Volume 43
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`Number 2
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`February 2015
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`ISSN 1521-0091
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`DRUG METABOLISM
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`AND DISPOSITION
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`SENJU EXHIBIT 2133
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`LUPIN V SENJU
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`IPR2015-01105
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`SENJU EXHIBIT 2133
`LUPIN v SENJU
`IPR2015-01105
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`DRUG METABOLISM
`
`AND DISPOSITION
`
`it Publication oi the American Society tor Pharmacology and Experimental Therapeutics
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`February 2015
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`Vol. 43, No. 2
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`CONTENTS
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`PERSPECTIVE
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`Mass Cytometry: A Highly Multiplexed Single—CeIl
`Technology for Advancing Drug Development.
`Kondala R. Arkurf. Jefiirey C. Stevens, and Herrdrik
`Nerrbert .
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`SHIJHT l3lJl'o‘lI'rlll|lll0ATl0ll
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`Quantitative Transporter Proteomics by Liquid Chrorna-
`tography with Tandem Mass Speclzrornetry: Address-
`ing Methodologic Issues of Plasma Membrane
`Isolation and Expression-Activity Relationship.
`Virreet Knrnar, Blragwat Prasad, Gabriela Patilea,
`Arrshnl Gupta, Larrrerrt Salpharf, Raymond Evers,
`Corrreiis E. C. A. Hop, and Jaslrvarrr D. Urradkaf.
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`llflTII3l.ES
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`Physiologically Based Pharmaookinetic Modeling to
`Predict Drug—Drug Interactions Involving Inhibitory
`Metabolite: A Case Study of Amiodamne. Hran
`Chen. J'r‘ar'r'n Mao, and Cornelis E. C. A. Hop .
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`. 182
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`Comparison of the Circulating Metabolite Profile of
`Pl-104991532, a Hepatoselective Glucokinase AC~
`tivator, Across Preclinical Species and Humans:
`Potential
`Implications in Metabolites in Safety
`Testing Assessment Raman Slrarnra, John Utcrfifield,
`Arthur‘ Ber'grnan, Karen Atkfnsorr, David Kazrerrrd,
`Sreplrarrie M. Grrstavsan, Li Dr", Jqfi‘i'eyA. Rfizfierkom,
`and Amir S. Katgrrtkar .
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`Zinc Finger Nuclease—Mediated Gene Knockout Results
`in Less of Transport Activity for P-Glycoprotein, BCRP,
`and MRP2 in Caco—2 Cells. Kathleen E. Sarnpsan,
`Anranda Banker‘, Jenrrgter‘ Pratt. Neetrr Verrkatrarrrarr,
`Yorrgling Xiao, Jirn Blasberg. Tani Steiner‘, Maureen
`Bormrer; and David C. Tlrarrrpsan.
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`. 199
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`‘ Characterization of CYPZB6 in a CYP2B6~Humanized
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`Mouse Model: Inclucibility in the Liver by Pheno-
`barbital and Dexamethasone and Role in Nico—
`tine Metabolism In Vivo. Zlirlrrra Lin. Lei Li,
`Hang Wu. J'r'rrg Ha, Jan Ma, Qing-Ya Zlrarrg,
`and Xr'rr).'r'n Ding .
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`. 203
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`Analysis of the Disposition of a Novel p38 MAPK
`Inhibitor, AKP-001. and Its Metabolites in Rats
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`with a Simple Physiologically Based Phanna~
`cokinetic Model. Kazrrhrko Shirota. Makata
`Kaneko, Makata Sasaki, Karachi Minato, Akira
`Fnjikata, Shrrji Ohta, Akihiro Hisakcr. and Hiroslri
`Srrzlrki .
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`21?
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`[:1 Investigation of the Impact of Substrate Selection on
`In Vitro Organic Anion Transporting Polypeptide
`1B1 Inhibition Profiles for the Prediction of Drug
`Drug Interactions. Saki‘ lzrrnii, Yoshirarre Nazaki,
`Kazrrya Maeda, Takafirrni Kornari, Osarna Takenaka,
`Himyrrki Kusrrlram, and Yrriclri Sugfyarna .
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`I3] Mass Spectrometric Evaluation of Mephedrone In
`Vivo Human Metabolism:
`Identification of
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`Including
`Phase I and Phase II Metabolites,
`a Novel Succinyl Conjugate. Oscar‘ J. Pczo,
`Maria Ibanez, Juan V. Sancho. Julio Lar'roz-
`Beneytez, Magi’ Farre’. Esther‘ Papaseit, Rafael
`ale la Torre. and Féltx Herrrcindez .
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`248
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`Drug—Metabolizing and Antioxidant Enzymes in
`Monosodium L~Glutamate Obese Mice. Petra
`Matonikovd, Hana Bcirfikovri, Iva Barrsova,
`Lucie Levarovci. Barbara Szotcfkovcf. and Lenka
`Slca‘lova’ .
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`258
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`3| Renal Xenobiotic Transporter Expression is Altered in
`Multiple Experimental Models of Nonalcoholic
`Steatohepatitis. Mark J. Caner. Rlrianrrorr N.
`Hardwick, April D. Lake, /lnrka L. Dzrerlerrga.
`John D. Clarke, Michael J. Goedken, and Natltarr
`J. Cherarrgtorr .
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`286
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`|§| A Systematic Comparison of the Impact of Inflam-
`matory Signaling on Absorption, Distribution,
`Metabolism, and Excretion Gene Expression and
`Activity in Primary Human Hepatocytes and
`I-lepaRG Cells. Marcus Kleirr, Maria Thontas,
`Ute Hofirrarrn. Daniel Seelrofer, Georg Darnrn,
`and Ulric}: M. Zanger’ .
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`273
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`E3] Absorption, Metabolism, and Excretion of Oral “C
`Radiolabeled Ibrutinib: An Open—LabeI. Phase I,
`Single-Dose Study in Healthy Men. Ellen Sclieers,
`Lauren! Leclerrq, Jan de Jong, Nini Bade. Mare
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`Cements (com ’d.)
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`Bockx, Ali.-re Laenen, Fflip Cuyckens, Domm Skee,
`Joe Murphy, Juthamas Sukbumhemg, and Gee:-I
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`. 239
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`NOTICE OF BETHABTIOH
`Notice of Retraction‘
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`IIIITIIIE [IF IIIIIIBERH
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`Notice of Concern .
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`Supplemental material is available online at http:!.*'drnd.aspetjournals.org.
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`About the cover: Correlation of IL-6-induced gene expression changes in PHH and HepaRG cells. See the article by Klein et al.
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`(dx.doi.orgf 10. 1 l24:'dmd.l 14.060962)
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`Notice of Retraction
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`lmmunohistochemical and functional characterization of
`Re: Kadarn RS, Vooturi SK, Kompella UB.
`peptide, organic cation, neutral and basic amino acid, and monocarboxylate drug transporters in human
`ocular tissues. Drug Merab Dfspos February 2013 4l:466—474; doi:10.l l24.r'dmd.l l2.D45674
`
`The University of Colorado and authors have requested that this article be withdrawn due to data integrity
`problems with some l2C—MS:’MS peak areas in Figure I0 (A-D) and Figure ll (A—C}. The data were found
`to be falsified to improve the differences or kinetics. Dmg Memb Dfspos has retracted this article.
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