Curriculum Vitae
`Robert O. Williams III
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`CURRICULUM VITAE
`Robert O. (Bill) Williams III
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`Home Address
`2305A Westlake Drive
`Austin, Texas 78746
`(512) 306-8396
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`Office Address
`The University of Texas at Austin
`College of Pharmacy
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`Division of Pharmaceutics
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`2409 University Ave., Room 4.214
`1 University Station A1920
`Austin, Texas 78712
`Office (512)471-4681 Fax (512)471-7474
`Email: Bill.Williams@austin.utexas.edu
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`I.
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`II. Education
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` Personal
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` Born September 11, 1956 in Beaumont, Texas. Citizen of the United States. Married; two
` children.
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` May 75 – May 79
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`Texas A&M University, College Station, Texas
`Bachelor of Science in Biology, Graduated with special honors
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` Sep 79 – Dec 81
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` Aug 82 – May 86
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`University of Texas at Austin, Austin, Texas.
`Bachelor of Science in Pharmacy, Graduated with special honors
`Registered Pharmacist – State of Texas
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`University of Texas at Austin, Austin, Texas
`Doctor of Philosophy, Pharmaceutics
`Major Professor: James W. McGinity, Ph.D.
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`III. Positions Held
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`1. January, 1982 to August, 1982 – Registered, Pharmacist, Walgreen’s Pharmacy,
`Beaumont, TX.
`2. August, 1986 to December, 1988 - Group Leader for Eli Lilly and Company,
`Indianapolis, IN.
`3. January, 1989 to December, 1990 - Director for Duramed Pharmaceuticals, Cincinnati,
`OH.
`4. January, 1991 to April, 1992 - Section Manager for Rhone-Poulenc Rorer
`Pharmaceuticals, Collegeville, PA.
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`5. April, 1992 to January, 1993 - Department Manager for Rhone-Poulenc Rorer
`Pharmaceuticals, Collegeville, PA.
`6. January, 1993 to August, 1995 - Director for Rhone-Poulenc Rorer Pharmaceuticals,
`Collegeville, PA.
`7. September, 1995 to August, 1999 - Assistant Professor of Pharmaceutics, College of
`Pharmacy, University of Texas at Austin, Austin, TX.
`8. January, 1996 to January, 2007 – President, PharmaForm LLC, Austin, TX.
`9. January, 2007 – June, 2010 – Consultant, PharmaForm LLC, Austin, TX.
`10. January, 2007 to June, 2010 – Board of Directors, Akela Pharma, Inc., Montreal,
`Canada
`11. September, 1999 to August, 2004 – Associate Professor of Pharmaceutics, College of
`Pharmacy, University of Texas at Austin, Austin, TX.
`12. September, 2004 to 2013 – Professor of Pharmaceutics, Johnson & Johnson Centennial
`Professor, College of Pharmacy, University of Texas at Austin, Austin, TX.
`13. September, 2007 to present – Division Head, Division of Pharmaceutics, College of
`Pharmacy, University of Texas at Austin, Austin, TX.
`14. 2009-2013, Founder and Chief Scientist, Enavail LLC, Austin, TX.
`15. January, 2013 to present – Visiting Professor, University of Chile, Santiago, Chile.
`16. September, 2013 to present – Professor of Pharmaceutics, Johnson & Johnson
`Centennial Chair, College of Pharmacy, University of Texas at Austin, Austin, TX.
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`IV. Graduate and Undergraduate Courses Presented
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`V. Professional Memberships
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`1985 - present
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` American Association of Pharmaceutical Scientists
` (Sections of Pharmaceutical Technology, and Pharmaceutics and
` Drug Delivery)
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`Member, Planning Committee, Pharmaceutical
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` Technology Section (1997-1998)
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`Member, Strategic Planning Committee (1999-2000)
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`Reviewer, Pharmaceutical Technology Screening Committee (2003, 2004)
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`Co-Chair, Strategic Visioning Process (2003-2004)
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`Reviewer, Annual Meeting and Exposition Abstract Screening Committee (2006)
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`Member, Pharmaceutical Technology Education Committee (2007-present)
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` Controlled Release Society
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`1995 - present
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` Pharmaceutics, PHR 356C and PHR 156P - UT Austin
` Advanced Manufacturing Pharmacy, PGS 381G - UT Austin
` Recent Advances in Pharmaceutics, PGS 382R - UT Austin
` Advanced Product Development, PGS 381D - UT Austin
` Advanced Pharmaceutical Processing, PGS 380Q - UT Austin
` Pharmaceutical Entrepreneurship, PHR 261J/PGS 280M – UT Austin
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`Robert O. Williams III
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` Association de Pharmacie Galenique Industrielle (APGI)
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` American Association of Colleges of Pharmacy
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` Rho Chi (Pharmacy Honor Society)
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` Kappa Psi (Graduate Chapter, Pharmacy Professional Fraternity),
` Grand Council Deputy - President
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` International Academy of Compounding
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` European Federation of Biotechnology
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` Product Quality Research Institute
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` (AAPS representative on Drug Product Technical Committee)
` Center for Microencapsulation and Drug Delivery,
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` Texas A&M University (Member – Strategic Advisory Board)
` Austin Technology Incubator University Development Portfolio,
` Member
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`1998 - present
`1995 - present
`1982 - present
`1979 - present
`1998 – present
`1999 – 2004
`2002 – 2013
`2004 – 2005
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`2003-2013
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`2014-present
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`1.
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`2.
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`3.
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`4.
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`5.
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`Small particle technology to enhance dissolution rates and bioavailability.
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`Formulation of novel liquid and semisolid drug delivery systems.
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`Study of novel controlled-release aqueous coating formulations.
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`Preformulation and formulation of novel delivery systems for pulmonary, nasal
`and buccal delivery.
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`Modified release oral dosage forms.
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`VI. Current Research Interests
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`VII. Honors and Awards
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`1. University Undergraduate Honors Fellow, Texas A&M University; 1978
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`2. Distinguished Student Award, Texas A&M University; 1979
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`3. Lemmon Award, University of Texas at Austin; 1981
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`4. Amaric Corporation Pre-doctoral Fellowship, University of Texas at Austin; 1983 -
`1985
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`5. Professional Development Award, University of Texas at Austin; 1985
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`6. Texas Excellence Teaching Award, University of Texas at Austin; 1998
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`7. Phi Lambda Sigma, the Pharmacy Leadership Society, Elected member - 1998
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`Robert O. Williams III
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`8. Leadership Fellow, American Association of Colleges of Pharmacy Academic
`Leadership Fellows Program, 2004-2005.
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`9. Paper awarded the Penwest Award for Best Scientific Paper, Novel Curing Process for
`Cellulose Acetate Phthalate Coated Beads. Proceedings of the 20th Pharmaceutical
`Technology Conference and Exhibition, Liverpool, UK, April, 2001.
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`10. Dean’s Fellow, College of Pharmacy, University of Texas at Austin, 2004-2005.
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`11. Fellow, Elected by the American Association of Pharmaceutical Scientists, 2006.
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`12. Paper awarded the Controlled Release Society’s Innovative Aspects of Oral Drug
`Delivery and Absorption Graduate/Post-Doc Award, Improved Dissolution Rate and
`Bioavailability Through the Formation of a Highly Miscible Binary Mixture,
`Proceedings of the Controlled Release Society Annual Meeting, Miami, FL, June, 2005.
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`13. Paper nominated for the Controlled Release Society’s Innovative Aspects of Oral Drug
`Delivery and Absorption Graduate/Post-Doc Award, Rapid Release, High Potency
`Itraconazole Formed by Evaporative Precipitation Into Aqueous Solution, Proceedings
`of the Controlled Release Society Annual Meeting, Miami, FL, June, 2005.
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`14. Outstanding Thesis Award, Barbara Jean Hoeben, M.S. (May, 2005) – Thesis Title:
`Comparison of Commercial Itraconazole to Aerosolized Nanoparticle Itraconazole in a
`Murine Model for the Prevention of Invasive Pulmonary Aspergillosis (IPA).
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`15. Elected “Fellow” of the American Association of Pharmaceutical Scientists, 2006.
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`16. Elected “Fellow” of the American Institute of Medical and Biological Engineering,
`2008.
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`17. Received the 2009 William J. Sheffield Outstanding Alumnus Award, Pharmacy
`Alumni Association, The University of Texas at Austin.
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`18. Invited paper by W. Yang, J. I. Peters and R. O. Williams III was recognized as one of
`the Top-10 most cited articles published in International Journal of Pharmaceutics
`during the period 2008-2010 (Elsevier Publishers; September 2010).
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`19. Teaching Excellence Award (P1), College of Pharmacy, University of Texas at Austin,
`2014-2015.
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`VIII. Committees
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`Academic Performance Committee - 1996 – present, Chairman and Member
`Faculty Retreat Planning Committee, Chair - 1996-1997, 2007, 2011
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`Robert O. Williams III
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`Committee on Committees - 1995 – 1997, 2004 – 2005, 2006
`Pharmacy Honors Course - Coordinator for Pharmaceutics - 1996 - 2001
`Honors and Awards Committee - 1995 - 2001
`Internship Region Assignment Committee, Chairman, 1998 - 2004
`Staff Excellence Awards Committee - 1998 – 2000
`Financial Aid Committee – 1999 – 2000
`College Accreditation Committee – 2002 – present
`Admissions and Registration Committee (University Committee) – 2001 – 2003
`Intellectual Property Committee (University Committee) – 2003- 2013
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`Co-Chair – Life Sciences
`(2004-2005)
`Faculty Advisor to:
`Kappa Psi Pharmaceutical Fraternity
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`Pharmaceutical Association of Compounding
`Drug Product Technical Committee, PQRI – representative for AAPS, 2004-2006
`Post-Tenure Review Committee – Chairman; 2005-2007
`College of Pharmacy, Dean Search Committee – Co-Chairman; 2007
`College of Pharmacy, Executive Committee – Chairman; 2008 – 2013
`University of Texas at Austin, Office of Technology Commercialization and Associate
`Vice President for Research for Commercialization Search Committee; 2008-
`2010
`Graduate Studies Committee, Pharmacy Doctoral Program (1995 – present)
`Graduate Studies Committee, Translational Science Doctoral Program (2011- 2013)
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`IX. Editorial Responsibilities
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`1.
`2.
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`AAPS PharmSciTech – Editor-in-Chief (2014 – present)
`Journal of Drug Delivery Science and Technology – member, Editorial Advisory
`Board (2015-present)
`3. Drug Development and Industrial Pharmacy – Editor-in-Chief (2000 – 2014)
`International Journal of Pharmaceutics – reviewer
`4.
`Pharmaceutical Research – reviewer
`5.
`European Journal of Pharmaceutics and Biopharmaceutics – reviewer
`6.
`Journal of the Controlled Release Society – reviewer
`7.
`S. T. P. Pharma. Sciences – reviewer
`8.
`Pharmaceutical Development and Technology – reviewer
`9.
`10. Pharmaceutical Technology Conference - International Advisory Board Member
`International Journal of Pharmaceutical Compounding – reviewer
`11.
`12. Journal of Membrane Science – reviewer
`13. AAPS PharmSciTech – reviewer
`14. Journal of Pharmaceutical Sciences – reviewer
`15. Journal of Pharmaceutical and Biomedical Analysis – reviewer
`16. Toxicology Letters – reviewer
`17. National Institutes of Health, National Institute of Allergy and Infectious Diseases,
`Pharmaceutical and Chemical Resources for AIDS Drug Development, invited
`reviewer.
`18. The Open Drug Delivery Journal, Member, Editorial Advisory Board, 2008-present.
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`Robert O. Williams III
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`19. Journal of Pharmaceutical Research & Clinical Practice, Editorial Advisory Board,
`2010-present.
`20. British Journal of Pharmaceutical Research, Editorial Advisory Board, 2013-present.
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`X. Students Currently Being Supervised
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` Siyuan Huang – Ph.D. Candidate
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` Soraya Hengsawas – Ph.D. Candidate
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` Justin LaFontaine – Ph.D. Candidate
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` Leena Prasad – Ph.D. Candidate
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` Julien Maincent – Ph.D.
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` Zachary Warnken – PharmD/Ph.D.
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` Daniel Ellenberger – Ph.D.
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`Robert O. Williams III
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`XI. Personnel Supervised (and Starting Position; if available)
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`1. Mongkol Sriwongjanya, Ph.D. (1996 – 1997; Post-doctoral Research Fellow)
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`Senior Research Scientist, Andrx Pharmaceuticals, Fort Lauderdale, FL
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`2. Jie Liu, Ph.D. (August, 1998) Senior Research Scientist, Baxter Healthcare, New
`Providence, NJ. Dissertation Title: Development, Characterization and Optimization
`of Pressurized Metered-Dose Inhalers Formulated to Delivery Small Organic Drugs or
`Proteins with Hydrofluoroalkane Propellants.
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`3. Chengjiu Hu, Ph.D. (August, 1999) Senior Research Scientist, DuPont
`Pharmaceuticals, Garden City, NY. Dissertation Title: Investigation of Factors
`Influencing the Development of Pressurized Metered Dose Inhalers.
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`4. Melisa K. Barron, Ph.D. (August, 2000) Senior Scientist, Dey Laboratories, Napa,
`CA. Dissertation Title: Investigation of Formulation and Processing Technique on
`the Characteristics of Polymeric Powders Produced for Suspension Type Pressurized
`Metered Dose Inhalers Systems.
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`5. Jiping Liu, Ph.D. (August, 2001) Research Investigator, Sanofi-Synthelabo,
`Philadelphia, PA. Dissertation Title: Applications of Cellulose Acetate Phthalate
`Aqueous Dispersion (Aquacoat CPD) for Enteric Coating.
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`6. Bobby J. Truong, M.S. (August, 2001). Thesis Title: Development of Insulin
`Pressurized Meter-Dose Inhaler for the Pulmonary Drug Delivery by Spray-Freezing
`into Cryogenic Vapor.
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`7. Marazban Sarkari, Ph.D. (2000-2001; Post-doctoral Research Fellow) Senior
`Scientist, RxKINETIX, Boulder, CO
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`8. Vorapann Mahaguna, Ph.D. (December, 2001) Senior Research Scientist, DuPont
`Pharmaceuticals, Garden City, NY. Dissertation Title: Investigation of Cellulose
`Ether Polymers in Controlled Drug Delivery.
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`9. Raouf Ghaderi, Ph.D. (2001-2002; Post-doctoral Research Fellow) Senior Research
`Scientist, KOS Pharmaceuticals, NJ
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`10. True L. Rogers, Ph.D. (June, 2002) Senior Research Scientist, The Dow Chemical
`Company, Midland, MI. Dissertation Title: A Novel Cryogenic Particle Engineering
`Technology to Micronize Water-Insoluble Drugs and Enhance Their Dissolution
`Properties: Spray-Freezing Into Liquid.
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`11. Jiahui Hu, Ph.D. (July, 2003) – Senior Research Scientist, Forest Laboratories,
`Garden City, NY. Dissertation Title: A Nanoparticle Engineering Process: Spray-
`Freezing into Liquid to Enhance the Dissolution of Poorly Water Soluble Drugs.
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`12. Bradi L. Jones, Pharm.D., M.S. (August, 2003) – Pharmacist, University of Texas
`Health Science Center at San Antonio, San Antonio, TX. Thesis Title – Investigation
`of Pulmonary and Oral Delivery of Itraconazole Produced by Evaporative
`Precipitation into Aqueous Solution and Spray Freezing into Liquid Technology in a
`Murine Model.
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`13. Thomas W. Leach, Ph.D. (2002-2004 – Post-doctoral Research Fellow) Senior
`Research Scientist, Curagen Inc., New Haven, CT
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`14. Zhongshui Yu, Ph.D. (July, 2004) – Senior Research Scientist, Hoffmann-La Roche
`Pharmaceuticals, Nutley, NJ. Dissertation Title: Spray Freezing into Liquid to
`Produce Protein Microparticles.
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`15. Xiaoxia Chen, Ph.D. (July, 2004) – Senior Research Scientist, Hoffmann-La Roche
`Pharmaceuticals, Nutley, NJ. Dissertation Title: Nanoparticle Engineering
`Processes: Evaporative Precipitation into Aqueous Solution (EPAS) and Anitsolvent
`Precipitation to Enhance the Dissolution Rates of Poorly Water Soluble Drugs.
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`16. Thiago Cardoso Carvalho, R.Ph. (July, 2004) – Visiting Scientist, Universidade
`Federal De Minas Gerais, Brazil.
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`17. Barbara Jean Hoeben, M.S. (May, 2005) – Pharmacist, United States Air Force, San
`Antonio, TX. Thesis Title: Comparison of Commercial Itraconazole to Aerosolized
`Nanoparticle Itraconazole in a Murine Model for the Prevention of Invasive
`Pulmonary Aspergillosis (IPA).
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`18. Jason M. Vaughn, Ph.D. (June, 2005) – Associate Director and Senior Research
`Scientist, PharmaForm LLC, Austin, TX. Dissertation Title: Improved
`Bioavailability and Site Specific Delivery of Poorly Water Soluble Drugs through the
`Production of Stabilized Drug Nanoparticles.
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`19. Jason T. McConville, Ph.D. – (2003-2006; Post-doctoral Research Fellow) –
`Assistant Professor of Pharmaceutics, University of Texas at Austin, Austin, TX.
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`20. Prapasri Sinswat, Ph.D. (August, 2006) – Assistant Professor of Pharmaceutics,
`Chulalongkorn University, Bangkok, Thailand. Dissertation Title: Enhancing the
`Delivery of Poorly Water Soluble Drugs Using Particle Engineering Technologies.
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`21. Kirk A. Overhoff, Ph.D. (August, 2006) – Senior Pharmaceutical Scientist, Schering
`Corporation, Kenilworth, NJ. Dissertation Title: Improved Oral Bioavailability of
`Poorly Water Soluble Drugs Using Rapid Freezing Processes.
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`22. Josh D. Engstrom, Ph.D. (August, 2007) – Senior Pharmaceutical Scientist, Bristol
`Meyers Squibb, Princeton, NJ. Dissertation Title: Stable Submicron Protein
`Particles: Formation, Properties and Pulmonary Applications.
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`23. Keat Chow, Ph.D. (2007-2008; Post-doctoral Research Fellow).
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`24. Masao Nagao, M.S. (2007-2008; Visiting Research Scholar; Takeda Pharmaceuticals,
`Japan).
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`25. Dave A. Miller, Ph.D. (August, 2007) – Senior Pharmaceutical Scientist, Hoffman La
`Roche, Nutley, NJ. Dissertation Title: Improved Oral Absorption of Poorly Water
`Soluble Drugs by Advanced Solid Dispersion Systems.
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`26. Michal P. Matteucci, Ph.D. (August, 2007) – Dissertation Title: Highly
`Supersaturated Aqueous Solutions by Design of Amorphous Pharmaceutical
`Nanoparticles.
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`27. Troy P. Purvis, Ph.D. (August, 2007) – Senior Pharmaceutical Scientist, Azaya
`Therapeutics, San Antonio, TX. Dissertation Title: Nanoparticle Formulations of
`Poorly Water Soluble Drugs and their Action In Vivo and In Vitro.
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`28. Yosuhiro Tsutsumi, Ph.D. (2008-2009; Visiting Research Scholar; Daiichi Sankyo
`Co., Ltd., Pharmaceutical Technology, Japan).
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`29. Rui Jia, Ph. D. (2008-2009); Visiting Research Scholar; China.
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`30. Justin A. Tolman, Pharm.D., Ph.D. (January, 2009) – Assistant Professor of
`Pharmaceutics, School of Pharmacy and Health Professions, Creighton University,
`Omaha, Nebraska. Dissertation Title: Pulmonary Delivery of Aqueous Voriconazole
`Solution.
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`31. Alan B. Watts, Ph.D (July 2009) – Senior Scientist, Microdose Inc., Princeton, NJ,
`Dissertation Title: Pulmonary Delivery of Tacrolimus for Lung Transplant and
`Asthma Therapy.
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`32. Wei Yang, Ph.D. (July 2009) – Senior Scientist, Enavail, LLC, Austin, TX,
`Dissertation Title: Improvement of Bioavailability of Poorly Water-Soluble Drug via
`Pulmonary Delivery of Nanoparticles.
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`33. James C. DiNunzio (July 2009) – Senior Scientist, PharmaForm LLC, Austin, TX,
`Dissertation Title: Formulation and Processing Technologies for Enhanced Oral
`Bioavailability of Poorly Water Soluble Compounds.
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`34. Ikumasa Ohno, Ph.D. (2010-2010; Visiting Research Scholar, Daiichi Sankyo Co.,
`Ltd., Pharmaceutical Technology, Japan).
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`35. Nicole A. Beinborn, Ph.D. (August 2011) – Senior Scientist, Aptalis, Dayton, OH,
`Dissertation Title: Inhaled Voriconazole Formulations for Invasive Fungal Infections
`in the Lungs.
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`36. Meimei Zhang (2009-2011) – Visiting Chinese Graduate Student Scholar, (Professor
`Chuanbin Wu) Department of Pharmaceutics, School of Pharmaceutical Sciences
`R&D Center of Pharmaceutics, Sun Yat-sen University, Guangzhou, Guangdong,
`China, Dissertation Title: Amorphous Fenobibrate Solid Dispersions Prepared by
`Thin-Film Freezing.
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`37. Houli Li (2009-2011) – Visiting Chinese Graduate Student Scholar, (Professor
`Ruichen Guo) Institute of Clinical Pharmacology, Qilu Hospital of Shandong
`University, Jinan, Shandong, China, Dissertation Title: Modified Release
`Carbamazepine Compositions Prepared by Thin-Film Freezing.
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`38. Kevin P. O’Donnell, Ph.D. (December 2011) – Senior Scientist, The Dow Chemical
`Company, Midland, MI, Dissertation Title: Pharmaceutical Technologies for
`Improving Drug Loading in the Formulation of Solid Dispersions.
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`39. Helene L. Dugas, Ph.D. (May 2012) – Territory Manager, Laboratory Sales, Wheaton
`Industries, Houston, TX, Dissertation Title: Mycophenolate Mofetil Inhaled
`Formulation for the Prevention of Lung Transplant Rejection.
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`40. Stephanie Bosselmann, Ph.D. (May 2012) – Senior Scientist, Berlin Chemie, Berlin,
`Germany, Dissertation Title: Nanoparticle Engineering for Enhanced Drug Delivery.
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`41. Javier O. Morales, Ph.D. (November 2012) – Assistant Professor, University of
`Santiago, Santiago, Chile, Dissertation Title: Mucoadhesive Films for the Buccal
`Delivery of Insulin.
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`42. Shih-Fan Jang, Ph.D. (January 2013) – Dissertation Title: Development of Lower
`Intestine Targeting Mucoadhesive Platform of Oral Drug Delivery.
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`43. Bo Lang, Ph.D. (June 2013) – Formulation Scientist, Mylan Pharmaceuticals,
`Morgantown, WV, Dissertation Title: Advanced Formulation and Processing
`Technologies in the Oral Delivery of Poorly Water Soluble Drugs.
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`44. Yi-Bo Wang, Ph.D. (November 2013) – Reviewer, Food and Drug Administration,
`Division of Bioequivalence, Washington D.C., Dissertation Title: Pulmonary
`Delivery of Brittle Matrix Powders Produced by Thin Film Freezing.
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`45. Simone Raffa Carvalho, Ph.D. (November 2013) – Principal Scientist, Evonik
`Corporation, Dissertation Title: Improved Inhalation Therapies of Brittle Powders.
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`46. Justin M. Keen, Ph.D. (November 2013) – Formulation Scientist, DisperSol
`Technologies, LLC, Austin, TX. Dissertation Title: Novel Formulations and Thermal
`Processes for Bioavailability Enhancement of Soluble and Poorly Soluble Drugs.
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`47. Ryan C. Bennett, Ph.D. (March 2014) – Pharmaceutical Scientist, Freund-Vector
`Corporation, Cedar Rapids, IA. Dissertation Title: Thermal Processing Cyclodextrins
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`and Thermoplastic Polymers for Bioavailability Enhancement of Poorly Water-
`Soluble Drugs.
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`48. Chris Brough, Ph.D. (August 2015) – Pharmaceutical Scientist, Dispersol
`Technologies, LLC, Georgetown, TX. Dissertation Title: Novel Uses of
`Pharmaceutical Polymers as Enabled by KinetiSol® Dispersing.
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`XII. Publications
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`1. R.O. Williams III and J.W. McGinity, The Use of Tableting Indices to Study the
`Compaction Properties of Powders, Drug Development and Industrial Pharmacy,
`14(1988) 1823-1844.
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`2. R.O. Williams III and J.W. McGinity, Compaction Properties of Microcrystalline
`Cellulose and Sodium Sulfathiazole in Combination with Talc or Magnesium
`Stearate, Journal of Pharmaceutical Sciences, 78(1989) 1025-1034.
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`3. M. Schulze, R.O. Williams III, and J.W. McGinity, Compaction Properties of Acrylic
`Resin Polymers with Plastic and Brittle Drugs, Drug Development and Industrial
`Pharmacy, 16(1990) 741-754.
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`4.
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` R.O. Williams III, J. Dorrell, K. Corti, and M. Connolly, Significance of Interactions
`of a Novel Anti-Emetic Drug and Packaging Components During Clinical Trials,
`Drug Development and Industrial Pharmacy, 18(1992) 2145-2161.
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`5. K. S. Balaji, R.O. Williams III, and E. R. Christensen, Comparison of Milling
`Process: Ball Mill versus Air Classifying Mill, Drug Development and Industrial
`Pharmacy, 20(1994) 841-851.
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`6.
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`7.
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`S. Li, M. Karth, K. Feld, L. DiPaolo, C. Pendharkar, and R. O. Williams III,
`Evaluation of Bilayer Tablet Machines — A Case Study, Drug Development and
`Industrial Pharmacy, 21(1995) 571-590.
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`S. Li, R. Felt, L. DiPaolo, M. Huang, and R.O. Williams III, Development and In
`Vitro - In Vivo Evaluation of a Multiparticulate Sustained Release Formulation of
`Diltiazem, Pharmaceutical Research, 12(1995) 1338-1342.
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`8. R. O. Williams III, M. Sriwongjanya, and J. Liu, An In Vitro Method to Investigate
`Food Effects on Drug Release From Film Coated Beads, Pharmaceutical
`Development and Technology, 2(1997) 1-9.
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`9. R. O. Williams III, M. Sriwongjanya, and M. Barron, Compaction Properties of
`Microcrystalline Cellulose Using Tableting Indices, Drug Development and Industrial
`Pharmacy, 23(1997) 695-704.
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`10. R. O. Williams III, J. Liu, and J. J. Koleng, Influence of Metering Chamber Volume
`and Water Level on the Emitted Dose of a Suspension-Based pMDI Containing
`Propellant 134a, Pharm. Res., Pharmaceutical Research,14(1997) 438-443.
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`11. R. O. Williams III and M. Sriwongjanya, Determination of Benzalkonium Chloride
`and Nonoxynol-9 by HPLC During a Preformulation Study, S.T.P. Pharma. Sciences,
`7(1997) 241-247.
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`Robert O. Williams III
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`12. R. O. Williams III, V. Mahaguna, and M. Sriwongjanya, Determination of
`Diazolidinyl Urea in a Topical Cream by High-performance Liquid Chromatography,
`Journal of Chromatography B, Biomedical Applications, 696(1997) 303-306.
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`13. R. O. Williams III and C. Hu, A Study of an Epoxy Aerosol Can Lining Exposed to
`Hydrofluoroalkane Propellants, European Journal of Pharmaceutics and
`Biopharmaceutics, 44(1997) 195-203.
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`14. R. O. Williams III and V. Mahaguna, Preformulation studies on Freund’s Incomplete
`Adjuvant Emulsion, Drug Development and Industrial Pharmacy, 24(1998) 157-162.
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`15. R. O. Williams III, M. Repka, and J. Liu, Influence of Propellant Composition on
`Drug Delivery From a Pressurized Metered-dose Inhaler, Drug Development and
`Industrial Pharmacy, 24(1998) 763-770.
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`16. R. O. Williams III and M. Barron, Influence of Temperature on the Emitted Dose of
`an Oral Metered Dose Inhaler, Drug Development and Industrial Pharmacy, 24(1998)
`1043-1048.
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`17. R. O. Williams III and J. Liu, Influence of Formulation Additives on the Vapor
`Pressure of Hydrofluoroalkane Propellants, International Journal of Pharmaceutics,
`166(1998) 99-103.
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`18. R. O. Williams III and J. Liu, Formulation of a Protein with Propellant HFA 134a for
`Aerosol Delivery, European Journal of Pharmaceutical Sciences, 7(1998) 137-144.
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`19. R. O. Williams III, V. Mahaguna and M. Sriwongjanya, Characterization of an
`Inclusion Complex of Cholesterol and Hydroxypropyl- cyclodextrin, European
`Journal of Pharmaceutics and Biopharmaceutics, 46(1998) 355-360.
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`20. R. O. Williams III, J. Brown, and J. Liu, Influence of Micronization Method on the
`Performance of a Suspension TAA pMDI Formulation, Pharmaceutical Development
`and Technology, 4(1999) 167-179.
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` 21. R. O. Williams III, M. K. Barron, M. J. Alonso and C. Remunan-Lopez, Investigation
` of a pMDI System Containing Chitosan Microspheres and P134a, International
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`Journal of Pharmaceutics, 174(1998) 209-222.
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`22. R. O. Williams III and J. Liu, Influence of Formulation Technique for Hydroxypropyl-
`beta-cyclodextrin on the Stability of Aspirin in HFA 134a, European Journal of
`Pharmaceutics and Biopharmaceutics, 47(1999) 145-152.
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`23. R. O. Williams III, T. Rogers, and J. Liu, Study of Solubility of Steroids in
`Hydrofluoroalkane Propellants, Drug Development and Industrial Pharmacy,
`25(1999) 1227-1234.
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`Robert O. Williams III
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`24. R. O. Williams III, M. A. Repka, and M. K. Barron, Application of Co-Grinding to
`Formulate a Model pMDI Suspension, European Journal of Pharmaceutics and
`Biopharmaceutics, 48(1999) 131-140.
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`25. R. O. Williams III and C. Hu, Moisture Uptake and Its Influence on Pressurized
`Metered-Dose Inhalers, Pharmaceutical Development and Technology, 5(2000) 153-
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`162.
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`26. R. O. Williams III, T. A. Wheatley and J. Liu, Influence of Plasticization and Curing
`Conditions on the Mechanical Properties of Aqueous Based Cellulose Acetate
`Phthalate Films, S. T. P. Pharma Sciences, 9(1999) 545-553.
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`27. R. O. Williams III and J. Liu, Influence of Processing and Curing Conditions on
`Beads coated with an Aqueous Dispersion of Cellulose Acetate Phthalate, European
`Journal of Pharmaceutics and Biopharmaceutics, 49(2000) 243-252.
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`28. R. O. Williams III and C. Hu, Investigation of Moisture Scavengers in Pressurized
`Metered Dose Inhalers, S. T. P. Pharma Sciences, 10(2000) 243-250.
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`29. R. O. Williams III, A. M. Patel, M. K. Barron and T. L. Rogers, Investigation of Some
`Commercially Available Spacer Devices for the Delivery of Glucocorticoid Steroids
`from a pMDI, Drug Development and Industrial Pharmacy, 27(2001) 401-412.
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`30. R. O. Williams III and J. Liu, The Influence of Plasticizer on Heat-Humidity Curing
`of Cellulose Acetate Phthalate Coated Beads, Pharmaceutical Development and
`Technology, 6(2001) 607-619.
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`31. R. O. Williams III, M. Sykora and V. Mahaguna, Method to Recover a Lipophilic
`Drug From Hydroxypropyl Methylcellulose Matrix Tablets, AAPS PharmSci Tech,
`2(2001) 1-9.
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`32. M. Sarkari, J. Brown, X. Chen, S. Swinnea, R. O. Williams III and K. Johnston,
`Enhanced Drug Dissolution Using Evaporative Precipitation into Aqueous Solution,
`International Journal of Pharmaceutics, 243(2002) 17-31.
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`33. T. L. Rogers, K. Johnston and R. O. Williams III, A Comprehensive Review –
`Solution Based Particle Formation of Pharmaceutical Powders by Supercritical or
`Compressed Fluid Carbon Dioxide and Cryogenic Spray-Freezing Technologies,
`Drug Development and Industrial Pharmacy, 27(2001) 1003-1015.
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`34. R. O. Williams III, T. D. Reynolds, T. D. Cabelka, M. Sykora and V. Mahaguna,
`Investigation of Excipient Type and Level on Drug Release from Controlled Release
`Tablets Containing HPMC, Pharmaceutical Development and Technology, 7(2002)
`181-193.
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`Page 15
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`35. R. O. Williams III, B. Browne, C. Augustine, B. Stewart, J. Kimble, T. Rogers, and J.
`Brown, Influence of Propeller Gas Composition on the Delivery of Drug by Air-Jet
`Nebulization, S.T.P. Pharma Sciences,11(2001) 443-448.
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`36. X. Chen, T. Young, M. Sarkari, R. O. Williams III, and K. Johnston, Preparation of
`Cyclosporine A Nanoparticles by Evaporative Precipitation into Aqueous Solution,
`International Journal of Pharmaceutics, 242(2002) 3-14.
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`37. T.L. Rogers, J. Hu, Z. Yu, K. Johnston, and R.O. Williams III, A Novel Particle
`Engineering Technology: Spray-Freezing into Liquid, International Journal of
`Pharmaceutics, 242(2002) 93-100.
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`38. J. Liu and R. O. Williams III, Long-term Stability of Heat-Humidity Cured Cellulose
`Acetate Phthalate Coated Beads, European Journal of Pharmaceutics and
`Biopharmaceutics, 53(2002) 167-173.
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`39. Z. Yu, T. Rogers, J. Hu, K. P. Johnston and R. O. Williams III, Preparation and
`Characterization of Microparticles Containing Peptide Produced by a Novel Process:
`Spray Freezing Into Liquid, European Journal of Pharmaceutics and
`Biopharmaceutics, 54(2002) 221-228.
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`40. J. Hu, T. Rogers, J. Brown, T. Young, K. Johnston, and R. O. Williams III,
`Improvement of Dissolution Rates of Poorly Water Soluble APIs Using the Novel
`Spray Freezing Into Liquid Technology, Pharmaceutical Research, 19(2002) 1278-
`1284.
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`41. T. L. Rogers, A. C. Nelson, J. Hu, J. N. Brown, M. Sarkari, T. J. Young, K. P.
`Johnston and R. O. Williams III, A Novel Particle Engineering Technology to
`Enhance Dissolution of Poorly Water Soluble Drugs: Spray-Freezing Into Liquid,
`European Journal of Pharmaceutics and Biopharmaceutics, 54(2002) 271-280.
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`42. J. Liu and R. O. Williams III, Properties of Heat-Humidity Cured Cellulose Acetate
`Phthalate Free Films, European Journal of Pharmaceutical Sciences, 17(2002) 31-41.
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`43. T. L. Rogers, K. P. Johnston and R. O. Williams III, Physical Stability of Micronized
`Powders Produced by Spray-Freezing into Liquid (SFL) to Enhance the Dissolution of
`an Insoluble Drug, Pharmaceutical Development and Technology, 8(2003) 187-197.
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`44. T. L. Rogers, A. C. Nelsen, M. Sarkari, T. J. Young, K. P. Johnston and R. O.
`Williams III, Enhanced Aqueous Dissolution of a Poorly Water Soluble Drug by
`Novel Particle Engineering Technology: Spray-Freezing into Liquid with
`Atmospheric Freeze-Drying, Pharmaceutical Research, 20(2003) 485-493.
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`45. T. L. Rogers, K. A. Overhoff, P. Shah, P. Santiago, J. Yacaman, K. P. Johnston and
`R. O. Williams III, Micronized Powders of a Poorly Water Soluble Drug Produced by
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`Robert O. Williams III
`Page 16
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`a Spray-Freezing into Liquid Emulsion Process, European Journal of Pharmaceutics
`and Biopharmaceutics, 55(2003) 161-172.
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`46. M.K. Barron, T.J. Young, K.P. Johnston and R.O. Williams III, Investigation of
`Processing Parameters of Spray Freezing Into Liquid to Prepare Polyethylene Glycol
`Polymeric Particles for Drug Delivery, AAPS PharmSciTech, 4(2003) 90-102.
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`47. X. Chen, R.O