Allergan Dry Eye Product Portfolio Fact Sheet
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`Dry eye affects approximately 20 million people in the United States1 and is one of the most
`common reasons that people visit their eye doctor.2 A national survey of 2,003 individuals found
`that nearly 40 percent of Americans experience dry eye symptoms,3 which may include dryness,
`itching, irritation, blurred vision, sensitivity to light, foreign body sensation and excessive tearing.
`Dry eye can be aggravated by a number of external factors such as hot, dry or windy
`environments, high altitudes, heating, air-conditioning, prolonged computer use and smoke.4,5,6 Dry
`eye can also be caused by medical factors, including hormonal changes due to aging and
`menopause, thyroid problems, vitamin deficiencies, rheumatoid arthritis, diabetes, lupus and
`Sjögren’s syndrome.1,4,5,6,7 Dry eye can progress, and if left untreated, chronic dry eye can lead to
`more serious problems, including impaired vision and an increased risk of eye infection.8 Chronic
`dry eye occurs when changes to the health of the tear-producing glands affect the quantity and
`quality of tears produced.
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`Allergan Dry Eye Product Portfolio
`Allergan products encompass the continuum of care for dry eyes, from symptom relief to the only
`prescription eye drop that is believed to treat an underlying cause of dry eye. Built on a nearly 60-
`year heritage in ophthalmology with expertise in discovering and developing new therapeutic
`agents to preserve and protect vision, Allergan is a global leader in eye care.
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`REFRESH® Brand
` The No. 1 selling brand of artificial tears, the
`REFRESH® Brand,9 introduced in 1986, offers a
`wide range of over-the-counter products including
`preserved and non-preserved drops as well as
`ointments to effectively treat dry eye symptoms.
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` Several of the REFRESH® Brand artificial tears, as well as OPTIVE™ Lubricant Eye Drops,
`contain carboxymethylcellulose, a unique compound that creates a shield of protection against
`further irritation while providing long-lasting lubrication for the eye.
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` The REFRESH® Brand line of products includes numerous different formulations to address
`specific needs including:
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`o REFRESH TEARS® Lubricant Eye Drops instantly moisturizes and relieves dry,
`irritated eyes with a fast-acting, long-lasting formula that mimics the soothing
`properties of natural tears. REFRESH TEARS® comes in a convenient multi-dose
`bottle and is safe to use as often as needed.
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` o
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` REFRESH PLUS® Lubricant Eye Drops instantly moisturizes and relieves dry,
`irritated eyes with a fast-acting, long-lasting formula for sensitive eyes that mimics
`the soothing properties of natural tears. Demonstrated to improve dry eye when
`used after LASIK, REFRESH PLUS® comes in convenient single use vials and is
`safe to use as often as needed.
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`APC025462008
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`APOTEX 1025, pg. 1
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`o REFRESH® Classic Sensitive Lubricant Eye Drops instantly moisturizes and relieves
`dry, irritated eyes with the original formula for sensitive eyes. REFRESH® Classic
`Sensitive comes in convenient single use vials and is safe to use as often as
`needed.
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`o REFRESH REDNESS RELIEF® Redness Reliever and Lubricant Eye Drops works
`two ways. Its unique formula quickly removes redness and instantly moisturizes to
`soothe and protect dry, irritated eyes.
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`o REFRESH CONTACTS® Contact Lens Comfort Drops instantly moisturizes and
`soothes dry eyes caused by soft and rigid gas permeable contact lens wear.
`Utilizing a unique, long-lasting lubricant, every application creates a liquid cushion
`that comforts and protects. REFRESH CONTACTS® Contact Lens Comfort Drops
`comes in a convenient multi-dose bottle and is safe to use as often as needed.
`
` o
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` REFRESH PM® Lubricant Eye Ointment is preservative free and provides strong,
`soothing nighttime relief for more intense dry, irritated eyes and is ideal for use at
`bedtime.
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`o REFRESH® LACRILUBE® Lubricant Eye Ointment provides strong, soothing
`nighttime relief for more intense dry, irritated eyes and is ideal for use at bedtime.
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`o REFRESH® CELLUVISC® Lubricant Eye Drops provides extra strength moisturizing
`relief plus protection for dry, irritated eyes with the thickest gel formula for sensitive
`eyes. REFRESH® CELLUVISC® comes in convenient single use vials and is safe to
`use as often as needed.
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`o REFRESH LIQUIGEL® Lubricant Eye Drops provides extra strength moisturizing
`relief plus protection for dry, irritated eyes with a thick gel formula. REFRESH
`LIQUIGEL® comes in a convenient multi-dose bottle and is safe to use as often as
`needed.
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`o REFRESH DRY EYE THERAPY® Lubricant Eye Drops provides extended
`moisturizing relief and protection for dry eyes. The advanced moisture lock formula
`reaches all three layers of the tear film to provide a long-lasting shield with minimal
`blur. REFRESH DRY EYE THERAPY® comes in a convenient multi-dose bottle and
`is safe to use as often as needed.
`
`o REFRESH DRY EYE THERAPY® Sensitive Lubricant Eye Drops provides extended
`moisturizing relief and protection for dry eyes. The advanced moisture lock formula
`for sensitive eyes reaches all three layers of the tear film to provide a long-lasting
`shield with minimal blur. REFRESH DRY EYE THERAPY® Sensitive comes in
`convenient single use vials and is safe to use as often as needed.
`
`o REFRESH® Eye Itch Relief Antihistamine Eye Drops quickly relieves itchy eyes due
`to allergens such as pollen, ragweed, grass, animal hair and dander. REFRESH®
`Eye Itch Relief provides up to 12 hours of eye itch relief and comes in a convenient
`30-day supply.
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`APC025462008
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` For more information about the REFRESH® Brand line of artificial tears, visit
`www.refreshbrand.com.
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`- more -
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`APOTEX 1025, pg. 2
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`OPTIVE™ Brand
` The OPTIVE™ Brand offers over-the-counter artificial tear products,
`including OPTIVE™ Lubricant Eye Drops and OPTIVE™ Sensitive
`Preservative-Free Lubricant Eye Drops.
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`o OPTIVE™ Lubricant Eye Drops is an over-the-counter artificial
`tear, with a unique dual-action formula that lubricates and
`hydrates eyes to provide long-lasting relief from dry eye
`symptoms.10 Introduced in the United States in 2006,
`OPTIVE™ works in two ways to relieve the symptoms of dry eye by moisturizing the
`surface of the eye while also hydrating the eye at the cellular level where dry eye
`starts.
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`o
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`In 2008, OPTIVE™ Sensitive Preservative-Free Lubricant Eye Drops was introduced
`as an over-the-counter artificial tear recommended for dry eye and post-LASIK
`dryness. OPTIVE™ Sensitive is preservative-free, containing no added sodium
`chloride.
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` For more information about the OPTIVE™ Brand , visit www.optivesolutions.com.
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`RESTASIS® (cyclosporine ophthalmic emulsion) 0.05%
` RESTASIS®, approved by the U.S. Food and Drug Administration in
`2002, is currently the only prescription eye drop to help increase the
`eyes’ natural ability to produce tears in cases where it may be reduced
`by inflammation due to chronic dry eye. RESTASIS® did not increase
`tear production in patients using topical steroids or tear duct plugs.
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` While artificial tears provide temporary relief by putting water and
`lubricants on the surface of the eye, RESTASIS® is the only prescription
`eye drop that addresses an underlying cause of chronic dry eye.
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` To date, more than 5 million prescriptions have been written for RESTASIS® ophthalmic
`emulsion.11
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` RESTASIS® has a favorable safety profile. In clinical studies, there was no increase in ocular
`infection, interaction with other drugs, increase in intraocular pressure or detectable systemic
`drug absorption in the blood of patients for up to 12 months of treatment with RESTASIS®
`ophthalmic emulsion.
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` RESTASIS® should not be used by patients with active eye infections and has not been studied
`in patients with a history of herpes viral infections of the eye. The most common side effect is a
`temporary burning sensation. Other side effects include eye redness, discharge, watery eyes,
`eye pain, foreign body sensation, itching, stinging and blurred vision.
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` For more information about RESTASIS® ophthalmic emulsion, please refer to the full
`prescribing information, enclosed package insert or the product Web site at www.restasis.com.
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`# # #
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`Additional Information
`For a complete list of products in the Allergan eye care portfolio and further information on each
`product, please visit www.allergan.com.
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`APC025462008
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`APOTEX 1025, pg. 3
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`Contact:
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` ®
`
`Cathy Taylor
`Allergan, Inc.
`(714) 246-5551
`taylor_cathy@allergan.com
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` and ™ Marks owned by Allergan, Inc.
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`1 Market Scope. Report on the Global Dry Eye Market. St. Louis, Mo: Market Scope, July 2004.
`2 Schaumberg D, Sullivan D, Buring J, Dana R. Prevalence of dry eye syndrome among U.S. women. Am J Ophthalmol. 2003;136:318-
` 326.
`3 Multi-sponsor surveys, Inc. Gallup study of dry eye sufferers. Princeton, NJ, 2006.
`4 Aging Eye Times. Artificial Tears. Available at: http://www.agingeyenet/dryeyesinformation.php. Accessed March 7, 2006.
`5 Mader T, Tabin G. Going to High Altitude with Preexisting Ocular Conditions. High Altitude Medicine & Biology. 2003; 4:419-430.
`6 Blehm C, Vishnu S, Khattak A. Computer vision syndrome: a review. Surv Ophthalmol. 2005 May-Jun;50(3):253-62.
`7 Pflugfelder SC, Beuerman RW, Stern ME, eds. Dry Eye and Ocular Surface Disorders. New York, NY: Marcel Dekker, Inc.; 2004.
`8 Pflugfelder S. Antiinflammatory Therapy for Dry Eye. Am J Ophthalmol. 2004; 127:337-342.
`9 IRI Retail Sales. September 2007.
`10 Data on file. Allergan, Inc.
`11 VONA March 2003-June 2007.
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`APC025462008
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`APOTEX 1025, pg. 4