`
`SENJU EXHIBIT 2099
`INNOPHARMA v. SENJU
`IPR2015-00903
`
`
`
`© Rob Lewis and Wynne Evans 1997,2001
`
`All rights reserved. No reproduction. copy or transmission of
`this publication may be made without written permission.
`
`No paragraph ofthis publication may be reproduced, copied or
`transmitted save with written permission or in accordance with
`the provisions of the Copyright, Designs and Patents Act 1988,
`or under the terms of any licence permitting limited copying
`issued by the Copyright Licensing Agency, 90 Tottenham Court
`Road, London W1 P 9H E.
`
`Any person who does any unauthorised act in relation to this
`publication may be liable to criminal prosecution and civil
`claims for damages.
`
`The authors have asserted their rights to be identified
`as the authors of this work in accordance with the
`Copyright, Designs and Patents Act 1988.
`
`First edition 1997
`Reprinted twice
`Second edition 2001
`Published by
`P A LG RAV E
`Houndmills, Basingstoke, Hampshire R G 21 6X S a n d
`175 Fifth Avenue, New York, N.Y. 10010
`Companies and representatives throughout the world
`
`PALGRAVE is the new global academic imprint of St. Martin's Press LLC
`Scholarly and Reference Division and Palgrave Publishers Ltd (formerly
`Macmillan Press Ltd).
`
`
`
`Page 2 of 4
`
`
`
`
`
`Solutions and Solubility
`
`contents
`
`11.1 Solubility
`
`170
`
`Objectives
`
`>Examines solvent miscibility and immiscibi|ity-
`
`11.2 Dynamic nature of
`dissolution
`
`176
`
`>Explains the idea of solubility product
`
`>Looks at distribution ratios and gas solubility
`
`>Discusses osmosis and its applications
`
`blntroduces colloids
`
` Solubility
`
`
`A solution is a mixture consisting of a solvent (the ‘dissolver’) and the solute (the
`substance that is being dissolved). For example, if we dissolve sugar in water, the
`water is the solvent, the sugar the solute and the sugary water is the solution. Ifwe
`keep adding sugar to some water, a point will be reached when the water will not be
`able to hold any more sugar. The solution is now said to be saturated. Adding more
`sugar simply results in sugar settling on the bottom of the container. Raising the ‘
`temperature of the solution allows the water to hold more sugar before it becomes
`
`
`
`11.3
`
`11.4
`
`Solubility of
`sparingly soluble
`ionic compounds
`Distribution of a
`solute between two
`solvents
`
`11.5 Solubility of gases
`in water
`
`11.6
`
`11.7
`
`Osmosis
`
`Colloids
`
`Revision questions
`
`176
`
`182
`
`183
`
`187
`
`190
`
`192
`
`Page 3 of 4
`
`
`
`SOLUBILITY
`
`171
`
`
`
`Ie_11.1 Polarity of common solvents — in order of
`easing polarity with heptane the least polar and water
`
`Formula
`
`CH3(CH2)5CH3
`CH3(CH2)4CH3
`C6H12
`CCI4
`CGHSCH3
`C2H50C2H5
`CH2Cl2
`CH3CH(0H)CH3
`C4H8O
`CHCI3
`CH3CH20H
`CH3COOC2H5
`CH3COCH3
`CH3OH
`CH3CN
`CH3SOCH3
`H20
`
`Density at
`25°C/g cm"3
`
`V 0.68
`0.66
`0.77
`1.58
`0.86
`0.71
`1.32
`0.78
`0.89
`1.48
`0.79
`0.90
`0.79
`0.79
`0.78
`1.10
`1.00
`
`,
`;"
`
`
`
`Ihoxyethane3
`ichloromethane
`
`trahydrofuran
`ich|oromethane4
`hanol5 (absolute)
`yhyl ethanoatee
`1
`
`hanenltrile9
`imethyl sulfoxide
`ater
`
`
`
`Page 4 of 4
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