`
`EPARTMENTOF COMMERCE
`UNITED STAT
`United States Pa ent and Trademark Office
`Address: COMMISSIONER FOR PATENTS
`P.O. Box 1450
`Alexandria, Virginia 22313-1450
`www.uspto.gov
`
`APPLICATION NO.
`
`FILING DATE
`
`FIRST NAMED INVENTOR
`
`ATTORNEY DOCKET NO.
`
`CONFIRMATION NO.
`
`10/525,006
`
`03/28/2005
`
`ShirouSawa
`
`2005_0232A
`
`1756
`
`09/2712007
`7590
`513
`WENDEROTH, LIND & PONACK, L.L.P.
`2033 K STREET N. W.
`SUITE 800
`WASHINGTON, DC 20006-1021
`
`EXAMINER
`
`THOMAS, TIMOTHY P
`
`ART UNIT
`
`PAPER NUMBER
`
`1614
`
`MAIL DATE
`
`DELIVERY MODE
`
`09/27/2007
`
`PAPER
`
`Please find below and/or attached an Office communication concerning this application or proceeding.
`
`The time period for reply, if any, is set in the attached communication.
`
`PTOL-90A (Rev. 04/07)
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`Page 1 of 14
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`SENJU EXHIBIT 2084
`LUPIN v. SENJU
`IPR2015-01097
`
`
`
`Office Action Summary
`
`Application No.
`
`10/525,006
`
`Examiner
`
`Applicant(s)
`
`SAWA ET AL.
`
`Art Unit
`
`1614
`Timothy P. Thomas
`:_ The MAILING DATE of this communication appears on the cover sheet with the correspondence address -(cid:173)
`Period for Reply
`
`A SHORTENED STATUTORY PERIOD FOR REPLY IS SET TO EXPIRE ~ MONTH(S) OR THIRTY (30) DAYS,
`WHICHEVER IS LONGER, FROM THE MAILING DATE OF THIS COMMUNICATION.
`Extensions of time may be available under the provisions of 37 CFR 1.136(a). In no event, however, may a reply be timely filed
`after SIX (6) MONTHS from the mailing date of this communication.
`If NO period for reply is specified above, the maximum statutory period will apply and will expire SIX (6) MONTHS from the mailing date of this communication.
`Failure to reply within the set or extended period for reply will, by statute, cause the application to become ABANDONED (35 U.S. C.§ 133).
`Any reply received by the Office later than three months after the mailing date of this communication, even if timely filed, may reduce any
`earned patent term adjustment. See 37 CFR 1.704(b).
`
`Status
`
`1)[8J Responsive to communication(s) filed on 20 August 2007.
`2a)0 This action is FINAL.
`2b)[8J This action is non-final.
`3)0 Since this application is in condition for allowance except for formal matters, prosecution as to the merits is
`closed in accordance with the practice under Ex parte Quayle, 1935 C.D. 11, 453 O.G. 213.
`
`Disposition of Claims
`
`4)[8J Claim{s) 19-40 is/are pending in the application.
`4a) Of the above claim(s) 39 and 40 is/are withdrawn from consideration.
`5)0 Claim(s) __ is/are allowed.
`6)[8J Claim(s) 19-38 is/are rejected.
`7)0 Claim{s) __ is/are objected to.·
`8}0 Claim(s} __ are subject to restriction and/or election requirement.
`
`Application Papers
`
`9)0 The specification is objected to by the Examiner.
`10)0 The drawing(s) filed on __ is/are: a)O accepted or b)O objected to by the Examiner.
`Applicant may not request that any objection to the drawing(s) be held in abeyance. See 37 CFR 1.85(a).
`
`Replacement drawing sheet(s) including the correction is required if the drawing(s) is objected to. See 37 CFR 1.121 (d).
`11 )[8J The oath or declaration is objected to by the Examiner. Note the attached Office Action or form PT0-152.
`
`Priority under 35 U.S.C. § 119
`
`12)[8J Acknowledgment is made of a claim for foreign priority under 35 U.S.C. § 119(a)-(d) or {f).
`a)[8J All b)O Some* c)O None of:
`1.[8J Certified copies of the priority documents have been received.
`2.0 Certified copies of the priority documents have been received in Application No. __ .
`3.0 Copies of the certified copies of the priority documents have been received in this National Stage
`application from the International Bureau (PCT Rule 17.2{a)).
`* See the attached detailed Office action for a list of the certified copies not received.
`
`Attachment(s)
`1) [8J Notice of References Cited (PT0-892)
`2) 0 Notice of Draftsperson's Patent Drawing Review (PT0-948)
`3) [8J Information Disclosure Statement(s) (PTO/SB/08)
`Paper No(s)/Mail Date See Continuation Sheet.
`
`4) 0 Interview Summary (PT0-413)
`Paper No(s)/Mail Date. __ .
`5) 0 Notice of Informal Patent Application
`6) 0 Other: __ .
`
`U.S. Patent and Trademark Office
`PTOL-326 (Rev. 08-06)
`
`Office Action Summary
`
`Part of Paper No./Mail Date 20070919
`
`Page 2 of 14
`
`
`
`Continuation Sheet (PTOL-326)
`
`Application No. 10/525,006
`
`Continuation of Attachment(s) 3). Information Disclosure Statement(s) (PTO/SB/08), Paper No(s)/Mail Date :2/17/2005,
`4/11/2005, 7/12/2007.
`
`2
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`Page 3 of 14
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`
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`Application/Control Number: 10/525,006
`Art Unit: 1614
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`Page 2
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`DETAILED ACTION
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`Elecuon/Restricuons
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`1.
`
`Applicant's election without traverse of group I, claims 19-38 in the reply filed on
`
`8/20/2007 is acknowledged.
`
`2.
`
`Applicant's election without traverse of claim 20 as the alkyl aryl polyether
`
`alcohol type polymer or polyethylene glycol fatty acid ester species (interpreted as
`
`tyloxapol, contained in the claim) in the reply filed on 8/20/2007 is acknowledged.
`
`3.
`
`Claims 39-40 are withdrawn from further consideration pursuant to 37 CFR
`
`1.142(b) as being drawn to a nonelected invention, there being no allowable generic or
`
`linking claim. Election was made without traverse in the reply filed on 8/20/2007.
`
`4.
`
`Claims 19-40 are pending. Claims 39-40 are withdrawn. Claims 19-38 are
`
`Status of Claims
`
`examined on the basis of the merits.
`
`Priority
`
`5.
`
`Applicant is advised of possible benefits Applicant is advised of possible benefits
`
`under 35 U.S.C. 119(a)-(d), wherein an application for patent filed in the United States
`
`may be entitled to the benefit of the filing date of a prior application filed in a foreign
`
`country.
`
`6.
`
`Receipt is acknowledged of papers submitted under 35 U.S. C. 119(a)-(d), which
`
`papers have been placed of record in the file.
`
`Acknowledgement is made of applicant's claim to foreign priority and the receipt
`
`of a copy of the application, JP2003-012427, filed 1/21/2003. However, since no
`
`Page 4 of 14
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`
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`Application/Control Number: 1 0/525,006
`Art Unit: 1614
`
`Page 3
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`translation has been provided, prior art dates have been determined with reference to
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`the priority date for the PCT application date, PCT/JP04/00350, filed 1/16/2004.
`
`Oath/Declaration
`
`7.
`
`The oath or declaration is defective. A new oath or declaration in compliance
`
`with 37 CFR 1.67(a) identifying this application by application number and filing date is
`
`required. See MPEP §§ 602.01 and 602.02.
`
`The oath or declaration is defective because:
`It was not executed in accordance with either 37 CFR 1.66 or 1.68.
`
`The oath or declaration contains no signatures of the inventors with date signed
`
`Claim Rejections- 35 USC§ 102
`
`8.
`
`The following is a quotation of the appropriate paragraphs of 35 U.S.C. 102 that
`
`form the basis for the rejections under this section made in this Office action:
`
`A person shall be entitled to a patent unless -
`
`(a) the invention was known or used by others in this country, o~ patented or described in a printed
`publication in this or a foreign country, before the invention thereof by the applicant for a patent.
`.
`
`.
`
`(b) the invention was patented or described in a printed publication in this or a foreign country or in public
`use or on sale in this country, more than one year prior to the date of application for patent in the United
`States.
`
`(e) the invention was described in (1) an application for patent, published under section 122(b), by
`another filed in the United States before the invention by the applicant for patent or (2) a patent
`granted on an application for patent by another filed in the United States before the invention by the
`applicant for patent. except that an international application filed under the treaty defined in section
`351 (a) shall have the effects for purposes of this subsection of an application filed in the United States
`only if the international application designated the United States and was published under Article 21 (2)
`of such treaty in the English language.
`
`9.
`
`Claims 19-24 and 31 are rejected under 35 U.S.C. 102(b) as being anticipated by
`
`Gamache, et al. (yVO 01/15677 A2; 03/2001).
`
`Gamache teaches all of the components of the claims: compositions for otic and
`
`intranasal use (p.6, lines 5-6) that contain a combination of a 5-HT agonist and an anti-
`
`Page 5 of 14
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`
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`Application/Control Number: 10/525,006
`Art Unit: 1614
`
`Page4
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`inflammatory agent (p. 6, lines 1-4; p. 12 lines 9-10) or alternatively sequential or
`
`concurrent dosing of separate compositions that contain the 5-HT antagonist in one
`
`composition and the anti-inflammatory agent in a second composition (p. 12, lines 9-
`
`11 ); specifically claimed is the anti-inflammatory specie bromfenac (the first compound
`
`of instant claim 19; claim 11; ); typical concentrations of anti-inflammatory agents, such
`
`as bromfenac, are taught in the range 0.01-1.0% (w/v) (overlapping with 0.01-0.5; p.
`
`13, lines 6-8); aqueous formulations are preferred (p. 10, lines 11-14); tyloxapol is
`
`taught at the concentration of 0.05% (w/v) (p. 16, line 30). It is noted that claim 21 and
`
`further dependent claims limit the options for the salt of bromfenac to the sodium salt,
`
`and that the specific concentrations recited in dependent claims apply to the sodium
`
`salt; the other options (bromfena~ or a hydrate of bromfenac) are still viable choices that
`
`are part of the claims 21 and dependent claims (which depend on and include the
`
`options of claim 20). Gamache anticipates 1) the claim to bromfenac in the
`
`concentration range of claim 20 (which is also an option of claims 21-24 and 31). 2)
`
`The form of bromfenac in solution will be the same when the acid is dissolved in a
`
`solution followed by adjustment to the desired pH with NaOH/HCI (Gamache, p. 15, line
`
`33) as when the sodium salt is dissolved in solution adjusted to the same pH; for this.
`
`case Gamache also anticipates the sodium salt limitation of claim 21, albeit not the
`
`sodium salt concentration limitation of claim 22 and further dependent claims, since the
`
`claim is drawn to an aqueous liquid preparation, irrespective of how it is prepared.
`
`10.
`
`Claim 19 is rejected under 35 U.S.C. 102(b) as being anticipated by Dobrozsi
`
`(US 6,319,513 81; 11/2001).
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`Page 6 of 14
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`
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`Application/Control Number: 10/525,006
`Art Unit: 1614
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`Page 5
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`Dobrozsi teaches aqueous liquid compositions comprising a pharmaceutically
`
`active agent selected from a group that includes analgesics (abstract); a specie taught
`
`is bromfenac {column 10, line 11); tyloxapol is taught at 0.15 and 0.035% (Example
`
`10).
`
`11.
`
`Claims 19-38 are rejected under 35 U.S.C. 1 02(e) as being anticipated by Sawa
`
`(US 2007/0082857 A 1; priority date 11/2003).
`
`The applied reference has a common inventor with the instant application.
`
`Based upon the earlier effective U.S. filing date of the reference, it constitutes prior art
`
`under 35 U.S.C. 102(e) . .This rejection under 35 U.S.C. 102(e) might be overcome
`
`either by a showing under 37 CFR 1.132 that any invention disclosed but not claimed in
`
`the reference was derived from the inventor of this application and is thus not the
`
`invention "by another," or by an appropriate showing under 37 CFR 1.131.
`
`Sawa teaches the elements of the claims: aqueous solution preparations
`
`comprising an aminoglycoside antibiotic and bromfenac or a salt of bromfenac
`
`(abstract); bromfenac sodium and bromfenac sodium hydrate is taught .at 0.1 and 0.2 %
`
`(Tables 1, 3, 6, 9-15); tyloxapol at 0.3 % resulted in solutions that were clear, when the
`
`control (no additive) was turbid (Table 5, 8), tyloxapol is also taught at 0·,02% (Table
`
`15); additives taught include benzalkonium chloride (Table 8), boric acid (Tables 9, 12),
`
`sodium edentate (Table 15), and sodium hydroxide {Table 15}; pH values include 7.5,
`
`7.8 and 8.0 (Tables 9-15); eye drop formulations are also taught {Examples 1-7). It is
`
`noted that the aqueous preparations contain an active ingredient not in the instant
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`Page 7 of 14
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`
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`Application/Control Number: 10/525,006
`Art Unit: 1614
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`Page6
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`claims. However, Sawa still anticipates the instant claims, due to the open language
`
`construction of the claims (use of "comprising").
`
`12.
`
`Applicant cannot rely upon the foreign priority papers to overcome this rejection
`
`because a translation of said papers has not been made of record in accordance with
`
`37 CFR 1.55. See MPEP § 201.15.
`
`Claim Rejections - 35 USC § 103
`
`13.
`
`The following is a quotation of 35 U.S.C. 103(a) which forms the basis for all
`
`obviousness rejections set forth in this Office action:
`
`(a) A patent may not be obtained though the invention is not identically disclosed or described as set
`forth in section 1 02 of this title, if the differences between the subject matter sought to be patented and
`the prior art are such that the subject matter as a whole would have been obvious at the time the
`invention was made to a person having ordinary skill in the art to which said subject matter pertains.
`Patentability shall not be negatived by the manner in which the invention was made.
`
`14.
`
`The factual-inquiries set forth in Graham v. John Deere Co., 383 U.S. 1, 148
`
`USPQ 459 (1966), that are applied for establishing a background for determining
`
`obviousness under 35 U.S.C. 1 03(a) are summarized as follows:
`
`1.
`2.
`3.
`4.
`
`Determining the scope and contents of the prior art.
`Ascertaining the differences between the prior art and the claims at issue.
`Resolving the level of ordinary skill in the pertinent art.
`Considering objective evidence present in the application indicating
`obviousness or nonobviousness.
`
`15.
`
`This application currently names joint inventors. In considering patentability of
`
`the claims under 35 U.S.C. 103(a), the examiner presumes that the subject matter of
`
`the various claims was commonly owned at the time any inventions covered therein
`
`I
`
`were made absent any evidence to the contrary. Applicant is advised of the obligation
`
`under 37 CFR 1.56 to point out the inventor and invention dates of each claim that was
`
`not commonly owned at the time a later invention was made in order for the examiner to
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`Page 8 of 14
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`
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`Application/Control Number: 10/525,006
`Art Unit: 1614
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`Page 7
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`consider the applicability of 35 U.S.C. 103(c) and potential 35 U.S.C. 1 02(e), (f) or (g)
`
`prior art under 35 U.S.C. 103(a).
`
`16.
`
`Claims 19-29,31-34, and 36-38 are rejected under 35 U.S.C. 103(a) as being
`
`unpatentable over Gamache, et al. (WO 01/15677 A2; 03/2001) and ISTA
`
`Pharmaceuticals ("New Drug Applications: Xibrom",
`
`http://www.drugs.com/nda/xibrom 040525.html, accessed online 9/19/2007) or Nolan,
`
`et al. ("The topical anti-inflammatory and analgesic properties of bromfenic in rodents:;
`
`Agents and Actions; 1988 Aug; 25(1-2):77-85, abstract).
`
`Claims 19-24 and 31 are rejected as outlined above. With respect to claims 21-
`
`38 (claims 21-24 and 31, with respect to the sodium salt of bromfenic and associated
`
`concentrations), in addition to the points made above, Gamache also teaches the
`
`additives and pH of the instant claims, edetate disodium, benzylalkonium chloride,
`
`sodium hydroxide, and a pH of 7.3-7.4 (Example 2); polyvinylpyrrolidone (p. 14, line 5);
`
`and sodium borate buffer (p. 13, line 11 ). Gamache does not specifically teach the
`
`sodium salt of bromfenic, nor a hydrate, nor the concentration range or specific
`
`bromfenic sodium concentrations of 0.05-0.2, or at 0.1 or 0.2 %, nor the tyloxapol
`
`concentrations of 0.02 or 0.3 %. The ISTA Pharmaceuticals news release
`
`demonstrates that products containing 0.1 % bromfenac sodium acquired US marketing
`
`rights for Xibrom in May 2002 {were known by others in this country before applicant's
`
`priority date, a 35 USC 1 02(a) date). Nolan teaches bromfenac (the sodium salt,
`
`sesquihydrate form) was effective as a topical analgesic at concentrations of 0.1-0.32 %
`
`in mice and more potent than the other drugs tested {abstract). It would have been
`
`Page 9 of 14
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`
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`Application/Control Number: 10/525,006
`Art Unit: 1614
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`Page 8
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`obvious for one of ordinary skill in the art at the time of the invention to select
`
`concentrations of bromfenac sodium, sesquihydrate of 0.1, about 0.2 and about 0.32 %,
`
`in the invention of Gamache, since these values have demonstrated efficacy for topical
`
`use. It would have been obvious to adjust the concentration of tyloxapol, to see what
`
`the effect would be on the solubility and stability of the aqueous preparations, which
`
`would have resulted in the effective concentrations of the instant claims. It would also
`
`have been obvious to adjust the pH to values in the 7.5 to 8.5 range, with the potential
`
`of dissolving and/or stabijizing more of the acidic drug, bromfenic, in a more aqueous
`
`soluble ionic form. The motivation would have been to prepare pharmaceutical
`
`products with optimal drug dosage and stability.
`
`17.
`
`Claims 19-30 are rejected under 35 U.S.C. 103(a) as being unpatentable over
`
`Yakuji Nippo Ltd. ("New Drugs in Japan"; 2001; English translation provided; IDS
`
`Reference AP) and Xia (US 6,369,112 81).
`
`Yakuji Nippo teaches a bromfenac sodium sesquihydrate ophthalmic formulation
`
`that contains: 0.1% (w/v) bromfenac (items 1-3); boric acid buffer, sodium sulfite,
`
`disodium eentate, polyvinylpyrrolidone, and benzalkonium chloride (item 2, additives); a
`
`pH of 8.0-8.6 (item 2, pH). Yakuji Nippo does not teach tyloxapol. Xia teaches a
`
`solution useful for contact lenses that provides enhanced cleaning and disinfecting
`
`efficacy of the contact lens (abstract), which contains tyloxapol as one of three
`
`ingredients (abstract; column 3, lines 7-21); tyloxapol is taught at concentrations of 0.25
`
`and 0.025 (about 0.02 and 0.3; Table 1 ). Xia teaches the addition of tyloxapol to the
`
`solution improves the stability and therefore the disinfecting efficacy over time of the
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`Page 10 of 14
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`
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`Application/Control Number: 10/525,006
`Art Unit: 1614
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`Page 9
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`active component (column 7, lines 8-18). It would have been obvious to one of ordinary.
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`skill in the art at the time of the invention to add tyloxapol to the ophthalmic formulation
`
`of Yakuji Nippo. The motivation to do so is that taught by Xia, the stability enhancing
`
`effect of this component on the active ingredient. There would have been an
`
`expectation of success, since tyloxapol has demonstrated efficacy with the contact lens
`
`cleaning solutions.
`
`18.
`
`Claim19-38 are rejected under 35 U.S.C. 103(a) as being unpatentable over
`
`Yakuji Nippo Ltd. ("New Drugs in Japan"; 2001; English translat~on provided; IDS
`
`Reference AP) and Xi a (US 6,369,112 B 1) as applied to claims 19-30 above, and
`
`further in view of Nolan, et al. {"The topical anti-inflammatory and analgesic properties
`
`of bromfenic in rodents:; Agents and Actions; 1988 Aug; 25(1-2):77-85, abstract).
`
`Neither Yakuji Nippo or Xia teach the bromfenac sodium hydrate solutions at a
`
`bromfenac concentration of 0.2 %. Nolan teaches topical solutions are efficacious in
`
`the concentration range of 0.1-0.32 %. It would have been obvious to one of ordinary
`
`skill in the art at the time of the invention to use a concentration of about 0.2%
`
`bromfenic sodium hydrate (right in the middle of the range Nolan teaches is effective), in
`
`the modified Yakuji Nippo ophthalmic solution with tyloxapol addeq. The motivation to
`
`use a higher bromfenac concentration would be to provide an option of a more
`
`concentrated solution for patients in cases where a physician determines that higher
`
`anti-inflammatory concentration is desirable, such as when the lower dosage does not
`
`completely relieve the inflammation or pain.
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`Page 11 of 14
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`
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`Application/Control Number: 10/525,006
`Art Unit: 1614
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`Page 10
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`Double Patenting
`
`19. · The nonstatutory double patenting rejection is based on a judicially created
`doctrine grounded in public policy (a policy reflected in. the statute) so as to prevent the
`unjustified or improper timewise extension of the "right to exclude" granted by a patent
`and to prevent possible harassment by multiple assignees. A nonstatutory
`obviousness-type double patenting rejection is appropriate where the conflicting claims
`are not identical, but at least one examined application claim is not patentably distinct
`from the reference claim(s) because the examined application claim is either anticipated
`by, or would have been obvious over, the reference claim(s). See, e.g., In re Berg, 140
`F.3d 1428, 46 USPQ2d 1226 (Fed. Cir. 1998); In re Goodman, 11 F.3d 1046, 29
`USPQ2d 2010 (Fed. Cir. 1993}; In re Longi, 759 F.2d 887, 225 USPQ 645 (Fed. Cir.
`1985); In re Van Omum, 686 F.2d 937, 214 USPQ 761 (CCPA 1982); In re Vogel, 422
`F.2d 438, 164 USPQ 619 (CCPA 1970); and In re Thorington, 418 F.2d 528, 163
`USPQ 644 (CCPA 1969).
`A timely filed terminal disclaimer in compliance with 37 CFR 1.321(c) or 1.321(d)
`may be used to overcome an actual or provisional rejection based on a nonstatutory
`double patenting ground provided the conflicting application or patent either is shown to
`be commonly owned with this application, or claims an invention made as a result of
`activities undertaken within the scope of a joint research agreement.
`Effective January 1, 1994, a registered attorney or agent of record may sign a
`terminal disclaimer. A terminal disclaimer signed by the assignee must fully comply with
`37 CFR 3.73(b).
`
`20.
`
`Claims 19-38 are provisionally rejected on the ground of nonstatutory
`
`obviousness-type double patenting as being unpatentable over claims 1-43 of
`
`copending Application No. 11/755662. Although the conflicting claims are not identical,
`
`they are not patentably distinct from each other because the copending application
`
`contains claims drawn to method of treating pain and/or inflammation associated with
`
`an ocular condition, by administering the aqueous solutions of the instant claims. It
`
`would have been obvious ·to one of ordinary skill in the art at the time of the invention to
`
`use the formulations of the instant claims in the methods of the copending application,
`
`since the claims recite that the formulations are eye drops, and the instant abstract also
`
`teaches some of the conditions treated of the copending application.
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`Page 12 of 14
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`
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`Application/Control Number: 10/525,006
`Art Unit: 1614
`
`Page 11
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`This is a provisional obviousness-type double patenting rejection because the
`
`conflicting claims have not in fact been patented.
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`Conclusion
`
`21.
`
`No claim is allowed.
`
`22.
`
`Any inquiry concerning this communication or earlier communications from the
`
`examiner should be directed to Timothy P. Thomas whose telephone number is (571)
`
`272-8994. The examiner can normally be reached on Monday-Thursday 6:30a.m. -
`
`5:00p.m ..
`
`If attempts to reach the examiner by telephone are unsuccessful, the examiner's
`
`supervisor, Ardin Marschel can be reached on (571) 272-0718. The fax phone number
`
`for the organization where this application or proceeding is assigned is 571-273-8300.
`
`Information regarding the status of an application may be obtained from the
`
`Patent Application Information Retrieval (PAIR) system. Status information for
`
`published applications may be obtained from either Private PAIR or Public PAIR.
`
`Status information for unpublished applications is available through Private PAIR only.
`
`For more information about the PAIR system, see http://pair-direct.uspto.gov. Should
`
`you have questions on access to the Private PAIR system, contact the Electronic
`
`Business Center (EBC) at 866-217-9197 (toll-free).-lf you would like assistance from a
`
`USPTO Customer Service Representative or access to the automated information
`
`system, call 800-786-9199 (IN USA OR CANADA) or 571-272-1000.
`
`ITPT/
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`Page 13 of 14
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`
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`Application/Control Number: 10/525,006
`Art Unit: 1614
`
`Timothy P. Thomas
`Patent Examiner
`
`Page 12
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`~~~r2~~7
`
`ARDIN H. MARSCHEL
`SUPERVISORY PATENT EXAMINER
`
`Page 14 of 14