EXHIBIT 1004
`
`AMENDIVIENT AND REMARKS RESPONSIVE TO RESTRICTION
`
`REQUIREMENT ISSUED ON MAY 6, 2005
`
`lnfopia Ex. 1004 pg. 1
`
`

`

`06:06-05
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`l2:44
`
`Front-PATTUN BOGGS
`
`+
`RECEIVED
`
`CENTRAL FAX CENTER
`
`'
`
`T-124
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`P.0l
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`F-ISB
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`BUSES
`PllllllNB
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`
`AllllllllEY 3 ll lllW
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`
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`
`'
`
`JUN 06 2005
`
`1660LlnoolnStreei,Stllt62050
`Denver CO 80264
`
`(303)830-1776 ‘
`
`Facsimile: (303) 894-9289
`
`To:
`
`Examiner Ralph J. Gitomer
`
`Company:
`Fax Number:
`Phone Number.
`
`USPTO
`1-703-872-9306
`1-571 -272-0916
`
`Serial Number:
`
`10l329,044
`
`Total Pages
`Including Cover:
`From:
`
`20
`Elaine c. VonSprecltelsen, IP Specialist
`
`Senders Direct Line:
`
`(303) 89443163
`
`Date:
`Client Number:
`
`June 6, 2005
`023134.0110PTUS
`
`Comments:
`
`WASHINGTON DC
`NOWHERN VIRGINIA
`DALI-AS
`
`101329.044
`Serial No.:
`23 Dec 2003
`Filing Date:
`Conflnnation No.:
`7458
`
`Group Art Unit: 1651
`. Examiner. V
`Gitomer. Ralph J.
`
`'
`
`Attached please find the following documents to be entered in the aboVe
`application:
`
`DENVER
`ANCHORAGE
`
`Dom, QATAR
`
`Amendment and Remarks responsive to the Office Action mailed May
`6,2005 (6 pages)
`
`1.
`
`2.
`
`*
`
`Confidentiality Note: The dowmnts
`eemwanline 10:6 (new? 1°32?“
`Copy'of Revocation Of Power Of Attorney With New Power Of
`Sggfl‘fl? (ml )3 film“; My;
`Attorney And Change Of Correspondence Address package filed
`privileged. The Information Is melded
`’
`today. (6/6/05) under separate cover (13 pages)
`onty for the use of the individual or
`3,253 "m 235 ‘23 gym if you have any questions. please do not hesitate to contact me. Thank you for
`redpienL you are hereby notified that
`your assistance.
`any dkdosure copying distribution or
`the taking ofany action in reliance on
`the centers of this facsimile ls strictly
`prohibited, and that
`the domrnenis
`should
`be
`retumod
`to
`this Firm
`inrnediatoly.
`If you have received this
`taminile In error, pieme notify us by
`telephone littlnedlallely so that we can
`amnge for tile room of the original
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`if you did not receivejall of the pages or find that they are illegible, please all (303) 830-1776; ~
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`215768111
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`1
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`lnfopia Ex. 1004 pg. 2
`
`

`

`mains-r15
`
`12:44
`
`Frum-PATTON BOGGS
`
`RECEWED
`CENTRAL FAX CENTER
`
`JUN 08 2005
`
`r—124
`
`PM
`
`r-rae
`
`IN THE UNITED STATES PATENT AND. TRADEMARKOFFICE
`
`Group Art Unit:
`
`1651 '
`
`Examiner:
`
`Gitomer. Ralph J.
`
`.
`
`Docket No: 023134.0110PTUS
`(Formerly 01726—0001(G))
`
`Confirmation .No.:
`
`7458
`
`10/329,044 )
`U.S. Patent Application No.:
`)
`.
`)
`Filing Date: December 23, 2003
`)
`‘
`'
`‘
`For: Test Strip And Method For Determining )
`HDL Concentration From Whole BlOOd
`)
`. Or Plasma
`
`) )
`
`A Ircants: Anaokar et al.
`.
`37
`3 Is 0 u
`F
`CA
`‘
`ndence. along with all papers referred to as being transmitted. are being facsimile transmitted to the
`i hereby certify that this cor:
`Patent and Trademark Office ax No. (703) 372-9306.
`
`Date
`
`.
`
`Elaine C. VonSpreckelsen
`
`MAIL STOP AMENDMENT
`COMMISSlONDER FOR PATENTS
`PO. BOX 1450
`
`ALEXANDRIA, VA 22313-1460
`
`Dear Sir:
`
`These Amendments and Remarks are responsive to the Office Action mailed May 6,
`
`2005. A copy of a Revocation Of Power Of Attorney With New Power Of Attomey And
`
`Change Of Correspondence Address (Form PTO/SB/82), along with a Statement Under 37
`
`CFR 3.73(b) (Form PTO/SB/QG), with attachments. which are being filed in the USPTO
`
`today in a separate paper are enclosed.
`
`,
`Serial No. 10I329,044
`Amendments And Remarks Responsive To 7
`Office Action Mailed 05/06/05
`Page 1 of 6
`. 215418v2
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`lnfopia Ex. 1004 pg. 3
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`

`

`06416-05
`
`l2144
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`From-PATTON 80585
`
`+
`
`IT~124
`
`P.03
`
`F-l38
`
`Claims‘l —20
`
`(Canceled) .
`
`own LISTING
`
`21.
`
`(New) A method of determining concentration of HDL cholesterol in a whole
`
`blood sample, said method comprising:
`
`‘
`
`a)
`
`providing a layered stack comprising a red blood cell separation layer, a non-
`
`HDL separation chemistry layer, and an HDL reaction layer. said non—HDL cholesterol
`
`separation chemistry layer containing non-HDL cholesterol separation chemicals for
`
`separating the non-HDL blood components from the HDL blood components so that the
`
`non-HDL components do not participate in the reaction in said HDL reaction layer; said
`
`HDL reaction layer containing chemicals fer reacting with said HDL; said layers arranged in
`
`a vertical stack;
`
`b)
`
`applying blood to the top of said stack and permitting it to flow vertically
`
`downward in said stack to said HDL reaction layer without substantial lateral migration of
`fluid;
`7
`l
`-
`
`separating said red blood cells from a fluid portiOn of said blood in said red
`c)
`blood cell separation layer,
`0
`d) '
`separating said non-HDL cholesterol from said HDL cholesterol using said
`
`non-HDL cholesterol separation chemicalsmnd
`
`e)
`
`reacting said HDL in said HDL reaction layer.
`
`22.
`
`(New) The method of claim 21 wherein:
`
`said providing comprises providing said red blood cell separation layer without
`
`including an agglutinin or a coagulant;
`and said separating said red blood cells is performed without .agglutinizing or
`coagulating said red blood cells.
`
`23.
`
`(New) The method of claim 21 wherein said reacting comprises generating a
`
`color response and said method further comprises reading said colored response at a
`
`location that is substantially vertically aligned with the blood application area of said stack.
`
`(New) The method of claim _21 wherein said providing said red blood cell
`. 24.
`separation layer comprises providing glass fibers having a first average diameter and glass
`
`Serial No. 10I329,044
`Amendments And Remarks Responsive To
`Office Actipn Mailed 05/06/05
`Page 2 of 6
`215mm
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`PAGE 3l20‘ RCVD AT 6l6l2005 2:45:10 PM [Eastern Daylight Time]‘ SVR1USPTO-EFXRF-1l6‘ DNIS:8729306 ' CSID:+' DURATION (mm-ss):05338
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`'
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`lnfopia Ex. 1004 pg. 4
`
`

`

`061-06435
`
`l2:44
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`me-PATTON BOGGS
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`+‘
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`T-lZ4
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`204/20
`
`F~138
`
`fibers having a second average diameter that is less than said first average diameter.
`25.
`(New) The method of claim 21 wherein said providing said red blood cell
`
`separation layer comprises impregnating said red blood cell separation layer with a salt.
`
`3
`
`(New) The method of claim 25 wherein said impregnating comprises
`. 26.
`impregnating said red blood cell separation layer with a solution in which the salt
`concentration comprises about 0.5-3.0% by weight of said solution.
`‘
`27.
`(New) The method of claim 21 wherein said providing said red blood cell
`
`separation layer comprises impregnating said red blood cell separation layer with a wetting
`agent.
`I
`(New) The method of claim 27 wherein said providing said red blood cell
`
`28.
`
`separation layer comprises impregnating said red blood cell separation Iayerw'rth a sugar.
`
`29.
`
`(New) The method of claim 28 wherein said impregnating comprises
`
`impregnating said red blood cell separation layer with a sorbitol solution, theconcentration
`
`of which comprises 3% tot 0% sorbitol by weight of said solution.
`
`30.
`
`(New) The method of claim 21 wherein said providing said non-HDL
`
`cholesterol separation chemistry layer comprises impregnating said non-HDL cholesterol
`
`separation chemistry layer with a precipitant, and said separating said non-HDL cholesterol
`
`from said HDL cholesterol comprises precipitating said non-HDL cholesterol.
`
`31.
`
`(New) The method of claim 30 wherein said providing said non-HDL
`
`cholesterol separation chemistry layer comprises impregnating said non~HDL cholesterol
`separation chemistry layer with phosphotungstic acid (PTA).
`32.
`(New) The method of claim 31 wherein said providing said non-HDL
`
`cholesterol separation chemistry layer comprises impregnating said non-HDL cholesterol
`separation chemistry layer with said PTA and a divalent cation.
`.
`33.
`(New) The method of claim 21 wherein said providing comprises stacking
`said red blood cell separation layer above said non-HDL cholesterol separation chemistry
`
`layer.
`(New) The method of claim 33 wherein said providing comprises providing a
`34.
`‘
`red blood cell separation layer comprising glass fiber.
`
`Serial No. 10/329,044
`Amendments AndsRemarks Responsive To
`Office Action Mailed 05/06/05
`Page 3 of 6
`3
`215418v2
`PAGE4i20’ RCVD AT 6i5l2l105 2:45:10 PM [Eastern Daylight Time]’ SVR:USPTO-EFXRF-1i6 "DNlS;8729306‘ CSID:+* DURATION (mln-ss):05a38
`
`lnfopia Ex. 1004 pg. 5
`
`

`

`06:06-05
`
`12:45
`
`Frum‘PATTON 80088
`
`+
`
`'T-124
`
`P.05/2l]
`
`F-lSB
`
`35.
`(New) The method of claim 34 wherein said providing said red blood cell
`separation layer comprises providing‘a first glass fiber layer with glass fibers having a first
`average diameter and providing a second glass fiber layer having glass fibers having a
`second average diameter that is less than said first average diameter.
`36.
`(New) The method of claim 35 wherein said providing said non-HDL
`cholesterol separation layer comprises proViding said second glass fiber layer and
`
`impregnating said second glass fiber layer with said non-HDL cholesterol separation
`
`.
`chemicals.
`(New) The method of claim 21 wherein:
`37.
`said providing further comprises providing said layered stack with a dispersement
`layer above said red blood cell separation layer, said non-HDL separation chemistry layer,
`
`and said HDL detection layer; and
`said method further comprising permitting said blood to disperse laterally across
`said dispersement layer.
`‘
`38.
`(New) A method as in claim 37 wherein said providing said dispersement
`layer comprises providing a woven mesh material.
`39.
`(New) A method of determining concentration of HDL cholesterol in a whole
`
`blood sample. said method comprising:
`
`a)”
`
`providing a layered stack comprising a dispersement layer, a red blood cell
`
`separation layer. a non--HDL separation chemistry layer, and an HDL reaction layer; said
`
`red blood cell separation layer not containing an agglutinin or a coagulant; said non-HDL
`cholesterol separation chemistry layer containing non—-HDL cholesterol separation
`
`chemicals for separating the non-HDL blood components from the HDL blood components
`so that the non-HDL components do not participate in the reaction in said "HDL reaction
`
`layer, said HDL reaction layer containing chemicals for reacting with said HDL; said layers
`
`arranged in a vertical stack with said dispersement layer at the top and said HDL reaction
`
`I
`layer at the bottom; '
`b)
`applying blood to said dispersement layer and permitting it to first flow
`laterally across said dispersement layer and then to flow vertically downward in said stack
`
`’
`Serial No 101329.044
`Amendments And Remarks Responsive To
`Office Actioanailed 05/06/05
`Page 4 of 6
`}
`215418v2
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`lnfopia Ex. 1004 pg. 6
`
`

`

`08-108-05
`
`12:45
`
`From-PATTDN 80668
`
`+
`
`,
`
`T-124
`
`008/20
`
`F-l38
`
`to said HDL reaction layer without substantial lateral migration of fluid;
`
`-
`
`c)
`
`separating said red blood cells from a fluid portion of said blooo in said red
`
`blood cell separation layer;
`
`d)
`
`separating said non-HDL cholesterol from said HDL cholesterol using said
`
`non-HDL cholesterol separation chemicals;
`e)
`reacting said HDL in said HDL reaction layer in a colorimetric reaction; and
`(f)
`determining the HDL cholesterol concentration in said reaction layer by
`
`measuring the reflectance of said reaction layer after said colorimetric reaction.
`40.
`(New) The method of claim 39 wherein said. providing comprises Stacking
`
`said red blood cell separation layer above said non-HDL cholesterol separation chemistry
`
`layer.
`
`‘
`
`Serial No. 10!329,044
`Amendments And Remarks Responsive To
`’
`Office Action Mailed 05106105
`
`Page 5 of 6
`2154i8v1
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`PAGE 6l20’ RCVD AT 6l6i2005 2:45:10 PM [Easlem Daylight Time] ‘ SVR:USPTO-IEFXRF-1lfi ’ DNIS:8729306‘ CSlDH" DURATlON (mm-ss):05;38
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`Infopia Ex. 1004 pg. 7
`
`

`

`08:06-05
`
`12:45
`
`Frum-PATTON 806.65
`
`+
`
`T424
`
`P.07/20
`
`F-138
`
`REMARKS
`
`.
`
`The Examiner has made a restriction requirement to either the claims of Group l,
`
`i.e., claims. 1 ~— 7. which are drawn to an apparatus with layers; or the claims of Group ll,
`
`i.e., claims 8 4 20. which are drawn to a method of determining HDL concentration.
`
`'
`
`Applicants elect the method claims of Group II, but have chosen to rewrite the method ‘
`
`claims as new claims 21 — 40. Therefore. claims 1 -— 20 have been canceled.
`
`in view of the foregoing amendment, it is believed that the application, including
`
`claims 21 — 40, is in condition for allowance. and favorable action is respectfully requested.
`it is believed no fees'are due.
`if any fee is seen to be required. please chargeDeposit
`Account No. 50-1848.
`
`Respectfully submitted,
`PATTON BOGGS LLP
`
`Date:
`
`K 0 5/
`
`By:
`
`Customer No;
`
`24283
`
`
`arl A. For
`. Reg. No. 28,494 '
`Telephone:
`(303) 894-6114 .
`Facsimile:
`(303) 894-9239
`
`Serial No. 101329.044
`Amendments And Remarks Responsive To
`Office Action Mailed 05/06/05
`
`Page 6 of 6
`.
`215418v2
`'1
`PAGE il20*RCVDAT 6iil2005 2:45:10 PM [Eastern Daylight Time] ‘-SVR:USPTO-EFXRF-1l6'DNlSI8729306*CSlD:+*DURATION (mm-ss):05-38
`
`.
`
`.
`
`lnfopia Ex. §1004 pg. 8
`
`

`

`atlas-us
`
`l2:45
`
`From-PATTON BOGGS
`
`T-124
`
`P.08/20
`
`F-l38
`
`Receipt acknowledged by USPTO on the date stamped below: .
`
`In Re: Patent apgliaation ol: _M_Qvas, @8625. g: misfits
`Serial No.:M
`Date tiled:W
`Title: “Surf 0 1.5
`a“,
`
`
`
`sheets)
`
`DProvisional Application for Patent COVBI' Sh'eet __._ page(s)
`DDrawings (
`DSpecitication_T___pag6(8)
`No. FIGS
`DResponse to Missing Paris __ page(s)
`Dianna! / Diniomlal
`DCombined Declaration and POAmpagds)
`
`Dfiecordation Form Cover Sheet
`page(s).
`
`[3le
`
`DAssignmeanang)
`page{s}
`
`cited US rel
`Ci
`
`UTransmittai
`page(s)
`DExt of time _____page(s)
`cited foreign ref.
`
`cited other ref.
`DAmendment ___..page(s)
`Elissue Fee Transmittal __ page(s)
`Payment: DOheck No
`ID DaposltAoct/amount of$
`
`
`Other.
`'QBIVI
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`C3- 90»!- c-u'to fill-0'6- Cs
`Atty Docket NoM Date Mailed. 96aE'M—.ums‘ Page 5,)
`
`PAGE 8i20 ' RCVD AT ii6i2005 2:45:10 PM [Easiem Daylight Time]‘ SVR'USPTO-EFXRF-1iG’DNiS:8729306 * CSiD:+' DURATION (mmssi'05-38
`
`Infopia EX. 1004 pg. 9
`
`

`

`06:06-05
`
`12:46
`
`From-PATTON BUGGS
`
`+
`
`T-i24
`
`PJJQ/ZU
`
`F-iEiB
`
`PTO/58,32 (0904)
`Approved for use through D7IS1I2006. OMB 0651-0031
`Patent and Trademark Office; U.S. DEPARTMENT OF GOMMERCE
`Undertha Paperwork Reduction Actof 1995. no persons are required to respond to a collection ofinfonnetion unless it contains a valid OMB control number.
`
`Certificate of Mailing under 37 CFR 1.8
`
`l hereby certify that this Correspondence is being deposited with the United States Postal
`Service with sufficient postage as first class mail in an envelope addressedto:
`
`Commissioner for Patents
`PO. Box 1450
`Alexandria. VA 22313-1450
`
`on
`
`June 6. 2005
`
`Copies of assignments yet to be recorded (2 for a total of 6 pages)
`
`5124..., d. mbwéé“
`Signature
`
`Elaine C. VonSpreckelsen
`
`Typed or printed name of person signing Certificate
`
`N/A
`
`7
`
`‘
`
`303-894-6163
`
`Registration Number, if applicable
`
`Telephone Number
`
`Note:
`
`Each paper must have its own certificate of mailing. or this certificate must identify each submitted
`papeh
`
`Revocation Of Power Of Attorney With New Power OfAtlomey And Change Of Correspondence
`1.
`Address Form PTO/SB/82 (1 page)
`2.
`Statement Under 87 CFR 3.730)) Form PTO/88196 (1 page)
`3.
`Application/Patent Spreadsheet for Polymer Technology Systems, Inc. (3 pages)
`4.
`
`This collection of informalion is required by 57 CFR 1.8. The infometion is required to obtain or retain arbertefit by the public Much Is tofilo
`(and by the USPTO to prooees) an appfioation. Confidentiality is governed by 35 U.S.C. 122 and 37 CFR 1.11 and 1.14. This collection is
`estimated to take 1.8 minutes to complete. including gathering. preparing. and Submitting the completed application {mute the USPTO.
`Time will vary depending upon the individual case. Any comments on the amount onlme you require to complete this form andlor
`suggestions for reducing this human. should be sent to the Chief Information Officer. U.S. Patent and Trademark Office. US. Department at
`Commerce. Po. Box 1450. Alexandria. VA 22313-1450. DO NOT SEND FEES OR COMPLETED FORMS TO THIS ADDRESS. SEND TO:
`Commissioner for Patents, no. Box 1450, Alexandria, VA 2231 2,1 45o.
`
`I/you need assistance In oomplellng the farm, call 1-800PT09199 and select option 2
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`;
`
`215743vi
`
`PAGE 9i20* RCVD AT 6i6i2005 2:45:10 PM [Easiem Daylight Time] ’ SVR:USPTO-EFXRF-116‘ DNIS:8?29306 * CSID:+ * DURATION (mmeslzo5-3ii
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`lnfopia Ex. 1004 pg. 10
`
`

`

`06:06-05
`
`I2i46
`
`From-PATTUN 80668
`
`+
`
`T-124
`
`RID/20
`
`F-138
`
`PTO/SB/82 (0904)
`Approved for use lhroueh 11/30/2005. OMB 0651-0035
`Patent and Trademark Office: U.S. DEPARTMENT OF COMMERCE
`respond m a eoiiauion of Information uniass it displays a vaiia OMB control number.
`Application Number
`See attached spreadsheet
`
`Filing Date
`
`See attached spreadsheet
`
`m Named Inventor
`
`.
`
`Alinmey Docket Number
`
`
`
`
`Under the Paoenvoiii Reduction Act M1995. no persuns are required to
`
`
`
`REVOCATION OF POWER OF
`ATTORNEY WITH
`
`new POWER. OF ATTORNEY
`
`
`See attached spreadsheet
`AND
`.
`'
`CHANGE OF CORRESPONDENCE
`
`
`
`ADDRESS
`'
`see attached spreadSheet
`See attached spreadsheet
`
`We 'in the above4dentified a dimiionz
`revoke all revious u are of atiome or authorizations ofa em
`
`
`
`
`El A Power of Attorney is submitted herewith.
`OR
`\
`
`l hereby appoint'the practitioners at Customer Number:
`
`
`
`
`
`E Please change the correspondence address for the above-identified application to:
`
`D The address associated with
`Customer Number:
`
`
`
`
`
`
` OR
`B Firm or
`Individual Name
`
`~
`
`24283
`
`_
`
`——
`
`_“— zip _
`-—
`”—
`
`I am the:
`
`
`
`[:1 Applicant/inventor.
`
`
`
`Aesignee of record of the entire interest. See 37 CFR 3.71.
`Statement under 37 CFR 3. 730;) is enclosed. (Form PTO/SB/QG)
`
`
`
`
`,.,,,$,,.,,.MM
`
`rg@m%¥fifim- ‘
`
`
`”my” M570 rib/0
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`
`
`NOTE: Signatures of ~: Ii 01-. inventors or assignees of record of the entire interest or [heir repreeemafive(8) are required.
`
`Submit multiple in
`if
`ore than one signature is required. see below.
`
`
`[I]
`‘Totai of
`forms are Submitted.
`2
`,
`
`
`
`This ooueciion of inronnaiim I3 required by 37 CFR 1.36.1116 information is require to --- in or retain a benefit by the public which Is In
`file (and by the USPTO tn process) an application. Confidentiality ls warned by 35 U.s.C. 122 and 87 CFR 1.11 and 1.1it This coiieciion
`is estimated to rake 3 minutes to complete. including gathering. preparing, and submitting me completed appilrarion form to the USPTO.
`Time win vary depending upon the individual case. Any comma-rte on me amount of time you requm to complete this form and/or
`suggasiiam tar reducing this burden, should be sent in the Chief Information Officer. u.s. Patent and Trademark Office, U.S. Department
`of Commerce, PD. Box 1450. Alexandria, VA 22313-1450. DO NOT SEND FEES OR COMPLEFED FORMS T0 THiS ADDRESS. SEND
`TO: Communal!" for Patients, Po. Box 1450, Alexandria. VA 22313-1460:
`Ifyou need assistance In compreung‘ine form call 1.§onim>-9199 and select option 2.
`
`21mm
`'
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`PAGE 10120‘ RCVDAT616120052145110 PM [Eastern Daylighi Time] * SVRIUSPTO-EFXRi-iifi " 011183729306” CSID:+’ DURATION (mm-ss):05-38
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`lnfopia EX. 1004 pg. 11
`
`

`

`05:06-05
`
`i2z46
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`Approved tor use through 07131r2006. OMB 0651-0031
`U.s. Patent and Trademark Office; US. DEPARTMENT OF COMMERCE
`Under the Papemodt Reductionmd 1 995. no perms are raqu’tea to respond to e ooiteaion of information unless it dispta-ys a vain OMB oortirul number.
`
`Applicant/Patent Owner: See attached spreadsheet
`
`STATEMENT UNDER 37 CFR 3.73m) '
`
`Entitled: see attached spreadsheet
`
`Polymer Iflngjogx Sfitems. IDS.
`(Name ofAssignoo)
`states that it is;
`
`Filedllssue Date: See attached spreadsneet
`
`, a Embration
`(Type oiAastgnae. 9.9.. corporation. partnersnlo. university. government agency. are)
`
`1. E the assigned 01 the entire right. Hits. and interest: or
`2. D an assignee of less than the entire right, title. and interest
`.
`The extent (by percentage) of its ownership interest is
`in the patent appiioafioNpatent identified ab0ve by virtue of either.
`
`%
`
`A. IE An assignment from the inventor(s) of the patent application/patent identified above. The assignment was
`recorded in ma United States Patent and Trademark Office at Reei See attached 5
`a . Frame §g§
`attached sgrggaheat. or for which a copy thereof is attached.
`
`OR
`
`a, 1:] A chain or title from the inventor(s), of the patent application/patent identified above. to the current assignee as
`shown baiow:
`'
`
` Application NoJPateni No.: See attemed spreadsheet
`
`To:
`1. From:
`The document was recorded in the United States Patent and Trademark Office at
`Reel __,,,_, Frame
`. or for which a copy thereof is amen.
`
`.
`TO:
`2. From.-
`The document was recorded in the United States Patent and Trademark Office at
`Real
`, Frame
`, or for which a copy thereof is attached.
`
`T°=__..'
`3. From:
`The document was recorded in the United States Patent and Trademark Office at
`Reel __. Frame __. or forwhich a copy thereof is attached.
`
`E] Additional documents in the chain of title are iisted on a supplemental sheet.
`
`1:] Copies of assigmnents or other documents in the chain of title are attached.
`mom: A separate copy (1.9., a true copy of the original documeni(s)) must be submitted to Assignment
`Division in accordance with 37, CFR Part 3. if the assignment is to be recorded in the records of the
`USPTO. gem MPEP 302.08]
`
`Telephone Number
`
`This collection of Information is required by 37 CFRBJStbi The infdm‘taiion is toquimd’w obtain or main a benefit by the public witch is in file (and
`,1); the USPTO to process) an nppliwtion. Confidsntlailw is governed by 35 U.S.C, 122 and 37 CFR 1.11 and 1.14.11“ collection is estimated 10ka
`1 minutes to dorm including Write. preparing, and emitting thB completed appilwilon him to the USPTO. Time win vary depending upon
`the individual case. Arty comments on the amomt of time you mqulra to complete the com and/or suggestions for reducing this burden. should be
`sent to tho Ghial mfermation omcer, US. Patent and Trademark Office. U3. Dapamnent or Continence, no. Boot 1450. Nemndna, VA 22313-1450.
`DO NOT SEND FEES 0R COMPLETED FORMS To THIS ADDRESS. SEND 1'0: commissioner for Patients, P.o. Box 1450,
`Alexandria, VA 22818—1450.
`'
`
`_,
`
`lfyorr WWW in completingtho loan. will twoftD-mWandsotocloption 2.
`
`21mm ‘
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`PAGE iiiiii‘ RCVDAT 6i6i2005 2:45:10 PM [Eastern Daylight iimei‘ SVR:USPTO£FXRF-116 * Dilemma * CSID:+*DURAii0ii (mmesimi-it
`
`lnfopia Ex. .1004 pg. 12
`
`
`
`
`
`

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`
`lnfopia Ex. 1004 pg. 13
`
`
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`mains-us
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`l2:47
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`PAGE 13m ' RCVD AT 61612005 2:45:10 PM [Eastern Daylight Time] ‘ SVR:USPTO-EFXRF-1!6 ‘ DNIS:8729306 ‘ CSID:+* DURATION (mm-ss):05-38:
`
`lnfopia Ex. 1004 pg. 14
`
`
`
`
`
`
`

`

`oséos—os
`
`12:47
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`From-PATTON 30668
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`PAGE 14I20 ‘ RCVD AT $512005 2:45:10 PM [Eastern Daylight Time] ‘ SVREUSPTO£FXRF-1!6 " DNIS:8729305 ‘ CSIDH' * DURATION (mm-ss):05-38
`
`lnfopia Ex. 1004 pg. 15
`
`
`
`
`
`
`
`
`
`

`

`06:06-05
`
`l2:47
`
`From-PATTON 80663
`
`+
`
`T-124
`
`P.l5/ZU
`
`F-l38
`
`ASSIGNMENT TO BUSINESS CONCERN
`
`0 27» ’ 3 '4 - 0 l “5 7"?“ 3
`
`
`Polymer Tech. Sys. Ref. No: _
`
`‘ASSIGNMENT
`
`ln ccmsit'lcration ol'lhe sum ol‘One Dollar (Eli l .00) and other good and valuable
`consideration paid to each ofthc undersigned.
`
`
`
`BI‘LICL: 5,333” Alexandra Mttchnik
`_
`
`maker of an invention which is the Subject of a United States Patent application entitled
`
`_§st Strip and Method fer Determiningjoncentration at grepflnine in a Body Fluid Sample
`‘
`the undersigned hereby seli(s), assign(s), and Seqs) over to
`
`_
`
`Pol ner Tec nolo
`
`S Stems Inc
`
`11§.(r_71ionsvllle Road
`-
`
`lndiannpolis. W 46268
`
`__“
`
`Natne(s)
`of inventor(s)
`
`Title of
`Application
`
`Name of
`Assignee
`
`Address of
`principal
`place of
`business
`
`insert Suite of
`lncmpotarion
`(if applicable)
`or "Not Applicable"
`
`
`.lndiana
`
`(hereinaller designated as the Assignec) their entire right, title, and interest in, to and under the Application(s), including all priority
`rights for the United States and for other countries arising therefrom, including any PCT application, all inventicms therein disclosed,
`and any and all Letters Patent of the United States and of all other countries, including patents issuing through the Eumpcan Patent
`Organization, which may be granted for such inventions, or any of them, all such inventions’and all rights in such Application(s) and
`Letters Patent to be held and enjoyed by Assignee for its own use and enjoyment to the full and of the term or terms for which such
`Letters Patent may be granted, as fully and entirely as the same would have been held and enjoyed by them had this assignment and
`sale not been made.
`
`.
`
`The undersigned agrcets) to execute‘ all papers necessary in connection with the Application(s) in the United States and
`counterpart applications in foreign countries and any continuing, divisional, or reissue applications thereof, and any reexamination of
`any 0f SUCh Applicati0n(s), and also to execute separate assignments in connection with such Application(s) as the Assignee may deem
`necessary or expedient.
`
`The undersigned agree(s) to execute all papers neceSSary in connccrion with any interference which may be declared or
`litigation concerning the Application(s), US national counterparts
`thereof, or continuation(s), division(s).
`reissne(s), or
`reexaminatioms) thereof. and to cooperate with the Assigned in every way possible in obtaining evidence and going forward with such
`interference or litigation.
`
`The undersigned agree(s) to execute all papers and documents and perform any act which may be necessary in connection
`with claims or provisions of the Intemnrlonal Canventiort for Protccdon of industrial Property or similar agreements.
`
`I
`
`PAGE 15/20 ‘ RCVD AT 6l6l2005 2:45:10 PM [Eastern Daylight Time] ’ SVR:USPTO-EFXRF-ll6 ‘ DNIS:8?29306 ‘ CSlD:+* DURATION (mm-sslzflfi-fls
`
`Infopia EX. 1004 pg. 16
`
`

`

`‘
`
`'
`
`06:08-05
`
`|2:47
`
`From-PATTUN BUGGS
`
`+
`
`T424
`
`Pris/20
`
`F-138
`
`ASSIGNMENT 'l'O BUSINESS CONCE KN
`
`The tinderslgned agree(s) to do all other nets which, in thc opinion of Assigneeymtty be necessary or desirable to secure the
`grant ot'l-cttcrs Parent to Assignee or its nominees, in the United Status tmd in all Other cauntries where Assignee may desire to have
`such inventions, or any of them, patented, with specifications and claims in such form as shall be approved by Assignee and to vast and
`com‘trm ln Assigncc or its nominees the full and complete legal and equitable title to all such Lullm's Patent.
`
`The undersigned hereby authorize(s) and request(s) the Conunissioner of Parents to issue any and all Letters Patent ohm;
`United States l‘éfitllIlng 0r following from said application“) or any (livisiOn or divisions or continuing or reissuc applications thereof,
`and any rcexmninntion Many of Such applications, to the said Assignee, ns Assignee of the entire interest, and hereby covenants that.
`the; undersigned has full right to convey the interest herein insigned, and that the undersigned has net executed, and will not execme,
`any agreement in confliCt herewith.
`
`'l‘hc ttndursigncd hereby grands) the attorney of record the power to insert on this assignment any fitrther identification whiCh
`may be necessary or desirable in order to comply with the rules of the United States Patent 8nd Trademark Office for recordation of
`this document.
`.
`BIS
`
`IN WITNESS WHEREOF, I have oxecuted this_ assignment at
`“£658 RUE? a? C;
`,2004.
`
`I N ct on ,u f} pay
`.
`
`this
`
`2"
`[ 5: 1‘
`
`day of
`
`Ontslde the USA:
`Witnesses or:
`required when
`acknowledment
`before a Nanny
`Public is not
`feasible.
`
`‘
`Witness
`
`“ 5 441.2%AW
`Inventor (Signaturc)
`
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`
`‘
`
`Brgco Sltttll
`inventor (Printed Name)
`
`ACKNOWLEDGMENT
`
`SS:
`
`'
`
`} }
`
`}
`
`STATE OF
`
`COUNTY 01:
`
`'
`
`Acknowledged before me, a Notary Public, within and for said County and State. Witness my hand and Notarial Seal this
`\
`
`., 2004.
`
`day of
`
`
`
`Notary Public
`
`Printed Namc
`
`My Commission Expires;
`
`
`
`\
`
`Resident of
`
`,
`
`County
`
`PAGE 16m * RCVD AT 6512005 2:45:10 PM [Eastern Daylight Time] * SVR:USPT0£FXRF-1l6x DNIS:8?29306* CSID:+* DURATION (mmcs):05-38
`
`_ lnfopia Ex. 1004 pg. 17
`
`t
`
`

`

`06:06-05
`
`l2:48
`
`From-PATTOH BOGGS
`
`_
`
`+
`
`T-124
`
`P.17/20
`
`F-138
`
`IN WITNESS WIJEREOF l have executed this assifinment at 1:41 C'l/GLMZQOC/S'
`".frivwi‘)__ 24
`.2004
`
`this 135—:”day of
`
`Outside the USA:
`
`.
`
`Witness
`
`Witnesses are
`required when
`acknowledgment
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`
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`
`ACKNOWLEDGMENT
`
`
`
`SS:
`
`} }
`
`}
`
`STATE OF
`
`COUNTY OF
`
`Acknowledged before me. a Notary‘Public, within and for said County and State. Witness my hand and Notarial Sea] this
`
`day of
`
`“mm
`
`.2004.
`
`'
`
`Notary Pubiic
`
`Primed Name
`
`My Commission Expires: ,_________~ 4
`
`Resident of
`
`County
`
`PAGE17WRCVDAT6!6!20052:45:10PM1EastemDaylightTime]*SVR:USPTO£FXRF-1!6*DNIS:8729306*CSID:+*DURATIOH(mm-ss):05-38
`
`lnfopia Ex. 1004 pg. 18
`
`

`

`06-08-05
`
`12:48
`
`From-PATTON BOEGS
`
`+
`
`T-124
`
`P.18/Zfl
`
`F-lSB
`
`ASSIGNMENT TO BUSINESS CONCERN
`
`.
`
`O 23“ 3"! - 010 b P TL}. 5
`-.-m.:-=..~y,-.¢ wu—ugggiu‘qgi
`
`ASSIGNMENT
`
`in consideration of the sum of One Dollar (til .00) and other good and valuable
`consideration paid to each of the undersigned,
`
`Name(s) mwflfiwmwfl—
`of Invenmris)W
`
`maker of an invention which is the subject of a United States Patent application entitled
`
`
` Titleof . ‘ ‘ ‘ '. .-‘ . n .
`
`
`
`.
`I ipgmgtcills g; Ambient Temmggmmg
`Application
`
`
`
`
`
`
`
`
`
`
`
`the undersigned hereby sell(s), assign(s), and Set(s) over to
`
`Name of
`Assignee
`
`Address of
`principal
`place of
`business
`
`y
`
`o
`
`ech olo
`
`3 nc..
`
`7 36 Zion '
`
`and
`
`Indianapolis, m @252
`
`Insert State of
`Incorporation
`(if applicable)
`or "Nor Applicable"
`
`Indiana
`
`,
`
`v
`
`(hereinafter designated as the Assignoe) their entire right, title, and interest in, to and under the Application(s), including all priority
`rights for the United States and for Other countries arising therefrom, including any PCT application, all inventions therein disClosed,
`and any and all Letters Patent ofthe United States and of all other com ‘es, including patents issuing through the European Patent
`Organization, which may be granted for Such inventions, or any of them, all such inventions and all rights in such Application(s) and
`Letters Patent to be held and enjoyed by Assignee for its own use and enjoyment to the full and of the term or terms for which such
`Letters Patent may be granted, as fully and entirely as the same would have been held and enjoyed by them had this assigmncnt and
`sale not been made.
`
`The undersigned ogreels) to execute all papers necessary in connection with the Ap