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`Mylan Exhibit 1005, Page 17
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`Mylan Exhibit 1005, Page 23
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`Mylan Exhibit 1005, Page 29
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`40
`
`Mylan Exhibit 1005, Page 43
`
`
`
`Mylan Exhibit 1005, Page 43
`
`
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`VH—13
`
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`
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`
`1.41 (d,6H,J==6Hz)
`
`2.47 (5,3H)5
`
`3.27 (73%, 1H,J=6Hz)
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`
`1.42 (d,6H,J=6Hz)
`
`Mylan Exhibit 1005, Page 44
`
`4 1
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`Mylan Exhibit 1005, Page 44
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`
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`
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`
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`
`0 ppm:
`
`0.97 (t,3H,J=7Hz). 1.43 (d,6H,J=6Hz)
`
`2.29 (s,6H),
`
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`
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`
`6
`
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`
`0.98 (t,3H,J=7Hz).
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`
`0 ppm:
`
`1.03 (t,3H,J=7Hz), 1.41 (d,6H,J=6Hz)
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`3.25 ('7E0i,1H,J=6Hz), 4.05(q,2H,J=7Hz),
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`Mylan Exhibit 1005, Page 45
`
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`Mylan Exhibit 1005, Page 45
`
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`140.‘5~
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`138.0
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`165.0
`
`Mylan Exhibit 1005, Page 46
`
`43
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`Mylan Exhibit 1005, Page 46
`
`
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`V1—17
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`141.5—
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`92~93
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`Mylan Exhibit 1-005, Page 47
`
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`Mylan Exhibit 1005, Page 47
`
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`
`Mylan Exhibit 1005, Page 48
`
`4 5
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`Mylan Exhibit 1005, Page 48
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`Mylan Exhibit 1005, Page 49
`
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`Mylan Exhibit 1005, Page 49
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`170-
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`
`47
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`Mylan Exhibit 1005, Page 50
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`Mylan Exhibit 1005, Page 50
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`124.8~
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`Mylan Exhibit 1005, Page 51
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`Mylan Exhibit 1005, Page 51
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`
`CH3 0sz
`
`105
`-106
`i-Pr 0sz 88.5
`-90.5
`77-82
`
`CH3 0sz
`
`i—Pr 0sz 96-98
`
`i—Pr 0sz
`
`1111111218
`
`i—Pr Csz
`
`H-8
`
`7~Me
`
`11-9
`.
`11-10
`
`11-11
`
`H
`
`H
`
`H
`
`H
`
`H
`
`H
`
`H
`
`H
`
`4-02
`
`4-0He
`
`4—0Me
`
`11-12 6-011 H
`
`2-02
`
`i-Pr (:sz
`
`68.5-
`74.0
`91.0
`-94.0
`i—Pr 0sz 78.0
`-78.5
`i—Pr 0sz 75.0
`-78.0
`1H11f%
`
`i-Pr 0sz
`
`H
`
`H
`
`H
`
`H
`
`H
`
`H-13
`
`H-14
`
`11—15
`
`H
`
`H
`
`H
`
`H
`
`H
`
`H
`
`4-CF3
`
`i-Pr Csz
`
`3—Me
`
`4-F
`
`i—Pr C2H5
`
`S-Me
`
`5—Me
`
`i-Pr (3sz
`
`78.0
`-83.0
`66.0
`—71.0
`$135493
`
`11-16 6—0Me 7-0118 4—F
`
`'
`
`H
`
`i-Pr 0sz 83.0
`-90.0
`
`Mylan Exhibit 1005, Page 52
`
`4 9
`
`
`
`
`
`Mylan Exhibit 1005, Page 52
`
`
`
`
`
`cszcsz 94.0
`-97.0
`n—Pr 0sz HWtW
`
`C-PI‘ (3sz
`
`i-Pr 0sz
`
`111.0-
`113.5
`91.0
`-93.0
`i—Pr csz 121.0-
`125.0
`i-Pr (:sz Wflw
`
`11-17
`
`11-18
`
`H
`
`H
`
`H
`
`H
`
`II—19 63-02 H
`
`H‘ZO H
`
`11-21
`
`H
`
`H
`
`H
`
`4-F
`
`4—H
`
`4-F
`
`4-9
`
`4—0211
`
`11-22 6—02
`
`8—02 4-F
`
`H
`
`H
`
`H
`
`H
`
`H
`
`H
`
`
`
`H H Ph11-23 6902 H 0sz WWW
`
`
`
`
`
`
`
`II — 7
`
`H—NHH( 000.23)
`
`6 bpm:
`
`1.21(t,3H,J=7Hz), 1.32(d,6H,J=6Hz)
`
`2.2-2.4(m,2H),
`
`2.5—2.7(m,1H)
`
`3.28(s,1H),
`
`3.34(7E$?,1H,J=6Hz)
`
`4.08(q.2H,J=7Hz). 4.3-4.6(m,1H)
`
`5.28(dd,1H,J=6Hz,J=15Hz),
`
`6.53(dd,1H,J=1.5Hz,J=15Hz), 6.9—8.0(m,8H)
`
`II *1 2
`
`H-NMR( CD023)
`
`6 ppm:
`
`1.25(t,3H,J=7Hz), 1.33(d,6H,J=6Hz)
`
`2.2-2.4(m,2H).
`
`2.5-2.8(m,1H)
`
`3.32(s.2H),
`
`3.38(7EHH,1H,J=6H2)
`
`5 0
`
`‘
`
`Mylan Exhibit 1005, Page 53
`
`
`
`Mylan Exhibit 1005, Page 53
`
`
`
`4.13(q,2H,J=7Hz), 4.2-4.6(m,1H)
`
`I5.34(dd,1H,J=6Hz,J=15Hz).
`
`6.53(dd,1H,J=1.5H2,J=15Hz), 7.0-8.0(m,7H)
`
`H — 1 5
`
`H-NMR( CDCQa)
`
`5 ppm:
`
`1.23(t,3H,J=7Hz), 1.35(d,6H,J=6HZ)
`
`2.242.4(m,2H),
`
`2.31(s,6H)
`
`2.6-2.8(m,1H),
`
`3.32(s,2H)
`
`3.35(7E¥$.1H,J=6Hz), 4.12(q,2H,J=7Hz)
`
`4.3-4.7(m,1H), 5.30(dd,1H,J=6Hz,J=IBHz)
`
`6.51(dd,1H,J=1Hz,J=16Hz), 6.7-8.0(m.7H)
`
`H - 1 8
`
`H-NMR( CDCEs)
`
`6 ppm:
`
`1.00(t,3H,J=7Hz), 1.26(t.3H,J=7Hz)
`
`1.6—2.3(m,2H);
`
`2.42(d,2H,J=6H2)
`
`2.6-3.2(m,3fl),
`
`3.35Cs,2H)
`
`4.11(q.2H,J=7Hz), 4.3—4.7(m,1H)
`
`5.27(dd,1H,J=6HZ.J=16HZ)
`
`6.46(dd,1H,J=1.5HZ,J=1682), 6.9—8.0(m.8H)
`
`H — 2 2
`
`Mylan Exhibit 1005, Page 54
`
`5
`
`1
`
`
`
`
`
`Mylan Exhibit 1005, Page 54
`
`
`
`
`
`H-NMR( 00023)
`
`6
`
`ppm :
`
`1.26(t,3H,J=7Hz), 1.33(d,6H,J=6Hz)
`
`2.43(d,2H,J=6Hz), 2.6-2.9(m,1H)
`
`3.36(s,2H), 3.44(7§¥7‘i,1H,J=6HZ)
`
`4.13(q.2H,J=7Hz). 4.3-4.7(m,1H)
`
`5.30(dd,1H,J=6Hz,J=16H2),
`
`6.53(dd,1H,J=1.5Hz,J=16Hz). 7.0-7.6(m,en)'
`
`II - 2 3
`
`H-NMR( once 3)
`
`6
`
`ppm :
`
`1.23Ct,3H,J=7Hz), 2.21Cd,2H,J=6Hz)
`
`2.4~2.6(m.1H),
`
`3.25(s,2H)
`
`4.09(q.2H,J=7Hz).
`
`4 1-4.4(m,1H)
`
`5.08(dd,1H,J=6Hz,J=16Hz),
`
`6.26(dd,1H,J=1.5H2,J=16Hz), 7.0 ~8.0
`
`(m,13H)
`
`(Bl—R $13)
`
`
`
`
`
`5 2
`
`Mylan Exhibit 1005, Page 55
`
`
`
`Mylan Exhibit 1005, Page 55
`
`
`
`fifit’EHUl — g £E§i®7fl£bzé
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