`
`ARISTOTLE G. KALIVRETENOS
`8616 Littlefield Court
`Ellicott City, MD 21043
`(443) 543-5799 office / (443) 745-3551 Cell
`akalivret@auroraanalytics.com
`
`CAREER SUMMARY:
`
`x Expertise in solution/solid-phase synthetic organic chemistry; methodology and total
`synthesis
`x Supervisory and Project Management experience
`x Product Development and Commercialization Experience (G-Mark and Si-HOBt
`products)
`x Track record of innovative accomplishment
`o Patents (6 issued, 5 pending)
`o Publications (18 in print; peer reviewed articles and book chapters)
`o Presentations (14 invited, 18 contributed)
`x Experience with FDA and OSHA compliance requirements
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`EDUCATION:
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`1990
`Ph.D. Colorado State University; Organic Chemistry
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`x Dissertation: “Synthesis of Macrolides via Organopalladium Chemistry. Application to
`the Synthesis of Zearalenone”
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`x Research Advisors: Prof. John K. Stille and Prof. Louis S. Hegedus
`B.S. Clemson University, Chemistry, summa cum laude.
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`1985
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`PROFESSIONAL EXPERIENCE:
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`AURORA ANALYTICS, LLC
`Chief Operating Officer, Co-Founder
`x Launched Si-HOBt product line
`x Launched G-Mark glucuronide and sulfate alcohol diagnostic standard product line
`x Development of food quality indicator products
`x Contract Chemical Synthesis and Analytical services
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`2004 - present
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`COLLEGE OF NOTRE DAME OF MARYLAND, BALTIMORE, MD
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`2005 – 2008
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`Adjunct Professor of Chemistry
`x Teaching efforts: Organic Chemistry and Laboratory in the Accelerated College for the
`B.S. Nursing Program
`SENSORS FOR MEDICINE AND SCIENCE, INC., GERMANTOWN, MD 1998 – 2004
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`Scientist
`1998 - 1999
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`x Design, synthesis and characterization of novel fluorescent chemosensors for glucose
`recognition
`Scientist II
`1999 - 2004
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`x Design, synthesis and characterization of novel fluorescent chemosensors for glucose
`recognition
`x Directed organic chemistry and sensor validation work
`x Conducted literature and patent searches
`x Developed protocols for FDA compliance requirements
`Safety Officer
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`x Maintained chemical inventory
`x Developed protocols for OSHA compliance requirements
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`2001 - 2004
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`PARAGON BIOTECH, INC., BALTIMORE, MD
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`1998
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`Consultant
`x Design of antiangiogenic target molecules
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`UNIV OF MARYLAND BALTIMORE COUNTY, BALTIMORE, MD
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`1992– present
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`Assistant Professor of Chemistry
`1992 - 1998
`x Research efforts: bioorganic studies of channel forming peptides; solution and solid-
`phase protein/peptide/amine modification
`technology; preparation of heterocyclic
`compounds.
`x Teaching efforts: Introductory Organic Chemistry; Organic Reaction Mechanisms;
`Organic Synthetic Methodology; Total Synthesis of Natural Products; Ion Channels of
`Excitable Membranes
`Adjunct Assistant Professor of Chemistry
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`1998 – present
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`x Teaching efforts: General Chemistry
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`UNILEVER RESEARCH, U.S., EDGEWATER, NJ
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`1991 – 1992
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`Synthetic Consultant
`x Developed strategies for the synthesis of radiolabeled compounds.
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`COLUMBIA UNIVERSITY, NEW YORK, NY
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`1990 – 1992
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`Post-doctoral Research Scientist (Research Advisor: Prof. Koji Nakanishi)
`x Synthetic and bioorganic studies of Philanthotoxin (PhTX) in neuronal receptor systems.
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`TECHNICAL SKILLS:
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`x Synthetic techniques: solid-phase and solution-phase organic synthesis, automated and
`manual solid-phase peptide synthesis, polymer synthesis/modification and radiosynthesis
`(3H and 125I)
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`x Polymer techniques: hydrophobic and hydrogel polymer synthesis and modification;
`molecular imprinted polymer design and synthesis
`x Chromatographic techniques: TLC, LC, HPLC (including maintenance and repair),
`GPC
`x Spectroscopic techniques: FT-IR, 1H, 13C and 31P NMR, UV-VIS, fluorescence, MS
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`HONORS RECEIVED:
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`x Researcher for Sinai Hospital of Baltimore (1997-1998), American Heart Assoc., MD
`Affiliate
`x NIH Post-doctoral Fellowship (1991)
`x Synaptic Corporation Post-doctoral Fellowship (1991)
`x Syntex Award for Excellence in Organic Chemistry, Colorado State University (1987)
`x Colorado State Graduate Fellowship (1985)
`x Michelin Undergraduate Grant for Study in France, Clemson University (1985)
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`PROFESSIONAL ACTIVITIES:
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`Membership
`x American Chemical Society, Division of Organic Chemistry
`Editor
`x Chemical Highlights, Columbia University, 1991-1992
`Activities at Conferences
`x Session Chair, 17th International Symposium on the Separation of Proteins, Peptides and
`Polynucleotides, Rockville, MD, October 26-29, 1997.
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`PATENTS: (6 issued, 5 pending)
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`x
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`“Butyryl-Tyrosinyl Spermine, Analogs thereof and Methods of Preparaing and Using
`Same” Koji Nakanishi, Danwen Huang, Soek-Ki Choi, Aristotle Kalivretenos and Robert
`Goodnow, US Patent # 6,001,824, December 14, 1999.
`“Detection of Analytes by Fluorescent Lanthanide Metal Chelate Complexes Containing
`Substituted Ligands” Arthur E. Colvin, George Y. Daniloff, Aristotle G. Kalivretenos,
`David Parker, Edwin E. Ullman and Alexandre V. Nikolaitchik, US Patent # 6,344,360,
`February 5, 2002.
`“Detection of glucose in solutions also containing an alpha-hydroxy acid or a beta-
`diketone” George Y. Daniloff, Aristotle G. Kalivretenos, and Alexandre V. Nikolaitchik,
`US Patent # 6,800,451, October 5, 2004.
`“Detection of glucose in solutions also containing an alpha-hydroxy acid or a beta-
`diketone” George Y. Daniloff, Aristotle G. Kalivretenos, and Alexandre V. Nikolaitchik,
`US Patent # 7,078,554, July 18, 2006.
`“Amine detection method and materials” Aristotle G. Kalivretenos, US Patent #
`7,229,835, June 12, 2007.
`“Amine detection method and materials” Aristotle G. Kalivretenos, US Patent #
`7,592,183, September 22, 2009.
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`“Nitric Oxide Releasing Polymers” Aristotle G. Kalivretenos, Robert E. Raulli, Blaine G.
`Doletski and Ernst V. Arnold, US Published Application # 20070196327, filed
`December 5, 2006.
`“Amine detection method and materials” Aristotle G. Kalivretenos, US Published
`Application # 20100010167, filed September 21, 2009.
`“Molecularly-imprinted polymeric materials for visual detection of explosives” Aristotle
`G. Kalivretenos, Kelly A. Van Houten, Jonathan P. Gluckman, Frank M. Hardy, Igor P.
`Dorovskoy, Robert Trower, US Published Application # 20120184044, filed December
`30, 2009.
`“Compounds, polymers and methods for treating gastrointestinal dysfunction” Aristotle
`G. Kalivretenos, Robert E. Raulli, Niaz Sahibzada, Richard Gillis, Mark S. Niedringhaus,
`US Published Application # 20100255062, filed June 14, 2010.
`“Amine detection method and materials” Aristotle G. Kalivretenos, US Published
`Application # 20120184683, filed January 20, 2012.
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`PUBLICATIONS: (18 in print)
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`Articles
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`"Elemental Carbon and Lead Content of Fine Particles from American and French Cities
`of Comparable Size and Industry, 1985." Delumyea, R. Del; Kalivretenos, A.
`Atmospheric Environment 1987, 21, 1643-1647.
`"Determination of the Fe2+/Fe3+ Ratio in Nuclear Waste Glass" Hawkes, A.E.; Brewer,
`K.M.; Brock, N.A.; Hunter, T.R.; Edge, M.; Kalivretenos, A.; Fanning, J.C. Journal of
`the American Ceramic Society 1989, 72, 943-947.
`"Synthesis of E-Resorcylic Macrolides via Organopalladium Chemistry. Application to
`the Total Synthesis of (S)-Zearalenone" Kalivretenos, A. G.; Stille, J. K.; Hegedus, L. S.
`J. Org. Chem. 1991, 56, 2883-2894.
`"Synthesis of Novel and Photolabile Philanthotoxin analogs" Choi, S.-K.; Goodnow, R.;
`Kalivretenos, A.; Chiles, G. W.; Fushiya, S.; Nakanishi, K. Tetrahedron 1992, 48, 4793-
`4822.
`"Synthesis of Philanthotoxin Analogs with a Branched Polyamine Moiety" Kalivretenos,
`A.; Nakanishi, K. J. Org. Chem. 1993, 58, 6596.
`"Bioorganic studies of transmitter receptors with philanthotoxin analogs" Nakanishi, K.;
`Choi, S.-K.; Hwang, D.; Lerro, K.; Orlando, M.; Kalivretenos, A.G.; Eldefrawi, A.;
`Eldefrawi, M.; Usherwood, P.N.R. Pure & Appl. Chem. 1994 66, 671.
`"Labeling Studies of photolabile philanthotoxins with nicotinic acetylcholine receptors:
`mode of interaction between toxin and receptor" Choi, S.-K.; Kalivretenos, A.G.;
`Usherwood, P.N.R.; Nakanishi, K. Chemistry & Biology 1995, 2, 23.
`"Lactams as Heterodienophiles in Diels-Alder Chemistry" Degnan, A.P.; Kim, C.S.;
`Stout, C.W.; Kalivretenos, A.G. J. Org. Chem. 1995, 60, 7724.
`"Synthesis of Medium Ring Lactams Via Cyclization Reactions Using Polymer Bound
`HOBT as Catalyst" Huang, W., Kalivretenos, A.G. Tetrahedron Lett. 1995, 36(50),
`9113.
`"Tetrameric Peptide Bundles Via A Highly Convergent Synthesis" Hirsch, J.; Huang, W.;
`Kalivretenos, A.G. Biopolymers 1996, 39, 761-763.
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`"Synthesis of N-Hydroxysuccinimide Esters Using Polymer Bound HOBT" Dendrinos,
`K.; Kalivretenos, A. G. Tetrahedron Lett., 1998, 39, 1321-1324.
`“HOBT immobilized on macroporous polystyrene beads: a useful reagent for the
`synthesis of amides” Dendrinos, K.G.; Jeong, J.; Huang, W.; Kalivretenos Chem.
`Commun., 1998, 499-500.
`"Convenient Protection of Amines as Carbamates Using Polymer Bound HOBT"
`Dendrinos, K.; Kalivretenos, A. G. Perkins Trans. I. 1998, 1463-1464.
`“Synthesis and Separation of Hydrophobic Peptides for Use in Biomimetic Ion Channels”
`Kassim, S.Y.; Restrepo, I.M.; Kalivretenos, A.G., J. Chromatogr. A, 1998 816, 11-20.
`“Synthesis of Amide Libraries with Immobilized HOBt” Vokkaliga, S.; Jeong, J.;
`LaCourse, W.; Kalivretenos, A. Tetrahedron Lett., 2011, 52, 2722-2724.
`“Engineering a Hyper-catalytic Enzyme by Photoactivated Conformation Modulation”
`Agarwal, P.K.; Schultz, C.; Kalivretenos, A.; Ghosh, B.; Broedel, S.E. J. Phys. Chem.
`Lett. 2011, 3, 1142-1146.
`Chapters in Books
`x
`"Synthetic and Bioorganic Studies with Philanthotoxin Analogs" Nakanishi, K.;
`Goodnow, R.; Kalivretenos, A.; Choi, S.-K.; Fushiya, S.; Chiles, G.; Eldefrawi, A.;
`Eldefrawi, M.; Usherwood, P. "New Leads and Targets in Drug Research", Alfred
`Benzon Symp. 33, Krogsgaard-Larsen, P.; BrÀgger Christensen, S.; Kofod, H., eds.,
`Munksgaard, Copenhagen, 1992, 138-148.
`"Philanthotoxin-433 and analogs, noncompetitive antagonists of glutamate and nicotinic
`acetylcholine receptors" Chiles, G.; Choi, S.-K.; Eldefrawi, A.; Eldefrawi, M.; Fushiya,
`S.;Goodnow, Jr., R.; Kalivretenos, A.; Nakanishi, K.; Usherwood, P. In Neurotox '91:
`Molecular Basis of Drug and Pesticide Action" Duce, I.R., ed., Elsevier Applied Science,
`London, 1992, 3-17.
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`PRESENTATIONS:
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`(14 invited, 18 contributed)
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`Invited Papers
`x
`"Bioorganic Studies of Philanthotoxin Analogs", Synaptic Corporation, Paramus, New
`Jersey, July, 1992.
`"Total Synthesis of (S)-Zearalenone; Bioorganic Studies of Philanthotoxin Analogues",
`Dept. of Chemistry and Biochemistry, UMBC, November, 1992.
`"Approaches to the Study of Ion Transport Across Excitable Membranes Through the
`Use of Ion Channel Models", Scios Nova Inc., Dundalk, Maryland, February 1994.
`"Ion Channels: From Biology to Biosensors" Dept. of Chemistry and Biochemistry,
`UMBC, November 21, 1994.
`"Biomimetic Ion Channels: Design, Synthesis and Function" Department of Biological
`Chemistry, UMAB, Baltimore, MD, February 5, 1996.
`"Biomimetic Ion Channels: Design, Synthesis and Function" Department of Chemistry,
`Western Maryland College, Westminster, MD, February 9, 1996.
`"Biomimetic Ion Channels: Design, Synthesis and Function" Department of Biology,
`UMBC, Baltimore, MD, March 13, 1996.
`"Biomimetic Ion Channels: Design, Synthesis and Function" Transcell Technologies,
`Inc., Monmouth Junction, NJ, May 23, 1996.
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`"Biomimetic Ion Channels: Design, Synthesis and Function" Department of Chemistry
`and Biochemistry, UMCP, April 8, 1997.
`"Synthesis and Separation of Hydrophobic Peptides for use in Biomimetic Ion Channels"
`Washington Chromatography Discussion Group, Gaithersburg, MD, May 15, 1997.
`"Biomimetic Ion Channels: Design, Synthesis and Function" Department of Chemistry,
`Catholic University, Washington, D.C., October 3, 1997.
`"Biomimetic Ion Channels: Design, Synthesis and Function" Department of Chemistry,
`Georgetown University, Washington, D.C., November 5, 1997.
`"Synthetic and Bioorganic Studies of Ion Channels" Insect Chemical Ecology
`Laboratory, USDA, Beltsville, MD, February 11, 1998.
`"Synthetic and Bio-organic Studies of Ion Channels" CombiChem, Inc., San Diego, CA,
`June 19, 1998.
`Contributed Papers
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`"Synthesis of E-Resorcylic Macrolides via Organopalladium Chemistry. Application to
`the Total Synthesis of (S)-Zearalenone", 198th American Chemical Society National
`Meeting, Division of Organic Chemistry, September, 1989.
`"Synthesis of Medium Ring Lactams via Cyclization Reactions Using a Polymer-
`Supported 1-Hydroxybenzotriazole Catalyst" Wei Huang and Aristotle G. Kalivretenos,
`Sixteenth Annual Graduate Student Research Day, UMBC, May 4, 1994.
`"Synthesis of Medium Ring Lactams via Cyclization Reactions Using a Polymer-
`Supported 1-Hydroxybenzotriazole Catalyst" Wei Huang and Aristotle G. Kalivretenos,
`28th Middle Atlantic Regional Meeting of the American Chemical Society, UMBC,
`Baltimore, MD, May 25-27, 1994.
`"Heteroatom Diels-Alder Reactions Involving the Amide Carbonyl Group as the
`Dienophile" Aristotle G. Kalivretenos and Charles W. Stout, 28th Middle Atlantic
`Regional Meeting of the American Chemical Society, UMBC, Baltimore, MD, May 25-
`27, 1994.
`"Lactams as Hetero-Dienophiles in Diels-Alder Chemistry" Degnan, A.P., Kim, C.S.,
`Stout, C.W. and Kalivretenos, A.G., 209th Annual American Chemical Society National
`Meeting, Anaheim, CA, April 2-6, 1995.
`"Synthetic Glutamate Receptor Protein Ion Channel Models" Kadavil, J.A., Maranto, A.
`and Kalivretenos, A.G., 1st Annual Joint Biochemistry Symposium on Molecular
`Recognition, UMBC, Baltimore, MD, May 25-26, 1995.
`"Glutamate Receptor Ion Channel Models" Kadavil, J.A., Maranto, A.R., Lin, T.K. and
`Kalivretenos, A.G., 211th Annual American Chemical Society National Meeting, New
`Orleans, LA, March 24-28, 1996.
`"Four-Helix Peptide Bundles Via a Highly Convergent Synthesis" Hirsch, J., Huang, W.
`and Kalivretenos, A.G., 211th Annual American Chemical Society National Meeting,
`New Orleans, LA, March 24-28, 1996.
`"Four-Helix Peptide Bundles Via a Highly Convergent Synthesis" Hirsch, J., Huang, W.
`and Kalivretenos, A.G., International Conference on Protein Folding and Design, NIH,
`Bethesda, MD, April 23-26, 1996.
`in Diels-Alder Chemistry" Douglas Wilkinson,
`"Lactams as Hetero-Dienophiles
`Kleanthis Dendrinos and Aristotle G. Kalivretenos, Sixteenth Annual Graduate Student
`Research Day, UMBC, May 1, 1996.
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`"Ion Channels Formed from Rat Connexin 32 Peptides Reconstituted into Lipid Bilayers"
`Kassim, S. and Kalivretenos, A.G., 213th Annual American Chemical Society National
`Meeting, San Francisco, CA, April 13-17, 1997.
`"Experimental Synthesis of Amide Combinatorial Libraries" Jeannie H. Jeong and
`Aristotle G. Kalivretenos, Ronald E. McNair Scholars Program Fifth Annual Research
`Conference, UMBC, September 20, 1997.
`"Synthesis and Separation of Hydrophobic Peptides for use in Biomimetic Ion Channels"
`17th
`International Symposium on
`the Separation of Proteins, Peptides and
`Polynucleotides, Rockville, MD, October 26-29, 1997.
`“Experimental Synthesis of Amide Combinatorial Libraries” Jeannie H. Jeong and
`Aristotle G. Kalivretenos, Sixth Annual National Ronald E. McNair Student Research
`Conference, Delavan, WI, November 8, 1997.
`"Experimental Synthesis of Combinatorial Amide Libraries Using Polymer-Bound
`Hydroxybenzotriazole (HOBt polymer)" Jeannie H. Jeong and Aristotle G. Kalivretenos,
`215th Annual American Chemical Society National Meeting, Dallas, TX, March 29 -
`April 2, 1998.
`"Biomimetic Ion Channels Formed From Rat Connexin 32 M3 Domain Peptides"
`Rebecca M. Meier, Aristotle G.Kalivretenos and Iliana M. Restrepo, 215th Annual
`American Chemical Society National Meeting, Dallas, TX, March 29 - April 2, 1998.
`“Off-Line Solid-Phase Derivatization of Biogenic Amines Using Polymer-Supported 1-
`Hydroxybenzotriazole” William R. LaCourse, Roujian Zhang, Jason Petroski, Aristotle
`G. Kalivretenos, ACS Pittcon ’99, Orlando, FL, March 7-12, 1999.
`“An Implantable, Wireless Glucose Sensor Providing Continuous Monitoring” Barrett, J.,
`Colvin, A.E., Czarnik, A.W., Kalivretenos, A.G., Lorenz, C.R., Lesho, J.C., Lynn, W.R.,
`Nikolaitchik, A.V., Schneebaum, M.R., Van Houten, K.A., Wahi, M.S. and Zerwekh,
`P.S., Diabetes Technology and Therapeutics Meeting, Atlanta, GA, October, 2002.
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