3-TIMES-A-WEEK COPAXONE® 40 MG‘
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`Make the move to 3-times-a-week COPAXONEG’ 40 mg, a therapy with proven results
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`Approved for relapsing-remitting multiple sclerosis (RRMS) in 1996, Teva’s COPAXONE® has proven effectiveness
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`and a demonstrated safety and tolerability profile across 5 rigorous, well-controlled clinical studies.1
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`3-times-a-week COPAXONE® 40 mg was studied in the largest pivotal trial ever conducted for C0PAXONE®.1
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`With 3—times—a—week COPAXONE® 40 mg, you can have the proven effectiveness of Teva’s COPAXONE® — plus
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`208 fewer injections per year compared to daily COPAXONE® 20 mg.1
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`.
`3't|mE5'a'WBBk
`
`iglatiramer acetate
`miectmn)
`mg
`
`“I'D:
`
`1404 llllpie 'll'ii2i"| FIRMS
`- 943 taking COP.ll)iDNE' 40 mg
`- 461 taking placebo
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`‘WI-lfiT:
`A12-month,doub|e-blind,
`placebocontrolled,
`multinational study
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`“HY:
`- The primary siudy objective
`was to measure the total
`
`number of confinned relapses
`||"| penple with RFIMS over a
`12-month period
`0 The secondary study objective
`was to measure the reduction
`in the cumulative number ofTl
`and T2 lesions—types of brain
`lesions as assessed by MRI—
`at 6 and 12 months
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`3—times—a—week COPAXONEQ 40 mg reduced the number of relapses by 34% compared with placebo (an inactive
`substance)
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`Primary Study Results:
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`
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`34%
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` Relapses, am) called flare-ups or attacks,
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`fewer relapses compared
`with placebo‘
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`can cause new symptoms to occur and
`make old symptoms worse.
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`3—times—a—week COPAXONE® 40 mg showed a significant cumulative reduction in the underlying disease activity
`as measured by brain lesions on magnetic resonance imaging (MRI) at 6 and 12 months compared to placebo.
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`Secondary Study Results:
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`35%
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` 1
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`retluctinn in the total
`number of new and
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`enlarging T2 lesions
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`45%
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`radiation in the total number
`of enhancing lesions on
`T1-weiglttetl images‘
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`- T2 Lesions snow areas
`where the brain tissue
`has been damaged
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`- T1—enhancing lesiens,a|so known
`as Gadolinium enhancing T1 Lesions,
`show areas where brain tissue is
`currently being attacked.
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`Make the move to a 3 times a week schedule that fits into your life
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`With 3-times-a-week COPAXONE® (glatiramer acetate injection) 40 mg, you have the freedom to choose a dosing
`schedule that works for you. For example, if you want your weekends to be injection free, you can choose
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`Monday, Wednesday, and Friday as your injection days.
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`SAMPLE SCHEDULE: 3-times-a-week oosel
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`Injections at least 48 hours apart
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`You should receive your first injection of Teva’s COPAXONE® with a doctor or nurse present. This might be in
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`your home or at your doctor's office with an injection training nursel
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`Make 3-times-a-week COPAXONE® 40 mg part of your routine
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`- 3-times-a-week COPAXONE® 40 mg should be given, if possible, at approximately the same time and on
`the same 3 days each week (for example, Monday, Wednesday, Friday); and at least 48 hours apart
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`- Keeping to a set schedule may help your injection become a more regular part of your routine, keep you
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`from forgetting to take it, and even help you stay on track with your therapy goals
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`- The 3—times-a-week COPAXONE® 40 mg injection is given just under the skin (subcutaneously)
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`How to make the move to 3-times-a-week COPAXONEQ 40 mg
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`- Speak with your doctor if you think 3-times-a-week COPAXONE® 40 mg is right for you.
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`- Call Shared Solutions® if you’d like us to reach out to your doctor on your behalf to request a change in
`your prescription. We will send your doctor our Prescription and Service Request Form.
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`- Your doctor may complete the form and send in your prescription, or he or she may ask to see you before a
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`prescription is written. If your doctor wants to see you, we will call you back to let you know.
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`Once you have your prescription and are ready to start 3-times-a-week COPAXONE® 40 mg
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`Follow these steps to ensure a smooth transition from daily COPAXONE® 20 mg. It is highly recommended that
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`you schedule injection training with a Shared Solutions® nurse before starting 3-times-a-week
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`COPAXONE® 40 mg.
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`Plan ahead. Choose a 3 times a week schedule that works for you
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`[for example: MC-nday,Wednesday,and Friday}; injections at Least 43 hours apart’-
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`Take your last dose of daily COPAXONEE‘ 20 mg
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`Start your 3-times-a—week CUPAXUNE5‘ 40 mg routine 1 to 2 days
`after your last dose of COPAXONE“-9 20 mg
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`Have questions about setting up your injection schedule for 3-times-a-week COPAXONE® 40 mg? Ask Claire, your
`Virtual Health Assistant, at the top right corner of this page. Once you've logged in, Claire can guide you through
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`the process of choosing your injection settings and creating your personalized injection schedule.
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`Use the information in this section as a springboard for discussions with your health care provider and for your
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`own research. Claire is not meant to provide medical advice or to replace the guidance ofa doctor.
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`Teva'sCOPAXONE® | YourCOPAXONE®Prescription
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