CURRICULUM VlTAE
`
`Name
`
`Dr. Roger Frank Newton.
`
`Date of birth
`
`26th May 1941.
`
`Address
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`Braddocks House, Camesworth Lane, Oxbridge,
`Briolport, Dorset DT6 3TZ
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`1953 - 1961
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`Hardye's School, Dorchester, Dorset.
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`1961 -1971
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`Portsmouth Polytechnic.
`
`1961 -1964
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`B.Sc External London.
`
`1964 - 1968
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`PhD External London. Thesis entitled "Stereo-
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`chemistry of compounds with bridgehead nitrogen
`atoms".
`
`1968 - 1971
`
`Teaching Research Fellow
`
`1981
`
`Fellow of the Royal Society of Chemistry
`
`1971 - 1996
`
`Allen & Hanburys and Glaxo Group Research Ltd.
`
`1971 - 1972
`
`Senior Research Chemist.
`
`1972 - 1974
`
`Research Leader.
`
`1974 - 1978
`
`Head of Exploratory Research Department.
`
`1978 - 1983
`
`Head of Chemical Research Department - Ware.
`
`1983 - 1988
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`Director of Chemistry - Ware.
`
`1989 - 1995
`
`Director of Chemical Research Division GGR Ltd.
`
`1995 -1996
`
`Secondment to The Department of Trade 8. Industry.
`
`1996
`
`Retired from Glaxo.
`
`Glaxo Group Research appointments
`
`1987 -1994
`
`Chairman of the respiratory research management
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`committee with responsibility for directing the
`companies giobal research in this area.
`
`1987 - 1988
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`Vice - Chairman of the cardiovascuiar research
`
`management committee.
`
`1989 -1992
`
`Vice - Chairman of the anti-infective research
`
`management committee.
`
`Appointments and directorships
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`1997 — 2006
`
`1998 - 2004
`
`Lead the MBOIMBI and then served as Chief Executive,
`and Director of science of Maybridge PLC.
`
`Consultant for Johnson 8; Johnson Pharmaceuticals,
`USA.
`
`2000
`
`Consultant for Sun Pharma Ltd, Mumbai, India.
`
`2001 ~ 2006
`
`Consultant for Sumitomo Chemicals Ltd, Osaka,
`Japan.
`
`2002 - 2004
`
`Consultant for Roche Pharmaceuticals, Switzerland.
`
`2005 - 2006
`
`Consultant for Novartis Institutes for BioMedical
`Research Inc.
`
`1992 - 1994
`
`Non-executive Director of Glaxochem Ltd.
`
`1995 - 1999
`
`1997- 1999
`
`Non-executive Director of Cerebrus Ltd. Company sold
`to Vanguard Medica.
`
`Non-executive Director of Cambridge Molecular
`Technologies Ltd. Company sold to Whatmans PLC.
`
`1998 ~ 2001
`
`Founder Director and non-executive Director of
`
`Cambridge Genetics Ltd and chairman of the scientific
`advisory board. Company sold to Biofocus Ltd.
`
`1999 — 2001
`
`Non-executive Director of Syngenix Ltd.
`
`1998 - 2003
`
`Member of the scientific affairs board of Celltech
`
`2003 - 2004
`
`Consultant for Celltech.
`
`1999 — 2003
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`Member of the scientific affairs board of PanTherix
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`Ltd.
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`2002 — 2004
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`Chairman of the scientific advisory board of Amedis
`Ltd.
`
`Academic appointments
`
`1976 -1982
`
`Honorary Lecturer in Chemistry, University of
`Sheffield.
`
`1984 - 1985
`
`Visiting Lecturer University of Warwick.
`
`1977 -1984
`
`Visiting Fellow University of Salford.
`
`1984 -1985
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`External Examiner University of Salford.
`
`1984 - 1989
`
`Visiting Professor University of Salford.
`
`1984 - 1998
`
`Visiting Professor Kings College, University of
`London.
`
`1985 - 1995
`
`Visiting Professor University of Warwick.
`
`1985 - 1990
`
`Visiting Professor University College of North
`Wales, Bangor.
`
`1987 - 1992
`
`and
`
`1994 - 1996
`
`Visiting Professor University of Bath.
`
`1991 - 1994
`
`Visiting Professor University of Southampton.
`
`1995 - 1997
`
`Visiting Professor University of Leeds.
`
`1993- 1997
`
`1996 — 2005
`
`Honorary Visiting Professor University of St.
`Andrews.
`
`Resident Medicinal Chemist in the Chemistry
`Department at The University of Cambridge.
`
`1996- present
`
`Visiting Professor University of Sussex.
`
`Related experience
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`1982 -1984
`
`Chairman of the Heterocyclic Group of the Royal
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`Society of Chemistry.
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`1984
`
`1985
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`Vice - Chairman European Symposium on Bio-
`organic chemistry.
`
`Chairman of the European Symposium on Bio-
`organic chemistry.
`
`1986 - 1991
`
`Editorial Board Member for Drug Design and Delivery.
`
`1989 -1998
`
`Honorary Advisory Board Member for Synlett.
`
`1980 — 1983
`
`1987 - 1990
`
`1991 -= 1993
`
`1992- 1998
`
`Member of the Perkin Council, Royal Society
`of Chemistry.
`
`Member of the Perkin Editorial Board, Royai
`Society of Chemistry.
`
`Vice-President Perkin Councii, Royal Society of
`Chemistry.
`
`Member of the Scientific Affairs Board, Royal
`Society of Chemistry.
`
`‘£977 - 1978
`
`Member of the S.R.C. Polytechnics Committee.
`
`1987 - 1990
`
`Member of the SERC Chemistry Committee.
`
`1988 - 1992
`
`Member of the SERC Molecuiar Recognition
`Committee.
`
`1988 -1992
`
`Member of the SERC Science Board Industrial
`
`Strategy Panel.
`
`Prizes
`
`1995
`
`1996
`
`Lectures
`
`Royal Society of Chemistry award for Medicinal
`Chemistry.
`
`Royal Society of Chemistry Biological and Medicinai
`Chemistry Sector Award.
`
`Invited lecturer at numerous national and
`
`International meetings.
`
`Sir Jesse Boot Foundation Lecturer, 1996.
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`Pubiications
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`Patents
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`Joint author of 139 refereed research papers and 7
`reviews mostly concerned with synthetic organic
`chemistry. Joint editor of 1 book.
`
`Joint author of 11 patents.
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`PUBLICATIONS
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`T. A. Crabb and R. F. Newton, Conformational analysis of 8-oxa-1—azabicyclo
`[4.3.0]nonanes using geminal coupling constants. Chem. and End. 1966, 339.
`
`T. A. Crabb and R. F. Newton, Stereochemical studies on 7-substituted 8-oxa-1-
`azabicyclo[4.3.0]nonanes. J. Heterocyclic Chem. 1966, 3,418.
`
`T. A. Crabb and R. F. Newton, Configurational and conformationat studies with
`derivatives of 8-oxa-1-azabIcycIo[4.3.0]nonanes. Tetrahedron, 1968, 24, 1997.
`
`T A. Crabb and R. F. Newton, Configurational and conformational studies with
`methyl substituted 8-thia-1-azabicycloI4.3.0]nonanes. Tetrahedron, 1968, 24,
`2485.
`
`T. A. Crabb and R. F. Newton, Configurational and conformational studies with
`derivatives of octahydropyrido[1,2-c] 1,3-oxazines. Tetrahedron, 1968, 24, 4423.
`
`T. A. Crabb and R. F. Newton, Configurational and conformational studies with
`substituted 1,8-diazabicyclo[4.3.0]nonanes. Tetrahedron, 1968, 24, 6327.
`
`T. A. Crabb and R. F. Newton, Configurational and conformational studies with
`methyl-substituted 8-phenyl-I, 8-diazabicyclo[4.3.0}nonanes. J. Heterocyclic
`Chem. 1969, 6, 301.
`
`T. A. Crabb and R. F. Newton, Conflgurational and conformational studies with
`derivatives of 1,3-diazabicyc|o[4.4.0]decanes. Tetrahedron, 1970,26, 701.
`
`T. A. Crabb and R. F. Newton, The NMR spectra and configurations of some
`2,5,5,-trisubstltuted 1,3-dioxans. Tetrahedron, 1970, 26, 693.
`
`T. A. Crabb and R. F. Newton, Conformational equilibria in bridgehead nitrogen
`systems. Tetrahedron Letters, 1970, 1551.
`
`T.A. Crabb, P.J. Chivers, E. R. Jones and R. F. Newton, The influence of an axial
`5-methyl group on the chemical shifts of C2 methylene protons in 1,3-
`heterosystems. J. Heterocyclic Chem. 1970, 7, 635.
`
`T. A. Crabb and R. F. Newton, The reactions of stereoisomeric
`decahydroquinolin-8-ois with formaldehyde. J. C. 3. Chem Comm. 1970, 1123.
`
`T. A. Crabb and R. F. Newton, Configurational and conformationai studies with
`derivatives of 3-thia-1-azabicyclo[4.4.0]decane. Tetrahedron,1970, 26, 3941.
`
`T. A. Crabb, R. F. Newton and D. Jackson, Stereochemical studies on nitrogen
`bridgehead compounds by spectral means. Chem. Rev. 1971, 71, 109.
`
`Y. Allingham, T. A. Crabb and R. F. Newton, The NMR spectra of some 1,3-
`oxathians and the influence of heteroatoms on the coupling constants of
`adjacent protons. Organic Magnetic Resonance, 1971, 3, 37.
`
`T. A. Crabb and R. F. Newton, The conformational equilibria of 4,4a,5,6-
`tetrahydro-1H-3H-[1,3]oxazino[3,4-a]quinoline, 3,4,11,11a-tetrahydro-1H-
`6H-[1,3}oxazino[3,4-b]isoquino|lne and 1,6,7,11b-tetrahydro-2H,4H-[1,3]
`
`10.
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`11.
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`21.
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`22.
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`24.
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`25.
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`26.
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`27.
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`28.
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`29.
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`30.
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`oxazino[4,3-a]isoquinoline.Tetrahedron Letters, 1971, 3361.
`
`R. Cahill, T. A. Crabb and R. F. Newton, Geminal coupling constants in
`methylene groups adjacent to nitrogen in indolizidine, quinolizidine and related
`systems. Organic Magnetic Resonance,1971, 3, 263.
`
`T. A. Crabb and R. F. Newton, The stereochemistry and 1H nuclear magnetic
`resonance spectra of some perhydro-2-methylimidazo[1,5-a]pyridin-1-ones and
`perhydro-2-methylpyrido{1,2-c] pyrimidin-3-ones. J. C. S. Perkin II, 1972, 1920.
`
`T. A. Crabb, P. J. Chivers and R. F. Newton, The stereochemistry of
`octahydroimidazo[1,5-a]pyrldine and of some N-acetyloctahydroimidazo[1,5-
`a]pyridines. Organic Magnetic Resonance,1973, 5, 397.
`
`T. A. Crabb and R. F. Newton, The effect ofa fused aromatic ring on the
`conformational preference of perhydropyridofi,2-c][1,3]oxazines and related
`compounds. J. C. S. Perkin II, 1977, 370.
`
`M. C. Cooper, G. J. Hignett, R. F. Newton, J. A. Joufe, M. Harris and J. D. Finchiey,
`Nucleophilic substitution at an indole 8- position. J.C.S. Chem Comm. 1977, 432.
`
`M. J. Dimsdale, T. V. Lee, R. F. Newton, D. K. Rainey, S. M. Roberts and C. F. Webb,
`Synthesis of prostaglandin-Fguby conjugate addition of a cuprate reagent to 3-t-
`butyl-dimethyisilyloxy-tricyclo[3.2.0.02‘71heptan-6-one.
`.1. c. s. Chem Comm. 1977,
`716.
`
`N. M. Crossiand, R. F. Newton and S. M. Roberts, Photosynthetic routes to
`prostanoids. Synthesis of alkyl and trialkylsiiyl derivatives of 9-hydroxy~9-
`deoxyprostagiandin-C2. J. C. S. Chem Comm. 1977, 886.
`
`N. M. Crossiand, R. F. Newton and S. M. Roberts, Photosynthetic routes to
`prostaglandins. Conversion of 2,3-endo-epoxybicycio-[3.2.t}]heptan-6~one into 6,7-
`endo-epoxy-3-alkoxy-2-oxahicyc[o{3.3.0]octanes. J. C. S. Chem Comm. 1978, 661.
`
`N. M. Crossiand, R. F. Newton, 3. M. Roberts and C. F.Webb, Synthesis of
`prostagiandin-E2 and prostaglandin-C2 from 5-endo,7~anti-disubstituted
`bicyclo[2.2.1]heptan-2-ones. J. C. 3. Chem Comm.1978, 660.
`
`N. M. Crossiand, C. C. Howard, R. F. Newton, D. P. Reynolds, 8. M. Roberts and A.
`H. Wadsworth, Novel synthesis of prostaglandin-E2 involving regioselective ring
`opening of a 2,3-endo- epoxybicyclo[3.2.0]heptan-6—one acetal with a mixed
`organocuprate reagent. J. C. 3. Chem Comm. 1978, 662.
`
`H. F. Beckford, R. M. King, R. F. Newton and J. F. Stoddart, Complexes of primary
`alkylammonlum salts and secondary dialkylammonium salts with
`diazaparacyclophanes. Tetrahedron Letters, 1978, 171.
`
`M. J. Dimsdale, T. V. Lee, R. F. Newton, D. K. Rainey, S. M. Roberts, Total synthesis
`of prostaglandin-F2“ through homoconjugate addition of an organocuprate reagent
`to tricyclo{3.2.0.02'7]heptan-6-one. J. C. S. Perkin I, 1978,1176.
`
`T. V. ‘Lee, R. F. Newton and S. M. Roberts, Preparation and some reactions of 3-
`endo-substituted tricyclo[3.2.0.02'7]heptan-6-ones. .1.c.s. Perkin I, 1978, 1179.
`
`Z. Grudzinski., C. C. Howard, R. F. Newton and S. M. Roberts, Factors governing the
`ratio of isomeric oxabicyclo[3.2.1] octanones formed on Baeyer-Villiger oxidation of
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`38.
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`39.
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`40.
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`41.
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`42.
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`43.
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`some 5-endo-7~anti disubstltuted bicyclo[2.2.'i] heptan-2-ones. J. C. S. Perkin I,
`1978, 1182
`
`S. M. Ali, R. F. Newton and S. M. Roberts, Novel polyunsaturated lactones from 2-
`oxabicyclo[3.3.0]oct-6-en-3-ones. Tetrahedron Letters, 1979, 71.
`
`S. M. Ali, T. V. Lee, R. F. Newton and S. M.Roberts, Synthesis of some cyclopropyt -
`lactones as analogues of cytotoxic - methylene -lactones. J. C. S. Perkin 1, 1979,
`708.
`
`R. F. Newton, E. F. Scriven, H. Suschitzky and D. R. Thomas, Decomposition of
`some substituted azictoindoles and azido-hexahydrocarbazoles. J. C. S. Perkin l,
`1979, 53.
`
`S. M.Aii, N. M. Crossland, T. V. Lee, R. F. Newton and S. M. Roberts, Some
`stereocontrolled reactions of bicyc[o[3.2.0] heptan-6-ones and 2-oxabicyclo[3.3.0]
`octan~3-ones. J. C. S. Perkin I, 1979, 122.
`
`N. M.Crossland, R. F. Newton, and S. M. Roberts, Photosynthetic routes to
`prostaglandins, synthesis of prostaglandin-C2 and anaiogues J. C. S. Perkin l, 1979,
`2397.
`
`M. R. Johnson, R. F. Newton and I. O. Sutheriand, The formation of complexes
`between aza derivatives of crown ethers and primary atkyiammonium thiocyanates.
`J. C. S. Perkin I, 1979, 357.
`
`L. G. l-iodgkinson, M. R. Johnson, S. J. Leigh, R. F. Newton, N. Spencer and I. 0.
`Sutherland, The formation of complexes between aza derivatives of crown ethers
`and primary alkylammoniurn thiocyanates: Diaza-18-crown-6 derivatives. J. C. S.
`Perkin i, 1979, 2193.
`
`M. R. Johnson, R. F. Newton and l. 0. Sutherland, The formation of inclusion
`complexes by tricyclic hosts. J. C. S. Chem Comm. 1979, 309.
`
`M. R. Johnson, R. F. Newton and l. O. Sutherland, Bis mono-aza crown ethers. The
`formation of intramoiecular complexes with dications. J. C. S. Chem Comm. 1979,
`306.
`
`R. F. Newton and S. M. Roberts, Bicycles, tricycles and prostaglandin synthesis.
`The chemistry, biochemistry and pharmacological activity of prostagiandins.
`Pergamon Press, Oxford, 1979.
`
`D. Kelly, R. F. Newton and S. M. Roberts, The use of boron trifiuoride etherate for
`the removal of t-butyl dimethylsilyl protecting groups. Synthetic Communications,
`1979, 295
`
`R. J. Cave, C. 0. Howard, G. Klinkert, R. F. Newton, D. P. Reynolds, 8. M. Roberts
`and A. H. Wadsworth, Regioselective reactions of 2,3-endo epoxybicyclo[3.2.0]
`heptanone ethylene acetai involving organometallic reagents. J. C. S. Perkin l,
`1979, 2954.
`
`S. M. Ali, M. A. Finch, R. F. Newton and S. M. Roberts, Synthesis of 9-deoxa-9, 10-
`dehydroprostaglandin-D2 through reaction of 2-oxatricyc|o[3.3.0.04’°]oct-7-en-3-one
`with a cuprate reagent. J. C. S. Chem Comm. 1979, 679.
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`M. A. Finch, T. V. Lee, R. F. Newton and S. M. Roberts, Total synthesis of
`prostaglandin-A2 through an Sn reaction of an allylic epoxide and a heterocuprate
`reagent. J. C. 3. Chem Comm. 1979, 677.
`
`C. B. Chapleo, R. F. Newton and S. M. Roberts, Synthesis of 12-aikyl analogues of
`prostaglandin-A2. J .C. S. Chem Comm. ‘I979, 680.
`
`N. M. Crossland, D. R. Kelly, R. F. Newton, D. P. Reynolds and S. M. Roberts,
`Photosynthetic routes to prostanoids. Ring expansions of some substituted cyclo
`butanones to form cyclic acetals or y-lactols. J. C. S. Chem Comm. 1979, 681.
`
`D. R. Kelly, R. F. Newton, D. P. Reynolds and S. M. Roberts, Synthesis of (1)
`prostaglandin-F-2,, involving photolytlc conversion of a cyclobutanone to a 3--lactol.
`J. C. 5. Chem Comm. 1979, 683.
`
`R. F. Newton, D. P. Reynolds and S. M. Roberts, Total synthesis of prostaglandin- D2
`methyl ester. J. C. S. Chem Comm. 1979, 1150.
`
`P. Murray Rust, J. Murray-Rust and R. F. Newton, 6,7-endo-epoxy-2-oxa-3-
`oxabicyclo {3.3.0}octane, Acta Crystallographica, 1979, 1918.
`
`P. Murray-Rust, J. Murray-Rust, A. Brown and R. F. Newton, c:'s- bicyclo[3.2.0.]hept-
`2-en-6-one p-nitrophenyl hydrazone, Acta Crystallographica, 1979, 1915.
`
`Z. Grudzinski, R. F. Newton, D. P. Reynolds, 8. M. Roberts, C. F. Webb and S. N.
`Young, Total synthesis of prostaglandin-E2 by rearrangement of a 6,8-disubstituted
`2-oxabicyclo[3.2.1]octan-3-one to a 4,5-disubstituted hexahydro-2H-cyclopenta
`[b]furan-2-one.J. C. S. Perkin I, 1979, 2789.
`
`C. B. Chapleo, M. A. W. Finch, T. V. Lee, S. M. Roberts and R. F. Newton, Sn
`reactions involving organocuprate reagents. J. C. S. Chem Comm. 1979. 676.
`
`R. F. Newton, D. P. Reynolds, M. A. W. Finch, D. R. Kelly and S. M. Roberts, An
`excellent reagent for the removal of the t«-butyldimethylsilyl protecting group.
`Tetrahedron Letters, 1979, 3981.
`
`A. Brown, R. Glen, P. Murray-Rust, J. Murray-Rust and R. F. Newton, X-ray
`Crystallographic determination of the conformation of bicycle [3.3.0] octane and
`bicyc|o[3.2.0.]heptane derivatives and evidence for an D...C=0 interaction. J. C. S.
`Chem Comm. 1979, 908.
`
`R. F. Newton, J. Paton, D. P. Reynolds, S. Young and S. M. Roberts, The substrate
`non-enantiospeclfic product enantioselective reduction of bicyclo[3.2.0.]hept-2-en-
`6-one using yeast. J. C. S. Chem Comm. 1979,1178.
`
`M. J. Bovill, D. J. Chadwick, M. R. Johnson, N. F. Jones, I. O. Sutherland and R. F.
`Newton, Formation of 2:1 complexes between alkylammoniurn cations and dlaza
`crown ethers. J. C. S. Chem Comm. 1979, 1065.
`
`C. C. Howard, R. F. Newton, D. P. Reynolds, A. H. Wadsworth, D. R. Kelly and S. M.
`Roberts, Total synthesis of prostaglandin-F2, involving stereocontrolled and photon
`induced reactions of bicyclo[3.2.0.]heptanones. J. C. S. Perkin I, 1989, 852.
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`71.
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`C. B. Chapleo, M. A. W. Finch, T. V. Lee, S. M. Roberts and R. F. Newton, Total
`synthesis of prostaglandin-A2 involving the reaction of a heterocuprate reagent with
`an aliyl epoxide. J. C. S. Perkin I, 1980,2084.
`
`R. F. Newton, D. P. Reynolds, N. M. Crossiand, D. R. Kelly and S. M. Roberts,
`Photolytic conversion of some bicylco[3.2.0]heptanones into 3-hydroxy- or 3-
`methoxy-2-oxabicyclo[3.3.0]octan-2-ones. J. C. S. Perkin I, 1980, 1583.
`
`C. B. Chapleo, S. M. Robert and R. F. Newton, Preparation and hydrolysis of some
`4-substituted bicyclo[3.’i.0}hex-2-one 6-carboxaldehydes: Synthesis of the
`prostaglandin—A2 analogue possessing a butyl group in place of the octenol side
`chain. J. C. S. Perkin I, 1980,2088.
`
`R. F. Newton, P. L. Pauson and R. G. Taylor, Alkyne-cobalt complexes as
`prostaglandin synthons. Simple preparations of known intermediates for 1- and 2-
`series prostaglandin formation and synthesis of (1)-11-deoxy-1 0a,11a-trirnethylene
`prostaglandin-E1 methyl ester. J. Chem. Research (S), 1980, 277.
`
`S. M. Ali, M. A.W. Finch, R. F. Newton and S. M. Roberts, Syntheses of
`prostaglandin-A2 from 3-endo-bromotricyclo[32.0.023} heptan-6-one. J. C. S. Chem
`Comm. 1930, 74.
`
`R. F. Newton and S. M. Roberts, Steric control in prostaglandin synthesis involving,
`bicyciic and tricyclic intermediates. Tetrahedron Reports, 1980, 90, 2163.
`
`C. B. Chapleo, M. A. W. Finch, R. F. Newton, D. W. Selby, S. M. Roberts and G. T.
`Woolley, SN reactions on some cyclopentene derivatives employing simple
`nucleophiies and organocuprate reagents. J. C. S. Perkin l, 1980, 1847.
`
`M .P. Carmody, R. F. Newton and M. Satnsbury, Electrochemical oxidation of
`aromatic ethers. The oxidation of 4-(3.4-dimethoxybenzyl)-6,7-dEmethoxy-2-methyl-
`1,2,3,4-tetrahydrolsoquinoline and the attempted synthesis of 4-(3,4-
`dimethoxybenzyl)-6,7-dimethoxy-2-methyl-‘E,2,3, 4-tetrahydro-3-isoquinolone. J. C.
`S. Perkin l, 1980, 2013.
`
`R. J. Batten, A. J. Dixon, R. J. K. Taylor and R. F. Newton, A new method for
`removing t-butyldimethylsilyl protecting groups, Synthesis, 1980, 234.
`
`R. F. Newton, D. P. Reynolds, J. Greenwood and F. Scheinmann, Conjugate,
`homoconjugate and 1,2-additions of acetyiene nucleophiles and their application to
`prostaglandin synthesis. J. C. S. Perkin I, 1980, 2346.
`
`M. R. Johnson, I. O. Sutherland and R. F. Newton, The formation of complexes
`between aza-derivatives of crown ethers and primary alkylammonium salts
`Bis(mono-aza) crown ethers. J. C. S. Perkin l, 1980, 586.
`
`S. P. Briggs, D. l. Davies, R. F. Newton and D. P. Reynolds, The structure of
`glutaconic anhydride and the synthetic utility of its Dieis-Alder adduct with
`cyclopentadiene. J. C. S. Perkin i,1980,146.
`
`S. P. Briggs, D. I. Davies, R. F. Newton and D. P. Reynolds, Synthesis of the 9,11-
`hydroxy ethane-prostaglandin endo peroxide 1-I2 analogue, J. C. S. Perkin l,
`1980,150.
`
`M. A. W. Finch, S. M. Roberts, and R. F. Newton, Total synthesis of (1)-68
`prostaglandin-I1, J. C. S. Chem. Comm, 1980, 589.
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`83.
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`84.
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`85.
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`S. M. Ali, G. B. Chapieo, R. J. Cave, M. A. W. Finch, R. F. Newton, S. M. Roberts and
`G. T. Woolley, Preparation and some reactions of 2-oxatricyc!o[3.3.0.04’E]oct-7-en-3-
`one: Synthesis of 9-deoxa, 9,10-dehydro prostaglandin-D2. J. C. S. Perkin I, 1980,
`2093.
`
`J. F. Collins, J. A. McDonald and R. F. Newton, Characterisation of the binding of
`3H-lsoguvaclne, a y-aminobutyric acid agonist, to brain synaptosomal membranes.
`Prog. in Brain Research, 1980, 141.
`
`M. A. W. Finch, S. M. Roberts, G. T. Woolley and R. F. Newton, Synthesis of
`prostaglandin-A2 through reaction of 3—endo—bromotricyc1o[3.2.0.02'7]heptan-6-one
`with a ouprate reagent. J. C. S. Perkin l, 1981,1725.
`
`R. F. Newton, D. P. Reynolds and S. M. Roberts, A short and efficient synthesis of
`(1) prostaglandin-D2 methyl ester involving a new method for the cleavage of a t-
`butyldimethylsilyl ether. J. C. S. Perkin l, 1981, 2049.
`
`C. C. Howard, R. F. Newton, D. P. Reynolds and S. M. Roberts, Total syntheses of Q)
`prostaglandin-E2 methyl ester from 2-exo-bromo-3-endo nydroxy
`bicyc|o[3.2.0]heptan-6-one using t-butyldimethysiiyl protected intermediates. J. C.
`S. Perkin I, 1981,2055.
`
`M. A. W. Finch, S. M. Roberts and R. F. Newton, Synthesis of Q)-613-prostagiandin»
`I1, and (_-I;)-613-ciecarboxyprostagiandin-1,. J. C. S. Perkin 1,1981, 1312.
`
`J. Davies, S. M. Roberts, R. F. Newton and D. P. Reynolds, Enantiocomplementary
`total asymmetric syntheses of prostaglandin-E2 and prostaglandin-F20, . J. C. S.
`Perkin 1,1981, 1317.
`
`S. M. Roberts, G. T. Wooliey and R. F. Newton, Factors influencing the
`regioselectivity of reactions involving organocuprate reagents and ally acylates:
`Synthesis of some phenyithioprostanoids. J. C. S. Perkin I, 1981, 1729.
`
`R. J. Cave, R. F. Newton, D. P. Reynolds and S. M. Roberts, Total synthesis of
`prostaglandin-F2, and 9-0-benzyl analogues of prostaglandins-F1“, F2, and D1. J. C.
`S. Perkin I, 1981, 646.
`
`D. E. Fenton, D. Parkin and R. F. Newton, The synthesis of adrenaline crown ethers
`from acetovanillone, J. C. S. Perkin I, 1981, 449.
`
`A. J. Dixon, R. J. K. Taylor and R. F. Newton, Organocuprate conjugate addition-
`enolate aikyiation reactions : A new synthesis of 11-desoxyprostaglandins. J. C. S.
`Perkin I, 1981, 1407.
`
`R. F. Newton, D. P. Reynolds and T. Eyre, Total synthesis of rnethylenomycin B,
`Synth. Comm. 1981, 527.
`
`R. F. Newton, S. M. Roberts, B. J. Wakefield and G. T. Wooley, Total synthesis of (1)-
`prostaglandin-12 methyl ester and (1)-15-epi-prostaglandin-12 methyl ester. J. C. S.
`Chem Comm. 1981, 922.
`
`D. J. Chadwick, l. A. Cliffe, i. O. Sutherland and R. F. Newton, Chiral diaza-’i8-crown-
`6 derivatives. J. C. S. Chem Comm.,1981, 992.
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`98.
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`99.
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`100.
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`101.
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`102.
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`P. Murray-Rust, R. C. Glen and R. F. Newton, N-(6-endo-methoxy- 3-oxo-2-
`oxabicyclo[3.2.1]oct-8-yI)-N-methyl-p-toluenesulphonamide, Acta Crystallographica,
`1982, 2696.
`
`P. Murray-Rust, R. C. Glen and R. F. Newton, 2,3-endo-epoxy-bicyclo
`[3.2.0.]heptan-6-one, p-nitrophenylhydrazone. Acta Crystallographica, 1982, 2698.
`
`P. Murray-Rust, R. C. Glen and R. F. Newton, (23, 3S)-2-exo-bromo-3-endo
`hydroxybicyclo[3.2.0.] heptan-6-one, Acta Crystallographica, 1982, 2700.
`
`P. Murray-Rust, R. C. Glen and R. F. Newton,3—exo-methoxy-6,7-endo-epoxy
`2-oxa~2-oxabicycIo[3.2.0.]octane, Acta Crystallographica, 1982, 2702.
`
`P. Murray-Rust, R .C. Glen and R. F. Newton and S. M. Ali, 7,8-endo-epoxy~ 2~oxa-
`tricyclo[3.3.0.0.4'°]octan-3-one. Acta Crystallographlca, 1982, 2704.
`
`R. F. Newton and A. H. Wadsworth, Synthesis of stable prostacyclin analogues
`from 2,3-disubstituted bicyclo[3.2.0]heptan-6-ones. J. C. S. Perkin I, 1982, 823.
`
`L. J. S. Knutsen, B. D. Judkins, R. F. Newton and D. I. C. Scopes, A novel
`elimination reaction of 3,4,6,~tri-0-benzoyl-2,5-anhyctro-D-alIonic acid: Ribosyl 2 -
`deoxyribosyl conversion. Tetrahedron Letters, 1982, 1013.
`
`D. E. Fenton, D. Parkln, R. F. Newton, I. W. Nowell and P. E. Walker, Alkali and
`alkaline-earth complexes of 4—acetobenzo-crown ethers. J. C. S. Dalton, 1982, 327.
`
`D. N. Jones, T. P. Kogan and R. F. Newton, Synthesis of some thietanoprostanoids,
`J. C. S. Perkin I, 1982, 1333.
`
`D. N. Jones, T. P. Kogan, P. Murray-Rust, J. Murray-Rust and R. F. Newton,
`Cyclization of Y5-unsaturated sulphenic acids to give thietan-1-oxide derivatives. J.
`C. S. Perkin I, 1982, 1325.
`
`T. A. Crabb, A. Patel, B. J. Price, M. Tucker and R. F. Newton, The synthesis of
`1,2,3,9b-tetrahydro-9b-hyciroxyI-I-phenylpyrrolo[2,1-a}isoindoE-5-one. J. C. S. Perkin
`I, 1982, 2783.
`
`A. J. Dixon, R. J. K. Taylor, R. F. Newton and A. H.Wadsworth,
`11-Deoxyhomoprostacyclin analogues. Tetrahedron Letters, 1982, 327.
`
`R. F. Newton, M. Sainsbury and P. L. R. Stanley, The synthesis of 7,8-dimethoxy-1-
`(3,-4,-dimethoxybenzyI)~2,3-dihydro-1H-3-benzazeplne and related compounds,
`Heterocycles, 1982, 19,2037.
`
`R. C. Glen, P. Murray-Rust, F. G. Ricidell, R. F. Newton and P. B. Kay, Ring-chain
`tautomerlsm frozen out by crystal packing forces, J. C. S. Chem Comm. ‘[982, 25.
`
`D. N. Jones, T. P. Kogan, R. F. Newton and S. Smith, Anionic [1,2]-rearrangements
`of 3-alkyl and 2,3-dialkyl-thietan1-oxides, J. C. S. Chem Comm. 1982, 589.
`
`L. J. S. Knutsen, R. F. Newton, D. I. C. Scopes and G. Kiinkert, Coupling-elimination
`reactions of 2,5-anhydro-3,4,6-tri-O-benzoyl-D-allonic acid; Synthesis of 2'-
`deoxyribo-C-nucleosides. Carbohydrate Research, 1982, 110, 5.
`
`A. J. Dixon, R. J. K. Taylor, R. F. Newton, A. H. Wadsworth and G. Kllnkert, Synthetic
`approaches to 11-deoxyhomoprostacyclin analogues, J. C. S. Perkin I, 1982, 1923.
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`114.
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`115.
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`R. F.Newton, D. P. Reynolds, J. Davies, P. B. Kay, S. M. Roberts and T. W. Wallace,
`Enantio-complementary total asymmetric syntheses of prostaglandin-A2. J. C. S.
`Perkin l, 1983, 683.
`
`R. Bonnett, S. A. North, R. F. Newton and D. I. Scopes, Substitution and addition
`reactions of isoindoies, Tetrahedron, 1983, 39, 1401.
`
`R. F. Newton, D. P. Reynolds, P. B. Kay, T. W. Wallace, S. M. Roberts, R. 0. Glen and
`P. Murray-Rust, Some stereocontrolied ring opening reactions of 6-substituted 2,3-
`epoxybicyico[3.2.0} heptans, J. C. S. Perkin I, 1983, 675.
`
`M. J. Dawson, G. C. Lawrence, G. Liiley, M. Todd. D. Noble, S. M. Green, S. M.
`Roberts, T. W. Wailace, R. F. Newton, M. C. Carter, P. Hailett, J. Paton, D. P.
`Reynolds and S. Young. Reduction of bicycio{3.2.0]hept-2-en-6-one with
`dehydrogenase enzymes in whole cell preparations of some fungi and yeasts, J. C.
`S. Perkin I, 1983, 2119.
`
`A. D. Baxter, S. M. Roberts, B. I. Wakefleid, G. T. Woolley and R. F. Newton
`Stereochemistry of the Aldoi Reaction between[4-t-butyidimethylsiiy|oxy-5-
`(3-t-butyldimethylsilyloxyoct-1-enyl) cyc|opent- 2-enyI]iethano| and cyicopentanone
`enolates; a key step in a total synthesis of prostacyclin. J. C. S. Perkin I, 1983,
`1809.
`
`A. D. Baxter, F. Scheinrnann, B. J. Wakefield, R. F. Newton and S. M. Roberts, The
`norbornadiene route to prostaglandin-I2 and other prostaglandins; preparation and
`rearrangement of 7-subsituted norbornadienes. J. C. 8. Chem. Comm, 1983, 932.
`
`A. D. Baxter, S. M. Roberts, 3. J. Wakefield, G. T. Woolley and R. F. Newton,
`Synthesis of (flprostaglandin-I2 methyl ester and its 15-epimer from 2~(cyclopent-2-
`enyl)~1-(cyclopentan-2-enyl)-1- ethanol derivatives. J. C. S. Perkin I, 1984, 675.
`
`L. J. S. Knutsen, B. D. Judkins, W. L. Mitchell, R. F. Newton and D. I. C. Scopes,
`Synthesis of imidazo-fused bridgehead-nitrogen C-nucleosides via dehydrative
`coupling reactions of 2,5-anhydro-3,4,6,-tri-D-benzoyl-D-aiionic acid. J. C. S. Perkin
`I, 1984, 229.
`
`W. L. Mitchell, M. L. Hill, R. F. Newton, P. Ravenscroft and D. i. C. Scopes, Synthesis
`of C~nucleoside isosteres of 9-(2-hydroxyethoxymethyl) guanine (Acyclovir).
`Heterocyclic Chem, 1984,21, 697.
`
`L. Daalman, R. F. Newton, P. L. Pauson and A. W. Wadsworth, Alkyne-Cobalt
`complexes as prostagiandin synthons .
`improved Route to Methyl z-non-5-en-8-
`ynoate and synthesis of a new prostagiandin-E2 analogue. J. Chem Res. 1984, 344.
`
`L. Daalman, R. F. Newton, P. L. Pauson and A. W. Wadsworth, Alkyne-Cobalt
`complexes as prostaglandin synthons. A possible approach via 2-phenylcyclopent-
`2—enone. J. Chem. Res.
`‘£984, 346.
`
`D. J. Chadwick, I. A. Cliffe, I. 0. Sutherland and R. F. Newton. The formation of
`complexes between Aza derivatives of Crown ethers and primary alkylammonium
`salts. Chiral derivatives of aza crown ethers. J. C. S. Perkin I, 1984, 1707.
`
`T. A. Crabb, A. Patel, R. F. Newton and T. J. Cholerton. Hydrazinoiysis of 2-phenyi-2-
`(phtha[imidoalky)indan~1,3-diones. J. C. S. Perkin I, 1985, 191.
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`127.
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`128.
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`129.
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`A. D. Baxter, J. Hoilerton, T. Javed, R. F. Newton, S. M. Roberts and B. J. Wakefield.
`Synthesis of 12,13-didehydroprostaglandin-J2 methyl ester. J. C. S. Perkin I, 1985,
`1803.
`
`L. J. S. Knutsen, B. D. Judkins, R. F. Newton, D. I. C. Scopes and G. Klinkert.
`Synthesis of imidazo-fused bridgehead-nitrogen 2'-deoxyribo-c-nucieosides:
`coupling-elimination reactions of 2,5-anhydro -3,4,6-tri-0-benzoyl-D-aiionic acid. J.
`C. S. Perkin 1, ‘I985, 621.
`
`M. R. Johnson, N. F. Jones, I. O. Sutherland and R. F. Newton. Formation of
`complexes between aza derivatives of crown ethers and primary atkyiammoniurn
`saIts,. 12-crown-4, 15-crown-5, 21-crown-7, and 24-crown-8 derivatives. J. C. S.
`Perkin I, 1985, 1637.
`
`R. C. Cookson, P. J. Dudfield, R. F. Newton, P. Ravenscroft, D. I. C. Scopes and J.
`Cameron. (-_I-_)-Carbocyclic(E)-5-(2-bromo-vinyi)2'-deoxyuridine: a potent antiherpes
`agent. Eur. J. Med. Chem. 1985, 20, 375.
`
`A. Ntete, J. B. Hobbs, D. I. C. Scopes and R. F. Newton. Novei nucieoside analogues
`via direct attack of carbon nucleophiles on nucleosides containing epoxy-sugars.
`Tetrahedron Letters, 1985, 26, 97.
`
`W. L. Mitchell, P. Ravenscroft, M. L. Hiii, L. J. S. Knutsen, R. F. Newton and D. I. C.
`Scopes. Synthesis and antiviral activity of 5-haII-tovinyl-6-aza»-2'~deoxyuridines.
`Nucleosides and Nucieotides, 1985, 4, 173.
`
`A. D. Baxter, F. Binns, T. Javed, S. M. Roberts, F. Scheinmann, B. J. Wakefieid, P.
`Sadler, M. Lynch and R. F. Newton. Synthesis and use of 7-substituted
`norbornadienes as intermediates for the preparation of prostaglandins and
`prostanoids. J. C. S. Perkin I, 1986, 889.
`
`W. L. Mitchell, P. Ravenscroft, M. L. Hili, L. Knutsen, B. Judkins, R. F. Newton and D.
`I. C. Scopes. Synthesis and antiviral properties of 5-(2-substituted vinyl)-6-aza-25
`deoxyuridines. J. Med. Chem. 1986, 29, 809.
`
`S. W. Jones, F. Scheinmann, B. J. Wakefield, D. Middlemiss and R. F. Newton. A
`photochemical synthesis of a thromboxane-A2 anaiogue via intramolecular trapping
`of an oxacarbene by an hydroxyi group. J. C. 3. Chem Comm. 1986, 1260.
`
`P. Ravenscroft, R. F. Newton, D. I. C. Scopes and C. Wiiliamson. A new Synthesis
`of (3) carbocyclic 2'-deoxyuridines. Tetrahedron Letters, 1986, 27, 747.
`
`A. B. Kyte, K. A. Owens, I. O. Sutherland and R. F. Newton. The formation of
`complexes between aza derivatives of crown ethers and primary alkylammonium
`salts. Bicyclic derivatives of diaza crown ethers. J. C. S. Perkin I, 1987, 1921.
`
`J. A. E. Pratt, I. O. Sutherland and R. F. Newton. Macrocyclic and macropotycyciic
`compounds based upon 1,3-disubstltuted propane units. J.C.S. Perkin I, 1988,13.
`
`S. W. Jones, D. Middlemiss, R. F. Newton, F. Scheinmann and B. J. Wakefield.
`Synthesis of Spirocyclopropylpentane derivatives. J. Chem. Res. 1988, 392.
`
`M. Azacti-Ardakani, G. G. Loftus, A. M. M. Mjalli, R. F. Newton and S. M. Roberts.
`Photochemistry of cyclopentanone derivatives in the synthesis of prostaglandin
`and thromboxane analogues. J. C. 3. Chem Comm. 1989, 1709.
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`138.
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`139.
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`S. G. Davies, R. F. Newton and J. M. J. Williams. Asymmetric synthesis of N-Acetyl-
`1-phenyiethyiamine. Tetrahedron Letters, 1989, 99, 2967.
`
`T. A. Crabb, C. A. J. Roxburgh and R. F. Newton. The synthesis and
`stereochemistry of derivatives of 1,2,3,4,6,11,12,13,14,14a-decahyc£ropyrido[1,2-b]
`[2]benzazonine. Crystal structure of 1,2,3,4,4a,5,6, 7,7a,12-decahydro-7-
`phenyiisoindolo [1 ,2,-d]quino!izin-13-ium Tosylate. J. C. S. Perkin i, 1989, 2431.
`
`M. S. Levitt, R. F. Newton, S. M. Roberts, and A. J. Wliletts. Preparation of optically
`active 6-fiuorocarbocyciic nucieosides utilising an enantiospecific enzyme-
`catalysed Baeyer-Viitiger type oxidation. J. C. 8. Chem Comm. 1990, 619.
`
`M. J. Keiiy, R. F. Newton, S. M. Roberts and J. F. Whitehead. Synthesis of Methyl-6 -
`oxo-9-deoxy-8,9-oxaprostaglandin:-E1. J. C. S. Perkin l, 1990, 2352.
`
`T. A. Crabb, R. F. Newton and C. J. Roxburgh. The Rearrangement of rel
`(4aR,7S,7aR, 13 S)1,2,3,4,4a,5,6,7,7a,12-decahydro-7-phenylisoindoio['i ,2-
`d]quino|ixin-13-ium tosylate to re