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`11/16/2015
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`SENJU EXHIBIT 2185
`LUPIN v. SENJU
`IPR2015-01097
`
`
`
`11/16/2015
`
`ISTA Pharmaceuticals Announces XIBROM(TM) Shipments to Bloomberg
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`ISTA Pharmaceuticals Announces XIBROM(TM) Shipments to Bloomberg
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`ISTA Pharmaceuticals Announces XIBROM(TM) Shipments to Bloomberg
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`ISTA Pharmaceuticals Announces XIBROM(TM)
`Shipments to
`
`ISTA Pharmaceuticals Announces XIBROM(TM) Shipments to Wholesalers to End on February 28, 2011
`
`BROMDAY(TM) Launch On Track Capturing 46% of Weekly New Prescriptions in the Bromfenac
`Franchise by the End of January
`
`IRVINE, CA (Marketwire) 02/08/11 ISTA Pharmaceuticals, Inc. (NASDAQ: ISTA), today announced
`that due to the rapid adoption of BROMDAY(TM) (bromfenac ophthalmic solution) 0.09%, the first and only
`oncedaily nonsteroidal antiinflammatory (NSAID) prescription eye drop for the treatment of postoperative
`inflammation and reduction of ocular pain in patients who have undergone cataract extraction, the company will
`stop selling twicedaily XIBROM (bromfenac ophthalmic solution)(R) 0.09%. ISTA no longer plans to supply
`XIBROM to pharmaceutical wholesalers after February 28, 2011. For approximately 23 weeks thereafter, there
`will be a limited supply of XIBROM available at wholesalers and pharmacies to fill remaining XIBROM
`prescriptions. ISTA anticipates wholesalers will continue to sell XIBROM to pharmacies until their inventory is
`depleted.
`
`As of Fall of 2010, according to data from IMS, twicedaily XIBROM (bromfenac ophthalmic solution)(R)
`0.09% had become the most prescribed branded ocular NSAID in the U.S. market for use following cataract
`surgery. Last October, ISTA received U.S. Food and Drug Administration (FDA) approval for
`BROMDAY(TM), a oncedaily formulation of bromfenac. BROMDAY has been granted three years of
`marketing exclusivity as provided under the Drug Price Competition and Patent Term Restoration Act,
`commonly known as the HatchWaxman Act. Under the HatchWaxman Act, the FDA may not approve an
`Abbreviated New Drug Application for a generic version of BROMDAY until October 2013. ISTA launched
`BROMDAY at the end of November 2010 and, since that time, has focused most of the sales team's efforts on
`converting physicians who prescribed XIBROM to prescribing BROMDAY.
`
`"The transition to BROMDAY has been swift. As of the last week in January, 46% of the XIBROM new
`prescriptions have been converted over to BROMDAY, according to weekly prescription data supplied by
`IMS," stated Vicente Anido, Jr., PhD, President and Chief Executive Officer of ISTA Pharmaceuticals. "Having
`the first and only onceaday NSAID for postoperative inflammation and reduction of ocular pain in patients
`who have undergone cataract extraction has proven to be a major differentiation in the eyes of our customers
`and their patients. We look forward to gaining even wider acceptance of BROMDAY throughout the
`prescribing ophthalmic community in the years to come."
`
`ABOUT ISTA PHARMACEUTICALS ISTA Pharmaceuticals, Inc., is the fourth largest and fastest growing
`branded prescription eye care business in the United States, with an expanding focus on allergy therapeutics.
`ISTA currently markets five products, including treatments for ocular inflammation and pain postcataract
`surgery, glaucoma and ocular itching associated with allergic conjunctivitis. The company's development
`pipeline contains additional candidates in various stages of development to treat dry eye, ocular inflammation
`and pain and nasal allergies. Headquartered in Irvine, California, the company generated 2009 revenues of $111
`million. For additional information about ISTA Pharmaceuticals, please visit the corporate website at
`www.istavision.com.
`
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`5/8
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`Page 5 of 8
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`
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`ISTA Pharmaceuticals Announces XIBROM(TM) Shipments to Bloomberg
`11/16/2015
`BROMDAY(TM) (bromfenac ophthalmic solution) 0.09% and XIBROM (bromfenac ophthalmic solution)(R)
`0.09%, are trademarks of ISTA Pharmaceuticals, Inc.
`
`FORWARDLOOKING STATEMENTS Any statements contained in this press release that refer to future
`events or other nonhistorical matters are forwardlooking statements. Without limiting the foregoing, but by
`way of example, statements contained in this press release related to the end of shipments of XIBROM, supplies
`of XIBROM, inventories of XIBROM and future acceptance of BROMDAY are forwardlooking statements.
`Except as required by law, ISTA disclaims any intent or obligation to update any forwardlooking statements.
`These forwardlooking statements are based on ISTA's expectations as of the date of this press release and are
`subject to risks and uncertainties that could cause actual results to differ materially. Important factors that could
`cause actual results to differ from current expectations are detailed from time to time in ISTA's public filings
`with the U.S. Securities and Exchange Commission, including but not limited to ISTA's Annual Report on Form
`10K for the year ended December 31, 2009, and its Quarterly Report on Forms 10Q for the quarters ended
`March 31, June 30 and September 30, 2010.
`
`CONTACTS
`
`For Investor Relations: Lauren Silvernail 9497885302 lsilvernail@istavision.com
`
`Jeanie Herbert 9497893159 jherbert@istavision.com
`
`Juliane Snowden Burns McClellan 2122130006 jsnowden@burnsmc.com
`
`For General Media: Justin Jackson Burns McClellan 2122130006 jjackson@burnsmc.com
`
`For Trade Media: Tad Heitmann BioComm Network 7142732937 theitmann@BioCommNetwork.com
`
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`HEALTHCARE
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`How social factors
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`Integrating the non-medical
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`ISTA Pharmaceuticals Announces XIBROM(TM) Shipments to Bloomberg
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`11/16/2015
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`ISTA Pharmaceuticals Announces XIBROM(TM) Shipments to Bloomberg
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