`
`UpidnTryin_:t>TunNuldRog:irIeSaos:CannIigI PlanedasBdmessR(maiyF:ilsbMeelMa1(etingExpedflas—Iaimes
`Advenasemenl
`
`-1:.-«lg-.lraoI.uIImM
`
`Join the Grilleys and speak up about your
`advanced prostate cancer symptoms
`
`!.“.!5.'.‘.‘!.‘.!*.9§.!.’§.*'.‘.!’..' %
`-2 an lqnOhdlhn nuuxnn:he
`I-vnnnllnluvovmnmmnu
`
`—
`\'()U.»\RE HERE [AT Home - (‘ofledmns — Rngninc (drug)
`
`Ens Angrlcs Eimrs
`
`U john Tryin to Turn Around Rogaine Sales : Campaign
`Plgumed as Ba dness Remedy Fails to Meet Marketing
`Expectations
`May 29, 1989 I Homassodatedrrm
`
`if-, _wns-~ go
`
`KAlAMAK)0,M’x'd). —WhenRogaimwasImveiledlastSeptanba'byUpjohnCo.asthefiIst
`sdenfifiaflyprownydr-hslmndy,&mfiflmflysBmvi§omd(kspaaebaMi1grmfi1gto
`
` tbdorsforpxeslzilmols.
`
`QC 25y,,_._,,._1;_-1 ._
`
`,_._,
`
`5,409 New
`
`Today,flwseanlyss—aflmnymmmnms—mdkq5admed,a1fiUpjohnkpepafingamw,mm
`aggresiwmrbfiigumpfiyadnaadunnnwhxmhnasammwnswflnglflpfmtlnirhdrbs
`mayhaveprevmtedtlnmfmmtlymgtlndrug.
`
`|"‘°“'|'“3/WCWVFS
`H.;,n,m,,,y,l,5;,m¢u,,|,§..;;.,,,
`
`Upjohnuysflkp|uwdwi&Rogaim3peHoImm2mflblmnsdrIghflmuymflysm—mnnofwbm
`;|'edided1989U.S.sa|eswunldtop$3oomfllion—foImmeaEsficupa1atius.
`
`M“"°89
`
`Sawmmawaysnwess
`Mnymwpmdlnthnnwflnsalesthakogphmdidhthefixstfewnnmhswuflbedeemedm
`outsmllings|Imess,'saidUpjohnspolnsmmanKayeBumat. 'Weupectedtommeedinthelmgrun,
`whilefl|eanalyststhm1gh1itIaouldbearunawaysIwum.'
`
`[bX
`
`My 1 Trick for Hair Loss
`caboki.com
`
`Watch How I Get Full Head of Hair With This 1 Simple Tn’ck. New
`Video
`
`: Dkamohnedwxmmnabomyhawsdmmfisficupanfiombyignfingmjohusmrfingsthm
`“°'ms'°'m's"°m
`Rngaimwuuldn'lwoI‘kforulJst
`
`"vim(d~‘)
`
`TMug1Upjomdo5mtrdease9lsfigm5forqndficpmdud3,dmghflmuymnly$RomH
`NordmamofPaineWd>bunx.esfimateddou|enicsalesfmRogaimaomunmedfor $11 millionofthe
`Kalmnnno-basedmmpanyswssmflliminmtulsforflnfirstthreennmlsofngflg.
`
`WhikRogpim'ssaloswuemmmmdouHethseforflnmumqumaof1988,Nordmmmailhe
`intapretedtlzfigulsasdisappoiming.
`
`'I1nproducthasoertainlybeenslowoutoffl)estattinggate,'hesaid.
`
`11n'eammnyrewomhrRogdm%dug3shsd5,leswdmsaMhfir4o$spedaH§ssay.Amng
`them:
`
`— Upjohn's &monflro|d, $2o—nifli>nadverfi§ngcanq)aign,featmhgaunnwalki1gahngabeachvfiflx
`the'seeyaur<b\1o1‘phrme,mayhavebeentookm—|2yandvague.
`
`-Thep|im,flmm$5ofmaom-nnmhsqsplyunlthemnmaryfifdongmnmfimmnmfisme.
`
`-()meyoustopusingRogaim,anyhah'youuuyhaveguwnbackwfllfalloIn. lfthedrugllasstopped
`yuurhairlos,ynu‘llmals2upforlostti|musoonasyuuquit.
`
`Mo$bafihg,hmwu,ismAmmpamesfemmhghgmbaHmsstmndismmemgntdevi§on
`fltpcIIalicles.limes wN1§D—(5-3u5iImsM—fl4_1_Inm'resds—Mr-loss-uemlwfiaudnmmawmamaewrm
`
`1I3
`
`Page 1 of 3
`
`SENJU EXHIBIT 2310
`
`LUPIN v. SENJU
`
`IPR2015—0ll00
`
`
`
`2/10/2016
`
`Upjohn Trying to Turn Around Rogaine Sales : Campaign Planned as Baldness Remedy Fails to Meet Marke ing Expectations - latimes
`
`continue to outsell Rogaine by a ratio of about 10 to one, said Mike Mahoney, president of the American
`Hair Loss Council.
`
`"The biggest deterrent to Rogaine is that the man has to go to his doctor and admit that he is not
`comfortable with his hair loss. With the others, he can call a 1-800 number from the privacy of his own
`home," said Mahoney, whose nonprofit organization provides consumer information on hair-loss
`treatments.
`
`Upjohn's new marketing campaign will feature a toll-free number. The consumer will be connected with a
`hair-care specialist to discuss Rogaine and then will receive information on Rogaine via mail.
`
`Like the previous ads, Upjohn still won't refer to the drug by name. Food and Drug Administration
`regulations prohibit companies from advertising prescription drugs by name unless there also is a full
`disclosure of any warnings and potential side effects.
`
`Expectations Too High
`
`The company has released few details about its new marketing strategy, but says it's designed to identify
`and target the market for the drug, which was approved by the FDA last August.
`
`Though analysts see the new campaign as Upjohn's reaction to slow sales, the company insists that the
`more aggressive campaign always was part of its marketing strategy.
`
`Some of the blame for disappointment with Rogaine's results also lies with the consumer, who may have
`been expecting too much. Upjohn warned consumers from the start that the tonic wouldn't work at all for
`most men.
`
`Rogaine, the trade name for a substance called minoxidil, is recommended for men younger than 40 who
`have been losing hair for 10 years or less and who have an area of baldness 4 inches in diameter or less on
`the crown of the head.
`
`Clinical trials showed about 39% of men suffering from male-pattern baldness will grow some new hair
`back or stop losing hair after six to eight months on the drug.
`
`"If you're going to use this stuff, you've got to be patient and use it for a year," said Dr. David Whiting,
`medical director of the Baylor (University) Hair Research and Treatment Center in Dallas. "Otherwise,
`you'll never know if it would have worked."
`
`Bert Camp, a railroad engineer in Mineola, Tex., saw results after about three months on Rogaine.
`
`"Since I started using it, I've definitely seen some new hair growing," said Camp, 46. "And for 10 years, I've
`been using everything that I could get my hands on to stop hair loss."
`
`More Effective on Women
`
`Still, Camp said Rogaine was "too expensive, especially since I'm going to have to use it for the next 20 or
`30 years."
`
`At the 2,270-store Rite Aid pharmacy chain in Harrisburg, Pa., a spokeswoman said Rogaine sales had been
`slower than expected.
`
`Rogaine may almost double its market if the FDA approves it for use by women. Of the 50 million
`Americans losing their hair, 20 million are women, and clinical trials have found the drug to be slightly
`more effective on women, Bennett said.
`
`Upjohn also is working on advanced application methods for the alcohol-based solution, which tends to be
`messy to apply, as well as teaming up with Procter & Gamble Co. on new ingredients designed to increase
`efficacy and to create new minoxidil products, such as a cream.
`
`http://ar icles latimes.com/1989-05-29/business/fi-774_1_rogaine-sales-hair-loss-treatments-upjohn-spokeswoman-kaye-bennett
`
`2/3
`
`Page 2 of 3
`
`
`
`2I1(YJ)16
`
`Upjdn Trying b Tun Arotnd Regine Sdes : Canpa'g1 Plamed 3 Bdthess Remedy Fdls to Meet Make my Expecfliols - ldimes
`
`E ‘_EJnI flame
`
`6.1
`
`o
`
`MORE:
`SeizureIedtoHoJo'sDeath
`
`His1o4scor5ma|'ehiscase
`
`Restaurant review: South Bevuly Grill
`
`Brutal Murderby Teen—Age Girls Adds to Britons‘ Shock
`
`(‘nmaneci Confirms Suicide Attempt, Magaine Says
`
`1105 Anneles Cimes
`
`mpdlz ides Ia?mes.oomI1QIEHISBlhnsinesslli—774_Lrogirrrsdes-h:ir—loss—tedrImisrqjdnspdteswanarkayebaI\at
`
`Page 3 of 3