`is
`to
`heart
`
`
`Claims 3, 5, 15, 16, 36, and 41 of the ʼ741 patent are unpatentable under 35
`U.S.C. § 103(a) as obvious over Bernasconi in view of Loh, Goyal, and Macrae.
`
`U.S. Pat. No.
`8,795,741
`CLAIM 3
`The method of claim
`1, wherein the left
`ventricular
`dysfunction of
`second
`patient
`attributable
`congenital
`disease.
`
`Beranasconi, Loh, Goyal, and Macrae
`
`
`All the elements of the independent claim from which this
`claim depends are disclosed in Bernasconi, Loh, and Goyal
`as outlined in Ex. 1042 in Claim 1.
`
`Macrae teaches left ventricular dysfunction (“LVD”) can be
`attributable to congenital heart disease.
`
`
`
`Ex. 1008 at 374.
`
`All the elements of the independent claim from which this
`claim depends are disclosed in Bernasconi, Loh, and Goyal
`as outlined in Ex. 1042 in Claim 4.
`
`Macrae teaches LVD can be attributable to congenital heart
`disease.
`
`CLAIM 5
`The method of claim
`4, wherein the left
`ventricular
`dysfunction of
`second
`patient
`attributable
`congenital
`disease.
`
`the
`is
`to
`heart
`
`CLAIM 15
`The method of claim
`9, wherein the left
`ventricular
`dysfunction of
`second
`patient
`
`the
`is
`
`Ex. 1008 at 374.
`
`All the elements of the independent claim from which this
`claim depends are disclosed in Bernasconi, Loh, and Goyal
`as outlined in Ex. 1042 in Claim 9.
`
`Macrae teaches LVD can be attributable to congenital heart
`
`
`
`
`
`1
`
`
`
`
`
`U.S. Pat. No.
`8,795,741
`attributable
`congenital
`disease.
`
`to
`heart
`
`disease.
`
`Beranasconi, Loh, Goyal, and Macrae
`
`
`
`Ex. 1008 at 374.
`
`All the elements of the independent claim from which this
`claim depends are disclosed in Bernasconi, Loh, and Goyal
`as outlined in Ex. 1042 in Claim 14.
`
`Macrae teaches LVD can be attributable to congenital heart
`disease.
`
`
`
`Ex. 1008 at 374.
`
`All the elements of the independent claim from which this
`claim depends are disclosed in Bernasconi, Loh, and Goyal
`as outlined in Ex. 1042 in Claim 34.
`
`Macrae teaches LVD can be attributable to congenital heart
`disease.
`
`CLAIM 16
`The method of claim
`14, wherein the left
`ventricular
`dysfunction of
`second
`patient
`attributable
`congenital
`disease.
`
`the
`is
`to
`heart
`
`CLAIM 36
`The method of claim
`34, wherein the left
`ventricular
`dysfunction of
`second
`patient
`attributable
`congenital
`disease.
`
`the
`is
`to
`heart
`
`
`
`
`
`2
`
`Ex. 1008 at 374.
`
`
`
`CLAIM 41
`
`
`
`
`
`
`
`U.S. Pat. No.
`8,795,741
`The method of claim
`37, wherein the left
`ventricular
`dysfunction of
`second
`patient
`attributable
`congenital
`disease.
`
`the
`is
`to
`heart
`
`Beranasconi, Loh, Goyal, and Macrae
`All the elements of the independent claim from which this
`claim depends are disclosed in Bernasconi, Loh, and Goyal
`as outlined in Ex. 1042 in Claim 1.
`
`Macrae teaches LVD can be attributable to congenital heart
`disease.
`
`
`
`Ex. 1008 at 374.
`
`
`
`3