT
`111
`GT0
`112
`TCT
`113
`.77 GGA
`
`F
`Fl
`1
`
`8
`R
`1
`
`F
`H
`2
`
`8
`H
`2
`
`F
`R
`3
`
`C
`R
`3
`
`F
`R
`4
`
`
`
`- —
`_ _
`7
`—
`- —
`_ -
`7 7
`-
`-
`7
`7
`———
`
`
`
`Sanofi/Regeneron Ex. 1029, pg 909
`
`

`
`25!)
`
`"
`
`SOURCE: CODONS OF VARIABLE REGION IIEAVV CHAINS
`LAMRDA VIIZG: HUMA