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`Transcutaneous immunization and immunostimulant strategies
`
`Table 1. Percent subject responders within experimental groups.
`Group
`Pretreatment
`LT (µg)
`IgG (%)
`Day 42
`88
`
`1
`
`Hydration
`
`50
`
`Day 21
`63
`
`Day 180
`100
`
`Day 21
`0
`
`IgA (%)
`Day 42
`50
`
`Day 180
`25
`
`2
`
`3
`
`4
`
`5
`
`Tape stripping
`
`Pumice pad
`
`Emery paper
`
`Hydration
`
`50
`
`50
`
`50
`
`400
`
`100
`
`25
`
`75
`
`63
`
`100
`
`86
`
`100
`
`88
`
`100
`
`100
`
`100
`
`100
`
`38
`
`13
`
`50
`
`25
`
`50
`
`0
`
`57
`
`38
`
`50
`
`0
`
`71
`
`38
`
`Ig: Immunoglobulin; LT: Heat-labile toxin of Escherichia coli.
`
`2
`
`3
`
`References
`Papers of special note have been highlighted as:
`(cid:127) of interest
`(cid:127)(cid:127) of considerable interest
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`16 Michetti P, Kreiss C, Kotloff KL et al.
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`Glenn, Kenney, Ellingsworth, Frech, Hammond & Zoeteweij
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`25 Glenn GM, Taylor DN, Li X, Frankel S,
`(cid:127)(cid:127) Montemarano A, Alving CR.
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`26 El-Ghorr AA, Williams RM, Heap C,
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`with herpes simplex virus stimulates
`immunity in mice. FEMS Immunol. Med.
`Microbiol. 29(4), 255–261 (2000).
`27 Gockel CM, Bao S, Beagley KW.
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`method for targeting immunity to the
`female reproductive tract. Mol. Immunol.
`37(9), 537–544 (2000).
`Jakob T, Walker PS, Krieg AM, von
`Stebut E, Udey MC, Vogel JC. Bacterial
`DNA and CpG-containing
`oligodeoxynucleotides activate cutaneous
`dendritic cells and induce IL-12
`production: implications for the
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`457–461 (1999).
`29 Kremer IB, Stevens SR, Gould JW,
`DiCarlo J, Quinby GE, Cooper KD.
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`differentially affects local versus distant
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`34 Guebre-Xabier M, Hammond SA,
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`containing heat labile enterotoxin from
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`injected influenza vaccine through
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`35 Hammond SA, Guebre-Xabier M, Yu J,
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`immunization: an emerging route of
`immunization and potent
`immunostimulation strategy. Crit. Rev.
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`(2001).
`36 Arrington J, Braun RP, Dong L et al.
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`dendritic cells appears to be important
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`antigens and adjuvants. Infect. Immun.
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`enterotoxigenic Escherichia coli contains
`two heterologous major subunits. FEMS
`Microbiol. Lett. 148(1), 35–42 (1997).
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`
`Patents
`101 Glenn GM, Alving CR. WO9943350
`(1999).
`102 Glenn GM, Alving CR. US5980898
`(1999).
`
`Affiliations
`(cid:127)
`Gregory M Glenn, MD, IOMAI Corporation, 20
`Firstfield Road, Suite 250, Gaithersburg, MD
`20878, USA, Tel.: +1 301 556 4500
`Fax: +1 301 556 4501, gglenn@iomai.com
`Richard T Kenney, MD, FACS, IOMAI
`Corporation, 20 Firstfield Road, Suite 250,
`Gaithersburg, MD 20878, USA
`Tel.: +1 301 556 4500
` Fax: +1 301 556 4501, rkenney@iomai.com
`
`(cid:127)
`
`(cid:127)
`
`(cid:127)
`
`(cid:127)
`
`(cid:127)
`
`Larry R Ellingsworth, PhD, IOMAI Corporation
`20 Firstfield Road, Suite 250, Gaithersburg,
`MD 20878, USA
`Tel.: +1 301 556 4500
` Fax: +1 301 556 4501
`lellingsworth@iomai.com
`Sarah A Frech, DVM, MPH, IOMAI
`Corporation, 20 Firstfield Road, Suite 250,
`Gaithersburg, MD 20878, USA
`Tel.: +1 301 556 4500
` Fax: +1 301 556 4501, sfrech@iomai.com
`Scott A Hammond, PhD, IOMAI Corporation,
`20 Firstfield Road, Suite 250, Gaithersburg,
`MD 20878, USA, Tel.: +1 301 556 4500
`Fax: +1 301 556 4501, shammond@iomai.com
`J Paul Zoeteweij, PhD, IOMAI Corporation, 20
`Firstfield Road, Suite 250, Gaithersburg, MD
`20878, USA, Tel.: +1 301 556 4500
`Fax +1 301 556 4501, pzoet@iomai.com
`
`www.future-drugs.com
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