throbber
(/nesina/)
`
`
`
`Important Safety
`Information
`
`
`
`Prescribing
`Medication
`Guide
`Information
`
`(http://general.takedapharm.com/content/file.aspx?(http://general.takedapharm.com/content/file.aspx?
`
`applicationcode=5D2277FD-applicationcode=5D2277FD-
`CFC0-423C-B543-
`CFC0-423C-B543-
`
`811D41F4771E&filetypecode=NESINAMG)811D41F4771E&filetypecode=NESINAPI)
`
`ABOUT NESINA (/nesina/about)
`SAVINGS & SUPPORT
`MANAGING TYPE 2 DIABETES (/nesina/managing-type-2-diabetes)
`TAKEDA DIABETES
`ADVANTAGE PROGRAM
`SAVINGS & SUPPORT (/nesina/diabetes-savings-program)
`SAFETY PROFILE (/nesina/side-effects)
`Eligible patients fill their
`NESINA prescriptions for no
`FAQs (/nesina/faq)
`more than $4*
`NESINAFamily.com (/)
`The Takeda Diabetes Advantage
`Program helps you manage your
`type 2 diabetes and can help
`lower your NESINA prescription
`costs.
`
`Eligible patients
`pay no more than
`$4 per month for
`up to 12 months
`on their NESINA
`prescriptions*
`Important Safety Information
`If you're taking
`NESINA (alogliptin) may not be right for everyone. NESINA can cause
`metformin, get it at
`serious side effects.
`no additional cost
`Do not take NESINA if you are allergic to any of its ingredients.
`when you refill your
`
`OPEN
`
`AstraZeneca Exhibit 2132
`Mylan v. AstraZeneca
`IPR2015-01340
`
`Page 1 of 6
`
`

`
`when you refill your
`
`
`
`
`Stop taking NESINA and contact your doctor or go to the nearest
`Important Safety
`Medication
`Prescribing
`Important Safety
`Medication
`Prescribing
`prescription for
`hospital emergency room right away if you experience swelling of your
`Information
`Guide
`Information
`Information
`Guide
`Information
`NESINA*
`
`(http://general.takedapharm.com/content/file.aspx?(http://general.takedapharm.com/content/file.aspx?
`
`(http://general.takedapharm.com/content/file.aspx?(http://general.takedapharm.com/content/file.aspx?
`
`applicationcode=5D2277FD-applicationcode=5D2277FD-
`
`applicationcode=5D2277FD-applicationcode=5D2277FD-
`CFC0-423C-B543-
`CFC0-423C-B543-
`CFC0-423C-B543-
`CFC0-423C-B543-
`
`811D41F4771E&filetypecode=NESINAMG)811D41F4771E&filetypecode=NESINAPI)
`
`811D41F4771E&filetypecode=NESINAMG)811D41F4771E&filetypecode=NESINAPI)
`
`(/nesina/)
`
`ABOUT NESINA (/nesina/about)
`You'll receive
`useful tips and
`MANAGING TYPE 2 DIABETES (/nesina/managing-type-2-diabetes)
`tools to help you
`manage your type
`SAVINGS & SUPPORT (/nesina/diabetes-savings-program)
`2 diabetes
`SAFETY PROFILE (/nesina/side-effects)
`FAQs (/nesina/faq)
`Activate a Takeda Diabetes
`NESINAFamily.com (/)
`Advantage Program Savings Card*
`you’ve received 
`(https://www.nesinafamily.com/registration?
`HaveCard=true)
`
`Important Safety Information
`
`OPEN
`
`NESINA (alogliptin) may not be right for everyone. NESINA can cause
`serious side effects.
`Do not take NESINA if you are allergic to any of its ingredients.
`
`Page 2 of 6
`
`

`
`(/nesina/)
`
`Sign up for the Takeda
`
`
`
`
`
`
`Stop taking NESINA and contact your doctor or go to the nearest
`Important Safety
`Medication
`Prescribing
`
`Important SafetyImportant Safety
`
`Medication Medication
`
`PrescribingPrescribing
`Diabetes Advantage
`hospital emergency room right away if you experience swelling of your
`Information
`Guide
`Information
`
`InformationInformation
`
`GuideGuide
`
`InformationInformation
`
`(http://general.takedapharm.com/content/file.aspx?(http://general.takedapharm.com/content/file.aspx?
`
`
`
`(http://general.takedapharm.com/content/file.aspx?(http://general.takedapharm.com/content/file.aspx?(http://general.takedapharm.com/content/file.aspx?(http://general.takedapharm.com/content/file.aspx?
`Program to get your
`
`applicationcode=5D2277FD-applicationcode=5D2277FD-
`
`
`
`applicationcode=5D2277FD-applicationcode=5D2277FD-applicationcode=5D2277FD-applicationcode=5D2277FD-
`savings card today! It only
`CFC0-423C-B543-
`CFC0-423C-B543-
`
`CFC0-423C-B543-CFC0-423C-B543-
`
`CFC0-423C-B543-CFC0-423C-B543-
`
`811D41F4771E&filetypecode=NESINAMG)811D41F4771E&filetypecode=NESINAPI)
`
`
`
`811D41F4771E&filetypecode=NESINAMG)811D41F4771E&filetypecode=NESINAMG)811D41F4771E&filetypecode=NESINAPI)811D41F4771E&filetypecode=NESINAPI)
`ABOUT NESINA (/nesina/about)
`takes a few minutes, and
`there is no cost to join.
`MANAGING TYPE 2 DIABETES (/nesina/managing-type-2-diabetes)
`Sign up now 
`(https://www.nesinafamily.com/registration)
`SAVINGS & SUPPORT (/nesina/diabetes-savings-program)
`Important Safety Information
`SAFETY PROFILE (/nesina/side-effects)
`NESINA may not be right for everyone. NESINA can cause serious side
`FAQs (/nesina/faq)
`effects.
`Do not take NESINA if you are allergic to any of its ingredients.
`NESINAFamily.com (/)
`Stop taking NESINA and contact your doctor or go to the nearest hospital
`emergency room right away if you experience swelling of your face, lips,
`throat, or other areas on your skin, difficulty swallowing or breathing,
`raised red areas on your skin (hives), skin rash, itching, flaking, or peeling,
`as these may be symptoms of a serious allergic reaction.
`Inflammation of the pancreas (pancreatitis) can happen to people taking
`NESINA. NESINA may cause pancreatitis which may be severe. Tell your
`doctor if you have ever had pancreatitis, kidney problems, or liver
`problems. Stop taking NESINA and call your doctor right away if you have
`pain in your stomach area (abdomen) that is severe and will not go away.
`The pain may be felt going from your abdomen through to your back. The
`pain may happen with or without vomiting. These may be symptoms of
`pancreatitis.
`Before taking NESINA, tell your doctor if you have ever had heart failure or
`have problems with your kidneys. Contact your doctor right away if you
`have any of the following symptoms: increasing shortness of breath or
`OPEN
`trouble breathing especially when lying down, an unusually fast increase
`Important Safety Information
`in weight, or swelling of feet, ankles, or legs. These may be symptoms of
`heart failure.
`NESINA (alogliptin) may not be right for everyone. NESINA can cause
`serious side effects.
`Do not take NESINA if you are allergic to any of its ingredients.
`NESINA may cause liver problems. Call your doctor right away if you
`
`Page 3 of 6
`
`

`
`NESINA may cause liver problems. Call your doctor right away if you
`
`
`
`
`
`
`
`
`Stop taking NESINA and contact your doctor or go to the nearest
`Important Safety
`Medication
`Prescribing
`
`
`Important SafetyImportant SafetyImportant Safety
`
`
`Medication Medication Medication
`
`
`PrescribingPrescribingPrescribing
`experience nausea, vomiting, stomach pain, unusual or unexplained
`hospital emergency room right away if you experience swelling of your
`Information
`Guide
`Information
`
`
`InformationInformationInformation
`
`
`GuideGuideGuide
`
`
`InformationInformationInformation
`tiredness, loss of appetite, dark urine, or yellowing of your skin or eyes.
`
`(http://general.takedapharm.com/content/file.aspx?(http://general.takedapharm.com/content/file.aspx?
`
`
`
`
`
`(http://general.takedapharm.com/content/file.aspx?(http://general.takedapharm.com/content/file.aspx?(http://general.takedapharm.com/content/file.aspx?(http://general.takedapharm.com/content/file.aspx?(http://general.takedapharm.com/content/file.aspx?(http://general.takedapharm.com/content/file.aspx?
`
`applicationcode=5D2277FD-applicationcode=5D2277FD-
`
`
`
`
`
`applicationcode=5D2277FD-applicationcode=5D2277FD-applicationcode=5D2277FD-applicationcode=5D2277FD-applicationcode=5D2277FD-applicationcode=5D2277FD-
`(/nesina/)
`If you take NESINA with another medicine that can cause low blood sugar,
`CFC0-423C-B543-
`CFC0-423C-B543-
`
`
`CFC0-423C-B543-CFC0-423C-B543-CFC0-423C-B543-
`
`
`CFC0-423C-B543-CFC0-423C-B543-CFC0-423C-B543-
`
`811D41F4771E&filetypecode=NESINAMG)811D41F4771E&filetypecode=NESINAPI)
`
`
`
`
`
`811D41F4771E&filetypecode=NESINAMG)811D41F4771E&filetypecode=NESINAMG)811D41F4771E&filetypecode=NESINAMG)811D41F4771E&filetypecode=NESINAPI)811D41F4771E&filetypecode=NESINAPI)811D41F4771E&filetypecode=NESINAPI)
`ABOUT NESINA (/nesina/about)
`such as a sulfonylurea or insulin, your risk of getting low blood sugar is
`higher. The dose of your sulfonylurea medicine or insulin may need to be
`MANAGING TYPE 2 DIABETES (/nesina/managing-type-2-diabetes)
`lowered while you take NESINA. If you have symptoms of low blood sugar,
`you should check your blood sugar and treat if low, and then call your
`doctor. Signs and symptoms of low blood sugar include shaking or feeling
`SAVINGS & SUPPORT (/nesina/diabetes-savings-program)
`jittery, sweating, fast heartbeat, change in vision, hunger, headache,
`change in mood, confusion, or dizziness.
`SAFETY PROFILE (/nesina/side-effects)
`Some people who take medicines called DPP-4 inhibitors like NESINA
`FAQs (/nesina/faq)
`may develop joint pain that can be severe. Call your doctor if you have
`severe joint pain.
`NESINAFamily.com (/)
`Before taking NESINA, you should tell your doctor if you are pregnant,
`planning to become pregnant, breastfeeding, or planning to breastfeed. It
`is not known if NESINA can harm an unborn baby, or if it passes into
`breast milk.
`The most common side effects of NESINA were stuffy or runny nose and
`sore throat (4.8%), cold-like symptoms (upper respiratory tract infection;
`4.5%), and headache (4.3%).
`Tell your doctor about all the medicines, vitamins, and supplements you
`take.
`Talk to your doctor or healthcare professional. Please see full Prescribing
`Information (http://general.takedapharm.com/content/file.aspx?
`applicationcode=5D2277FD-CFC0-423C-B543-
`811D41F4771E&filetypecode=NESINAPI), including Medication Guide
`(http://general.takedapharm.com/content/file.aspx?
`applicationcode=5D2277FD-CFC0-423C-B543-
`811D41F4771E&filetypecode=NESINAMG) for NESINA.
`OPEN
`Indication for NESINA
`Important Safety Information
`NESINA is a prescription medicine used along with diet and exercise to
`improve blood sugar (glucose) control in adults with type 2 diabetes.
`NESINA (alogliptin) may not be right for everyone. NESINA can cause
`serious side effects.
`NESINA is not for people with type 1 diabetes or diabetic ketoacidosis
`(increased ketones in blood or urine).
`Do not take NESINA if you are allergic to any of its ingredients.
`You are encouraged to report negative side effects of prescription drugs to
`
`Page 4 of 6
`
`

`
`You are encouraged to report negative side effects of prescription drugs to
`
`
`
`
`
`
`
`
`
`
`Stop taking NESINA and contact your doctor or go to the nearest
`Important Safety
`Medication
`Prescribing
`
`
`
`Important SafetyImportant SafetyImportant SafetyImportant Safety
`
`
`
`Medication Medication Medication Medication
`
`
`
`PrescribingPrescribingPrescribingPrescribing
`the FDA. Visit www.fda.gov/medwatch (http://www.fda.gov/medwatch) or
`hospital emergency room right away if you experience swelling of your
`Information
`Guide
`Information
`
`
`
`InformationInformationInformationInformation
`
`
`
`GuideGuideGuideGuide
`
`
`
`InformationInformationInformationInformation
`call 1-800-FDA-1088.
`
`(http://general.takedapharm.com/content/file.aspx?(http://general.takedapharm.com/content/file.aspx?
`
`
`
`
`
`
`
`(http://general.takedapharm.com/content/file.aspx?(http://general.takedapharm.com/content/file.aspx?(http://general.takedapharm.com/content/file.aspx?(http://general.takedapharm.com/content/file.aspx?(http://general.takedapharm.com/content/file.aspx?(http://general.takedapharm.com/content/file.aspx?(http://general.takedapharm.com/content/file.aspx?(http://general.takedapharm.com/content/file.aspx?
`
`applicationcode=5D2277FD-applicationcode=5D2277FD-
`
`
`
`
`
`
`
`applicationcode=5D2277FD-applicationcode=5D2277FD-applicationcode=5D2277FD-applicationcode=5D2277FD-applicationcode=5D2277FD-applicationcode=5D2277FD-applicationcode=5D2277FD-applicationcode=5D2277FD-
`(/nesina/)
`*Eligibility Restrictions Apply: This offer cannot be used if you are a
`CFC0-423C-B543-
`CFC0-423C-B543-
`
`
`
`CFC0-423C-B543-CFC0-423C-B543-CFC0-423C-B543-CFC0-423C-B543-
`
`
`
`CFC0-423C-B543-CFC0-423C-B543-CFC0-423C-B543-CFC0-423C-B543-
`
`811D41F4771E&filetypecode=NESINAMG)811D41F4771E&filetypecode=NESINAPI)
`
`
`
`
`
`
`
`811D41F4771E&filetypecode=NESINAMG)811D41F4771E&filetypecode=NESINAMG)811D41F4771E&filetypecode=NESINAMG)811D41F4771E&filetypecode=NESINAMG)811D41F4771E&filetypecode=NESINAPI)811D41F4771E&filetypecode=NESINAPI)811D41F4771E&filetypecode=NESINAPI)811D41F4771E&filetypecode=NESINAPI)
`ABOUT NESINA (/nesina/about)
`beneficiary of, or any part of your prescription is covered by: (1) any
`federal or state healthcare program (Medicare, Medicaid, TRICARE, etc)
`MANAGING TYPE 2 DIABETES (/nesina/managing-type-2-diabetes)
`including a state pharmaceutical assistance program, (2) the Medicare
`Prescription Drug Program (Part D), or if you are currently in the
`coverage gap, or (3) insurance that is paying the entire cost of the
`SAVINGS & SUPPORT (/nesina/diabetes-savings-program)
`prescription. Save up to $100 on NESINA and up to $10 on metformin
`each month when your prescriptions are filled at the same time.
`SAFETY PROFILE (/nesina/side-effects)
`Depending on insurance coverage, savings and co-pay may vary.
`FAQs (/nesina/faq)
`What you'll find
`NESINAFamily.com (/)
`About NESINA (/nesina/about)
`For HCPs
`(http://www.takedadiabetes.com/)
`Managing Type 2
`Other Takeda Products
`Diabetes (/nesina/managing-type-2-
`(http://www.takeda.us/products/default.aspx)
`diabetes)
`Contact Us
`Savings & Support
`(http://www.takeda.us/home/contact_us.aspx)
`(/nesina/diabetes-savings-program)
`Privacy Policy
`Safety Profile (/nesina/side-effects)
`(http://www.takeda.us/home/privacy_policy.aspx)
`FAQs (/nesina/faq)
`Terms and Conditions
`Site Map
`(http://www.takeda.us/home/terms_of_use.aspx)
`(https://www.nesinafamily.com/sitemap)
`Unsubscribe
`(https://www.nesinafamily.com/unsubscribe)
`
`More links
`
`Sign up to save*
`OPEN
`Save on your next prescription and get tools and tips.
`Important Safety Information
`GO
`Email Address
`NESINA (alogliptin) may not be right for everyone. NESINA can cause
`serious side effects.
`Do not take NESINA if you are allergic to any of its ingredients.
`
`Page 5 of 6
`
`

`
` (http://www.takeda.us)
`
`
`
`
`
`
`
`
`
`
`
`
`
`Stop taking NESINA and contact your doctor or go to the nearest
`Important Safety
`Medication
`Prescribing
`
`
`
`
`Important SafetyImportant SafetyImportant SafetyImportant SafetyImportant Safety
`
`
`
`
`Medication Medication Medication Medication Medication
`
`
`
`
`PrescribingPrescribingPrescribingPrescribingPrescribing
`Is it time to discuss your treatment plan?
`hospital emergency room right away if you experience swelling of your
`Information
`Guide
`Information
`
`
`
`
`InformationInformationInformationInformationInformation
`
`
`
`
`GuideGuideGuideGuideGuide
`
`
`
`
`InformationInformationInformationInformationInformation
`
`(http://general.takedapharm.com/content/file.aspx?(http://general.takedapharm.com/content/file.aspx?
`
`
`
`
`
`
`
`
`
`(http://general.takedapharm.com/content/file.aspx?(http://general.takedapharm.com/content/file.aspx?(http://general.takedapharm.com/content/file.aspx?(http://general.takedapharm.com/content/file.aspx?(http://general.takedapharm.com/content/file.aspx?(http://general.takedapharm.com/content/file.aspx?(http://general.takedapharm.com/content/file.aspx?(http://general.takedapharm.com/content/file.aspx?(http://general.takedapharm.com/content/file.aspx?(http://general.takedapharm.com/content/file.aspx?
`Use the discussion guide to find out
`
`applicationcode=5D2277FD-applicationcode=5D2277FD-
`
`
`
`
`
`
`
`
`
`applicationcode=5D2277FD-applicationcode=5D2277FD-applicationcode=5D2277FD-applicationcode=5D2277FD-applicationcode=5D2277FD-applicationcode=5D2277FD-applicationcode=5D2277FD-applicationcode=5D2277FD-applicationcode=5D2277FD-applicationcode=5D2277FD-
`(/nesina/)
`(/Content/pdf/DiscussionGuide.pdf)
`CFC0-423C-B543-
`CFC0-423C-B543-
`
`
`
`
`CFC0-423C-B543-CFC0-423C-B543-CFC0-423C-B543-CFC0-423C-B543-CFC0-423C-B543-
`
`
`
`
`CFC0-423C-B543-CFC0-423C-B543-CFC0-423C-B543-CFC0-423C-B543-CFC0-423C-B543-
`
`811D41F4771E&filetypecode=NESINAMG)811D41F4771E&filetypecode=NESINAPI)
`
`
`
`
`
`
`
`
`
`811D41F4771E&filetypecode=NESINAMG)811D41F4771E&filetypecode=NESINAMG)811D41F4771E&filetypecode=NESINAMG)811D41F4771E&filetypecode=NESINAMG)811D41F4771E&filetypecode=NESINAMG)811D41F4771E&filetypecode=NESINAPI)811D41F4771E&filetypecode=NESINAPI)811D41F4771E&filetypecode=NESINAPI)811D41F4771E&filetypecode=NESINAPI)811D41F4771E&filetypecode=NESINAPI)
`ABOUT NESINA (/nesina/about)
`MANAGING TYPE 2 DIABETES (/nesina/managing-type-2-diabetes)
`SAVINGS & SUPPORT (/nesina/diabetes-savings-program)
`©2016 Takeda Pharmaceuticals U.S.A., Inc.
`This site is intended for use by U.S. residents only.
`SAFETY PROFILE (/nesina/side-effects)
`NESINA is a trademark of Takeda
`Pharmaceutical Company Limited
`registered with the U.S. Patent and
`FAQs (/nesina/faq)
`Trademark Office and used under
`license by Takeda Pharmaceuticals
`NESINAFamily.com (/)
`America, Inc.
`All other trademarks are the property of
`their respective owners.
`
` 
`
`Important Safety Information
`
`OPEN
`
`NESINA (alogliptin) may not be right for everyone. NESINA can cause
`serious side effects.
`Do not take NESINA if you are allergic to any of its ingredients.
`
`Page 6 of 6

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