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`STEPHEN G. DAVIES D.PHIL.
`
`would a person of ordinary skill
`
`in the art
`
`consider which ingredients had already been
`
`used in approved ophthalmic solutions
`
`MS. LEBEIS Objection. Calls for
`
`speculation.
`
`A
`
`I
`
`think it
`
`depends entirely on the
`
`material
`
`they try to formulate.
`
`Q
`
`What
`
`--
`
`can you give me some examples
`
`of what
`
`factors it would depend on in terms of
`
`whether
`
`a person of skill
`
`in the art would
`
`consider using ingredients that had already
`
`been used and approved in ophthalmic solutions
`
`A
`
`Well materials end up being approved
`
`because
`
`theyre put
`
`into a formulation that
`
`is
`
`then approved by the FDA and then any
`
`ingredient gets added to the list.
`
`So you can
`
`actually use any set of
`
`ingredients you like
`
`provided you can persuade -- or provided the
`
`FDA are confident
`
`in the end that thats a good
`
`medication.
`
`Q
`
`And if
`
`a formulator faced with the
`
`task of
`
`formulating an ophthalmic solution has
`
`the choice between two ingredients one of
`
`which has been previously approved in an
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`STEPHEN G. DAVIES D.PHIL.
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`ophthalmic
`
`formulation by FDA and one which is
`
`not which one would the formulator prefer
`
`MS. LEBEIS Objection.
`
`Incomplete
`
`hypothetical. Calls for speculation.
`
`A
`
`I have no idea.
`
`I guess
`
`it would
`
`depend on the formulator and on what
`
`theyre
`
`trying to formulate.
`
`Q
`
`You would agree though that
`
`if
`
`a
`
`formulator faced with the task of
`
`formulating
`
`an ophthalmic solution has the choice between
`
`two ingredients one of which has been
`
`previously approved in an ophthalmic solution
`
`and one which has not
`
`there are fewer
`
`regulatory hurdles involved in using the
`
`ingredient
`
`that has been previously approved by
`
`the FDA right
`
`MS. LEBEIS Objection asked and
`
`answered
`
`I dont.
`
`18
`
`19
`
`21
`
`22
`
`23
`
`24
`
`25
`
`--20A
`
`MS. LEBEIS
`
`-- assumes facts not
`
`in
`
`evidence
`
`and incomplete hypothetical.
`
`A
`
`I dont
`
`know thats true that
`
`its
`
`easier
`
`to get
`
`it approved.
`
`Q
`
`Have
`
`you had any experience trying to
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`STEPHEN G. DAVIES D.PHIL.
`
`get ophthalmic solution formulations approved
`
`302
`
`by FDA
`
`A
`
`Q
`
`No.
`
`Have you had any experience trying to
`
`get pharmaceutical
`
`formulations approved by
`
`FDA
`
`A
`
`Is that
`
`a different question to the
`
`one previously
`
`Q
`
`A
`
`to me.
`
`Yes.
`
`Maybe you can
`
`repeat
`
`them both back
`
`Q
`
`I
`
`think you answered the first
`
`one.
`
`The second question was have you had any
`
`experience trying to get pharmaceutical
`
`formulations approved by FDA
`
`A
`
`Q
`
`No.
`
`Have you had any experience trying to
`
`get ophthalmic
`
`formulations approved by a
`
`European regulatory authority
`
`A
`
`Q
`
`No.
`
`Do you know what studies need to be
`
`submitted to FDA with respect
`
`to ingredients in
`
`an ophthalmic pharmaceutical
`
`formulation
`
`MS. LEBEIS Objection.
`
`No
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`
`STEPHEN G. DAVIES D.PHIL.
`
`foundation. Calls for speculation.
`
`I wasnt asked to consider
`
`that so
`
`Have
`
`you ever published a paper on
`
`no.
`
`A
`
`Q
`
`NSAIDs
`
`A
`
`I dont
`
`recall.
`
`I may well have done
`
`it
`
`in the 560-plus.
`
`Q
`
`But you cant
`
`recall specifically any
`
`paper related to on work
`
`on NSAIDs
`
`MS. LEBEIS Objection asked and
`
`answered.
`
`A
`
`I cant
`
`recall.
`
`MS. RAPALINO
`
`I have no further
`
`questions.
`
`MS. LEBEIS
`
`We have just a few
`
`questions
`
`on redirect.
`
`EXAMINATION BY COUNSEL
`
`FOR PLAINTIFFS
`
`BY MS. LEBEIS
`
`Q
`
`So Dr. Davies
`
`do you remember
`
`that
`
`Ms. Rapalino was asking you some questions
`
`earlier regarding your definition of
`
`a person
`
`of ordinary skill
`
`in the art
`
`A
`
`Q
`
`Yes.
`
`So lets turn to that section of your
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`304
`
`STEPHEN G. DAVIES D.PHIL.
`
`report which I believe is Davies Exhibit 1.
`
`A
`
`Q
`
`Okay.
`
`In particular paragraph 11.
`
`In setting forth your definition of a
`
`person of ordinary skill
`
`in the art did you
`
`consider
`
`the patents-in-suit
`
`MS. RAPALINO Objection leading.
`
`A
`
`I had read the patents-in-suit.
`
`Thats the first
`
`thing I did.
`
`So would have
`
`considered them when
`
`formulating the paragraph
`
`on person of ordinary skill
`
`in the art.
`
`Q
`
`And what
`
`is your definition of a
`
`in the art
`person of ordinary skill
`Its in paragraph 11. As of
`
`A
`
`January 21st 2003 a person of ordinary skill
`
`in the art would have had at
`
`least a bachelors
`
`degree in a field such as pharmaceutical
`
`chemistry chemistry or a related discipline
`
`with about
`
`three to five years of work
`
`experience in this area or comparable level of
`
`education and training.
`
`Q
`
`A
`
`What
`
`is a related discipline
`
`Anything that
`
`is relevant
`
`to the
`
`science being considered.
`
`So in this case it
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`STEPHEN G. DAVIES D.PHIL.
`
`would be -- since the patents are to do with
`
`aqueous
`
`liquid formulation it would be things
`
`like formulation.
`
`Science would be in there.
`
`305
`
`I guess
`
`toxicology would also be in there if
`
`theres any toxicological effects.
`
`Those sort
`
`of areas.
`
`Anything that relies on -- anything
`
`that relies on chemistry as a part.
`
`So
`
`formulation science for example relies on
`
`in
`
`5
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`21
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`22
`
`23
`
`24
`
`25
`
`--10significantly on chemistry as shown
`
`Dr. Lawrences
`
`report.
`
`MS. LEBEIS
`
`Thank
`
`you.
`
`We have no
`
`further questions.
`
`MS. RAPALINO
`
`Thank you Dr. Davies.
`THE VIDEOGRAPHER Were going off
`
`the record at 521 p.m.
`
`Signature having not been waived
`
`the
`
`deposition of Stephen G. DAVIES D.Phil. was
`concluded at 521 p.m.
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`STEPHEN G. DAVIES D.PHIL.
`
`306
`
`J U R A T
`
`I
`
`STEPHEN G. DAVIES D. PHIL.
`
`do hereby
`
`certify under penalty of perjury that
`
`I have read
`
`the foregoing transcript of my deposition taken
`
`on February 22 2016 that
`
`I have made such
`
`corrections
`
`as appear noted herein in ink
`
`initialed by me that my testimony as contained
`
`herein as corrected is true and correct.
`
`Signature
`
`Dated
`
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`STEPHEN G. DAVIES D.PHIL.
`
`C E R T
`
`I F I C A T E
`
`307
`
`DISTRICT OF COLUMBIA
`
`I MICHELE E. EDDY
`
`shorthand reporter
`
`do hereby certify that
`
`the witness whose
`
`deposition is hereinbefore set
`
`forth was duly
`
`sworn and that such deposition is a true
`
`correct
`
`and full
`
`record of
`
`the testimony
`
`given.
`
`I
`
`further certify that
`
`I am not
`
`related
`
`to any of
`
`the parties to this action by blood or
`
`by marriage and that
`
`I
`
`am in no way
`
`interested
`
`in the outcome of
`
`this matter.
`
`IN WITNESS WHEREOF
`
`I have hereunto set
`
`my hand this 25th day of February 2016.
`
`MICHELE E. EDDY Shorthan Reporter
`
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`308
`
`STEPHEN G. DAVIES D.PHIL.
`
`NAME OF CASE
`
`SENJU V. BAUSCH
`
`LOMB et al.
`
`DATE OF DEPOSITION
`
`February 22 2016
`
`1.
`
`2.
`
`3.
`
`To clarify the record.
`
`To conform to the facts.
`
`To correct
`
`transcription error.
`
`Page
`
`From
`
`Page
`
`From
`
`Page
`
`From
`
`Page
`
`From
`
`Page
`
`From
`
`Page
`
`From
`
`Line
`
`Line
`
`Line
`
`Line
`
`Line
`
`Line
`
`Reason
`
`to
`
`Reason
`
`to
`
`Reason
`
`to
`
`Reason
`
`to
`
`Reason
`
`to
`
`Reason
`
`to
`
`STEPHEN G. DAVIES D.PHIL.
`
`SUBSCRIBED
`
`AND SWORN
`
`TO BEFORE ME
`
`THIS
`
`DAY OF
`
`2016.
`
`Notary Public
`
`My Commission expires
`
`The Little Reporting Company
`646 650-5055 I www.littlereporting.com
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`Page 308
`
`
`
`A
`a.m 26 93 5725
`584 10624 1073
`AB 1722 1810 195
`abbreviated 15511
`Abe 45 103
`ability 11910 1217
`12115 12219
`14515 14823
`1498 1515 1528
`15221
`able 10218 11520
`1173 13620 1496
`1732 2653
`absence 10923 1254
`1401325 19118
`absolute 1835
`absolutely 8225
`1079
`absorption 21518
`abstract 8958
`18512 1867911
`197112025 1985
`1981114
`academia 3611
`academic 36512
`3713 3818
`acceptable 4715
`1971322
`Accepted 819
`accurately 158
`Acetanilide 717
`acetanilides 619
`2806 2885 28922
`28924
`acetic 23925
`acid 617 711 810
`816 4714 78268
`781323 796 829
`8651419 873
`12024 137423
`13810 14412
`1616 1696911
`18524 1899 2064
`2096 2402 2503
`29813
`Acid-catalysed 716
`
`acidic 78 881124
`8911 90322 9723
`10113 119318
`15815 1594 1604
`16020 16825
`16958 17112
`20061118 20169
`acids 77 1052
`acronyms 23515
`act 1048
`acting 8017 1044
`action 14 7920 809
`10413 1213
`1261422 30712
`active 621722 802
`8016 9614 9717
`9913 1383 14213
`1431123 15811
`19615 21511
`2162223 21714
`21920 22012
`22424 22623
`2273 23121
`actives 22418
`activity 12712
`13513 1382
`19517
`actual 406 8220
`1212 14217 1463
`15091123
`acyl 2807 28225
`acylanilide 2908
`add 14923
`added 17415 30017
`adding 1.5020
`15118
`addition 23925
`2404923 24178
`26914
`Additionally 20321
`address 494 989
`25914
`addressed 713 1004
`100613 1259
`addressing 499
`9812 1009
`adjusted 15022
`
`adjusting 2372
`administration 4717
`4825 6311
`advantage 263912
`2632224
`advantages 26316
`adverse 20712
`affect 19020 26922
`29714 29817
`Affidavit 68
`agent 646 10213
`20514
`agents 7914 20489
`21511
`agree 7725 916
`9222 9817 10019
`10120 1023 1106
`11019 1114
`11223 113913
`11819 12016
`12821 13520
`13820 1487
`16012 16111
`16220 16424
`16514 16712
`17321 1747 1767
`17913 180919
`1946 2001023
`20138 2171025
`21822 2191415
`22020 2244
`22919 24013
`24118 24519
`24818 2579
`25922 2602
`26424 27223
`27316 27524
`27612 3019
`agreed 2766
`agreement 107
`Ahmed 79
`aim 1138
`al 977 1722 1810
`195 21510 29619
`29623 3082
`Alcon 8815 1298
`13071217
`
`309
`
`alkaloid 409
`alkaloids 3321
`alkyl 24769
`alkylphenol 21512
`2167
`Allergan 15622
`1576
`allow 13712
`allowed 337
`Alston 4614 102
`alter 27018 2712
`altering 27112
`altogether 17410
`Aman 79 2871518
`28725
`ambiguous 177
`2921 3025 323
`46211 5212 5816
`5914 60220 616
`6211 638 86822
`879 9413 11419
`1237 12612 1292
`1538 204212142
`2162 2661622
`2671825 26814
`26825 2699 2734
`27320 27413
`27811 2804
`29311 2943
`amendment 16423
`amide 27821
`amines 10824
`10912 12419
`1408 19112
`Amino 810
`ammonium 642023
`6529131820
`666 905 975
`9924 1095 11810
`11825 13124
`1322122 137724
`15519 1565 1583
`17631623 17727
`17710 17812
`185925 1885
`1895 19822
`215151622
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`
`
`21613 2301115
`23317 24041023
`24024 24148917
`242418 24622
`29018 2921318
`2922122 29312
`29314
`amount 1217 8321
`1029 27113
`analogy 29320
`analysis 679 7120
`7231523 73925
`74101213 7527
`7519 7925 8219
`846 132101317
`13223 13351014
`1941724 23024
`2316 24315
`25015 2531011
`25317 2701016
`analytical 1484
`analyze 4723
`analyzed 2412 2953
`Andrew 721
`Angeles 49
`anilide 2908
`anilides 622 7612
`2822424 28525
`28623 28868
`anilines 77 2807
`28225
`anion 2452125
`24619
`anionic 8019 1353
`13511 136513
`14415 15613
`16113 1641522
`16517 167624
`168811 16913
`18121 18820
`19913 200410
`202451818
`23123 232412
`2332
`answer 1117 1820
`441414 483 5425
`5615 7425 756119
`
`777 9821 11247
`11617 13111
`13414 165711
`166211161719
`16625 19211
`20925 24611
`269419 27913
`28119
`answered 2114 234
`2310 2418 254
`369 4412 535
`55618 5641425
`57617 7019 727
`73224 7481722
`75617 765 7816
`8513 8623 93725
`955617 9714
`10423 10514
`10615 10915
`11024 11111
`11218 1149 1153
`11511 1161224
`1201121 122522
`13216 13313
`13523 13616
`13717 13817
`1598 160824
`16119 1621011
`16716 1756 1774
`17725 18312
`18720 19423
`19620 19813
`20722 208717
`209414 21216
`21341018 22413
`22525 22614
`2271119 22812
`2281824 2297
`2314 24822
`24916 25122
`2681425 269910
`27015 2716
`27618 2783
`28814 30119
`30213 30312
`answering 1129
`1348 1656110925
`
`1665622 17911
`answers 102525
`
`anti-inflammatory
`2725 2824 3220
`347 4713 4816
`791320 1375
`antimicrobial 17021
`171314 1729
`1733 2047
`
`antimicrobially
`18515
`antioxidant 26915
`26922 27036
`anybody 1271019
`8221 107111315
`anyway 1869
`apart 144 2320
`2424 3513 13325
`13410
`apologize 4516
`apparently 22419
`24018
`appear 2256 24324
`24425 25822
`30614
`appearances 921
`appears 9624 2258
`appendix 2614
`3917 8311 2365
`236131924
`2371017 238812
`238142023
`applicant 1303613
`15621
`application 517
`1541723 15522
`15523 15622
`17018
`appointment 3819
`approach 813
`appropriate 6624
`2552
`approved 1941420
`253813 300413
`300141625
`301131624 3022
`30261619
`
`310
`
`approximately 2411
`April 19514
`aqueous 78 4712
`4811 1862 20524
`2062 2721623
`2731418 27523
`276315 278914
`3053
`area 293 30421
`areas 3057
`Aree 817 2972024
`2987
`argumentative 377
`49716 50822
`5115 5219 535
`564 7422 7712
`10224 1062
`13016 13313
`16615 183312
`207622 208717
`209414 2109
`23215 23313
`2383 26710 2688
`26815 280419
`28310 29911
`arguments 1725
`arms 25524
`aromatic 86 29616
`2992
`arrived 1973
`art 4622 4723567
`5025 5135912
`5122 52825 5316
`542616 55313
`551524 561021
`5713 67112124
`6881318192122
`699171824 703
`70710172025
`71712131622
`724111424 734
`7311918921 7436
`741519 7541422
`7523 76224 772
`8518 86317 875
`10421417 10558
`10521 10611
`
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`
`
`116619 117716
`14916 1502 1527
`17322 1825610
`2122121322
`22920 23125
`2321022 251210
`25115 252623
`25319 25415
`25510 26315
`26516 27513
`28015 281620
`29351523 2996
`300211 30323
`3046121417
`art 673
`article 6101721 75
`71115 85914
`279617 28613
`28817 2893813
`29022 2951924
`296181923
`2972024 298710
`29815 2994
`ary1274151822
`2759 2768 29511
`29813
`asked 2113 239
`2417 253 369
`4411 4515 4619
`4722 5342124
`54111322 5558
`5517 5641324
`5725 7019 726
`7225 7323 74716
`7421 75616 764
`7815 84142224
`8512 8622 93624
`95416 9713
`10422 10513
`10614 10914
`11023 11110
`11217 1149 1152
`11511 1161124
`1201020 122521
`13216 13312
`13523 13615
`13716 13816
`
`1598 160824
`16119 1621011
`1638 16618
`16716 1756 1773
`17725 18312
`18720 19422
`19619 19719
`19812 20722
`208717 209414
`21215 2134917
`22412 22524
`22613 2271019
`228121723 2296
`2314 24822
`24916 25121
`268913161725
`26929 27015
`2716 27617 2782
`2856 28813
`30118 303311
`asking 1023 4616
`561819 639 689
`6810 7424 7811
`7812 9313515
`9511 9644 977
`1053 1128 11618
`1654 16721
`2222225 22423
`2384 24825 2492
`2681718 2857
`30321
`aspects 4011 7521
`asserts 13521
`assessing 26612
`26841122 2696
`assigned 8814
`20316
`association 15814
`1593
`assume 11 17 9117
`9520 965 12214
`1239 1481011
`1872
`assumes 30121
`assuming 9923
`2089 225112267
`assumption 9523
`
`963 12213 1386
`22520 29214
`AstraZeneca 1722
`1724 181013 194
`197
`asymmetric 3625
`3810 3922
`Atlanta 310
`attached 511 1418
`8716 11723
`12914 15420
`18417 19310
`1955 2033 21418
`22916 23324
`24720 26020
`27921 28617
`28722 28823
`28916 29114
`2967 2973 2984
`ATTENDANCE 42
`attention 1178
`attests 2363
`August 818
`aureus 1037
`author 15220 25123
`26017
`authored 4025
`authority 228915
`22821 30220
`authors 11119
`17913 18723
`20918 210515
`available 5825
`13725 14912
`1897 24424
`25116
`Avenue 210 914
`avoid 27325 27416
`avoided 21614
`avoiding 2168
`avoids 21513
`awarded 3310
`aware 823 86216
`134211 25016
`25815
`
`B
`B 510 2614 17013
`
`311
`
`17024 171722
`1722025 1736
`17411
`b-cyclodextrin 815
`B.W 623
`BA 27381722 282
`BAC 90722 10419
`1059 10922 1108
`11824 1191017
`1216 12410 125 3
`1251325 13116
`1352911 1365913
`1377 13912
`15515 156412
`16414 16515
`16723 17917
`181521 1861923
`18771317 18819
`1895 20217 2048
`20615 20919
`21025111316
`2116920 21212
`21223 218323
`21981722 2203
`2201123 22118
`23019
`bachelors 517
`30417
`back 583 6716
`107217 128711
`13422 14821
`1508 15411
`15620 15715
`15917 1648 1793
`1978 2041623
`21411 22025
`2222 2454 25213
`25216 2725
`27521 2847
`29921 30211
`background 8918
`902 10416 1056
`10720 11310J4
`11323 114711
`11557 116719
`backup 15822
`balance 15022 2462
`
`The Little Reporting Company
`646 650-5055 1 www.littlereporting.com
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`Page 311
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`
`
`Banner 1917
`Barnett 717 2898
`28912
`base 7723
`based 5220 757
`13310 26524
`29317
`basic 1022 29615
`basically 21025
`21114
`basis 363 454 568
`7617 9018 9218
`9778 12014 2117
`23025 2638 2846
`Bausch 1910 1011
`3082
`bearing 6720 28614
`29111 2964
`bears 27918
`beginning 945 1315
`2176 23820
`begins 9215 10312
`11817 1904
`20122
`behalf 3514 44
`923 1010 1525
`166911 211116
`behaved 307
`belaboring 1021
`believe 13923 1514
`222023 2612
`3511 3720 382
`499 5717 6617
`6724 6812 7917
`8724 10012
`10520 1093 1126
`13417 1423
`15513 15713
`16622 19512
`2083 2099 2124
`212212219
`27517 28622
`2884 2978 3042
`believed 2115
`21212
`benefit 265317
`benzalkonium 6417
`
`6422 65425 865
`861419 873 906
`927 93A20 9514
`9522 9691518
`97111824 9816
`9825 10121 1025
`1021421 10317
`10324 1043 1052
`10722 1098
`11820 12025
`12314 13123
`132424 13316
`134412 13811
`1458 14724
`1521117 15814
`1593 160520
`161513 162222
`16315 1675 1692
`170111925
`1711224 17324
`17325 17491619
`1742325 17512
`1768 17817
`18112 1829
`18318 1844 1884
`18811 19517
`1971524 19868
`19821 19911
`200162325 2014
`20159 2023
`20717 2097 2175
`21713 22251421
`22223 223313
`2246 23014
`23110 232412
`2333117 24120
`24289212449
`246725 2476
`291182123 2922
`29271724 293A7
`29317
`benzene 2715
`benzoic 816 29813
`benzyl 13221 15519
`242418 24622
`292131821
`29312
`
`benzyl-lauryl-dime...
`155810
`Benzylpenicillin 712
`best 1469
`better 3424 2079
`26521
`BHT 270471124
`27188
`billions 12214
`biologically 809
`19615
`Bird 4614 102
`bit 9124 2755
`blood 30712
`board 3518
`body 1982
`bonding 1132 1263
`14115 1928
`book 19617
`Boston 320
`bottom 175 23
`18724 21616
`23924 2959
`Boulevard 415
`bound 21141725
`21314
`box 15017
`boxes 14210 1444
`brand 2112 224
`break 115 572021
`10620 10771115
`1471517 15435
`214567 2712123
`29916
`breaks 114
`Breslow 2951923
`2964
`brief 582 10625
`19614 21410
`2724 29920
`British 1736
`broad 2034 2813
`2959 944 13525
`136312 2047
`23115
`broadest 257 2613
`broadly 1293
`
`312
`
`bromfenac 4715
`77182325 78512
`7981218 8019
`827 8519 10020
`10022 1015616
`169813 19017
`21323 236425
`23911 24028
`241720 242713
`2421721 24318
`24489 245916
`2465618 248619
`24824 24912
`252624 2534
`28522 2865 2926
`29512 29611
`2971015 29811
`298121718 2995
`2998
`bromophenyl 29512
`Bronuck239610
`24861318 24924
`2496712
`Brown 79 2871518
`28725
`bulk 16217 20520
`Butylated 2705
`by-products 2953
`
`C
`C 33 3917 21616
`21620 217723
`21812 22579
`30722
`C1100 6225 6313
`caffeine 102910
`10314 1041113
`calcium 2066 21324
`California 49
`call 3018 8725
`19317
`called 314 6225
`19214 23417
`calls 2215 4611
`49716 6712 682
`6814 6911 7011
`7018 71924 727
`7417 76515 774
`
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`646 650-5055
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`
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`313
`
`88619 1131819
`11611122325
`11713 1309 1328
`1474 157311
`158518 1597
`160723 16118
`1628 1755 18319
`1848 1854 19415
`19611 20112
`2058 20923
`21325 22718
`228611 22922
`230422 2313
`240112474 2487
`24821 25013
`25119 25725
`25825 26418
`26518 2664 2673
`27014 2715
`27516 28218
`2942 3005 3015
`3032
`Campbell 2951923
`2964
`Carbohydrate 820
`carbohydrates 3321
`carbon 2924
`carboxyl 904 9724
`carboxyl-containing
`2063
`
`carboxyl-group-co...
`9023
`carboxylate 9924
`carboxylic 77 7868
`781322 796 865
`861419 873
`12024 137423
`13810 14412
`1616 1696911
`18524 1899
`
`carboxylic-acid-co...
`13912
`career 361113
`3713 399 4316
`442124 26612
`26716
`Carolina 416
`
`carry 2004612
`charged 11911
`29313
`case 99 1223 133
`12117 15891015
`cause 12125 1354
`1594 2001724
`1311 1421 15923
`13512 1535
`201257 2925
`15614 16416
`1621924 171013
`chart 2442
`16519 1677 1683
`172123 183511
`check 265 958
`18111619 19410
`19914
`1962 2339 27914
`19161922 2016
`causing 1531621
`chemical 6112714
`20019 2019 2096
`202023 2217
`29161824 3010
`251115192425
`cavity 29814
`3023 648 1084
`2611 371523 386 certain 7014 729
`3810 465 7710
`8225 20116 2137
`12324 13915
`17612 20122
`8511 8723 9624
`certainly 216 2318
`804 839 9116
`25322 27823
`9625 972 10124
`28115 2827 2859
`9914 1069 11322
`1038 11615
`28521 28610
`12224 12918
`14821 17422
`2629 26424
`287214 29026
`1373 15424
`29714 29818
`18420 1898
`27915 28223
`2993
`certainty 123312
`19421 19511
`chemically 25414
`Certified 212
`19810 19923
`chemist 255 2613
`20016 2037
`certify 30611 3076
`379 49216114919
`21421 21820
`30711
`6123 642 2916
`cetera 16518 1682
`2341222 24425
`24725 2508 2537
`chemists 1836
`18822
`chemistry 720 1625
`26024 26421
`Chaichit 818 29721
`171415 184689
`29321 2954
`29724 2987
`30425 3082
`181718212122
`chains 193916
`1824 19111313
`cases 911 146911
`24769 25721
`1914142325 202
`2585
`15162021 1645
`2029101024
`chairman 3519
`1671216 1720
`21233789 2414
`challenges 443916
`201414 211016
`21192425 2258
`241415192425
`chance 24815
`2224 23251218
`2425 252714517
`change 9823 22311
`2520 273 285
`2452 2702324
`23202125 24512
`3210 362222
`2907 29825
`982324 13517
`37101620 38415
`changed 2272122
`16121 16215
`45367788911
`20120
`changes 27021
`Catalysed 617
`4511 5189 29110
`changing 1029
`catalysis 6419 659
`3041919 305810
`character 29715
`29819
`651421
`chemists 6115 1972
`characteristics 3010 Chiral 810
`categories 191225
`2025
`characterized 23710
`chloride 641722
`cation 17710 2012
`2388
`654 662 86615
`2115 2121122
`characterizes 2629
`8620 873 906
`2425 2452125
`927 93420 9514
`charge 177151618
`24619
`9522 9691518
`1832425 18445
`2005712 20117
`97111824 9816
`cationic 23121
`cations 2066 21115
`20118 24713
`9825 10121 1025
`
`The Little Reporting Company
`646 650-5055 1 www.littlereporting.com
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`Page 313
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`
`
`2951518 29618
`1021422 10317
`29720 2981523
`10324 1043 1052
`2994
`10722 1098
`cited 124 6816
`11820 12025
`20222 28624
`12314 13123
`289423 29117
`132525 13316
`2977 2988
`134413 13811
`cites 671023 6811
`145816 14725
`202916
`1481224 149911
`15020 1516 1522 Civil 14
`1521118 155811
`claim 2051122
`15815 1594 1605
`claimed 20523
`16020 161513
`claims 849151822
`8425 85391016
`162323 16316
`914 20425
`1675 1692 17011
`clarify 1116 28119
`170141925 1712
`3084
`171122425 1732
`class 2813 295913
`17324 17421013
`2918 304141922
`174161923 1752
`4512 652 7911
`17512 1768
`2835
`17817 1829
`18318 188411
`classic 16825
`Clayton 722
`19517 1971524
`clear 6015 1349
`1986822 19912
`2001623 2019
`14517 1461024
`2023 20717
`1473 14820 1722
`2132424 217513
`1725 18515
`18714 2113 2136
`2226152123
`223314 2246
`2131320 2224
`2258 23014
`22416 2387
`23111 23212
`clearly 2869
`2333 24120 2429
`closely 29122
`24221 2449
`cloud 612 2661925
`291182124 2922
`2671421 268411
`26822 2692512
`292724 29345717
`choice 132262025
`cloudiness 1588
`1338 1887 30024
`17119 17432024
`30111
`17513 19924
`24237131819
`chose 3621
`chromanone 2879
`cloudy 1355 15615
`circle 2773617
`16417 16520
`1678 1684 17020
`circumstances
`17717 20116
`171131820
`cite 68810 2792
`17414 19914
`2821016 28711
`240522 24121
`28816 2897
`2421622 2432
`CLR 125
`29022 2922
`
`clue 2112 28421
`CMC 259202223
`26023891314
`263616 265216
`26524 2672
`CMGs 264314
`266613
`co- 19314
`color 2452
`Columbia 213 3074
`column 891518
`9411 9721 1019
`10221 1039
`10416 1056
`11813 1215
`12217 12881419
`1282224 13825
`179589 18017
`18613 18725
`189224 19125
`19215 19817
`20123 20319
`2052222 2069
`21023 2156
`21615 2212 2484
`24812 24919
`columns 244367
`come 206 2217
`242024 692023
`8525 2206 29424
`comes 256 7611
`2753
`comment 9116
`9314 11413
`25023 2863
`comments 6817
`10516 11414
`commercial 2319
`24913
`Commission 30825
`common 3023 4010
`19625 2301520
`24020 29318
`Commonwealth 213
`communication
`29631014
`companies 341517
`
`314
`
`3419 352J01317
`3523 365 6117
`company 961619
`2112 225 3536
`351821 633 8817
`1295 1307 15625
`1571014 20210
`comparable 22510
`22623 30421
`comparative 21616
`2161920 217711
`21723 21812
`22579
`compare 22323
`24825 26223
`2947
`compared 365 2173
`2489
`compares 1457
`comparing 610
`2945
`comparison 224315
`2271322 256918
`2621824
`compatible 20616
`2071115 20920
`21025111317
`21110 23123
`compensated 2121
`completely 1121
`938 2128 22417
`22421 26411
`complex 8716 864
`861318 872 932
`9318 9619 9723
`991323 11616
`12313 13115
`13610 13723
`14516 1481224
`149911 1501520
`152217 1622
`176413212223
`1776 17871115
`178222425 1828
`18224 183515
`1861822 187615
`1871621 189623
`
`The Little Reporting Company
`646 650-5055 I www.littlereporting.com
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`Page 314
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`
`
`20619 21516
`292817 29824
`complexation 919
`953913121968
`971017 9815
`10419 1059
`10721 10821
`109721 110818
`111617 1121425
`12218 12323
`12492023 1252
`1251225 13511
`13641.3 1389
`13911 14015
`14191724 14724
`15718 29713
`29816
`complexes 876 905
`9021 926 974
`1191118 121616
`12124 1234 1354
`1521022 1592
`16416 16519
`1683 17813
`17918182325
`18036101120
`181241020 1822
`1823 1991325
`20018 24039
`2411011 29511
`complexing 211621
`2121223
`complicated 23514
`Complying 2778
`components 21817
`24820
`composition 15317
`2031422 20523
`206217
`compositions 1189
`1193 12616 1557
`205612
`compound 314 402
`4010 4171216
`4211 431420
`4417 6117 6222
`632 7820 792
`
`28519 2933
`13124 13222
`concluded 5712 703
`13724 1454 1565
`744 29415 30520
`17631623 17727
`conclusion 221517
`1845 1885 19823
`3017 461149817
`21516 23015
`6221 6713 68215
`23115 26913
`69122123 7012
`27113 28122
`282346 29324
`7019 71101425
`727 7417 76516
`compounds 192
`775 84816 887
`25 22 26210 2715
`11319 1161124
`272025 281924
`2959101419
`11714 175710
`1855 2059 2206
`3031822 319
`321520 344 3624 conclusions 6625
`2632
`37324 38712
`3910132024
`concrete 12216
`4016 412 43411
`conditions 1461120
`431317 4524 666
`2227 223162324
`7912 808 82711
`224815 22510
`8217 835 925
`confident 30020
`1017 10924
`confirmed 1093
`1181025 11912
`conform 3085
`connection 1058
`12117 1255 1276
`2122 328 521025
`1377 139121423
`5316 544 8722
`15614 158313
`24724
`1677 17812
`consider 4619 493
`18121 1895 1935
`54517 5548914
`19413 202519
`5522 5621 5724
`2151522 21613
`807 8359 8422
`23011 23123
`232412 2332
`8424 19418 2537
`25513 25822
`25312 26515
`2595 2801616
`300312 3033
`2835 293619
`3047
`comprising 1557
`considerable 1217
`2062
`consideration 339
`compromising 2644
`9311
`26415 2654
`considered 1510
`concede 672 7111
`53131423 577
`8721 1182 1192
`concentration 25521
`25817
`12917 13125
`1353 15423
`concept 15923
`concepts 114615
`15613 16415
`16516 167624
`concerned 10017
`188620 1959
`1398
`19912 2036
`conclude 17325
`21420 2402
`17417 24513
`
`315
`
`3041125
`considering 5711
`5825
`consistent 12823
`1293 1381123
`1443 1591324
`1601317 16114
`1623 16324 1645
`16713 1681317
`18810 18916
`199381722
`20417 21522
`2163
`consolidated 15 910
`constitute 673 7025
`711221
`constitutes 7017
`7214
`consult 19617 2302
`contain 2911 7858
`7813 13315 1344
`13412 1374
`14419 17412
`1899 21323
`22518 22618
`24117
`contained 17024
`21826 24819
`30615
`containing 2813
`295 8824 8910
`1189 14412 1859
`19518 2197 2417
`2448
`contains 7822 795
`1701013 20025
`20322 21823
`2414 24282125
`2485 2491222
`28220
`content 559
`context 6438 6627
`6610 1081819
`109620 1115
`11212 11317
`1525 16468
`19023 19121
`
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`Page 315
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`
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`1110 1610 2117
`19212
`2121 227 7113
`contexts 6410
`Continued 42 62
`7221113 73317
`74291823 7522
`72 82
`7525 7625 15416
`control 21819 2197
`22911 23319
`23925
`cover 896 15620
`controls 21620
`2171114 2185
`18513
`covered 5110 522
`Conventional 613
`2047
`covering 1971221
`COX 7921
`conversations 1077
`critical 25520
`1071014
`25817
`copy 1420 2615
`CORP 110
`crosslinked 2063
`correct 1019 157919 CRR 125
`1622 226 251115 Crystal814
`251619 2617 275 curriculum 2616
`CV 325 341315
`286 297 327
`415
`401417 4131014
`4118 421215
`Cyclic 811
`43141525 4419
`cyclodextrin 87
`4624 492 5920
`2981417
`608 6320 8179
`cyclodextrins 2957
`811314 8210
`29510 29617
`8411 885 9011
`1291025 13713
`1697 1701215
`1792 19515
`20014 21425
`2317 23915
`27312 2786
`30616 3079 3086
`corrected 30616
`corrections 1512
`30614
`counsel 920 10615
`1129 21813
`30318
`counsels 1348
`counterions 23925
`couple 1211 2812
`course 279 399
`4316 442124
`19618 2302
`26611 26715
`courses 45510
`court 12 9818 112
`
`D
`D.C 122 210 914
`D.D 622
`D.Phil 121 28 514
`91 10113 111
`121 131 14116
`151 161 171 181
`191 201 211 221
`231241251 261
`2712819411721
`2825 2914 301
`311 321 331 341
`351 361 371 381
`391401411421
`431441 451 461
`471481491 501
`511 521 531 541
`551 561 571 581
`591 601 611 621
`631 641 651 661
`671 681 691 701
`
`cyclooxygenase
`7921
`
`711 721 731 741
`751 761 771 781
`791 801 811 821
`831 841 851 861
`871 881 891 901
`911 921 931 941
`951 961 971 981
`991 1001 1011
`1021 1031 1041
`1051 1061 1071
`1081 1091 1101
`1111 1121 1131
`1141 1151 1161
`1171 1181 1191
`1201 1211 1221
`1231 1241 1251
`1261 1271 1281
`1291 1301 1311
`1321 1331 1341
`1351 1361 1371
`1381 1391 1401
`1411 1421 1431
`1441 1451 1461
`1471 1481 1491
`1501 1511 1521
`1531 1541 1551
`1561 1571 1581
`1591 1601 1611
`1621 1631 1641
`1651 1661 1671
`1681 1691 1701
`1711 1721 1731
`1741 1751 1761
`1771 1781 1791
`1801 1811 1821
`1831 1841 1851
`1861 1871 1881
`1891 1901 1911
`1921 1931 1941
`1951 1961 1971
`1981 1991 2001
`2011 20212031
`2041 20512061
`2071 2081 2091
`2101 2111 2121
`2131 2141 2151
`2161 2171 2181
`
`316
`
`219122012211
`222122312241
`225122612271
`228122912301
`231123212331
`234123512361
`237123812391
`240124112421
`243124412451
`246124712481
`249125012511
`252125312541
`255125612571
`258125912601
`261126212631
`264126512661
`267126812691
`270127112721
`273127412751
`276127712781
`279128012811
`282128312841
`285128612871
`288128912901
`291129212931
`294129512961
`297129812991
`3001 3011 3021
`3031 3041 3051
`30519 306110
`3071 308121
`D.Sc 326172124
`3359
`data 8221 9423
`957 9617 9814
`1017192425
`1047 1131625
`11416 1151314
`11517 123515
`1261321 12719
`12845 14841921
`1521520 17418
`17516 20215
`20416 20622
`207419 2083
`20910 2265
`24424
`
`The Little Reporting Company
`646 650-5055
`www.littlereporting.com
`
`Page 316
`
`
`
`date 2619 889 1185
`12923 1555 1853
`1856 19513 2039
`20311 21423
`24911 3083
`dated 2392 26018
`30621
`Davies 12128 514
`915 10171317
`111 121 131 141
`141416 151 161
`171 181 191 201
`211221231241
`251 261 271 281
`291 301 311 321
`331 341 351 361
`371 381 391 401
`411 421 431 441
`451461471 481
`491 501 511 521
`531 541 551 561
`57121 5816 591
`601 611 621 631
`641 651 66119
`671 681 691 701
`711 721 731 741
`751 761 771 781
`791 801 811 821
`831 841 851 861
`87113 881 891
`901 911 921 931
`941 951961 971
`981 991 1001
`1011 1021 1031
`1041 1051 1061
`10715617 1081
`1091 1101 1111
`11213 1131 1141
`1151 1161 1171
`11721 1181 1191
`1201 1211 1221
`1231 1241 1251
`1261 1271 1281
`12911116 1301
`1311 1321 1331
`13416 1351 1361
`1371 1381 1391
`
`1401 1411 1421
`1431 1441 1451
`1461 1471 1481
`1491 1501 1511
`1521 153123
`154141416 1551
`1561 1571 1581
`1591 1601 1611
`1621 1631 1641
`165114 166168
`1671 1681 1691
`1701 1711 1721
`1731 1741 1751
`1761 1771 1781
`1791 1801 1811
`1821 1831 1841
`18414 1851 1861
`1871 1881 1891
`1901 1911 1921
`1931 1941 19512
`1961 1971 1981
`19912001 2011
`202124 2031
`204120512061
`207120812091
`2101 2111 2121
`2131 21411415
`215121612171
`218111 2191
`220122112221
`223122412251
`226122712281
`229111 2301
`2311 2321 2331
`23319 23416
`235118 2361
`2371 2381 2391
`2401 2411 2421
`2431 2441 24514
`2461 247118
`2481 2491 2501
`2511 2521 2531
`2541 2551 2561
`2571 2581 2591
`260116 2611
`262126312641
`265126612671
`
`2681 2691 2701
`2711 2721810
`2731 27412751
`2761 2771 2781
`279117 2801
`2811 2821 2831
`2841 2851 2861
`28613 287117
`288121 289112
`2901 29119 2921
`2931 2941 2951
`2961222 297123
`2981299124
`3001 3011 3021
`303120 30412
`30511419 3061
`30610 3071 3081
`30821
`day 1216 30716
`30823
`days 121517 21824
`21991122122
`dealing 9120 1268
`26921
`deals 2822323
`decide 7113 72211
`73317 742918
`742023 7522
`decision 7214
`decisions 621314
`declaration 23320
`235423 23722
`24016 2427
`declarations 23425
`decrease 13512
`defendants 11518
`314 44 924 104
`1015
`define 1824 27220
`27425 2752
`27714
`defined 2518 516
`275419 27712
`defini- 17825
`defining 17620
`1787
`definite 23116
`
`317
`
`definition 523 5325
`7021 14925
`17811 1835
`30322 304513
`definitional 1786
`definitions 1775
`
`definitive 9121
`degradation 26916
`2707 27823
`28123 2833
`28417 2852913
`28725814 2902
`2942025
`degrade 26913
`2829 28525 2862
`degrades 2855 2904
`degrading 28113
`28418
`degree 2771822
`28248101721
`2825 294 3269
`3210172125 336
`338 517 1101021
`1117 1132 1263
`1418141522
`1927 30418
`degrees 21824
`21910 22122
`22216 22359
`demonstrated 19924
`demonstration
`18922
`density 10813
`12411 13924
`1912 29825
`depend 2462 26511
`26920 27324
`30010 3017
`dependent 10411
`depending 7611
`depends 168 324
`8222 11320
`13218 1336
`17717 24520
`27322 28020
`3007
`depict 2566 2575
`
`The Little Reporting Company
`646 650-5055 1 www.littlereporting.com
`
`Page 317
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`
`
`25949
`depicted 25710
`25820 25910
`deposed 1019
`deposition 120 28
`512 64 74 84 95
`912 1023 1124
`12814202224
`133114522 14518
`585 8716 1074
`11723 12914
`1541320 18417
`1955 2033 21413
`21418 22916
`23324 24720
`26020 2727
`27921 28617
`28722 28823
`28916 29114
`2967 2973 2984
`30519 30612
`30778 3083
`derivative 2502
`derivatives 783
`2807 28225
`describe 3617 863
`8617 8711 11514
`1395 15717 1814
`18120 18219
`18622 19018
`25516
`described 976
`13114 18617
`28012
`describes 875 903
`92323 1315
`14513 1851422
`1971220 20524
`21510 21619
`2805
`describing 623
`180212098
`29615
`description 985
`15010 16021517
`1611114 16824
`20724 2082
`
`descriptions 18811
`desirable 92425
`9331719 1472
`desired 926
`despite 23115
`29413
`destroy 28116
`detail 4723 5214
`53822 54131723
`5549 5617 7925
`8018 8510 1158
`24823 2495
`detailed 13314
`16823 20724
`2082 29525
`details 4620
`detergents 202418
`determination 7320
`7413 7512 7623
`determine 3114
`9415 1432 25117
`281822 2826
`determining 26516
`develop 21825 2199
`21911
`developed 6313
`devoted 3522
`diagram 8312
`diagrams 25724
`258720
`diclofenac 771923
`782513 79812
`7919 814 828
`101216 1022
`12625 1271115
`12721241286
`20645