Long-term Trends in Diabetes
`April 2016
`
`CDC’s Division of Diabetes Translation. United States
`Diabetes Surveillance System available at
`http://www.cdc.gov/diabetes/data
`
`0001
`
`MYLAN - EXHIBIT 1039
`Mylan et al. v. AstraZeneca
`IPR2015-01340
`
`

`
`This slide shows the trend in diagnosed diabetes in the United States from 1958 through
`2014. The prevalence of diagnosed diabetes increased from 0.93% in 1958 to 7.02% in
`2014. In 2014, 21.9 million people had diagnosed diabetes, compared to only 1.6 million
`in 1958. How the trend has changed was described in detail elsewhere1.
`
`Data Source and Methodology
`
`Number and percentage of the U.S. population with diagnosed diabetes were obtained
`from the National Health Interview Survey (NHIS, available at
`http://www.cdc.gov/nchs/nhis.htm) of the National Center for Health Statistics (NCHS),
`Centers for Disease Control and Prevention (CDC). Conducted continuously since 1957,
`the NHIS is a health survey of the civilian, noninstitutionalized population of the United
`States. The survey provides information on the health of the United States population,
`including information on the prevalence and incidence of disease, the extent of disability,
`and the use of health care services. The multistage probability design of the survey has
`been described elsewhere.2,3,4 Estimates for years 1958–1979 were obtained from
`published data,5 and estimates from 1980 forward were derived directly from the NHIS
`survey data. Because diabetes questions were not included in the survey for some years
`before 1980, the estimates were missing for these years.
`
`References:
`
`1. Geiss LS, Wang J, Cheng YJ. Thompson TJ, Barker L; Li Y, Albright AL, Gregg
`EW. Prevalence and incidence trends for diagnosed diabetes among adults aged 20 to
`79 years, United States, 1980-2012. JAMA 2014; 312:1218-1226.
`
`2. Massey JT, Moore TF, Parsons VL, Tadros W. Design and estimation for the
`National Health Interview Survey, 1985–1994. Hyattsville, MD: National Center for
`Health Statistics. Vital and Health Statistics 1989;2(110).
`
`3. Botman SL, Moore TF, Moriarity CL, Parsons VL. Design and estimation for the
`National Health Interview Survey, 1995–2004. National Center for Health Statistics.
`Vital and Health Statistics 2000;2(130).
`
`4. Parsons VL, Moriarity C, Jonas K, et al. Design and estimation for the National
`Health Interview Survey, 2006–2015. National Center for Health Statistics. Vital
`Health Stat Vital and Health Statistics 2014; 2(165).
`
`5. Harris MI: Prevalence of noninsulin-dependent diabetes and impaired glucose
`tolerance. Chapter VI In: Diabetes in America, Harris MI, Hamman RF, eds. NIH
`publ. no. 85-1468, 1985.
`
`http://www.cdc.gov/diabetes/data
`
`0002
`
`

`
`Data for the Graph
`
`Number and Percentage of U.S. Population with Diagnosed Diabetes 1958–2014
`
`Year
`
`Percentage
`
`Number (in
`millions)
`
`1958
`
`1959
`
`1960
`
`1961
`
`1962
`
`1963
`
`1964
`
`0.93
`
`0.87
`
`0.91
`
`1.05
`
`1.06
`
`1.15
`
`1.24
`
`1.58
`
`1.49
`
`1.59
`
`1.87
`
`1.91
`
`2.10
`
`2.31
`
`http://www.cdc.gov/diabetes/data
`
`0003
`
`

`
`1965
`
`1966
`
`1967
`
`1968
`
`1969
`
`1970
`
`1971
`
`1972
`
`1973
`
`1974
`
`1975
`
`1976
`
`1977
`
`1978
`
`1979
`
`1980
`
`1981
`
`1982
`
`1983
`
`1984
`
`1985
`
`1986
`
`1987
`
`1.27
`
`1.45
`
`1.61
`
`1.62
`
`–
`
`–
`
`–
`
`–
`
`2.04
`
`–
`
`2.29
`
`2.36
`
`–
`
`2.37
`
`2.49
`
`2.54
`
`2.51
`
`2.52
`
`2.45
`
`2.59
`
`2.62
`
`2.78
`
`2.77
`
`2.39
`
`2.77
`
`3.09
`
`3.18
`
`–
`
`–
`
`–
`
`–
`
`4.19
`
`–
`
`4.78
`
`4.97
`
`–
`
`5.19
`
`5.47
`
`5.53
`
`5.65
`
`5.73
`
`5.61
`
`6.00
`
`6.13
`
`6.56
`
`6.61
`
`http://www.cdc.gov/diabetes/data
`
`0004
`
`

`
`1988
`
`1989
`
`1990
`
`1991
`
`1992
`
`1993
`
`1994
`
`1995
`
`1996
`
`1997
`
`1998
`
`1999
`
`2000
`
`2001
`
`2002
`
`2003
`
`2004
`
`2005
`
`2006
`
`2007
`
`2008
`
`2009
`
`2010
`
`2.56
`
`2.66
`
`2.52
`
`2.90
`
`2.93
`
`3.06
`
`2.98
`
`3.30
`
`2.89
`
`3.80
`
`3.90
`
`4.00
`
`4.40
`
`4.75
`
`4.84
`
`4.93
`
`5.29
`
`5.61
`
`5.90
`
`5.86
`
`6.29
`
`6.86
`
`6.95
`
`6.16
`
`6.47
`
`6.21
`
`7.21
`
`7.37
`
`7.78
`
`7.74
`
`8.66
`
`7.63
`
`10.11
`
`10.48
`
`10.87
`
`12.05
`
`13.11
`
`13.49
`
`14.10
`
`15.24
`
`16.32
`
`17.32
`
`17.40
`
`18.81
`
`20.67
`
`21.13
`
`http://www.cdc.gov/diabetes/data
`
`0005
`
`

`
`2011
`
`2012
`
`2013
`
`2014
`
`6.78
`
`6.96
`
`7.18
`
`7.02
`
`Note: Data not available.
`
`20.74
`
`21.47
`
`22.30
`
`21.95
`
`http://www.cdc.gov/diabetes/data
`
`0006