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`U8008846112B2
`
`(12) United States Patent
`Baldassarre
`
`(10) Patent No.:
`
`(451 Date of Patent:
`
`US 8,846,112 32
`*Sep.30,2014
`
`(54)
`
`METHODS OF DISTRIBUTING A
`PHARMACEUTICAL PRODUCT
`COS/[PRISING NITRIC OXIDE GAS FOR
`INIIALA’I‘ION
`
`(71)
`
`Appliczuit: INO Therapeutics LLC, l-lampton. NJ
`(US)
`
`(72)
`
`Inventor:
`
`James S. Baldassarre. Doylestown. PA
`(US)
`
`(73)
`
`Assignee:
`
`INO Therapeutics LLC. Hampton. NJ
`(US)
`
`(*1
`
`Notice:
`
`Subject to any disclaimer. the term of this
`patent is extended or adjusted under 35
`11.51:. 1540:) by 0 days.
`
`This patent is subject to a terminal dis-
`claimer.
`
`120
`
`Appl. No: 13/683,236
`
`021
`
`l’iled:
`
`Nov. 21, 2012
`
`051
`
`(60)
`
`(51)
`
`(52)
`
`(53)
`
`Prior Publication Data
`
`US 201370068223 Al
`
`Mar. 21. 2013
`
`Related US. Application Data
`
`Division of application No. 127820.866, filed on Jun.
`22. 2010. now abandoned, which is a continuation of
`application No. 127494.598. filed on Jun. 30. 2009.
`now abandoned. application No. 137683.236. which is
`a division ot‘application No. 137651.660. filed on Oct.
`15. 2012. now Pat. No. 8,431,163, which is a
`continuation ofapplication No. 12/821,041. filed on
`Jun. 22. 2010, now Pat. No. 8,293,284. which is a
`continuation of application No. 127494.598. filed on
`Jun. 30. 2009. now abandoned.
`
`(2006.01 )
`(2006.01)
`(2006.01)
`(2006.01 )
`(2006.01)
`(2006.01 1
`{2006.01 )
`(2006.01 )
`(2006.01)
`
`Int. (:1.
`A01N59/00
`can: 21/24
`A6IM 111/00
`A61K 31/21
`A6113 3/03
`A61‘M its/12
`(161K 45/116
`Air/K 33/00
`(mg 99/00
`0.5. (:1.
`CPC‘ ................. A61K33/00 (2013.01): A61K 31/91
`(2013.01 ): A613 8/48 (2013.01):A6I1W 113/12
`(2013.01); A61K 45/196 (2013.01 ): GflfiQ 99200
`(201301)
`4247718; 128720024; 423K405
`USPC
`Field of Classification Search
`USPC.‘
`4247718: 128720024; 4237405
`See application file for complete search history.
`
`(56)
`
`References Cited
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`
`EP
`W0
`W0
`W0
`
`1682672
`W02 005 004 884
`WO2006 | 27907
`W02010019540
`
`7-2006
`112005
`11-"2006
`2.12010
`
`OTHER PUBLlCATlONS
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`merriain-webster.com-"dictionary.-"supplying 4 pages.*
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`Ernst V Arnold
`Prinmry Exmniner
`(74) Arm/trier. .vigem‘. or I‘i‘mi — liislt 8.: Richardson RC.
`
`(57)
`
`ABSTRACT
`
`Disclosed are methods ofdistributing a pharmaceutical prod-
`uct comprising nitric oxide gas. The methods include supply-
`ing a source ofnitric oxide gas to a medical provider. inform-
`ing the medical provider about a recommended dose of
`inhaled nitric oxide gas For treatment of neonates with
`hypoxic respiratory failure. and providing a warning about
`use of inhaled nitric oxide in patients with preexisting left
`ventricular dysfunction.
`
`19 Claims, .Vo Drawings
`
`001
`
`PRAXAIR 1001
`
`PRAXAIR 1001
`
`001
`
`

`

`US 8,846,112 BZ
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