Table of Contents For Ex. 1025A
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`Declaration of Christopher Butler
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`Affidavit of Christopher Butler ---------------------------------------------------- page 2
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`Exhibit A (Webpage Galenic development) ------------------------------------- page 4
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`Page 1 of 4
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`\nuL'.archi\'¢.-.urp,
`415.561 6767
`-815.840-D391 c—f.Ix
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`lntemet \fchl\'c
`300 Funston Avenue
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`Sm l-rmciscn, (.'.\ 941 I8
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`AFFIDAVIT OF CHRISTOPHER BUTLER
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`l. I am the Office Manager at the lntemet Archive, located in San Francisco.
`California. I make this declaration of my own personal knowledge.
`2. The lntemet Archive is a website that provides access to a digital library of
`Internet sites and other cultural artifacts in digital fonn. Like a paper library. we provide
`free access to researchers. historians. scholars. and the general public. The lntemet
`Archive has partnered with and receives suppon from various institutions. including the
`Library of Congress.
`3. The Internet Archive has created a service known as the Wayback Machine. The
`Wayback Machine makes it possible to surf more than 400 billion pages stored in the
`Internet Archive's web archive. Visitors to the Wayback Machine can search archives
`by URL (i.e.. a website address). If archived records for a URL are available, the visitor
`will be presented with a list of available dates. The visitor may select one of those
`dates. and then begin surfing on an archived version of the Web. The links on the
`archived files, when served by the Wayback Machine. point to other archived files
`(whether HTML pages or images). If a visitor clicks on a link on an archived page. the
`Wayback Machine will serve the archived tile with the closest available date to the page
`upon which the link appeared and was clicked.
`4. The archived data made viewable and browseable by the Wayback Machine is
`compiled using soflware programs known as crawlers. which surf the Web and
`automatically store copies of web files. preserving these files as they exist at the point of
`time of‘ capture.
`5. The lntemet Archive assigns a URL on its site to the archived files in the fonnat
`http://web.archive.org/web/[Year in yyyy][Month in mrn][Day in dd]['l"ime code in
`hh:mm:ss]/[Archived URL]. Thus. the lntemet Archive URL
`http://web.archive.org/web/ l9970!26045828/http://www.archive.org/ would be the
`URL for the record of the lntemet Archive home page HTML file
`(http://www.archive.org/) archived on January 26. I997 at 4:58 a.m. and 28 seconds
`(1997/0|/26 at 04:58:28). A web browser may be set such that a printout from it will
`display the URL of a web page in the printout‘s footer. The date assigned by the lntemet
`Archive applies to the HTML file but not to image files linked therein. Thus images that
`appear on a page may not have been archived on the same date as the HTML file.
`Likewise. if a website is designed with "frames," the date assigned by the lntemet
`Archive applies to the frameset as a whole. and not the individual pages within each
`frame.
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`6. Attached hereto as Exhibit A are true and accurate copies of printouts of the
`lntemet Archive's records of the HTML files for the URLs and the dates specified in the
`footer of the printout.
`7. I declare under penalty of perjury that the foregoing is true and correct.
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`DATE: [31 '2
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`/1
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`Christopher Butler
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`Page 2 of 4
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`Page 2 of 4
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`Exhibit A
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`Exhibit A
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`Page 3 of 4
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`Page 3 of 4
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`Fumapharm AG - Galenical Development
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`1 of 1
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`NEWS PROFILE CONGRESS
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`RESEARCH
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`LITERATURE
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`SALES FUMARATES
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`PSORIASIS
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`MULTIPLE SCLEROSIS
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`CONTACT
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`GALENICAL DEVELOPMENT | PIPELINE | STUDIES
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` » EN » Research » Galenical Development
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` search Language
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`Galenic development
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`First-Generation Product
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`Since August 1994 preparations have been available containing fumaric acid derivatives as the
`active substance, that have been granted marketing authorisation by the Federal Institute for
`Drugs and Medical Devices (BfArM) in Germany for treatment of psoriasis. These preparations
`are administered in the form of enteric film-coated tablets. However there are patients in whom
`these tablets cause gastrointestinal symptoms, making further treatment problematic or
`impossible.
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`Second-Generation Product
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`For this reason another pharmaceutical form has been developed and at the same time a
`monosubstance has been used. This new development involves enteric-coated microtablets in
`capsules intended to guarantee a finer distribution in the gastrointestinal tract, in order to
`achieve better gastrointesinal tolerance. This has been confirmed by initial results from a pilot
`study. Other very positive results for the new product from the dose-finding study (Phase II)
`carried out in 2003 in Poland have already been presented at a conference. Additional studies
`(Phase III) are either in progress or are in the pipeline and we hope to be able to publish new
`data soon.
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`Relevant Links
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`- Pipeline
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`© Fumapharm AG
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`Legal Statement
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`created by H2G Internetagentur
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`http://web.archive.org/web/20050803080203/http://www.fumapharm.ch/EN/Research/Galenical_Development/index.php
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`Page 4 of 4