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Dr. Ziemssen’s Participation in MS Clinical Trials Over The Past Five Years
`
`Clinical Trial Comparing Treatment of Relapsing-Remitting Multiple Sclerosis (RR-MS) With
`Two Doses of Glatiramer Acetate (GA) (FORTE)
`
`BRAVO Study: Laquinimod Double Blind Placebo Controlled Study in RRMS Patients With a
`Rater Blinded Reference Arm of Interferon β-1a (Avonex®)
`
`Efficacy and Safety of Oral BG00012 in Relapsing-Remitting Multiple Sclerosis (DEFINE)
`
`Comparison of Alemtuzumab and Rebif® Efficacy in Multiple Sclerosis, Study One (CARE-MS
`I) (CAMMS 323)
`
`Comparison of Alemtuzumab and Rebif® Efficacy in Multiple Sclerosis, Study Two (CARE-MS
`II) (CAMMS 324)
`
`A Study to Evaluate the Effectiveness, Tolerability and Safety of Laquinimod
`
`Efficacy and Safety of Fingolimod in Patients With Relapsing-remitting Multiple Sclerosis With
`Optional Extension Phase (TRANSFORMS)
`
`Treatment Interruption of Natalizumab (RESTORE)
`
`FTY720 in Patients With Primary Progressive Multiple Sclerosis (INFORMS)
`
`BG00012 Monotherapy Safety and Efficacy Extension Study in Multiple Sclerosis (ENDORSE)
`
`A Study in Subjects With Relapsing-Remitting Multiple Sclerosis (RRMS) to Assess the
`Efficacy, Safety and Tolerability of Glatiramer Acetate (GA) Injection 40 mg Administered
`Three Times a Week Compared to Placebo (GALA)
`
`STudy to vAlidate telemetRic ECG Systems for firsT Dose Administration of Fingolimod
`(START)
`
`Exploratory Study of the Safety, Tolerability and Efficacy of Multiple Regimens of Natalizumab
`in Adult Participants With Relapsing Multiple Sclerosis (MS) (REFINE)
`
`A Clinical Study of the Efficacy of Natalizumab on Reducing Disability Progression in
`Participants With Secondary Progressive Multiple Sclerosis (ASCEND in SPMS)
`
`A 3-year Multi-center Study to Describe Changes of OCT Parameters Under Treatment With
`Gilenya® (PASSOS)
`
`The Efficacy and Safety and Tolerability of Laquinimod in Subjects With Relapsing Remitting
`Multiple Sclerosis (RRMS) (CONCERTO)
`
`
`
`Page 1 of 2
`
`YEDA EXHIBIT NO. 2132
`MYLAN PHARM. v YEDA
`IPR2015-00644
`
`

`
`
`
`A Phase 2 Clinical Study in Subjects With Primary Progressive Multiple Sclerosis to Assess the
`Efficacy, Safety and Tolerability of Two Oral Doses of Laquinimod Either of 0.6 mg/Day or
`1.5mg/Day (Experimental Drug) as Compared to Placebo
`
`Efficacy and Safety of Teriflunomide in Patients With Relapsing Multiple Sclerosis and Treated
`With Interferon-beta (TERACLES)
`
`Phase IIIB-IV Long-Term Follow-up Study for Patients Who Participated in CAMMS03409
`(TOPAZ)
`
`Biomarker Study After Initiation of Treatment With Fingolimod (FTY720) in Patients With
`Relapsing-remitting Multiple Sclerosis (Biobank)
`
`(CBAF312A2201) - A phase II, double-blind, randomized, multi-center, adaptive dose-ranging,
`placebo-controlled, parallel-group study evaluating safety, tolerability and efficacy on MRI
`lesion parameters and determining the dose response curve of BAF312 given orally once daily in
`patients with relapsing-remitting multiple sclerosis
`
`Tolerability and Safety and Health Outcomes in Relapsing Multiple Sclerosis (MS) Patients
`
`JC-virus (JCV) Epidemiology in Multiple Sclerosis (MS) (JEMS)
`
`A Phase I, sequential group, randomized, double-blind, placebo-controlled study to assess the
`tolerability and safety of escalating doses of oral laquinimod administered daily in subjects with
`relapsing remitting multiple sclerosis (RRMS)
`
`Long-term Safety, Tolerability and Efficacy of BAF312 Given Orally in Patients With
`Relapsing-remitting Multiple Sclerosis
`
`A Study To Evaluate the Long-Term Safety, Tolerability and Effect on Disease Course
`
`Efficacy and Safety of BIIB019 (Daclizumab High Yield Process) Versus Interferon β 1a in
`Participants With Relapsing-Remitting Multiple Sclerosis ((DECIDE))
`
`A Study of Ocrelizumab in Comparison With Interferon Beta-1a (Rebif) in Patients With
`Relapsing Multiple Sclerosis
`
`A Study of Ocrelizumab in Patients With Primary Progressive Multiple Sclerosis
`
`Dose-finding Study of MT-1303
`
`Phase 3 Study of RPC1063 in Relapsing MS
`
`
`
`
`
`
`2
`
`Page 2 of 2
`
`YEDA EXHIBIT NO. 2132
`MYLAN PHARM. v YEDA
`IPR2015-00644

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