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`LUPIN V. SENJU
`IPR2015-01100
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`SENJU EXHIBIT 2133
`LUPIN v. SENJU
`IPR2015-01100
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`

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`DRUG METABOLISM
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`AND DISPOSITION
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`A Publication at the American Society tar Pharmacology and Experimental Therapeutics
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`February 2015
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`Vol. 43. No. 2
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`CONTENTS
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`PERSPECTIVE
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`Mass Cytometry: A Highly Multiplexed Sir1gle—Cell
`Technology for Advancing Drug Development.
`'_'1mndal'a R. Atkarf. Jefirey C. Stevens, and Herrdrik
`Nenberl‘ .
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`SHORT COMMUNICATION
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`Quantitative Transporter Proteomics by Liquid Chroma-
`tography with Tandem Mass Spoctr0I'nelIy: Address-
`ing Methodologic Issues of Plasma Membrane
`Isolation and Expression-Activity Relationship.
`Vfrreet Knmar, Bhagwar Prasad, Gabriela Pafilea,
`Arrshrrl Gupta, Lauren! Salphari, Rayrnond Evers,
`Comelis E. C. A. Hop. and Jaslrvanl‘ D. Unadkar. .
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`llflTlCl.ES
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`Physiologically Based Pharrnaookinetic Modeling to
`Predict Drug—Dr'ug Interactions Involving Inhibitory
`Metabolite: A Case Study of Amiodarone. Hrarr
`Chen. Jialirr Mao, and Carnelis E. C. A. Hop .
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`. 182
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`Comparison of the Circulating Metabolite Profile of
`Pl-104991532, a Hepatoselective Glucokinase AC~
`tivator, Across Precl.inica.l Species and Humans:
`Potential
`Implications in Metabolites in Safety
`Testing Assessment Roman Snarnra, John Lftclrfleld,
`Arflrrrr Bergrrrarr, Karen Atkfnsott, David Kaaemd,
`Stephanie M. Grrsravsan, Li Di, Jefr'e3JA. Ifefierkom,
`and Arnif S. Kalgnrkar.
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`19!]
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`Zinc Finger Nuclease—Mediated Gene Knockout Results
`in Loss of Transport Activity for P-Glycoprotein, BCRP,
`and MRP2 in Caco—2 Cells. Kathleen E. Scnnpsrm,
`Anrrmda Brinker; Jenr1&‘erPran'. Neeni ‘Venlratraman,
`Yartgtfrtg Xiao, Jirrr Blmberg Tani Steiner‘, Maureen
`Barrrner; and David C. Nranrpsan.
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`. 199
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`‘ Characterization of CYPZB6 in a CYP2B6~Humanized
`Mouse Model: Inducibility in the Liver by Pheno-
`barbital and Dexarnethasone and Role in Nico—
`tine Metabolism In Vivo. Zhilnra Lin. Let’ Li,
`Hang Wu. Jing Hn, Jun Ma, Qing-Ya Zlrarrg,
`and Xr'n).'r'n Ding .
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`ZOO
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`Analysis of the Disposition of a Novel p38 MAPK
`Inhibitor, AKP-001. and Its Metabolites in Rats
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`with a Simple Physiologically Based Pharma-
`cokinetic Model. Kazirhiko Shirora. Mrrkara
`Kaneka, Makata Sasaki, Kouichi Minato, Akira
`Fnjikarn, Shaft‘ Ohm, Akihiro Hisakrr. and Hiroshi
`Strzrtki .
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`. .. 217
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`5] Investigation of the Impact of Substrate Selection on
`In Vitro Organic Anion Transporting Polypeptide
`1B1 Inhibition Profiles for the Prediction of Drug-
`Drug Interactions. Saki Iznmi, Yoslrirarae Nazaki,
`Kaznyrt Maeda, Takafiimi Komori, Osnmrr Takerraka,
`Hirayrrki Knsnlrara, and Ynicfri Srrg1'j=arrra .
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`IS] Mass Spectrornetric Evaluation of Mephedrone In
`Vivo Human Metabolism:
`Identification of
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`Including
`Phase I and Phase II Metabolites,
`a Novel Succinyl Conjugate. Oscar‘ J. Pozo,
`Maria Ibririez. Juan V. Saricho. Julio Lalr0z-
`Beneytez, Magi’ Farre’. Esther Papaseir, Rafael
`de la Torre, and Félix Herrrcfndez .
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`Drug—Metab0lizing and Antioxidant Enzymes in
`Monosodium L—Glutamate Obese Mice. Petra
`Matozrikovti. Hana Brir'tr’kovri, Iva Boniovd,
`Lucie Levorowf. Barbara Szotdkovrf. and Lenka
`Skalowi .
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`. 258
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`5| Renal Xenobiolic Transporter Expression is Altered in
`Multiple Experimental Models of Nonalcoholic
`Steatohepatitis. Mark J. Caner. Rlricrnrron N.
`Hardwick, April D. Lake, Anika L. Dzjerlenga,
`John D. Clarke, Michael‘ J. Goedken, and Nathan
`J. Cherrirrgfarr .
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`. 255
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`[El A Systematic Comparison of the Impact of Inflam-
`matory Signaling on Absorption, Distribution,
`Metabolism. and Excretion Gene Expression and
`Activity in Primary Human Hepatocytes and
`I-lepaRG Cells. Marcus Klein, Maria Thontas,
`Ute Hofinann. Daniel Seelrofer, Georg Danrrrr,
`and Ulrich M. Zanger .
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`Es] Absorption, Metabolism, and Excretion of Oral “C
`Radiolabeled lbrutinib: An Open—Label. Phase I,
`Single-Dose Study in Healthy Men. Ellen Scheers,
`Lauren! Leclercq, Jan de Jarrg, Nr'nr' Bode, Marc
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`Corrtirrrred on next page
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`Confems (com ’d_)
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`Bockx, Aline Laenerr, Filip Cuyckens, Danna Slcee,
`Jae Murphy, Jurhamas Sukbunthemg, and Gear:
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`NOTICE 0|’ IIETHICTIIIH
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`_ 239
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`Notice of Retracuon.
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`IIIITEIIE IJF IIIIIIIIEIIH
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`Notice of Concern .
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`Supplemental material is available online at http:/ldrnd.aspetjournals.org.
`
`About the cover: Correlation of IL-6-induced gene expression changes in PHH and HepaRG cells. See the article by Klein el al.
`(dx.doi.orgI‘10. l l24fdrnd.l E4-060962)
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`Page 3 of 4
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`

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`Notice of Retraction
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`Re: Kadarn RS, Vooturi SK, Kompella UB. Immunohistochemical and functional characterization of
`peptide, organic cation, neutral and basic amino acid, and monocarboxylate drug transporters in human
`ocular tissues. Drug Metab Dispos February 2013 4l:466—474; doi:l0.1124fdmd.1l2.D456?4
`
`The University of Colorado and authors have requested that this article be withdrawn due to data integrity
`problems with some l£—MSfMS peak areas in Figure I0 (A-D) and Figure ll (A—C}. The data were found
`to be falsified to improve the differences or kinetics. Drug Memb Dfspos has retracted this article.
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