US008795741B2
`
`(12)
`
`United States Patent
`
`Baldassarre
`
`(10) Patent No.:
`(45) Date of Patent:
`
`US 8,795,741 B2
`*Aug. 5, 2014
`
`(54) METHODS FOR TREATING PATIENTS WHO
`ARE CANDIDATES FOR INHALED NITRIC
`OXIDE TREATMENT
`
`A
`(71) Applicant: INO Therapeutics LLC. llainplon. NJ
`(US)
`
`(72)
`
`Inventor:
`
`James S. Baldassarre, Doylestown. PA
`(US)
`
`(73) Assigncc:
`
`[N0 Therapeutics LLC. llaniplon. NJ
`(US)
`
`1‘
`
`_
`) Notice:
`
`(
`
`A
`_
`_
`A
`‘
`Subject to any disclaimer. the term of 1111s
`patent is extended or adjusted under 35
`U.S.C. 15-'-l(b) by 0 days.
`
`This patent is subject to a terminal dis—
`claimer.
`
`(21) Appl‘ Nu: 13f683,4] 7
`
`(22) Wed:
`
`(65)
`
`Us
`
`NW‘ 21’ 2012
`‘
`_
`‘
`Prlor Publlcatmn Data
`Mar‘ 28. 20l3
`
`(56)
`
`References Cited
`
`U.S. PATENT DOCUMENTS
`
`5.558.083 A
`5.651.358 A
`5.873.359 A
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`
`(63) Continuation of application No. 127820.866. filed on
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`N 12,821 mu m _d
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`8,293,284. which is a continuation ofapplication No.
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`127494.598, tiled on Jun. 30. 2009, now abandoned.
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`specllye ol Etiology. Journal ol the Alnerlean College ()1 Cardiology
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`Krohn "I.-Effect of inhaled nitric oxide on left ventricular 1nd ulmo-
`'
`.
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`‘
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`P
`nary vascular l'lIl‘lCilOl'].
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`.-"r.r‘mr:rr_1-‘ liraiiriner
`(74) /trmrnq1=.Agem.or Fire:
`1"is11 & Richardson 1-’.C.
`
`J
`
`ABSTRACT
`(57)
`Disclosed are methods of reducing the risk that a medical
`treatment comprising inhalation of nitric oxide gas will
`‘
`‘
`-
`-
`-
`induce an increase in pulmonary capillary wedge pressure 111
`the patient. leading to pulmonary edema.
`
`See application lile R11" complete search history.
`
`44 Claims, N0 Drawings
`
`001
`
`PRAXAIR 1001
`
`PRAXAIR 1001
`
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`
`

`
`US 8,795,741 B2
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`
`US 8,795,741 B2
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